Professor Irina Vetter
NHMRC Leadership Fellow - Group Leader
Institute for Molecular Bioscience
NHMRC Leadership Fellow - Group Leader
School of Pharmacy
+61 7 334 62660
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Researcher biography
I am an NHMRC R.D. Wright Career Development Fellow and Director of the recently established Centre for Pain Research at the Institute for Molecular Bioscience (IMB), UQ. My research interests lie in the fields of peripheral pain mechanisms, target identification and analgesic drug discovery. I investigate the contribution of ion channels to sensory neuronal physiology using highly subtype-selective toxins isolated from venomous animals with the aim to develop novel analgesics with improved efficacy and tolerability.
Book Chapters
Vetter, Irina, Carter, David, Bassett, John, Deuis, Jennifer R., Tay, Bryan, Jami, Sina and Robinson, Samuel D. (2020). High-throughput fluorescence assays for ion channels and GPCRs. Calcium Signaling. (pp. 27-72) edited by Md. Shahidul Islam. Cham, Switzerland: Springer. doi: 10.1007/978-3-030-12457-1_3
Inserra, Marco, Lavrukhina, Yelena, Jones, Alun, Lewis, Richard J. and Vetter, Irina (2017). Ciguatoxin detection methods and high-throughput assays. Analysis of food toxins and toxicants. (pp. 469-487) edited by Yiu-Chung Wong and Richard J. Lewis. Oxford, United Kingdom: Wiley Blackwell. doi: 10.1002/9781118992685.ch15
Lewis, Richard J. and Vetter, Irina (2016). Ciguatoxin and ciguatera. Marine and freshwater toxins. (pp. 71-92) edited by P. Gopalakrishnakone, Vidal Haddad Jr., Aurelia Tubaro, Euikyung Kim and William R. Kem. Dordrecht, The Netherlands: Springer. doi: 10.1007/978-94-007-6419-4_13
Fry, B. G., Undheim, E. A. B., Jackson, T. N. W., Georgieva, D., Vetter, I., Calvete, J. J., Schieb, H., Cribb, B. W., Yang, D. C., Daly, N. L., Manchadi, M. L. Roy, Gutierrez, J. M., Roelants, K., Lomonte, B., Nicholson, G. M., Dziemborowicz, S., Lavergne, V., Ragnarsson, L., Rash, L. D., Mobli, M., Hodgson, W. C., Casewell, N. R., Nouwens, A., Wagstaff, S. C., Ali, S. A., Whitehead, D. L., Herzig, V., Monagle, P., Kurniawan, N. D. ... Sunagar, K. (2015). Research methods. Venomous reptiles and their toxins: evolution, pathophysiology and biodiscovery. (pp. 153-214) New York, NY, United States: Oxford University Press.
Vetter, Irina, Hodgson, Wayne C., Adams, David J. and McIntyre, Peter (2015). Venoms-based drug discovery: bioassays, electrophysiology, high-throughput screens and target identification. Venoms to drugs: venom as a source for the development of human therapeutics. (pp. 97-128) edited by Glenn F. King. Cambridge, United Kingdom: Royal Society of Chemistry. doi: 10.1039/9781849737876-00097
Fry, Bryan G., Koludarov, Ivan, Jackson, Timothy N. W., Holford, Mandë, Terrat, Yves, Casewell, Nicholas R., Undheim, Eivind A. B., Vetter, Irina, Ali, Syed A., Low, Dolyce H. W. and Sunagar, Kartik (2015). Seeing the woods for the trees: understanding venom evolution as a guide for biodiscovery. Venoms to drugs: venom as a source for the development of human therapeutics. (pp. 1-36) edited by Glenn F. King. Cambridge, United Kingdom: Royal Society of Chemistry. doi: 10.1039/9781849737876-00001
Lewis, Richard J., Vetter, Irina, Cardoso, Fernanda C., Inserra, Marco and King, Glenn (2015). Does nature do ion channel drug discovery better than us?. Ion channel drug discovery. (pp. 297-313) edited by Brian Cox and Martin Gosling. Cambridge, United Kingdom: Royal Society of Chemistry. doi: 10.1039/9781849735087-00297
Vetter, Irina, Zimmermann, Katharina and Lewis, Richard J. (2014). Ciguatera toxins: pharmacology, toxicology and detection. Seafood and freshwater toxins: pharmacology, physiology, and detection. (pp. 925-950) edited by Luis M. Botana. Boca Raton, FL, United States: CRC Press. doi: 10.1201/b16662-32
Vetter, I. and Lewis, R. J. (2014). Toxicology of ciguatoxins. Toxins and biologically active compounds from microalgae: Volume 2: biological effects and risk management. (pp. xx-xx) Boca Raton, FL, United States: CRC Press. doi: 10.1201/b16806-17
Deuis, Jennifer, Vetter, Irina and Zimmermann, Katharina (2013). Characterizing response properties of cutaneous nociceptors using in vitro skin-nerve preparations. Pain models: translational relevance and applications. (pp. 33-46) edited by Hermann Handwerker and Lars Arendt-nielsen. Washington, United States: IASP Press.
Vetter, Irina (2012). Development and optimization of FLIPR high throughput calcium assays for ion channels and GPCRs. Calcium signaling. (pp. 45-82) edited by Md Shahidul Islam. Dordrecht, Netherlands: Springer. doi: 10.1007/978-94-007-2888-2_3
Wingerd, Joshua S., Vetter, Irina and Lewis, Richard J. (2012). Voltage-gated sodium channels as therapeutic targets.. Therapeutic targets: Modulation, Inhibition and Activation.. (pp. 63-122) edited by Luis M. Botana and Mabel Loza. Hoboken NJ, United States: John Wiley and Sons.
Vetter, Irina and Lewis, Richard J. (2011). Natural product ligands of TRP channels. Transient receptor potential channels. (pp. 41-85) edited by Md. Shahidul Islam. New York, United States: Springer. doi: 10.1007/978-94-007-0265-3_3
Journal Articles
Deuis, Jennifer R., Klasfauseweh, Tabea, Walker, Lucinda and Vetter, Irina (2024). The ‘dispanins’ and related proteins in physiology and neurological disease. Trends in Neurosciences, 47 (8), 622-634. doi: 10.1016/j.tins.2024.06.004
Kalia, Anil Kumar, Roesseler, Corinna, Granja-Vazquez, Rafael, Ahmad, Ayesha, Pancrazio, Joseph J., Neureiter, Anika, Zhang, Mei, Sauter, Daniel, Vetter, Irina, Andersson, Asa, Dussor, Gregory, Price, Theodore J., Kolber, Benedict J., Truong, Vincent, Walsh, Patrick and Lampert, Angelika (2024). How to differentiate induced pluripotent stem cells into sensory neurons for disease modelling: a functional assessment. Stem Cell Research & Therapy, 15 (1) ARTN 99. doi: 10.1186/s13287-024-03696-2
Raffaelli, Tiziano, Wilson, David T., Dutertre, Sebastien, Giribaldi, Julien, Vetter, Irina, Robinson, Samuel D., Thapa, Ashvriya, Widi, Antin, Loukas, Alex and Daly, Norelle L. (2024). Structural analysis of a U-superfamily conotoxin containing a mini-granulin fold: Insights into key features that distinguish between the ICK and granulin folds. Journal of Biological Chemistry, 300 (4) 107203, 107203. doi: 10.1016/j.jbc.2024.107203
Rahaman, Md. Habibur, Thygesen, Sara J., Maxwell, Michael J., Kim, Hyoyoung, Mudai, Prerna, Nanson, Jeffrey D., Jia, Xinying, Vajjhala, Parimala R., Hedger, Andrew, Vetter, Irina, Haselhorst, Thomas, Robertson, Avril A. B., Dymock, Brian, Ve, Thomas, Mobli, Mehdi, Stacey, Katryn J. and Kobe, Bostjan (2024). o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2. Journal of Enzyme Inhibition and Medicinal Chemistry, 39 (1) 2313055, 2313055. doi: 10.1080/14756366.2024.2313055
