Speaker

Prof Ian Henderson (UQ Institute for Molecular Bioscience)

Abstract

Pseudomonas aeruginosa is an opportunistic pathogen known for its ability to cause chronic lung infections in patients with cystic fibrosis.  Such infections lead to chronic inflammation, deteriorating lung function and increased morbidity and mortality. P. aeruginosa is also a major cause of nosocomial infections. It is problematic to manage clinically as it is intrinsically resistant to many antibiotics. Recently, the WHO named P. aeruginosa as a Priority 1 pathogen for which new antibiotics and treatments are desperately needed. Antibodies normally protect individuals against infection. However, we recently identified patients with chronic P. aeruginosa infection that produced specific antibody that protected the infecting bacterium from both serum- and cell-mediated killing. We demonstrated that these ‘inhibitory antibodies’ (iAb) belong to the IgG2 subclass and target lipopolysaccharide on the bacterial surface. Importantly, patients with iAb had worse lung function than infected patients with normal serum killing. Here we describe the successful treatment of patients with chronic P. aeruginosa infections by modulating antibodies. These findings have important consequences for vaccine development and the treatment of multidrug resistant infections.

Speaker Bio

https://imb.uq.edu.au/profile/9708/ian-henderson

Professor Henderson's research group studies bacteria and their interaction with humans and animals. Their research is focused on the discovery of genes that are important for building the cell membrane of bacteria. Using genetic, biochemical and structural techniques they study the activity, regulation and function of these genes and their products. Using mice as a model they assess if the products of these genes are important for infectious disease. The group's purpose is to apply this understanding to the diagnosis, prevention and treatment of infections that can lead to life-threatening disease in humans and animals. Professor Henderson seeks targets for developing new antibiotics, vaccines and novel therapies.

Qualifications: B.Sc. (Hons) University College Dublin 1990, Ph.D. Trinity College Dublin 1996, PGCertLTHE University of Birmingham 2002.

Current roles: Deputy Director Research; Institute of Molecular Biology, University of Queensland 2018-present, Professor of Microbial Biology; Institute of Microbiology and Infection, University of Birmingham, 2015-present.

About Seminar Series

The School of Pharmacy Seminar Series involves regular formal presentations of high-quality scholarly work with broad appeal.

The wider School community is invited to attend, including academic and professional staff, special guests, visitors, as well as HDR, postgraduate, masters and honours students.

Seminars are held on Fridays from 12pm–1pm in room 5034 in the Pharmacy Australia Centre of Excellence, 20 Cornwall St Woolloongabba (next to TRI and the PA Hospital).

Confirmed 2021 seminars

Date Presenter
12-1pm, Friday 19 March
(PACE R5034 and Zoom)
Professor Paul Clarke, Director Diamantina Institute        
12-1pm, Friday 16 April
(Zoom only)
Associate Professor Francine Marques, Monash University     
12-1pm, Friday 23 April
(Zoom only)
Associate Professor Ben Colagiuri, Sydney University 
12-1pm, Friday 7 May
(Zoom only)
Dr Laurence Cheung, Curtin University
12-1pm, Friday 30 July
(location TBC)
Dr Gary Chan, UQ CYSUR
12-1pm, Friday 13 August
(Zoom only)
Professor Sanjay Garg, University of South Australia
12-1pm, Friday 3 September
(PACE R5034 and Zoom)
Associate Professor Michael Barras, UQ Pharmacy
12-1pm 10 September
(Online via Zoom)

Professor Josephine Forbes, Mater Research

 

12-1pm, Friday 17 September
(PACE R5034 and Zoom)

Professor Nigel McMillan, Program Director: Infectious Diseases and Immunology, Menzies Health Institute QLD, Griffith University

12-1pm, Friday 24 September
(Location TBC)
Denuja Karunakaran, IMB Fellow, Institute for Molecular Bioscience (IMB), UQ

Venue

Pharmacy Australia Centre of Excellence, 20 Cornwall St, Woolloongabba
Room: 
5034