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Associate Professor Allan Coombes

Honorary Associate Professor
School of Pharmacy

Publications

Journal Articles (52)
Conference Papers (2)

Journal Articles

Samak, Yassmin O., Santhanes, Diviya, El-Massik, Magda A. and Coombes, Allan G. A. (2019). Formulation strategies for achieving high delivery efficiency of thymoquinone-containing Nigella sativa extract to the colon based on oral alginate microcapsules for treatment of inflammatory bowel disease. Journal of Microencapsulation, 36 (2), 204-214. doi: 10.1080/02652048.2019.1620356
Saleem, Imran, Coombes, Allan G. A. and Chambers, Mark A. (2019). In vitro evaluation of eudragit matrices for oral delivery of BCG vaccine to animals. Pharmaceutics, 11 (6) 270, 270. doi: 10.3390/pharmaceutics11060270
Fernando, Hevanshi Vidhushika, Chan, Li Li, Dang, Nhung, Santhanes Sandanaeaspuran, Diviya, Banneheke, Hasini, Nalliah, Sivalingam and Coombes, Allan Ga (2018). Controlled delivery of the antiprotozoal agent (tinidazole) from intra-vaginal polymer matrices for treatment of the sexually transmitted infection, trichomoniasis. Pharmaceutical Development and Technology, 24 (3), 1-9. doi: 10.1080/10837450.2018.1481430
Pathak, Meenakshi, Coombes, Allan G. A., Ryu, BoMi, Cabot, Peter J., Turner, Mark S., Palmer, Cheryn, Wang, Dongjie and Steadman, Kathryn J. (2018). Sustained Simultaneous Delivery of Metronidazole and Doxycycline From Polycaprolactone Matrices Designed for Intravaginal Treatment of Pelvic Inflammatory Disease. Journal of Pharmaceutical Sciences, 107 (3), 863-869. doi: 10.1016/j.xphs.2017.09.033
Pathak, Meenakshi, Coombes, Allan G. A., Turner, Mark S., Palmer, Cheryn, Wang, Dongjie and Steadman, Kathryn J. (2015). Investigation of polycaprolactone matrices for intravaginal delivery of doxycycline. Journal of Pharmaceutical Sciences, 104 (12), 4217-4222. doi: 10.1002/jps.24652
Ma, Yiming, Fuchs, Adrian V., Boase, Nathan R. B., Rolfe, Barbara E., Coombes, Allan G. A. and Thurecht, Kristofer J. (2015). The in vivo fate of nanoparticles and nanoparticle-loaded microcapsules after oral administration in mice: evaluation of their potential for colon-specific delivery. European Journal of Pharmaceutics and Biopharmaceutics, 94, 393-403. doi: 10.1016/j.ejpb.2015.06.014
Dang, Nhung T. T., Sivakumaran, Haran, Harrich, David, Shaw, Paul N., Davis-Poynter, Nicholas and Coombes, Allan G. A. (2014). Synergistic activity of tenofovir and nevirapine combinations released from polycaprolactone matrices for potential enhanced prevention of HIV infection through the vaginal route. European Journal of Pharmaceutics And Biopharmaceutics, 88 (2), 406-414. doi: 10.1016/j.ejpb.2014.05.018
Dang, Nhung, Sivakumaran, Haran, Harrich, David, Shaw, P. Nicholas and Coombes, Allan G. A. (2014). Evaluation of polycaprolactone matrices for sustained vaginal delivery of nevirapine in the prevention of heterosexual HIV transmission. Journal of Pharmaceutical Sciences, 103 (7), 2107-2115. doi: 10.1002/jps.24030
Pathak, Meenakshi, Turner, Mark, Palmer, Cheryn and Coombes, Allan G. A. (2014). Evaluation of polycaprolactone matrices for the intravaginal delivery of metronidazole in the treatment of bacterial vaginosis. Journal of Biomaterials Applications, 29 (3), 354-363. doi: 10.1177/0885328214528256