McMahon, Kirsten L., Vetter, Irina and Schroeder, Christina I. (2024). Voltage-gated sodium channel inhibition by µ-conotoxins. Toxins, 16 (1) 55. doi: 10.3390/toxins16010055
Ramanujam, Venkatraman, Crawford, Theo, Cristofori‐Armstrong, Ben, Deuis, Jennifer R., Jia, Xinying, Maxwell, Michael J., Jami, Sina, Ma, Linlin, Vetter, Irina and Mobli, Mehdi (2024). Structural basis of the bivalency of the TRPV1 agonist DkTx. Angewandte Chemie, 136 (3), 1-8. doi: 10.1002/ange.202314621
Ramanujam, Venkatraman, Crawford, Theo, Cristofori-Armstrong, Ben, Deuis, Jennifer, Jia, Xinying, Maxwell, Michael, Jami, Sina, Ma, Linlin, Vetter, Irina and Mobli, Mehdi (2024). Structural basis of the bivalency of the TRPV1 agonist DkTx. Angewandte Chemie International Edition, 63 (3) e202314621, 1-8. doi: 10.1002/anie.202314621
Robinson, Samuel D., Deuis, Jennifer R., Niu, Pancong, Touchard, Axel, Mueller, Alexander, Schendel, Vanessa, Brinkwirth, Nina, King, Glenn F., Vetter, Irina and Schmidt, Justin O. (2024). Peptide toxins that target vertebrate voltage-gated sodium channels underly the painful stings of harvester ants. Journal of Biological Chemistry, 300 (1) 105577, 1-15. doi: 10.1016/j.jbc.2023.105577
Deuis, Jennifer R., Kumble, Smitha, Keramidas, Angelo, Ragnarsson, Lotten, Simons, Cas, Pais, Lynn, White, Susan M and Vetter, Irina (2024). Erythromelalgia caused by the missense mutation p.Arg220Pro in an alternatively spliced exon of SCN9A (NaV1.7). Human Molecular Genetics, 33 (2), 103-109. doi: 10.1093/hmg/ddad152
Xie, Fengjuan, Lin, Yingying, Andersson, Åsa, Vetter, Irina, Zhao, Liang and Wan, JingJing (2023). Self-assembly of alkylated lysine-dendron oxytocin amphiphiles for enhanced stability and sustained pharmacological activity. Chemical Communications, 59 (93), 13855-13858. doi: 10.1039/d3cc03801g
Pérez, Rebeca, Figueredo, Claudia, Burgos, Viviana, Cabrera-Pardo, Jaime R., Schmidt, Bernd, Heydenreich, Matthias, Koch, Andreas, Deuis, Jennifer R., Vetter, Irina and Paz, Cristian (2023). Natural compounds purified from the leaves of Aristotelia chilensis: Makomakinol, a new alkaloid and the effect of aristoteline and hobartine on NaV channels. International Journal of Molecular Sciences, 24 (21) 15504, 1-10. doi: 10.3390/ijms242115504
Ragnarsson, Lotten, Zhang, Zihan, Das, Sooraj S., Tran, Poanna, Andersson, Åsa, Portes, Vincent Des, Demestre, Cecilia Altuzzara, Remerand, Ganaelle, Labalme, Audrey, Chatron, Nicolas, Sanlaville, Damien, Lesca, Gaetan, Anggono, Victor, Vetter, Irina and Keramidas, Angelo (2023). GRIN1 variants associated with neurodevelopmental disorders reveal channel gating pathomechanisms. Epilepsia, 64 (12), 3377-3388. doi: 10.1111/epi.17776
McMahon, Kirsten L., O’Brien, Henrik, Schroeder, Christina I., Deuis, Jennifer R., Venkatachalam, Dhananjeyan, Huang, Di, Green, Brad R., Bandyopadhyay, Pradip K., Li, Qing, Yandell, Mark, Safavi-Hemami, Helena, Olivera, Baldomero M., Vetter, Irina and Robinson, Samuel D. (2023). Identification of sodium channel toxins from marine cone snails of the subgenera Textilia and Afonsoconus. Cellular and Molecular Life Sciences, 80 (10) 287, 287. doi: 10.1007/s00018-023-04935-0
Galante, Priscilla, Campos, Gabriel A. A., Moser, Jacqueline C. G., Martins, Danubia B., Dos Santos Cabrera, Marcia P., Rangel, Marisa, Coelho, Luiza C., Simon, Karina S., Amado, Veronica M., de A. I. Muller, Jessica, Koehbach, Johannes, Lohman, Rink-Jan, Cabot, Peter J., Vetter, Irina, Craik, David J., Toffoli-Kadri, Monica C., Monge-Fuentes, Victoria, Goulart, Jair T., Schwartz, Elisabeth F., Silva, Luciano P., Bocca, Anamelia L. and Mortari, Márcia R (2023). Exploring the therapeutic potential of an antinociceptive and anti-inflammatory peptide from wasp venom. Scientific Reports, 13 (1) 12491, 1-15. doi: 10.1038/s41598-023-38828-w
Zhou, Yan, Harvey, Peta J., Koehbach, Johannes, Chan, Lai Yue, Jones, Alun, Andersson, Åsa, Vetter, Irina, Durek, Thomas and Craik, David J. (2023). A chemoenzymatic approach to produce a cyclic analogue of the analgesic drug MVIIA (Ziconotide). Angewandte Chemie, 135 (29) e202302812, 1-5. doi: 10.1002/ange.202302812
Tran, Poanna, Crawford, Theo, Ragnarsson, Lotten, Deuis, Jennifer R., Mobli, Mehdi, Sharpe, Simon J., Schroeder, Christina I. and Vetter, Irina (2023). Structural conformation and activity of spider-derived inhibitory cystine knot peptide Pn3a are modulated by pH. ACS Omega, 8 (29), 26276-26286. doi: 10.1021/acsomega.3c02664
Walker, Andrew A., Robinson, Samuel D., Merritt, David J., Cardoso, Fernanda C., Goudarzi, Mohaddeseh Hedayati, Mercedes, Raine S., Eagles, David A., Cooper, Paul, Zdenek, Christina N., Fry, Bryan G., Hall, Donald W., Vetter, Irina and King, Glenn F. (2023). Horizontal gene transfer underlies the painful stings of asp caterpillars (Lepidoptera: Megalopygidae). Proceedings of the National Academy of Sciences, 120 (29) e2305871120, e2305871120. doi: 10.1073/pnas.2305871120
Ahmed, Jamila, Walker, Andrew A., Perdomo, Hugo D., Guo, Shaodong, Nixon, Samantha A., Vetter, Irina, Okoh, Hilary I., Shehu, Dalhatu M., Shuaibu, Mohammed N., Ndams, Iliya S., King, Glenn F. and Herzig, Volker (2023). Two novel mosquitocidal peptides isolated from the venom of the Bahia scarlet tarantula (Lasiodora klugi). Toxins, 15 (7) 418, 1-14. doi: 10.3390/toxins15070418
Tran, Hue N. T., Budusan, Elena, Saez, Natalie J., Norman, Alexander, Tucker, Isaac J., King, Glenn F., Payne, Richard J., Rash, Lachlan D., Vetter, Irina and Schroeder, Christina I. (2023). Evaluation of peptide ligation strategies for the synthesis of the bivalent acid-sensing ion channel inhibitor Hi1a. Organic Letters, 25 (24), 4439-4444. doi: 10.1021/acs.orglett.3c01346
Tran, Poanna, Tran, Hue N. T., McMahon, Kirsten L., Deuis, Jennifer R., Ragnarsson, Lotten, Norman, Alexander, Sharpe, Simon J., Payne, Richard J., Vetter, Irina and Schroeder, Christina I. (2023). Changes in potency and subtype selectivity of bivalent NaV toxins are knot-specific. Bioconjugate Chemistry, 34 (6), 1072-1083. doi: 10.1021/acs.bioconjchem.3c00135
Robinson, Samuel D., Deuis, Jennifer R., Touchard, Axel, Keramidas, Angelo, Mueller, Alexander, Schroeder, Christina I., Barassé, Valentine, Walker, Andrew A., Brinkwirth, Nina, Jami, Sina, Bonnafé, Elsa, Treilhou, Michel, Undheim, Eivind A. B., Schmidt, Justin O., King, Glenn F. and Vetter, Irina (2023). Ant venoms contain vertebrate-selective pain-causing sodium channel toxins. Nature Communications, 14 (1) 2977, 1-11. doi: 10.1038/s41467-023-38839-1
