Dr James Robert Falconer
Chair Facilities & Equipment Committee
Lecturer
School of Pharmacy
+61 7 334 61852
Researcher biography
Doctor James Falconer has been an academic at the School of Pharmacy, The University of Queensland since June 2015. Dr Falconer was an assistant lecturer, then research & teaching fellow at the School of Pharmacy, the University of Auckland from 2011 – 2015.
In 2007 he was awarded with the Technology for Industry Fellowship (TIF) from the New Zealand Foundation for Research, Science & Technology (FRST) from the NZ Government with joint funding from Pharmaceutical Compounding New Zealand (PCNZ) to complete a PhD under A/Professor Jingyuan Wen and Professor Raid Alany from the University of Auckland, New Zealand for development of a supercritical fluid platform and transdermal delivery of poorly aqueous soluble steriods. As a post-doctoral researcher under A/Professor Zimei Wu and collaboration with Argenta Global in Auckland he worked to help stabilise a veterinary pour-on which resulted in international patents and registered product for cattle. He was then appointed as a lecturer in pharmacy practice and pharmaceutical sciences at The University of Queensland in Brisbane, Australia. Prior to his academic career, he received a BSc in Genetics 1999 and a Masters in Health Sciences (Bioethics) in 2003 under A/Professor Neil Pickering on the anatomy of the GMO debate from the University of Otago, Dunedin, New Zealand. In 2005, he completed a BPharm (Hons) from the University of Auckland and undertook an internship at Middlemore Hospital in 2006, then was employed from 2007 as a ward pharmacist in general surgery and the hospital dispensary and as a community pharmacist - including the 'graveyard' shifts at day/night pharmacies.
Doctor Falconer has established research in supercritical fluid applications for selective extraction as well as in engineering advanced nanoparticulate dosage forms based on lipid and polymeric systems. A backbone to this work is the search for green/er technology to replace organic solvent driven material manufacturing processes and the repurposing of carbon dioxide for good.
Journal Articles
Tan, Madeleine S. A., Pandey, Preeti, Lohman, Rink-Jan, Falconer, James R., Siskind, Dan J. and Parekh, Harendra S. (2022). Fabrication and Characterization of Clozapine Nanoemulsion Sol–Gel for Intranasal Administration. Molecular Pharmaceutics, 19 (11), 4055-4066. doi: 10.1021/acs.molpharmaceut.2c00513
Ndayishimiye, John, Kumeria, Tushar, Popat, Amirali, Falconer, James Robert and Blaskovich, Mark A. T. (2022). Nanomaterials: the new antimicrobial magic bullet. ACS Infectious Diseases, 8 (4), 693-712. doi: 10.1021/acsinfecdis.1c00660
Li, Danhui, Martini, Nataly, Wu, Zimei, Chen, Shuo, Falconer, James Robert, Locke, Michelle, Zhang, Zhiwen and Wen, Jingyuan (2022). Niosomal nanocarriers for enhanced dermal delivery of epigallocatechin gallate for protection against oxidative stress of the skin. Pharmaceutics, 14 (4) 726, 726. doi: 10.3390/pharmaceutics14040726
Ndayishimiye, John, Kumeria, Tushar, Popat, Amirali, Blaskovich, Mark A.T. and Falconer, James Robert (2022). Understanding the relationship between solubility and permeability of γ-cyclodextrin-based systems embedded with poorly aqueous soluble benznidazole. International Journal of Pharmaceutics, 616 121487, 121487. doi: 10.1016/j.ijpharm.2022.121487