Hariyadi, D. M., Ma, Y., Wang, Y., Bostrom, T., Malouf, J., Turner, M. S., Bhandari, B. and Coombes, A. G. A. (2014). The potential for production of freeze-dried oral vaccines using alginate hydrogel microspheres as protein carriers. Journal of Drug Delivery Science and Technology, 24 (2), 178-184. doi: 10.1016/S1773-2247(14)50029-9
Asvadi, Naghme Hajarol, Dang, Nhung T. T., Davis-Poynter, Nicholas and Coombes, Allan G. A. (2013). Evaluation of microporous polycaprolactone matrices for controlled delivery of antiviral microbicides to the female genital tract. Journal of Materials Science: Materials in Medicine, 24 (12), 2719-2727. doi: 10.1007/s10856-013-5010-6
Ma, Yiming and Coombes, Allan G. A. (2013). Designing colon-specific delivery systems for anticancer drug-loaded nanoparticles: an evaluation of alginate carriers. Journal of Biomedical Materials Research: Part A, Early View (9), 1-10. doi: 10.1002/jbm.a.34988
Sohail, Asma, Turner, Mark S., Coombes, Allan and Bhandari, Bhesh (2013). The Viability of Lactobacillus rhamnosus GG and Lactobacillus acidophilus NCFM Following Double Encapsulation in Alginate and Maltodextrin. Food and Bioprocess Technology, 6 (10), 2763-2769. doi: 10.1007/s11947-012-0938-y
Dang, Nhung T. T., Sivakumaran, Haran, Harrich, David and Coombes, Allan G. A. (2013). An evaluation of polycaprolactone matrices for vaginal delivery of the antiviral, tenofovir, in preventing heterosexual transmission of HIV. Journal of Pharmaceutical Sciences, 102 (10), 3725-3735. doi: 10.1002/jps.23684
Dang, Nhung T. T., Turner, Mark S. and Coombes, Allan G. A. (2013). Development of intra-vaginal matrices from polycaprolactone for sustained release of antimicrobial agents. Journal of Biomaterials Applications, 28 (1), 74-83. doi: 10.1177/0885328212437393
Sohail, Asma, Turner, Mark S., Prabawati, Elisabeth Kartika, Coombes, Allan G. A. and Bhandari, Bhesh (2012). Evaluation of Lactobacillus rhamnosus GG and Lactobacillus acidophilus NCFM encapsulated using a novel impinging aerosol method in fruit food products. International Journal of Food Microbiology, 157 (2), 162-166. doi: 10.1016/j.ijfoodmicro.2012.04.025
Hariyadi, Dewi Melani, Wang, Yiwei, Lin, Sharon Chien-Yu, Bostrom, Thor, Bhandari, Bhesh and Coombes, Allan G. A. (2012). Novel alginate gel microspheres produced by impinging aerosols for oral delivery of proteins. Journal of Microencapsulation, 29 (3), 250-261. doi: 10.3109/02652048.2011.646329
Sohail, A., Bhandari, B., Turner, M. S. and Coombes, A. G. A. (2012). Direct encapsulation of small molecule hydrophilic and hydrophobic actives in alginate microspheres using a novel impinging aerosols method. Journal of Drug Delivery Science and Technology, 22 (2), 139-143. doi: 10.1016/S1773-2247(12)50018-3
Hariyadi, Dewi Melani, Bostrom, Thor, Bhandari, Bhesh and Coombes, Allan G. A. (2012). A novel impinging aerosols method for production of propranolol hydrochloride-loaded alginate gel microspheres for oral delivery. Journal of Microencapsulation, 29 (1), 63-71. doi: 10.3109/02652048.2011.629746
Sohail, Asma, Turner, Mark, Coombes, Allan, Bostrom, Thor and Bhandari, Bhesh R. (2011). Survivability of probiotics encapsulated in alginate gel microbeads using a novel impinging aerosols method. International Journal of Food Microbiology, 145 (1), 162-168. doi: 10.1016/j.ijfoodmicro.2010.12.007