Zhou, Yan, Harvey, Peta J., Koehbach, Johannes, Chan, Lai Yue, Jones, Alun, Andersson, Åsa, Vetter, Irina, Durek, Thomas and Craik, David J. (2023). A chemo-enzymatic approach to produce a cyclic analogue of the analgesic drug MVIIA (Ziconotide). Angewandte Chemie, 62 (29) e202302812, e202302812. doi: 10.1002/anie.202302812
Jami, Sina, Deuis, Jennifer R., Klasfauseweh, Tabea, Cheng, Xiaoyang, Kurdyukov, Sergey, Chung, Felicity, Okorokov, Andrei L., Li, Shengnan, Zhang, Jiangtao, Cristofori-Armstrong, Ben, Israel, Mathilde R., Ju, Robert J., Robinson, Samuel D., Zhao, Peng, Ragnarsson, Lotten, Andersson, Åsa, Tran, Poanna, Schendel, Vanessa, McMahon, Kirsten L., Tran, Hue N. T., Chin, Yanni K.-Y., Zhu, Yifei, Liu, Junyu, Crawford, Theo, Purushothamvasan, Saipriyaa, Habib, Abdella M., Andersson, David A., Rash, Lachlan D., Wood, John N. ... Vetter, Irina (2023). Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function. Nature Communications, 14 (1) 2442. doi: 10.1038/s41467-023-37963-2
Giribaldi, Julien, Chemin, Jean, Tuifua, Marie, Deuis, Jennifer R., Mary, Rosanna, Vetter, Irina, Wilson, David T., Daly, Norelle L., Schroeder, Christina I., Bourinet, Emmanuel and Dutertre, Sébastien (2023). Pmu1a, a novel spider toxin with dual inhibitory activity at pain targets hNaV1.7 and hCaV3 voltage‐gated channels. The FEBS Journal, 290 (14), 3688-3702. doi: 10.1111/febs.16773
Castro, Joel, Maddern, Jessica, Chow, Chun Yuen, Tran, Poanna, Vetter, Irina, King, Glenn F. and Brierley, Stuart M. (2023). The voltage‐gated sodium channel NaV 1 .7 underlies endometriosis‐associated chronic pelvic pain. Journal of Neurochemistry. doi: 10.1111/jnc.15795
Maxwell, Michael J., Thekkedam, Chris, Lamboley, Cedric, Chin, Yanni K.-Y., Crawford, Theo, Smith, Jennifer J., Liu, Junyu, Jia, Xinying, Vetter, Irina, Laver, Derek R., Launikonis, Bradley S., Dulhunty, Angela, Undheim, Eivind A. B. and Mobli, Mehdi (2023). A bivalent remipede toxin promotes calcium release via ryanodine receptor activation. Nature Communications, 14 (1) 1036, 1-13. doi: 10.1038/s41467-023-36579-w
Robinson, Samuel D., Schendel, Vanessa, Schroeder, Christina I., Moen, Sarah, Mueller, Alexander, Walker, Andrew A., McKinnon, Naomi, Neely, G. Gregory, Vetter, Irina, King, Glenn F. and Undheim, Eivind A. B. (2023). Intra-colony venom diversity contributes to maintaining eusociality in a cooperatively breeding ant. BMC Biology, 21 (1) 5, 5. doi: 10.1186/s12915-022-01507-9
Kuanyshbek, Alibek, Wang, Meng, Andersson, Åsa, Tuifua, Marie, Palmer, Elizabeth E., Sachdev, Rani K., Mu, Ting-Wei, Vetter, Irina and Keramidas, Angelo (2022). Anti-seizure mechanisms of midazolam and valproate at the β2(L51M) variant of the GABAA receptor. Neuropharmacology, 221 109295, 109295. doi: 10.1016/j.neuropharm.2022.109295
Shi, Naiqi, Szanto, Tibor G., He, Jia, Schroeder, Christina I., Walker, Andrew A., Deuis, Jennifer R., Vetter, Irina, Panyi, György, King, Glenn F. and Robinson, Samuel D. (2022). Venom composition and pain-causing toxins of the Australian great carpenter bee Xylocopa aruana. Scientific Reports, 12 (1) 22168, 1-13. doi: 10.1038/s41598-022-26867-8
Starobova, Hana, Alshammari, Ammar, Winkler, Ingrid G. and Vetter, Irina (2022). The role of the neuronal microenvironment in sensory function and pain pathophysiology. Journal of Neurochemistry. doi: 10.1111/jnc.15724
Robinson, Samuel D., Deuis, Jennifer R., Klasfauseweh, Tabea, Schendel, Vanessa and Vetter, Irina (2022). Venom-derived pain-causing toxins: insights into sensory neuron function and pain mechanisms. Pain, 163 (S1), S46-S56. doi: 10.1097/j.pain.0000000000002701
Tay, Nicolette, Laakso, E-Liisa, Schweitzer, Daniel, Endersby, Raelene, Vetter, Irina and Starobova, Hana (2022). Chemotherapy-induced peripheral neuropathy in children and adolescent cancer patients. Frontiers in Molecular Biosciences, 9 1015746, 1015746. doi: 10.3389/fmolb.2022.1015746
McMahon, Kirsten L., Tran, Hue N. T., Deuis, Jennifer R., Craik, David J., Vetter, Irina and Schroeder, Christina I. (2022). µ-Conotoxins targeting the human voltage-gated sodium channel subtype NaV1.7. Toxins, 14 (9) 600, 1-16. doi: 10.3390/toxins14090600
Xie, Jing, Robinson, Samuel D., Gilding, Edward K., Jami, Sina, Deuis, Jennifer R., Rehm, Fabian B.H., Yap, Kuok, Ragnarsson, Lotten, Chan, Lai Yue, Hamilton, Brett R., Harvey, Peta J., Craik, David J., Vetter, Irina and Durek, Thomas (2022). Neurotoxic and cytotoxic peptides underlie the painful stings of the tree nettle Urtica ferox. Journal of Biological Chemistry, 298 (8) 102218, 1-12. doi: 10.1016/j.jbc.2022.102218
Klasfauseweh, Tabea, Israel, Mathilde R., Ragnarsson, Lotten, Cox, James J., Durek, Thomas, Carter, David A., Leffler, Andreas, Vetter, Irina and Deuis, Jennifer R. (2022). Low potency inhibition of NaV1.7 by externally applied QX-314 via a depolarizing shift in the voltage-dependence of activation. European Journal of Pharmacology, 925 175013, 175013. doi: 10.1016/j.ejphar.2022.175013
Stables, Jennifer, Green, Emma K., Sehgal, Anuj, Patkar, Omkar L., Keshvari, Sahar, Taylor, Isis, Ashcroft, Maisie E., Grabert, Kathleen, Wollscheid-Lengeling, Evi, Szymkowiak, Stefan, McColl, Barry W., Adamson, Antony, Humphreys, Neil E., Mueller, Werner, Starobova, Hana, Vetter, Irina, Shabestari, Sepideh Kiani, Blurton-Jones, Matthew M., Summers, Kim M., Irvine, Katharine M., Pridans, Clare and Hume, David A. (2022). A kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy has a dominant inhibitory impact on CSF1R signalling. Development, 149 (8) dev200237. doi: 10.1242/dev.200237
Eagles, David A., Saez, Natalie J., Krishnarjuna, Bankala, Bradford, Julia J., Chin, Yanni K.-Y., Starobova, Hana, Mueller, Alexander, Reichelt, Melissa E., Undheim, Eivind A. B., Norton, Raymond S., Thomas, Walter G., Vetter, Irina, King, Glenn F. and Robinson, Samuel D. (2022). A peptide toxin in ant venom mimics vertebrate EGF-like hormones to cause long-lasting hypersensitivity in mammals. Proceedings of the National Academy of Sciences, 119 (7) e2112630119. doi: 10.1073/pnas.2112630119
Tran, Hue N. T., McMahon, Kirsten L., Deuis, Jennifer R., Vetter, Irina and Schroeder, Christina I. (2022). Structural and functional insights into inhibition of human voltage-gated sodium channels by μ‐conotoxin KIIIA disulfide isomers. Journal of Biological Chemistry, 298 (3) 101728, 1-13. doi: 10.1016/j.jbc.2022.101728