Raza, A., Kamato, D., Sime, F.B., Roberts, J.A., Popat, A., Falconer, J.R. and Kumeria, T. (2022). Influence of PEGylated porous silicon nanoparticles on permeation and efflux of an orally administered antibiotic. Materials Today Advances, 13 100210, 100210. doi: 10.1016/j.mtadv.2022.100210
Tan, Madeleine S. A., Pandey, Preeti, Falconer, James R., Siskind, Dan J., Balmanno, Alexandra and Parekh, Harendra S. (2022). Clozapine-encapsulated binary mixed micelles in thermosensitive sol–gels for intranasal administration. Gels, 8 (1) 38, 38. doi: 10.3390/gels8010038
Qamar, Sadia, Torres, Yady J. M., Parekh, Harendra S. and Falconer, James Robert (2022). Fractional factorial design study for the extraction of cannabinoids from CBD-dominant cannabis flowers by supercritical carbon dioxide. Processes, 10 (1) 93. doi: 10.3390/pr10010093
Xu, Weizhi, Maqbool, Faheem, Kumar, Vinod, Falconer, James R., Cui, Cedric S., Woodruff, Trent M., Borges, Karin, Whittaker, Andrew K., Smith, Maree T. and Han, Felicity Y. (2021). Sustained-release ketamine-loaded lipid-particulate system: in vivo assessment in mice. Drug Delivery and Translational Research, 12 (10), 2518-2526. doi: 10.1007/s13346-021-01093-3
Qamar, Sadia, Torres, Yady J. M., Parekh, Harendra S. and Falconer, James Robert (2021). Effects of ethanol on the supercritical carbon dioxide extraction of cannabinoids from near equimolar (THC and CBD balanced) cannabis flower. Separations, 8 (9) 154, 154. doi: 10.3390/separations8090154
Qamar, Sadia, Manrique, Yady J., Parekh, Harendra S. and Falconer, James R. (2021). Development and optimization of supercritical fluid extraction setup leading to quantification of 11 cannabinoids derived from medicinal cannabis. Biology, 10 (6) 481, 1-20. doi: 10.3390/biology10060481
Raza, Aun, Alavi, Seyed Ebrahim, Sime, Fekade Bruck, Han, Felicity Y., Roberts, Jason A., Popat, Amirali, Falconer, James R. and Kumeria, Tushar (2021). Microfluidic assembly of pomegranate-like hierarchical microspheres for efflux regulation in oral drug delivery. Acta Biomaterialia, 126, 277-290. doi: 10.1016/j.actbio.2021.03.042
Xu, Weizhi, Zhao, Zonglan, Falconer, James, Whittaker, Andrew K., Popat, Amirali, Smith, Maree T., Kumeria, Tushar and Han, Felicity Y. (2021). Sustained release ketamine-loaded porous silicon-PLGA microparticles prepared by an optimized supercritical CO2 process. Drug Delivery and Translational Research, 12 (3), 676-694. doi: 10.1007/s13346-021-00991-w
Raza, Aun, Miles, Jared A., Bruck Sime, Fekade, Ross, Benjamin P., Roberts, Jason A., Popat, Amirali, Kumeria, Tushar and Falconer, James R. (2021). PLGA encapsulated γ-cyclodextrin-meropenem inclusion complex formulation for oral delivery. International Journal of Pharmaceutics, 597 120280, 120280. doi: 10.1016/j.ijpharm.2021.120280
Qamar, Sadia, Torres, Yady J.M., Parekh, Harendra S. and Falconer, James Robert (2021). Extraction of medicinal cannabinoids through supercritical carbon dioxide technologies: a review. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 1167 122581, 1-10. doi: 10.1016/j.jchromb.2021.122581
Ndayishimiye, John, Popat, Amirali, Kumeria, Tushar, Blaskovich, Mark A.T. and Falconer, James Robert (2021). Supercritical carbon dioxide assisted complexation of benznidazole: γ-cyclodextrin for improved dissolution. International Journal of Pharmaceutics, 596 120240, 120240. doi: 10.1016/j.ijpharm.2021.120240