Hariyadi, Dewi M., Lin, Sharon Chien-Yu, Wang, Yiwei, Bostrom, Thor, Turner, Mark S., Bhandari, Bhesh and Coombes, Allan G. A. (2010). Diffusion loading and drug delivery characteristics of alginate gel microparticles produced by a novel impinging aerosols method. Journal of Drug Targeting, 18 (10), 831-841. doi: 10.3109/1061186X.2010.525651
Wang, Yiwei, Lam, Jenny, Zhang, Bufa, Tomlins, Paul E., Li, Xiongwei, Alpar, Oya, Wertheim, David F., Jones, Allan S. and Coombes, Allan G. A. (2010). Biomechanical characterization of a micro/macroporous polycaprolactone tissue integrating vascular graft. Cardiovascular Engineering and Technology, 1 (3), 202-215. doi: 10.1007/s13239-010-0019-1
Wang, Yiwei, Wertheim, David F., Jones, Allan S., Chang, Hsin-I and Coombes, Allan G.A. (2010). Micro-CT analysis of matrix-type drug delivery devices and correlation with protein release behaviour. Journal of Pharmaceutical Sciences, 99 (6), 2854-2862. doi: 10.1002/jps.22027
Chang, H.-I., Wang, Y., Perrie, Y. and Coombes, A. G. A. (2010). Microporous polycaprolactone matrices for drug delivery and tissue engineering: The release behaviour of bioactives having extremes of aqueous solubility. Journal of Drug Delivery Science and Technology, 20 (3), 207-212. doi: 10.1016/S1773-2247(10)50031-5
Wang, Yiwei, Tomlins, Paul E, Coombes, Allan G. A. and Rides, Martin (2010). On the determination of Darcy permeability coefficients for a microporous tissue scaffold. Tissue Engineering Part C- Methods, 16 (2), 281-289. doi: 10.1089/ten.tec.2009.0116
Wang, Y., Wertheim, DF, Jones, AS and Coombes, A. (2010). Micro-CT in drug delivery. European Journal of Pharmaceutics and Biopharmaceutics, 74 (1), 41-49. doi: 10.1016/j.ejpb.2009.05.008
Wang, Yiwei, Chang, Hsin-I., Li, Xiongwei, Alpar, Oyar and Coombes, Allan G. A. (2009). Delivery of bioactive macromolecules from microporous polymer matrices: Release and activity profiles of lysozyme, collagenase and catalase. European Journal of Pharmaceutical Sciences, 37 (3-4), 387-394. doi: 10.1016/j.ejps.2009.03.010
Chang, H.-I., Lau, Y.-C., Yan, C. and Coombes, A. G .A. (2008). Controlled release of an antibiotic, gentamicin sulphate, from gravity spun polycaprolactone fibers. Journal of Biomedical Materials Research Part A, 84A (1), 230-237. doi: 10.1002/jbm.a.31476
Kirby, D. J., Rosenkrands, I., Agger, E. M., Andersen, P., Coombes, A. G. A. and Perrie, Y. (2008). Liposomes act as stronger sub-unit vaccine adjuvants when compared to microspheres. Journal of Drug Targeting, 16 (7-8), 543-554. doi: 10.1080/10611860802228558
Kirby, D. J., Rosenkrands, I., Agger, E. M., Andersen, P., Coombes, A. G. A. and Perrie, Y. (2008). PLGA microspheres for the delivery of a novel subunit TB vaccine. Journal of Drug Targeting, 16 (4), 282-293. doi: 10.1080/10611860801900462
Wang, Yiwei, Chang, Hsin-I, Wertheim, David F., Jones, Allan S., Jackson, Chris and Coombes, Allan G. A. (2007). Characterisation of the macroporosity of polycaprolactone-based biocomposites and release kinetics for drug delivery. Biomaterials, 28 (31), 4619-4627. doi: 10.1016/j.biomaterials.2007.07.006
Mohammed, Afzal R., Coombes, Allan G. A. and Perrie, Yvonne (2007). Amino acids as cryoprotectants for liposomal delivery systems. European Journal of Pharmaceutical Sciences, 30 (5), 406-413. doi: 10.1016/j.ejps.2007.01.001
Wang, Y, Chang, HI, Wertheim, DF, Jones, AS and Coombes, AGA (2007). Polycaprolactone-based biocomposite scaffolds for tissue engineering: Assessment of macroporosity using micro computed tomography (micro-CT). Tissue Engineering, 13 (7), 1742-1743.