Finol-Urdaneta, Rocio K., Ziegman, Rebekah, Dekan, Zoltan, McArthur, Jeffrey R., Heitmann, Stewart, Luna-Ramirez, Karen, Tae, Han-Shen, Mueller, Alexander, Starobova, Hana, Chin, Yanni K.-Y., Wingerd, Joshua S., Undheim, Eivind A. B., Cristofori-Armstrong, Ben, Hill, Adam P., Herzig, Volker, King, Glenn F., Vetter, Irina, Rash, Lachlan D., Adams, David J. and Alewood, Paul F. (2022). Multitarget nociceptor sensitization by a promiscuous peptide from the venom of the King Baboon spider. Proceedings of the National Academy of Sciences, 119 (5) e2110932119. doi: 10.1073/pnas.2110932119
Deuis, Jennifer R., Ragnarsson, Lotten, Robinson, Samuel D., Dekan, Zoltan, Chan, Lerena, Jin, Ai-Hua, Tran, Poanna, McMahon, Kirsten L., Li, Shengnan, Wood, John N., Cox, James J., King, Glenn F., Herzig, Volker and Vetter, Irina (2022). The tarantula venom peptide Eo1a binds to the domain II S3-S4 extracellular loop of voltage-gated sodium channel NaV1.8 to enhance activation. Frontiers in Pharmacology, 12 789570, 789570. doi: 10.3389/fphar.2021.789570
Wu, Yue, Cui, Zhenling, Huang, Yen-Hua, de Veer, Simon J., Aralov, Andrey V., Guo, Zhong, Moradi, Shayli V., Hinton, Alexandra O., Deuis, Jennifer R., Guo, Shaodong, Chen, Kai-En, Collins, Brett M., Vetter, Irina, Herzig, Volker, Jones, Alun, Cooper, Matthew A., King, Glenn F., Craik, David J., Alexandrov, Kirill and Mureev, Sergey (2022). Towards a generic prototyping approach for therapeutically-relevant peptides and proteins in a cell-free translation system. Nature Communications, 13 (1) 260, 260. doi: 10.1038/s41467-021-27854-9
Paz, Cristian, Ortiz, Leandro, Deuis, Jennifer R. and Vetter, Irina (2022). Polygodial, a drimane sesquiterpenoid dialdehyde purified from Drimys winteri, inhibits voltage-gated sodium channels. Natural Product Research, 36 (24), 1-6. doi: 10.1080/14786419.2022.2025592
Dashevsky, Daniel, Deuis, Jennifer R., Vetter, Irina, Huynh, Tam, Hodgson, Wayne C., Tan, Choo Hock, Nouwens, Amanda and Fry, Bryan G. (2021). Novel neurotoxic activity in Calliophis intestinalis venom. Neurotoxicity Research, 40 (1), 173-178. doi: 10.1007/s12640-021-00413-2
Tran, Hue N. T., Tran, Poanna, Deuis, Jennifer R., McMahon, Kirsten L., Yap, Kuok, Craik, David J., Vetter, Irina and Schroeder, Christina I. (2021). Evaluation of efficient non-reducing enzymatic and chemical ligation strategies for complex disulfide-rich peptides. Bioconjugate Chemistry, 32 (11) acs.bioconjchem.1c00452, 2407-2419. doi: 10.1021/acs.bioconjchem.1c00452
Robinson, Samuel D., Kambanis, Lucas, Clayton, Daniel, Hinneburg, Hannes, Corcilius, Leo, Mueller, Alexander, Walker, Andrew A., Keramidas, Angelo, Kulkarni, Sameer S., Jones, Alun, Vetter, Irina, Thaysen-Andersen, Morten, Payne, Richard J., King, Glenn F. and Undheim, Eivind A.B. (2021). A pain-causing and paralytic ant venom glycopeptide. iScience, 24 (10) 103175, 1-21. doi: 10.1016/j.isci.2021.103175
Nixon, Samantha A., Robinson, Samuel D., Agwa, Akello J., Walker, Andrew A., Choudhary, Shivani, Touchard, Axel, Undheim, Eivind A.B., Robertson, Alan, Vetter, Irina, Schroeder, Christina I., Kotze, Andrew C., Herzig, Volker and King, Glenn F. (2021). Multipurpose peptides: the venoms of Amazonian stinging ants contain anthelmintic ponericins with diverse predatory and defensive activities. Biochemical Pharmacology, 192 114693. doi: 10.1016/j.bcp.2021.114693
Hu, Huiyu, Mawlawi, Saja, Zhao, Tianjiao, Jami, Sina, Deuis, Jennifer R., Vetter, Irina, Lewis, Richard J. and Cardoso, Fernanda C. (2021). Engineering of a spider peptide via conserved structure-function traits optimizes sodium channel inhibition in vitro and anti-nociception in vivo. Frontiers in Molecular Biosciences, 8 742457, 742457. doi: 10.3389/fmolb.2021.742457
Gulsevin, Alican , Papke, Roger L., Stokes, Clare, Tran, Hue N. T., Jin, Aihua H., Vetter, Irina and Meiler, Jens (2021). The allosteric activation of α7 nAChR by α-Conotoxin MrIC is modified by mutations at the vestibular site. Toxin, 13 (8) 555, 555. doi: 10.3390/toxins13080555
Braga Emidio, Nayara, Tran, Hue N. T., Andersson, Asa, Dawson, Philip E., Albericio, Fernando, Vetter, Irina and Muttenthaler, Markus (2021). Improving the gastrointestinal stability of linaclotide. Journal of Medicinal Chemistry, 64 (12) acs.jmedchem.1c00380, 8384-8390. doi: 10.1021/acs.jmedchem.1c00380
Jensen, Timo, Walker, Andrew A., Nguyen, Son H., Jin, Ai-Hua, Deuis, Jennifer R., Vetter, Irina, King, Glenn F., Schmidt, Justin O. and Robinson, Samuel D. (2021). Venom chemistry underlying the painful stings of velvet ants (Hymenoptera: Mutillidae). Cellular and Molecular Life Sciences, 78 (12), 5163-5177. doi: 10.1007/s00018-021-03847-1
Walker, Andrew A., Robinson, Samuel D., Paluzzi, Jean-Paul V., Merritt, David J., Nixon, Samantha A., Schroeder, Christina I., Jin, Jiayi, Goudarzi, Mohaddeseh Hedayati, Kotze, Andrew C., Dekan, Zoltan, Sombke, Andy, Alewood, Paul F., Fry, Bryan G., Epstein, Marc E., Vetter, Irina and King, Glenn F. (2021). Production, composition, and mode of action of the painful defensive venom produced by a limacodid caterpillar, Doratifera vulnerans. Proceedings of the National Academy of Sciences of the United States of America, 118 (18) 2023815118, e2023815118. doi: 10.1073/pnas.2023815118
Starobova, Hana, Monteleone, Mercedes, Adolphe, Christelle, Batoon, Lena, Sandrock, Cheyenne J., Tay, Bryan, Deuis, Jennifer R., Smith, Alexandra V., Mueller, Alexander, Nadar, Evelyn Israel, Lawrence, Grace Pamo, Mayor, Amanda, Tolson, Elissa, Levesque, Jean-Pierre, Pettit, Allison R., Wainwright, Brandon J., Schroder, Kate and Vetter, Irina (2021). Vincristine-induced peripheral neuropathy is driven by canonical NLRP3 activation and IL-1β release. Journal of Experimental Medicine, 218 (5) e20201452. doi: 10.1084/jem.20201452
Koopman, Charlotte D., De Angelis, Jessica, Iyer, Swati P., Verkerk, Arie O., Da Silva, Jason, Berecki, Geza, Jeanes, Angela, Baillie, Gregory J., Paterson, Scott, Uribe, Veronica, Ehrlich, Ophelia V., Robinson, Samuel D., Garric, Laurence, Petrou, Steven, Simons, Cas, Vetter, Irina, Hogan, Benjamin M., de Boer, Teun P., Bakkers, Jeroen and Smith, Kelly A. (2021). The zebrafish mutant uncovers an evolutionarily conserved role for Tmem161b in the control of cardiac rhythm. Proceedings of the National Academy of Sciences of the United States of America, 118 (9) e2018220118, e2018220118. doi: 10.1073/pnas.2018220118
Hasan, Md. Mahadhi, Starobova, Hana, Mueller, Alexander, Vetter, Irina and Lewis, Richard J. (2021). Subcutaneous ω-conotoxins alleviate mechanical pain in rodent models of acute peripheral neuropathy. Marine Drugs, 19 (2) 106, 1-15. doi: 10.3390/md19020106