Raza, Aun, Sime, Fekade Bruck, Cabot, Peter J., Roberts, Jason A., Falconer, James R., Kumeria, Tushar and Popat, Amirali (2021). Liquid CO2 formulated mesoporous silica nanoparticles for pH-responsive oral delivery of meropenem. ACS Biomaterials Science and Engineering, 7 (5) acsbiomaterials.0c01284, 1836-1853. doi: 10.1021/acsbiomaterials.0c01284
Tan, Madeleine S. A., Honarparvar, Faraz, Falconer, James R., Parekh, Harendra S., Pandey, Preeti and Siskind, Dan J. (2021). A systematic review and meta-analysis of the association between clozapine and norclozapine serum levels and peripheral adverse drug reactions. Psychopharmacology, 238 (3), 615-637. doi: 10.1007/s00213-020-05746-y
Ndayishimiye, John, Cao, Yuxue, Kumeria, Tushar, Blaskovich, Mark A. T., Falconer, James Robert and Popat, Amirali (2021). Engineering mesoporous silica nanoparticles towards oral delivery of vancomycin. Journal of Materials Chemistry B, 9 (35), 7145-7166. doi: 10.1039/d1tb01430g
Raza, Aun, Ngieng, Shih Chen, Sime, Fekade Bruck, Cabot, Peter J., Roberts, Jason A., Popat, Amirali, Kumeria, Tushar and Falconer, James R. (2020). Oral meropenem for superbugs: challenges and opportunities. Drug Discovery Today, 26 (2), 551-560. doi: 10.1016/j.drudis.2020.11.004
Li, Danhui, Martini, Nataly, Liu, Mengyang, Falconer, James R., Locke, Michelle, Wu, Zimei and Wen, Jingyuan (2020). Non-ionic surfactant vesicles as a carrier system for dermal delivery of C and their antioxidant effects. Journal of Drug Targeting, 29 (3), 1-31. doi: 10.1080/1061186x.2020.1835923
Ndayishimiye, John, Popat, Amirali, Blaskovich, Mark and Falconer, James Robert (2020). Formulation technologies and advances for oral delivery of novel nitroimidazoles and antimicrobial peptides. Journal of Controlled Release, 324, 728-749. doi: 10.1016/j.jconrel.2020.05.002
Maqbool, Faheem, Falconer, James R. and Moyle, Peter M. (2020). Supercritical fluid assembly of albendazole liposomes targeting gastrin-releasing peptide receptor overexpressing tumors. Nanomedicine, 15 (13), 1315-1330. doi: 10.2217/nnm-2020-0048
Khaw, Kooi-Yeong, Shaw, Paul Nicholas, Parat, Marie-Odile, Pandey, Saurabh and Falconer, James Robert (2020). Compound identification and in vitro cytotoxicity of the supercritical carbon dioxide extract of papaya freeze-dried leaf juice. Processes, 8 (5) 610, 610. doi: 10.3390/pr8050610
Tan, Madeleine S. A., Parekh, Harendra S., Pandey, Preeti, Siskind, Dan J. and Falconer, James R. (2020). Nose-to-brain delivery of antipsychotics using nanotechnology: a review. Expert Opinion on Drug Delivery, 17 (6) 17425247.2020.1762563, 839-853. doi: 10.1080/17425247.2020.1762563
Qamar, Sadia, Manrique, Yady J., Parekh, Harendra and Falconer, James Robert (2019). Nuts, cereals, seeds and legumes proteins derived emulsifiers as a source of plant protein beverages: a review. Critical Reviews in Food Science and Nutrition, 60 (16), 1-21. doi: 10.1080/10408398.2019.1657062
Chen, Shuo, Hanning, Sara, Falconer, James, Locke, Michelle and Wen, Jingyuan (2019). Recent advances in non-ionic surfactant vesicles (niosomes): fabrication, characterization, pharmaceutical and cosmetic applications. European Journal of Pharmaceutics and Biopharmaceutics, 144, 18-39. doi: 10.1016/j.ejpb.2019.08.015
Maqbool, Faheem, Moyle, Peter M., Thurecht, Kristofer J. and Falconer, James R. (2019). Dispersibility of phospholipids and their optimization for the efficient production of liposomes using supercritical fluid technology. International Journal of Pharmaceutics, 563, 174-183. doi: 10.1016/j.ijpharm.2019.03.053