Kavvada, Klairi M., Murray, James G., Moore, Vanessa A., Coombes, Alan G. A. and Hanson, Peter J. (2006). High permeability of the anionic form restricts accumulation of indomethacin by cultured gastric surface epithelial cells exposed to low apical pH. European Journal of Pharmacology, 549 (1-3), 41-49. doi: 10.1016/j.ejphar.2006.08.033
Mohammed, Afzal R., Bramwell, Vincent W., Coombes, Allan G. A. and Perrie, Yvonne (2006). Lyophilisation and sterilisation of liposomal vaccines to produce stable and sterile products. Methods, 40 (1), 30-38. doi: 10.1016/j.ymeth.2006.05.025
Williamson, Matthew Richard, Adams, Eric F. and Coombes, Allan G. A. (2006). Gravity spun polycaprolactone fibres for soft tissue engineering: Interaction with fibroblasts and myoblasts in cell culture. Biomaterials, 27 (7), 1019-1026. doi: 10.1016/j.biomaterials.2005.06.018
Chang, H. I., Perrie, Y. and Coombes, A. G. A. (2006). Delivery of the antibiotic gentamicin sulphate from precipitation cast matrices of polycaprolactone. Journal of Controlled Release, 110 (2), 414-421. doi: 10.1016/j.jconrel.2005.10.028
Williamson, Matthew R., Woollard, Kevin J., Griffiths, Helen R. and Coombes, Allan G. A. (2006). Gravity Spun Polycaprolactone Fibers for Applications in Vascular Tissue Engineering: Proliferation and Function of Human Vascular Endothelial Cells. Tissue Engineering, 12 (1), 45-51. doi: 10.1089/ten.2006.12.45
Chang, H. I., Williamson, M. R., Perrie, Y. and Coombes, A. G. A. (2005). Precipitation casting of drug-loaded microporous PCL matrices: Incorporation of progesterone by co-dissolution. Journal of Controlled Release, 106 (3), 263-272. doi: 10.1016/j.jconrel.2005.05.013
Kavvada, Klairi M., Murray, James G., Moore, Vanessa A., Coombes, Alan G. A. and Hanson, Peter J. (2005). A Collagen IV Matrix Is Required for Guinea Pig Gastric Epithelial Cell Monolayers to Provide an Optimal Model of the Stomach Surface for Biopharmaceutical Screening. Journal of Biomolecular Screening, 10 (5), 495-507. doi: 10.1177/1087057105276035
Dai, Niann-Tzyy, Yeh, Ming-Kung, Liu, Demeral David, Adams, E. F., Chiang, Chiao-Hsi, Yen, Chung-Yang, Shih, Chien-Ming, Sytwua, Huey-Kang, Chen, Tim-Mo, Wang, Hsian-Jenn, Williamson, M. R. and Coombes, A. G. A. (2005). A Co-cultured Skin Model Based on Cell Support Membranes. Biochemical and Biophysical Research Communication, 329 (3), 905-908. doi: 10.1016/j.bbrc.2005.02.059
Saleem, I. Y., Vordermeier, M., Barralet, J. E. and Coombes, A. G. A. (2005). Improving Peptide-based Assays to Differentiate Between Vaccination and Mycobacterium Bovis Infection in Cattle Using Nanoparticle Carriers for Adsorbed Antigens. Journal of Controlled Release, 102 (3), 551-561. doi: 10.1016/j.jconrel.2004.10.034
Williamson, M. R., Chang, H-I. and Coombes, A. G. A. (2004). Gravity spun polycaprolactone fibres : controlling release of a hydrophilic macromolecule (ovalbumin) and a lipophilic drug (progesterone).. Biomaterials, 25 (20), 5053-5060. doi: 10.1016/j.biomaterials.2004.02.027