Kazandjian, T. D., Petras, D., Robinson, S. D., van Thiel, J., Greene, H. W., Arbuckle, K., Barlow, A., Carter, D. A., Wouters, R. M., Whiteley, G., Wagstaff, S. C., Arias, A. S., Albulescu, L.-O., Plettenberg Laing, A., Hall, C., Heap, A., Penrhyn-Lowe, S., McCabe, C. V., Ainsworth, S., da Silva, R. R., Dorrestein, P. C., Richardson, M. K., Gutiérrez, J. M., Calvete, J. J., Harrison, R. A., Vetter, I., Undheim, E. A. B., Wüster, W. and Casewell, N. R. (2021). Convergent evolution of pain-inducing defensive venom components in spitting cobras. Science, 371 (6527), 386-390. doi: 10.1126/science.abb9303
Peigneur, Steve, da Costa Oliveira, Cristina, de Sousa Fonseca, Flávia Cristina, McMahon, Kirsten L., Mueller, Alexander, Cheneval, Olivier, Cristina Nogueira Freitas, Ana, Starobova, Hana, Dimitri Gama Duarte, Igor, Craik, David J., Vetter, Irina, de Lima, Maria Elena, Schroeder, Christina I. and Tytgat, Jan (2021). Small cyclic sodium channel inhibitors. Biochemical Pharmacology, 183 114291, 114291. doi: 10.1016/j.bcp.2020.114291
Robinson, Samuel D. and Vetter, Irina (2020). Pharmacology and therapeutic potential of venom peptides. Biochemical Pharmacology, 181 114207, 114207. doi: 10.1016/j.bcp.2020.114207
McMahon, Kirsten L., Tran, Hue N.T., Deuis, Jennifer R., Lewis, Richard J., Vetter, Irina and Schroeder, Christina I. (2020). Discovery, pharmacological characterisation and NMR structure of the novel µ-Conotoxin SxIIIC, a potent and irreversible NaV channel inhibitor. Biomedicines, 8 (10) 391, 1-15. doi: 10.3390/biomedicines8100391
Herzig, Volker, Sunagar, Kartik, Wilson, David T. R., Pineda, Sandy S., Israel, Mathilde R., Dutertre, Sebastien, McFarland, Brianna Sollod, Undheim, Eivind A. B., Hodgson, Wayne C., Alewood, Paul F., Lewis, Richard J., Bosmans, Frank, Vetter, Irina, King, Glenn F. and Fry, Bryan G. (2020). Australian funnel-web spiders evolved human-lethal δ-hexatoxins for defense against vertebrate predators. Proceedings of the National Academy of Sciences, 117 (40), 24920-24928. doi: 10.1073/pnas.2004516117
Gilding, Edward K., Jami, Sina, Deuis, Jennifer R., Israel, Mathilde R., Harvey, Peta J., Poth, Aaron G., Rehm, Fabian B. H., Stow, Jennifer L., Robinson, Samuel D., Yap, Kuok, Brown, Darren L., Hamilton, Brett R., Andersson, David, Craik, David J., Vetter, Irina and Durek, Thomas (2020). Neurotoxic peptides from the venom of the giant Australian stinging tree. Science Advances, 6 (38) eabb8828, 1-10. doi: 10.1126/sciadv.abb8828
Starobova, Hana, Nadar, Evelyn Israel and Vetter, Irina (2020). The NLRP3 inflammasome: role and therapeutic potential in pain treatment. Frontiers in Physiology, 11 1016, 1016. doi: 10.3389/fphys.2020.01016
Sharma, Gagan, Deuis, Jennifer R., Jia, Xinying, Mueller, Alexander, Vetter, Irina and Mobli, Mehdi (2020). Recombinant production, bioconjugation and membrane binding studies ofPn3a, a selective Nav1.7 inhibitor. Biochemical Pharmacology, 181 114148, 114148. doi: 10.1016/j.bcp.2020.114148
Nixon, Samantha A., Dekan, Zoltan, Robinson, Samuel D., Guo, Shaodong, Vetter, Irina, Kotze, Andrew C., Alewood, Paul F., King, Glenn F. and Herzig, Volker (2020). It takes two: dimerization is essential for the broad-spectrum predatory and defensive activities of the venom peptide Mp1a from the jack jumper ant Myrmecia pilosula. Biomedicines, 8 (7) 185, 1-13. doi: 10.3390/biomedicines8070185
Israel, Mathilde R., Dash, Thomas S., Bothe, Stefanie N., Robinson, Samuel D., Deuis, Jennifer R., Craik, David J., Lampert, Angelika, Vetter, Irina and Durek, Thomas (2020). Characterization of synthetic Tf2 as a NaV1.3 selective pharmacological probe. Biomedicines, 8 (6) 155, 155. doi: 10.3390/biomedicines8060155
McMahon, Kirsten L., Tay, Bryan, Deuis, Jennifer R., Tanaka, Brian S., Peigneur, Steve, Jin, Ai-Hua, Tytgat, Jan, Waxman, Stephen G., Dib-Hajj, Sulayman D., Vetter, Irina and Schroeder, Christina I. (2020). Pharmacological activity and NMR solution structure of the leech peptide HSTX-I. Biochemical Pharmacology, 181 114082, 114082. doi: 10.1016/j.bcp.2020.114082
Aili, Samira R., Touchard, Axel, Hayward, Regan, Robinson, Samuel D., Pineda, Sandy S., Lalagüe, Hadrien, Mrinalini, Vetter, Irina, Undheim, Eivind A. B., Kini, R. Manjunatha, Escoubas, Pierre, Padula, Matthew P., Myers, Garry S. A. and Nicholson, Graham M. (2020). An integrated proteomic and transcriptomic analysis reveals the venom complexity of the bullet ant Paraponera clavata. Toxins, 12 (5) 324, 1-30. doi: 10.3390/toxins12050324
Wilson, David T., Bansal, Paramjit S., Carter, David A., Vetter, Irina, Nicke, Annette, Dutertre, Sébastien and Daly, Norelle L. (2020). Characterisation of a novel a-superfamily conotoxin. Biomedicines, 8 (5) 128, 128. doi: 10.3390/BIOMEDICINES8050128
Agwa, Akello J., Tran, Poanna, Mueller, Alexander, Tran, Hue N. T., Deuis, Jennifer R., Israel, Mathilde R., McMahon, Kirsten L., Craik, David J., Vetter, Irina and Schroeder, Christina I. (2020). Manipulation of a spider peptide toxin alters its affinity for lipid bilayers and potency and selectivity for voltage-gated sodium channel subtype 1.7. The Journal of Biological Chemistry, 295 (15), 5067-5080. doi: 10.1074/jbc.ra119.012281
Weuring, Wout J., Singh, Sakshi, Volkers, Linda, Rook, Martin B., Van't Slot, Ruben H., Bosma, Marjolein, Inserra, Marco, Vetter, Irina, Verhoeven-Duif, Nanda M., Braun, Kees P. J., Rivara, Mirko and Koeleman, Bobby P. C. (2020). NaV1.1 and NaV1.6 selective compounds reduce the behavior phenotype and epileptiform activity in a novel zebrafish model for Dravet syndrome. PLoS ONE, 15 (3) e0219106, e0219106. doi: 10.1371/journal.pone.0219106
Yin, Kathleen, Deuis, Jennifer R., Dekan, Zoltan, Jin, Ai-Hua, Alewood, Paul F., King, Glenn F., Herzig, Volker and Vetter, Irina (2020). Addition of K22 converts spider venom peptide Pme2a from an activator to an inhibitor of NaV1.7. Biomedicines, 8 (2) 37, 37. doi: 10.3390/biomedicines8020037
Mueller, Alexander, Dekan, Zoltan, Kaas, Quentin, Agwa, Akello J., Starobova, Hana, Alewood, Paul F., Schroeder, Christina I., Mobli, Mehdi, Deuis, Jennifer R. and Vetter, Irina (2020). Mapping the molecular surface of the analgesic NaV1.7-selective peptide Pn3a reveals residues essential for membrane and channel interactions. ACS Pharmacology and Translational Science. doi: 10.1021/acsptsci.0c00002
Azimi, Iman, Stevenson, Ralph J., Zhang, Xuexin, Meizoso-Huesca, Aldo, Xin, Ping, Johnson, Martin, Flanagan, Jack U., Chalmers, Silke B., Yoast, Ryan E., Kapure, Jeevak S., Ross, Benjamin P., Vetter, Irina, Ashton, Mark R., Launikonis, Bradley S., Denny, William A., Trebak, Mohamed and Monteith, Gregory R. (2020). A new selective pharmacological enhancer of the Orai1 Ca2+ channel reveals roles for Orai1 in smooth and skeletal muscle functions. ACS Pharmacology and Translational Science, 3 (1) acsptsci.9b00081, 135-147. doi: 10.1021/acsptsci.9b00081