Khaw, Kooi-Yeong, Parat, Marie-Odile, Shaw, Paul Nicholas, Nguyen, Thao T. T., Pandey, Saurabh, Thurecht, Kristofer J. and Falconer, James Robert (2019). Factorial design-assisted supercritical carbon-dioxide extraction of cytotoxic active principles from Carica papaya leaf juice. Scientific Reports, 9 (1) 1716, 1716. doi: 10.1038/s41598-018-37171-9
Maqbool, Faheem, Moyle, Peter M., Tan, Madeleine S. A., Thurecht, Kristofer J. and Falconer, James R. (2019). Preparation of albendazole-loaded liposomes by supercritical carbon dioxide processing. Artificial Cells, Nanomedicine, and Biotechnology, 46 (sup3), 1-7. doi: 10.1080/21691401.2018.1536059
Raza, Aun, Sime, Fekade Bruck, Cabot, Peter J., Maqbool, Faheem, Roberts, Jason A. and Falconer, James Robert (2019). Solid nanoparticles for oral antimicrobial drug delivery: a review. Drug Discovery Today, 24 (3), 858-866. doi: 10.1016/j.drudis.2019.01.004
Khaw, Kooi-Yeong, Parat, Marie-Odile, Shaw, Paul Nicholas and Falconer, James Robert (2017). Solvent supercritical fluid technologies to extract bioactive compounds from natural sources: a review. Molecules, 22 (7) 1186, 1186. doi: 10.3390/molecules22071186
Falconer, James R. and Steadman, Kathryn J. (2017). Erratum: Extemporaneously compounded medicines (vol 40, pg 5, 2017). Australian Prescriber, 40 (3), 119-119. doi: 10.18773/austprescr.2017.042
Falconer , James R. and Steadman, Kathryn J. (2017). Extemporaneously compounded medicines. Australian Prescriber, 40 (1), 5-8. doi: 10.18773/austprescr.2017.001
Zhang, Wenli, Falconer, James R., Baguley, Bruce C., Shaw, John P., Kanamala, Manju, Xu, Hongtao, Wang, Guangji, Liu, Jianping and Wu, Zimei (2016). Improving drug retention in liposomes by aging with the aid of glucose.. International Journal of Pharmaceutics, 505 (1-2), 194-203. doi: 10.1016/j.ijpharm.2016.03.044
Falconer, James R., Svirskis, Darren, Adil, Ali A. and Wu, Zimei (2015). Supercritical fluid technologies to fabricate proliposomes. Journal of Pharmacy and Pharmaceutical Sciences, 18 (5), 747-764. doi: 10.18433/j3qp58
Zhang, Wenli, Wang, Guangji, Falconer, James R., Baguley, Bruce C., Shaw, John P., Liu, Jianping, Xu, Hongtao, See, Esther, Sun, Jianguo, Aa, Jiye and Wu, Zimei (2015). Strategies to maximize liposomal drug loading for a poorly water-soluble anticancer drug. Pharmaceutical Research, 32 (4), 1451-1461. doi: 10.1007/s11095-014-1551-8
Falconer, James R., Wu, Zimei, Lau, Hugo, Suen, Joanna, Wang, Lucy, Pottinger, Sarah, Lee, Elaine, Alazawi, Nawar, Kallesen, Molly, Gargiulo, Derryn A., Swift, Simon and Svirskis, Darren (2014). An investigation into the stability and sterility of citric acid solutions used for cough reflex testing. Dysphagia, 29 (5), 622-628. doi: 10.1007/s00455-014-9558-1
Wu, Zimei, Alany, Raid G., Tawfeek, Noor, Falconer, James, Zhang, Wenli, Hassan, Ibrahim M., Rutland, Michael and Svirskis, Darren (2014). A study of microemulsions as prolonged-release injectables through in-situ phase transition. Journal of Controlled Release, 174 (1), 188-194. doi: 10.1016/j.jconrel.2013.11.022
Falconer, James R., Wen, Jingyuan, Zargar-Shoshtari, Sara, Chen, John J., Farid, Mohammed, Tallon, Stephen J. and Alany, Raid G. (2014). Preparation and characterization of progesterone dispersions using supercritical carbon dioxide. Drug Development and Industrial Pharmacy, 40 (4), 458-469. doi: 10.3109/03639045.2013.768630