Dai, N. -T., Williamson, M. R., Khammo, N., Adams, E. F. and Coombes, A. G. A. (2004). Composite Cell Support Membranes Based on Collagen and Polycaprolactone for Tissue Engineering of Skin. Biomaterials, 25 (18), 4263-4271. doi: 10.1016/j.biomaterials.2003.11.022
Turner, P., Coombes, A. G. A. and Al-Rubeai, M. (2004). Measuring the heterogeneity of protein loading in PLG microspheres using flow cytometry. Journal of controlled release, 96 (1), 193-205. doi: 10.1016/j.jconrel.2004.01.015
Williamson, Matthew R. and Coombes, Allan G. A. (2004). Gravity spinning of Polycaprolactone Fibres for Applications in Tissue Engineering. Biomaterials, 25 (3), 459-465. doi: 10.1016/S0142-9612(03)00536-2
Coombes, A. G. A., Rizzi, S. C., Williamson, M., Barralet, J. E., Downes, S. and Wallace, W. A. (2004). Precipitation Casting of Polycaprolactone for Applications in Tissue Engineering and Drug Delivery. Biomaterials, 25 (2), 315-325. doi: 10.1016/S0142-9612(03)00535-0
Mohammed, A. R., Weston, N., Coombes, A. G. A., Fitzgerald, M. and Perrie, Y. (2004). Liposome formulation of poorly water soluble drugs: Optimisation of drug loading and ESEM analysis of stability. International Journal of Pharmaceutics, 285 (1-2), 23-34. doi: 10.1016/j.ijpharm.2004.07.010
Yeh, M.-K, Coombes, A. G. A., Chen, J.-L. and Chiang, C.-H. (2002). Japanese Encephalitis Virus Vaccine Formulations Using PLA Lamellar and PLG Microparticles. Journal Microencapsulation, 19 (5), 671-682. doi: 10.1080/02652040210142551
Coombes, A. G. A., Verderio, E., Shaw, B., Li, X., M. Griffin and Downes, S. (2002). Biocomposites of Non-crosslinked Natural and Synthetic Polymers. Biomaterials, 23 (10), 2113-2118. doi: 10.1016/S0142-9612(01)00341-6
Moynihan, Jennifer S., Blair, Julian, Coombes, Allan, D’Mello, Felicity and Howard, Colin R. (2002). Enhanced Immunogenicity of a Hepatitis B Virus Peptide Vaccine using Oligosaccharide Ester Derivative Microparticles. Vaccine, 20 (13-14), 1870-1876. doi: 10.1016/S0264-410X(01)00494-7
Barralet, J. E., Aldred, S., Wright, A. J. and Coombes, A. G. A. (2002). In vitro behavior of albumin-loaded carbonate hydroxyapatite gel. Journal of Biomedical Materials. Research Part A, 60 (3), 360-367. doi: 10.1002/jbm.10070

Conference Papers

Coombes, Allan, Wang, Yiwei, Wertheim, David and Jones, Allan (2011). Elucidating the protein release behaviour of matrix-type delivery devices using micro-CT. 3rd International Conference on Drug Discovery and Therapy (ICDDT), Dubai, United Arab Emirates, 7-11 February 2011. Bussum, Netherlands: Bentham Science.
Wang, Yiwei, Chang, Hsin-I, Wertheim, David F., Jones, Allan S., Jackson, Chris and Coombes, Allan G.A. (2007). Characterising the macroporosity Of polymeric matrices designed for protein delivery and tissue engineering. 2007 Annual Confernece Medicines: Design to Delivery, Sydney, Australia, 8 - 11 December 2007.