Herzig, Volker, Cristofori-Armstrong, Ben, Israel, Mathilde R., Nixon, Samantha A., Vetter, Irina and King, Glenn F. (2020). Animal toxins — Nature's evolutionary-refined toolkit for basic research and drug discovery. Biochemical Pharmacology, 181 114096, 114096. doi: 10.1016/j.bcp.2020.114096
Rupasinghe, Darshani B., Herzig, Volker, Vetter, Irina, Dekan, Zoltan, Gilchrist, John, Bosmans, Frank, Alewood, Paul F., Lewis, Richard J. and King, Glenn F. (2020). Mutational analysis of ProTx-I and the novel venom peptide Pe1b provide insight into residues responsible for selective inhibition of the analgesic drug target NaV1.7. Biochemical Pharmacology, 181 114080, 114080. doi: 10.1016/j.bcp.2020.114080
Tran, Hue, Tran, Poanna, Deuis, Jennifer R., Agwa, Akello Joanna, Zhang, Alan H., Vetter, Irina and Schroeder, Christina I (2019). Enzymatic ligation of a pore blocker toxin and gating modifier toxin; creating double-knotted peptides with improved sodium channel NaV1.7 inhibition. Bioconjugate Chemistry, 31 (1) acs.bioconjchem.9b00744, 64-73. doi: 10.1021/acs.bioconjchem.9b00744
Shenoy, Priyank A., Kuo, Andy, Leparc, German, Hildebrandt, Tobias, Rust, Werner, Nicholson, Janet R., Corradini, Laura, Vetter, Irina and Smith, Maree T. (2019). Transcriptomic characterisation of the optimised rat model of Walker 256 breast cancer cell-induced bone pain. Clinical and Experimental Pharmacology and Physiology, 46 (12) 1440-1681.13165, 1201-1215. doi: 10.1111/1440-1681.13165
Walker, Andrew A., Robinson, Samuel D., Undheim, Eivind A. B., Jin, Jiayi, Han, Xiao, Fry, Bryan G., Vetter, Irina and King, Glenn F. (2019). Missiles of mass disruption: Composition and glandular origin of venom used as a projectile defensive weapon by the assassin bug Platymeris rhadamanthus. Toxins, 11 (11) 673, 673. doi: 10.3390/toxins11110673
Mueller, Alexander, Starobova, Hana, Morgan, Michael, Dekan, Zoltan, Cheneval, Olivier, Schroeder, Christina I., Alewood, Paul F., Deuis, Jennifer R. and Vetter, Irina (2019). Antiallodynic effects of the selective NaV1.7 inhibitor Pn3a in a mouse model of acute postsurgical pain: evidence for analgesic synergy with opioids and baclofen. Pain, 160 (8), 1766-1780. doi: 10.1097/j.pain.0000000000001567
Starobova, H., Mueller, A., Allavena, R., Lohman, R. J., Sweet, M. J. and Vetter, I. (2019). Minocycline prevents the development of mechanical allodynia in mouse models of vincristine-induced peripheral neuropathy. Frontiers in Neuroscience, 13 (JUN) 653, 653. doi: 10.3389/fnins.2019.00653
Starobova, Hana, Mueller, Alexander, Deuis, Jennifer R., Carter, David A. and Vetter, Irina (2019). Inflammatory and neuropathic gene expression signatures of chemotherapy-induced neuropathy induced by vincristine, cisplatin and oxaliplatin in C57BL/6J mice. The Journal of Pain, 21 (1-2), 182-194. doi: 10.1016/j.jpain.2019.06.008
Israel, Mathilde R., Tanaka, Brian S., Castro, Joel, Thongyoo, Panumart, Robinson, Samuel D., Zhao, Peng, Deuis, Jennifer R., Craik, David J., Durek, Thomas, Brierley, Stuart M., Waxman, Stephen G, Dib-Hajj, Sulayman D. and Vetter, Irina (2019). NaV1.6 regulates excitability of mechanosensitive sensory neurons. Journal of Physiology, 597 (14), 3751-3768. doi: 10.1113/JP278148
Jin, Ai-hua, Cristofori-Armstrong, Ben, Rash, Lachlan D., Román González, Sergio Agustín, Espinosa, Roberto Arreguín, Lewis, Richard J., Alewood, Paul F. and Vetter, Irina (2019). Novel conorfamides from Conus austini venom modulate both nicotinic acetylcholine receptors and acid-sensing ion channels. Biochemical Pharmacology, 164, 342-348. doi: 10.1016/j.bcp.2019.04.025
Mostyn, Shannon N., Rawling, Tristan, Mohammadi, Sarasa, Shimmon, Susan, Frangos, Zachary J., Sarker, Subhodeep, Yousuf, Arsalan, Vetter, Irina, Ryan, Renae M., Christie, Macdonald J. and Vandenberg, Robert J. (2019). Development of an N-acyl amino acid that selectively inhibits the glycine transporter 2 to produce analgesia in a rat model of chronic pain. Journal of Medicinal Chemistry, 62 (5), 2466-2484. doi: 10.1021/acs.jmedchem.8b01775
Tay, Bryan, Stewart, Teneale A., Davis, Felicity M., Deuis, Jennifer R. and Vetter, Irina (2019). Development of a high-throughput fluorescent no-wash sodium influx assay. PLOS One, 14 (3) e0213751, e0213751. doi: 10.1371/journal.pone.0213751
Dash, Thomas S., Shafee, Thomas, Harvey, Peta J., Zhang, Chuchu, Peigneur, Steve, Deuis, Jennifer R., Vetter, Irina, Tytgat, Jan, Anderson, Marilyn A., Craik, David J., Durek, Thomas and Undheim, Eivind A. B. (2019). A centipede toxin family defines an ancient class of CSαβ defensins. Structure, 27 (2), 315-326. doi: 10.1016/j.str.2018.10.022
Walker, Andrew, Dobson, James, Jin, Jiayi, Robinson, Samuel, Herzig, Volker, Vetter, Irina, King, Glenn and Fry, Bryan (2018). Buzz kill: Function and proteomic composition of venom from the Giant Assassin Fly Dolopus genitalis (Diptera: Asilidae). Toxins, 10 (11) 456, 456. doi: 10.3390/toxins10110456
Starobova, H., S. W. A., Himaya, Lewis, R. J. and Vetter, I. (2018). Transcriptomics in pain research: insights from new and old technologies. Molecular Omics, 14 (6), 389-404. doi: 10.1039/c8mo00181b
Sousa, Silmara R., McArthur, Jeffrey R., Brust, Andreas, Bhola, Rebecca F., Rosengren, K. Johan, Ragnarsson, Lotten, Dutertre, Sebastien, Alewood, Paul F., Christie, Macdonald J., Adams, David J., Vetter, Irina and Lewis, Richard J. (2018). Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides. Scientific Reports, 8 (1) 13397, 13397. doi: 10.1038/s41598-018-31245-4
Bicknell, Brendan A., Pujic, Zac, Feldner, Julia, Vetter, Irina and Goodhill, Geoffrey J. (2018). Data descriptor: chemotactic responses of growing neurites to precisely controlled gradients of nerve growth factor. Scientific Data, 5 (1) 180183, 180183. doi: 10.1038/sdata.2018.183
Robinson, Samuel D., Mueller, Alexander, Clayton, Daniel, Starobova, Hana, Hamilton, Brett R., Payne, Richard J., Vetter, Irina, King, Glenn F. and Undheim, Eivind A. B. (2018). A comprehensive portrait of the venom of the giant red bull ant, Myrmecia gulosa, reveals a hyperdiverse hymenopteran toxin gene family. Science Advances, 4 (9) eaau4640, eaau4640. doi: 10.1126/sciadv.aau4640
