Speaker

Assistant Professor Jinmyoung Joo (Ulsan National Institute of Science and Technology)

Abstract

Versatile nanoplatforms based on biodegradable porous silicon nanoparticles have attracted great attention as a potential biomedical agent. In this talk, biomedical strategy of photoluminescent silicon nanoparticles will be presented. Molecular therapeutics and oligonucleotides are readily loaded to the porous silicon nanoparticles, which securely protects the drug payloads from burst release and possible deactivation in physiological condition. Conjugating to a homing peptide, screened from in vivo phage displays, the nanoparticles show greater targeting capability and cellular uptake, resulting in remarkably enhanced therapeutic efficiency. Systemic administration of the peptide-targeted nanoparticles into mice shows significant accumulation of the drug payloads to the target organs while reduces unwanted side effects in healthy tissues. These biocompatible and selfdestructive nanocarriers present promising potential for therapeutic application via targeted delivery. Tailoring design strategies of the silicon nanoparticle platforms and their practical applications as a theranostic agent are also discussed.

Speaker Bio

Jinmyoung JooJinmyoung Joo is an Assistant Professor of Biomedical Engineering at the Ulsan National Institute of Science and Technology (UNIST), where he holds an affiliate appointment in the Chemical Engineering. He received B.S. (2007) and Ph.D. (2012) degrees in Chemical Engineering from Pohang University of Science and Technology. His thesis involved the studies on the synthesis of nanoscale materials and the characterization of the unique properties of inorganic nanoparticles, along with the demonstration in environmental and biological applications. He then continued his studies on the functional nanomaterials for biomedical applications as a postdoctoral research associate in the Department of Chemistry and Biochemistry at University of California, San Diego. He started his independent career as an Assistant Professor in the Department of Convergence Medicine at the University of Ulsan College of Medicine and Asan Medical Center in 2016, and he joined the faculty in the School of Life Science at the UNIST in January, 2019. He has been interested in understanding the interaction of nanomaterials with complex biological systems, engineering novel nanostructures that can effectively understand tissue microenvironment and target diseases such as cancer and neurodegenerative diseases. His lab has focuses on leveraging nanoscale materials to study biological findings and to bridge them to translational medical platforms such as bioimaging and drug delivery systems.

About Seminar Series

The School of Pharmacy Seminar Series involves regular formal presentations of high-quality scholarly work with broad appeal.

The wider School community is invited to attend, including academic and professional staff, special guests, visitors, as well as HDR, postgraduate, masters and honours students.

Seminars are held on Fridays from 12pm–1pm in room 5034 in the Pharmacy Australia Centre of Excellence, 20 Cornwall St Woolloongabba (next to TRI and the PA Hospital).

Confirmed 2022 seminars

Date

Presenter

12-1pm, Friday 1st April (PACE R5034 and Zoom)

Dr Ran Wang, Mater Research Institute, UQ

12-1pm, Friday 22nd April (Zoom Only)

Dr Joanna Harnett, School of Pharmacy, The University of Sydney

12-1pm, Friday 29th April (PACE R5034 and Zoom)Dr Iman Azimi, Lecturer in Pharmaceutical Science, University of Tasmania

12-1pm, Friday 6th May (PACE R5034 and Zoom)

Dr Larisa Labzin, Institute of Molecular Bioscience, UQ

12-1pm, Friday 20th May (PACE R5034 and Zoom)

Prof Nina Barnett, Consultant Pharmacist,

Visiting Professor Kingston University, UK, London

11am-12pm, Friday 27th May (Zoom only)

Prof Terry Hebert, Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada

12-1pm, Friday 3rd June (PACE R5034 and Zoom)

A/Prof Joy Wolfram, School of Chemical Engineering, UQ

12-1pm, Friday 17th June (PACE R5034 and Zoom)

Dr Rink-Jan Lohman, School of Pharmacy, UQ and

Dr Karnaker Reddy Tupally, School of Pharmacy, UQ

12-1pm, Friday 1st July (PACE R5034 and Zoom)

Dr Khay Fong, School of Environmental Life Sciences, University of Newcastle

Venue

Pharmacy Australia Centre of Excellence, 20 Cornwall St, Woolloongabba
Room: 
5034