Speaker

Assistant Professor Jinmyoung Joo (Ulsan National Institute of Science and Technology)

Abstract

Versatile nanoplatforms based on biodegradable porous silicon nanoparticles have attracted great attention as a potential biomedical agent. In this talk, biomedical strategy of photoluminescent silicon nanoparticles will be presented. Molecular therapeutics and oligonucleotides are readily loaded to the porous silicon nanoparticles, which securely protects the drug payloads from burst release and possible deactivation in physiological condition. Conjugating to a homing peptide, screened from in vivo phage displays, the nanoparticles show greater targeting capability and cellular uptake, resulting in remarkably enhanced therapeutic efficiency. Systemic administration of the peptide-targeted nanoparticles into mice shows significant accumulation of the drug payloads to the target organs while reduces unwanted side effects in healthy tissues. These biocompatible and selfdestructive nanocarriers present promising potential for therapeutic application via targeted delivery. Tailoring design strategies of the silicon nanoparticle platforms and their practical applications as a theranostic agent are also discussed.

Speaker Bio

Jinmyoung JooJinmyoung Joo is an Assistant Professor of Biomedical Engineering at the Ulsan National Institute of Science and Technology (UNIST), where he holds an affiliate appointment in the Chemical Engineering. He received B.S. (2007) and Ph.D. (2012) degrees in Chemical Engineering from Pohang University of Science and Technology. His thesis involved the studies on the synthesis of nanoscale materials and the characterization of the unique properties of inorganic nanoparticles, along with the demonstration in environmental and biological applications. He then continued his studies on the functional nanomaterials for biomedical applications as a postdoctoral research associate in the Department of Chemistry and Biochemistry at University of California, San Diego. He started his independent career as an Assistant Professor in the Department of Convergence Medicine at the University of Ulsan College of Medicine and Asan Medical Center in 2016, and he joined the faculty in the School of Life Science at the UNIST in January, 2019. He has been interested in understanding the interaction of nanomaterials with complex biological systems, engineering novel nanostructures that can effectively understand tissue microenvironment and target diseases such as cancer and neurodegenerative diseases. His lab has focuses on leveraging nanoscale materials to study biological findings and to bridge them to translational medical platforms such as bioimaging and drug delivery systems.

About Seminar Series

The School of Pharmacy Seminar Series involves regular formal presentations of high-quality scholarly work with broad appeal.

The wider School community is invited to attend, including academic and professional staff, special guests, visitors, as well as HDR, postgraduate, masters and honours students.

Seminars are held on Fridays from 12pm–1pm in room 5034 in the Pharmacy Australia Centre of Excellence, 20 Cornwall St Woolloongabba (next to TRI and the PA Hospital).

Confirmed 2021 seminars

Date Presenter
12-1pm, Friday 19 March
(PACE R5034 and Zoom)
Professor Paul Clarke, Director Diamantina Institute        
12-1pm, Friday 16 April
(Zoom only)
Associate Professor Francine Marques, Monash University     
12-1pm, Friday 23 April
(Zoom only)
Associate Professor Ben Colagiuri, Sydney University 
12-1pm, Friday 7 May
(Zoom only)
Dr Laurence Cheung, Curtin University
12-1pm, Friday 30 July
(location TBC)
Dr Gary Chan, UQ CYSUR
12-1pm, Friday 13 August
(Zoom only)
Professor Sanjay Garg, University of South Australia
12-1pm, Friday 3 September
(PACE R5034 and Zoom)
Associate Professor Michael Barras, UQ Pharmacy
12-1pm 10 September
(Online via Zoom)

Professor Josephine Forbes, Mater Research

 

12-1pm, Friday 17 September
(PACE R5034 and Zoom)

Professor Nigel McMillan, Program Director: Infectious Diseases and Immunology, Menzies Health Institute QLD, Griffith University

12-1pm, Friday 24 September
(Location TBC)
Denuja Karunakaran, IMB Fellow, Institute for Molecular Bioscience (IMB), UQ

Venue

Pharmacy Australia Centre of Excellence, 20 Cornwall St, Woolloongabba
Room: 
5034