Stevenson, Ralph J, Azimi, Iman, Flanagan, Jack U, Inserra, Marco, Vetter, Irina, Monteith, Gregory R and Denny, William A (2018). An SAR study of hydroxy-trifluoromethylpyrazolines as inhibitors of Orai1-mediated store operated Ca2+ entry in MDA-MB-231 breast cancer cells using a convenient Fluorescence Imaging Plate Reader assay. Bioorganic & Medicinal Chemistry, 26 (12), 3406-3413. doi: 10.1016/j.bmc.2018.05.012
Shenoy, Priyank A., Kuo, Andy, Khan, Nemat, Gorham, Louise, Nicholson, Janet, Corradini, Laura, Vetter, Irina and Smith, Maree T. (2018). The somatostatin receptor-4 agonist J-2156 alleviates mechanical hypersensitivity in a rat model of breast cancer induced bone pain. Frontiers in Pharmacology, 9 (MAY) 495, 495. doi: 10.3389/fphar.2018.00495
Yapa, Kunsala T. D. S., Deuis, Jennifer, Peters, Amelia A., Kenny, Paraic A., Roberts-Thomson, Sarah J., Vetter, Irina and Monteith, Gregory R. (2018). Assessment of the TRPM8 inhibitor AMTB in breast cancer cells and its identification as an inhibitor of voltage gated sodium channels. Life Sciences, 198, 128-135. doi: 10.1016/j.lfs.2018.02.030
Morgan, Michael, Deuis, Jennifer R., Woodruff, Trent M., Lewis, Richard J. and Vetter, Irina (2018). Role of complement anaphylatoxin receptors in a mouse model of acute burn-induced pain. Molecular Immunology, 94, 68-74. doi: 10.1016/j.molimm.2017.12.016
Israel, Mathilde R., Thongyoo, Panumart, Deuis, Jennifer R., Craik, David J., Vetter, Irina and Durek, Thomas (2018). The E15R Point Mutation in Scorpion Toxin Cn2 Uncouples Its Depressant and Excitatory Activities on Human NaV1.6. Journal of Medicinal Chemistry, 61 (4), 1730-1736. doi: 10.1021/acs.jmedchem.7b01609
Jami, Sina, Erickson, Andelain, Brierley, Stuart M and Vetter, Irina (2018). Pain-causing venom peptides: insights into sensory neuron pharmacology. Toxins, 10 (1) ARTN 15, 15. doi: 10.3390/toxins10010015
Muttenthaler, Markus, Andersson, Asa, Vetter, Irina, Menon, Rohit, Busnelli, Marta, Ragnarsson, Lotten, Bergmayr, Christian, Arrowsmith, Sarah, Deuis, Jennifer R., Chiu, Han Sheng, Palpant, Nathan J., O'Brien, Margaret, Smith, Terry J., Wray, Susan, Neumann, Inga D., Gruber, Christian W., Lewis, Richard J. and Alewood, Paul F. (2017). Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species. Science Signaling, 10 (508) eaan3398, 1-13. doi: 10.1126/scisignal.aan3398
Jin, Ai-Hua, Dekan, Zoltan, Smout, Michael J., Wilson, David, Dutertre, Sébastien, Vetter, Irina, Lewis, Richard J., Loukas, Alex, Daly, Norelle L. and Alewood, Paul F. (2017). Conotoxin Φ-MiXXVIIA from the superfamily G2 employs a novel cysteine framework that mimics granulin and displays anti-apoptotic activity. Angewandte Chemie, 129 (47), 15169-15172. doi: 10.1002/ange.201708927
Vetter, Irina (2017). Toxins in neurobiology: new tools from old molecules. Neuroscience Letters, 679, 1-3. doi: 10.1016/j.neulet.2017.11.002
Jin, Ai-Hua, Dekan, Zoltan, Smout, Michael J., Wilson, David, Dutertre, Sébastien, Vetter, Irina, Lewis, Richard J., Loukas, Alex, Daly, Norelle L. and Alewood, Paul F. (2017). Conotoxin Φ-MiXXVIIA from the Superfamily G2 Employs a Novel Cysteine Framework that Mimics Granulin and Displays Anti-Apoptotic Activity. Angewandte Chemie (International ed. in English), 56 (47), 14973-14976. doi: 10.1002/anie.201708927
Morgan, Michael, Deuis, Jennifer R., Frøsig-Jørgensen, Majbrit, Lewis, Richard J., Cabot, Peter J., Gray, Paul D. and Vetter, Irina (2017). Burn pain: a systematic and critical review of epidemiology, pathophysiology, and treatment. Pain Medicine, 19 (4), 708-734. doi: 10.1093/pm/pnx228
Sousa, Silmara R., Wingerd, Joshua S., Brust, Andreas, Bladen, Christopher, Ragnarsson, Lotten, Herzig, Volker, Deuis, Jennifer R., Dutertre, Sebastien, Vetter, Irina, Zamponi, Gerald W., King, Glenn F., Alewood, Paul F. and Lewis, Richard J. (2017). Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi. PLoS One, 12 (9) e0182848, e0182848. doi: 10.1371/journal.pone.0182848
Deuis, Jennifer R., Dvorakova, Lucie S. and Vetter, Irina (2017). Methods used to evaluate pain behaviors in rodents. Frontiers in Molecular Neuroscience, 10 284, 284. doi: 10.3389/fnmol.2017.00284
Shenoy, Priyank, Kuo, Andy, Vetter, Irina and Smith, Maree T. (2017). Optimization and in vivo profiling of a refined rat model of Walker 256 breast cancer cell-induced bone pain using behavioral, radiological, histological, immunohistochemical and pharmacological methods. Frontiers in Pharmacology, 8 (JUL) 442, 442. doi: 10.3389/fphar.2017.00442
Dekan, Zoltan, Headey, Stephen J., Scanlon, Martin, Baldo, Brian A., Lee, Tzong-Hsien, Aguilar, Marie-Isabel, Deuis, Jennifer R., Vetter, Irina, Elliott, Alysha G., Amado, Maite, Cooper, Matthew A., Alewood, Dianne and Alewood, Paul F. (2017). Δ-Myrtoxin-Mp1a is a helical heterodimer from the venom of the jack jumper ant that has antimicrobial, membrane-disrupting, and nociceptive activities. Angewandte Chemie, 56 (29), 8495-8499. doi: 10.1002/anie.201703360
Starobova, Hana and Vetter, Irina (2017). Pathophysiology of chemotherapy-induced peripheral neuropathy. Frontiers in Molecular Neuroscience, 10 174. doi: 10.3389/fnmol.2017.00174
Deuis, Jennifer R., Dekan, Zoltan, Wingerd, Joshua S., Smith, Jennifer J., Munasinghe, Nehan R., Bhola, Rebecca F., Imlach, Wendy L., Herzig, Volker, Armstrong, David A., Rosengren, K. Johan, Bosmans, Frank, Waxman, Stephen G., Dib-Hajj, Sulayman D., Escoubas, Pierre, Minett, Michael S., Christie, Macdonald J., King, Glenn F., Alewood, Paul F., Lewis, Richard J., Wood, John N. and Vetter, Irina (2017). Corrigendum: Pharmacological characterisation of the highly Na v 1.7 selective spider venom peptide Pn3a (Scientific Reports (2017) 7 (40883). Scientific Reports, 7 (1) 46816, 46816. doi: 10.1038/srep46816
Cardoso, Fernanda Caldas, Dekan, Zoltan, Smith, Jennifer J., Deuis, Jennifer R., Vetter, Irina, Herzig, Volker, Alewood, Paul F., King, Glenn F and Lewis, Richard J. (2017). Modulatory features of the novel spider toxin μ-TRTX-Df1a isolated from the venom of the spider Davus fasciatus. British Journal of Pharmacology, 174 (15), 2528-2544. doi: 10.1111/bph.13865
Casewell, Nicholas R., Visser, Jeroen C., Baumann, Kate, Dobson, James, Han, Han, Kuruppu, Sanjaya, Morgan, Michael, Romilio, Anthony, Weisbecker, Vera, Mardon, Karine, Ali, Syed A., Debono, Jordan, Koludarov, Ivan, Que, Ivo, Bird, Gregory C., Cooke, Gavan M., Nouwens, Amanda, Hodgson, Wayne C., Wagstaff, Simon C., Cheney, Karen L., Vetter, Irina, van der Weerd, Louise, Richardson, Michael K. and Fry, Bryan G. (2017). The Evolution of Fangs, Venom, and Mimicry Systems in Blenny Fishes (vol 27, pg 1184, 2017). Current Biology, 27 (10), 1549-1550. doi: 10.1016/j.cub.2017.05.009