Falconer, James R., Wen, Jingyuan, Zargar-Shoshtari, Sara, Chen, John J., Farid, Mohammed, El Maghraby, Gamal M. and Alany, Raid G. (2014). Evaluation of progesterone permeability from supercritical fluid processed dispersion systems. Pharmaceutical Development and Technology, 19 (2), 238-246. doi: 10.3109/10837450.2013.769570
Falconer, J. R., Wen, J., Zargar-Shoshtari, S., Chen, J. J., Farid, M., Young, S. and Alany, R. G. (2013). Effects of supercritical carbon dioxide processing on optical crystallinity and in vitro release of progesterone and Gelucire 44/14 solid and semi-solid dispersions. Journal of Drug Delivery Science and Technology, 23 (5), 477-483. doi: 10.1016/S1773-2247(13)50069-4
Falconer, James R., Wen, Jingyuan, Zargar-Shoshtari, Sara, Chen, John J., Mohammed, Farid, Chan, Judy and Alany, Raid G. (2012). The effects of supercritical carbon dioxide processing on progesterone dispersion systems: a multivariate study. AAPS PharmSciTech, 13 (4), 1255-1265. doi: 10.1208/s12249-012-9850-z
Meng, Dan, Falconer, James, Krauel-Goellner, Karen, Chen, John J. J. J., Farid, Mohammed and Alany, Raid G. (2008). Self-built supercritical CO2 anti-solvent unit design, construction and operation using Carbamazepine. AAPS PharmSciTech, 9 (3), 944-952. doi: 10.1208/s12249-008-9130-0
Conference Papers
Tan, Madeleine S.A., Pandey, Preeti, Falconer, James R., Siskind, Dan J. and Parekh, Harendra S. (2021). Thermosensitive nanoemulsion-based Sol-Gel of Clozapine for nose-to-brain delivery. Micro and Nanoparticles in Drug and Vaccine Delivery Symposium, Brisbane, QLD Australia, 3 December 2021.
Tan, Madeleine S. A., Pandey, Preeti, Falconer, James R., Siskind, Dan J. and Parekh, Harendra S. (2021). Nanoemulsion-based sol-gel of Clozapine for nose-to-brain delivery. Drug Delivery Australia Virtual Meeting: Advanced Materials in Drug Delivery, Online, 18 - 19 November 2021.
Tan, Madeleine SA, Pandey, Preeti, Balmanno, Alexandra, Falconer, James R., Siskind, Dan J. and Parekh, Harendra S. (2021). Thermosensitive Micellar Hydrogels of Clozapine for Nose-to-Brain Delivery. 2021 CRS Virtual Annual Meeting, Mount Laurel, NJ United States, 25-29 July 2021 .
Tan, Madeleine S. A., Honarparvar, Faraz , Falconer, James R., Parekh, Harendra S., Pandey, Preeti and Siskind, Dan J. (2020). Can monitoring clozapine and norclozapine levels reduce the occurrence of peripheral ADRs?. ASCEPT-APSA Joint Virtual Scientific Meeting, Hamilton Central, QLD, Australia, 24-26 November 2020.
Tan, Madeleine , Honarparvar, Faraz , Falconer, James , Parekh, Harendra , Pandey, Preeti and Siskind, Dan (2020). Therapeutic drug monitoring as a tool for clozapine therapy in minimising peripheral ADRs. Australian Society for Medical Research (ASMR) Queensland Post Graduate Students Virtual Scientific Symposium, Sydney, NSW Australia, 10-11 November 2020.
Tan, Madeleine S. A. , Parekh, Harendra S., Pandey, Preeti , Siskind, Dan J. and Falconer, James R. (2020). Development and optimization of clozapine-loaded PLGA nanoparticles for nose-to-brain delivery using supercritical fluid technology. 7th FIP Pharmaceutical Sciences World Congress, The Hague, Netherlands, 4-6 October 2020.
Falconer, James R. (2019). The solvent power of supercritical carbon dioxide technology. Drug Delivery Australia (DDA), Brisbane, Australia, 18-19 November 2019.
Maqbool, Faheem, Moyle, Peter M. and Falconer, James R. (2019). Production of liposomes using supercritical fluid technology and active targeting peptide to a gastrointestinal receptor in cancer cells. Controlled Release Society (CRS), Valencia, Spain, 21-24 July 2019.
Maqbool, Faheem, Moyle, Peter M. and Falconer, James R. (2018). Novel preparation of proliposomes with various phospholipids in Supercritical Carbon Dioxide. Controlled Release Society (CRS), New York City, United States, 22-25 July 2018.
Tan, Madeleine, Maqbool, Faheem and Falconer, James (2018). Preparation of proliposomes using supercritical fluid. Pharmaceutical Society of Australia 2018, Sydney, Australia, 27-29 July 2018.
Maqbool, Faheem, Moyle, Peter M. and Falconer, James R. (2017). A static and gravimetric method for the determination of solubility of Albendazole and its characterization in supercritical carbon dioxide. Drug Delivery Australia (DDA), Wollongong, Australia, 23-24 October 2017.
Khaw, Kooi Yeong, Parat, Marie-Odile, Shaw, Paul N. and Falconer, James R. (2017). Screening of parameters affecting supercritical CO2 extraction of freeze-dried leaf juice of Carica papaya. Drug Delivery Australia (DDA), Wollongong, NSW Australia, 23-24 October 2017.
Falconer, James R., Eng, P.L., Huang, Y., Nasef, N., Nguyen, I., Song, Y., Wu, Zimei and Darren M Sirvirkis (2014). Study of phase-transitioning microemulsions for sustained-release dermal/transdermal drug delivery. HealtheX, Auckland, New Zealand, 18 September 2014.
Huang, I., Abdulqadir, A., Lee, E., Choi, J., Kim, J. and Falconer, James R. (2013). Development and validation of an efficient HPLC method for quantitative analysis of Coenzyme Q10. HealtheX, Auckland, New Zealand, 15 September 2013.
Falconer, James R. , Wen, Jingyuan , Zargar-Shoshtari, Sara , Chen, John J. , Farid, Mohammed , El Maghraby, Gamal M. and Alany, Raid G. (2013). Permeability and stability of dispersion systems in the presence of penetration enhancers. Controlled Release Society (CRS), Hawaii, United States, 21-24 July 2013.
Falconer, James R. , Wen, Jingyuan , Zargar-Shoshtari, Sara , Chen, John J. , Farid, Mohammed , Tallon, Steven J. and Alany, Raid (2013). Supercritical Fluids - what are they? A case for delivery of brick dust bioactives. Found in Translation - Formulation and Delivery of Bioactives (FDB), Dunedin, New Zealand, 13 - 14 February 2013. Otago, New Zealand: School of Pharmacy, University of Otago.
Falconer, James R. , Tallon, Steven , Farid, Mohammed , Chen, John J. and Alany, Raid (2009). Formation of progesterone loaded-solid dispersion systems prepared using a particle from gas-saturated suspension (PGSS) method. Out Of The Wilderness: Australasian Pharmaceutical Science Association Annual Conference 2009 (APSA), Hobart, TAS Australia, 8-11 December 2009. Mt. Waverley, VIC Australia: Australasian Pharmaceutical Science Association Conference (APSA).
Ng, Jerome , Falconer, James R., Nguyan, Truc and Brkic, Lejla (2008). Medication Reconciliation - Easy concept, difficult task. Centre for Clinical Research and Effective Practice (CCRep), Auckland, New Zealand, 15 July 2008. Middlemore Hospital, Counties Manukau District Health Board (CMDHB):
Data Collection
Han, Felicity, Kumeria, Tushar and Falconer, James R. (2019). HaBS-Med Collaborative Seeding Grants 2019. The University of Queensland. (Dataset) doi: 10.14264/uql.2019.756
Patent
Batt, Laurie Robert, Win, Su, Davies, Keryn, Gill, David Anthony, Falconer, James Robert, Cleverly, Douglas Robert and Wu, Zimei (2016). Transdermal formulations. WO 2014132227 A1.