Deuis, Jennifer R., Mueller, Alexander, Israel, Mathilde R. and Vetter, Irina (2017). The pharmacology of voltage-gated sodium channel activators. Neuropharmacology, 127, 87-108. doi: 10.1016/j.neuropharm.2017.04.014
Windley, Monique J., Vetter, Irina, Lewis, Richard J. and Nicholson, Graham M. (2017). Lethal effects of an insecticidal spider venom peptide involve positive allosteric modulation of insect nicotinic acetylcholine receptors. Neuropharmacology, 127, 224-242. doi: 10.1016/j.neuropharm.2017.04.008
Israel, Mathilde R., Tay, Bryan, Deuis, Jennifer R. and Vetter, Irina (2017). Sodium Channels and Venom Peptide Pharmacology. Advances in Pharmacology, 79, 67-116. doi: 10.1016/bs.apha.2017.01.004
Prashanth, Jutty Rajan, Hasaballah, Nojod and Vetter, Irina (2017). Pharmacological screening technologies for venom peptide discovery. Neuropharmacology, 127, 4-19. doi: 10.1016/j.neuropharm.2017.03.038
Casewell, Nicholas R., Visser, Jeroen C., Baumann, Kate, Dobson, James, Han, Han, Kuruppu, Sanjaya, Morgan, Michael, Romilio, Anthony, Weisbecker, Vera, Ali, Syed A., Debono, Jordan, Koludarov, Ivan, Que, Ivo, Bird, Gregory C., Cooke, Gavan M., Nouwens, Amanda, Hodgson, Wayne C., Wagstaff, Simon C., Cheney, Karen L., Vetter, Irina, van der Weerd, Louise, Richardson, Michael K. and Fry, Bryan G. (2017). The evolution of fangs, venom, and mimicry systems in blenny fishes. Current Biology, 27 (8), 1184-1191. doi: 10.1016/j.cub.2017.02.067
Rahnama, Sassan, Deuis, Jennifer R., Cardoso, Fernanda C., Ramanujam, Venkatraman, Lewis, Richard J., Rash, Lachlan D., King, Glenn F., Vetter, Irina and Mobli, Mehdi (2017). The structure, dynamics and selectivity profile of a NaV 1.7 potency-optimised huwentoxin-IV variant. PLoS One, 12 (3) e0173551, e0173551. doi: 10.1371/journal.pone.0173551
Inserra, Marco C., Isreal, Mathilde, Caldwell, Ashlee, Castro, Joel, Deuis, Jennifer R., Harrington, Andrea M., Keramidas, Angelo, Garcia-Caraballo, Sonia, Maddern, Jessica, Erickson, Andelain, Grundy, Luke, Rychkov, Grigori Y., Zimmerman, Katharina, Lewis, Richard J., Brierley, Stuart M. and Vetter, Irina (2017). Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1. Scientific Reports, 7 (1) 42810, 42810. doi: 10.1038/srep42810
Wan, Jingjing, Mobli, Mehdi, Brust, Andreas, Muttenthaler, Markus, Andersson, Asa, Ragnarsson, Lotten, Castro, Joel, Vetter, Irina, Huang, Johnny X., Nilsson, Mathias, Brierley, Stuart M., Cooper, Matthew A., Lewis, Richard J. and Alewood, Paul F. (2017). Synthesis of multivalent [Lys8]-oxytocin dendrimers that inhibit visceral nociceptive responses. Australian Journal of Chemistry, 70 (2), 162-171. doi: 10.1071/CH16407
Deuis, Jennifer R., Dekan, Zoltan, Wingerd, Joshua S., Smith, Jennifer J., Munasinghe, Nehan R., Bhola, Rebecca F., Imlach, Wendy L., Herzig, Volker, Armstrong, David A., Rosengren, K. Johan, Bosmans, Frank, Waxman, Stephen G., Dib-Hajj, Sulayman D., Escoubas, Pierre, Minett, Michael S., Christie, Macdonald J., King, Glenn F., Alewood, Paul F., Lewis, Richard J., Wood, John N. and Vetter, Irina (2017). Pharmacological characterisation of the highly Nav1.7 selective spider venom peptide Pn3a. Scientific Reports, 7 (1) 40883, 40883. doi: 10.1038/srep40883
Barry, Guy, Briggs, James A., Hwang, Do Won, Nayler, Sam P., Fortuna, Patrick R. J., Jonkhout, Nicky, Dachet, Fabien, Maag, Jesper L. V., Mestdagh, Pieter, Singh, Erin M., Avesson, Lotta, Kaczorowski, Dominik C., Ozturk, Ezgi, Jones, Nigel C., Vetter, Irina, Arriola-Martinez, Luis, Hu, Jianfei, Franco, Gloria R., Warn, Victoria M., Gong, Andrew, Dinger, Marcel E., Rigo, Frank, Lipovich, Leonard, Morris, Margaret J., O'Brien, Terence J., Lee, Dong Soo, Loeb, Jeffrey A., Blackshaw, Seth, Mattick, John S. and Wolvetang, Ernst J. (2017). The long non-coding RNA NEAT1 is responsive to neuronal activity and is associated with hyperexcitability states. Scientific Reports, 7 (1) 40127, 40127. doi: 10.1038/srep40127
Deuis, Jennifer R., Yin, Kathleen, Cooper, Matthew A., Schroder, Kate and Vetter, Irina (2016). Role of NLRP3 inflammasome in a model of acute burn-induced pain. Burns, 43 (2), 304-309. doi: 10.1016/j.burns.2016.09.001
Vetter, Irina, Deuis, Jennifer, Mueller, Alexander, Israel, Mathilde R., Hana Starobova, Zhang, Alan, Rash, Lachlan D. and Mobli, Mehdi (2016). NaV1.7 as a pain target – from gene to pharmacology. Pharmacology and Therapeutics, 172, 73-100. doi: 10.1016/j.pharmthera.2016.11.015
Lolignier, Stéphane, Gkika, Dimitra, Andersson, David, Leipold, Enrico, Vetter, Irina, Viana, Felix, Noel, Jacques and Busserolles, Jérôme (2016). New insight in cold pain: role of ion channels, modulation, and clinical perspectives. The Journal of Neuroscience, 36 (45), 11435-11439. doi: 10.1523/JNEUROSCI.2327-16.2016
Bressan, Elisangela, Touska, Filip, Vetter, Irina, Kistner, Katrin, Kichko, Tatjana I., Teixeira, Nathalia B., Picolo, Gisele, Cury, Yara, Lewis, Richard J., Fischer, Michael J. M., Zimmermann, Katharina and Reeh, Peter W. (2016). Crotalphine desensitizes TRPA1 ion channels to alleviate inflammatory hyperalgesia. Pain, 157 (11), 2504-2516. doi: 10.1097/j.pain.0000000000000669
Yang, Daryl C., Deuis, Jennifer R., Dashevsky, Daniel, Dobson, James, Jackson, Timothy N. W., Brust, Andreas, Xie, Bing, Koludarov, Ivan, Debono, Jordan, Hendrikx, Iwan, Hodgson, Wayne C., Josh, Peter, Nouwens, Amanda, Baillie, Gregory J., Bruxner, Timothy J. C., Alewood, Paul F., Peng Lim, Kelvin Kok, Frank, Nathaniel, Vetter, Irina and Fry, Bryan G. (2016). The snake with the scorpion's sting: novel three-finger toxin sodium channel activators from the venom of the long-glanded blue coral snake (Calliophis bivirgatus). Toxins, 8 (10) A034, 303. doi: 10.3390/toxins8100303
Shenoy, Priyank A., Kuo, Andy, Vetter, Irina and Smith, Maree T. (2016). The Walker 256 breast cancer cell-induced bone pain model in rats. Frontiers in Pharmacology, 7 (AUG) 286, 286. doi: 10.3389/fphar.2016.00286
Yin, Kathleen, Deuis, Jennifer R., Lewis, Richard J. and Vetter, Irina (2016). Transcriptomic and behavioural characterisation of a mouse model of burn pain identify the cholecystokinin 2 receptor as an analgesic target. Molecular Pain, 12, 1-13. doi: 10.1177/1744806916665366
Troeira Henriques, Sonia, Deplazes, Evelyne, Lawrence, Nicole, Cheneval, Olivier, Chaousis, Stephanie, Inserra, Marco, Thongyoo, Panumart, King, Glenn F., Mark, Alan E., Vetter, Irina, Craik, David J. and Schroeder, Christina Ingrid (2016). Interaction of tarantula venom peptide ProTx-II with lipid membranes is a prerequisite for its inhibition of human voltage-gated sodium channel NaV1.7. The Journal of Biological Chemistry, 291 (33), 17049-17065. doi: 10.1074/jbc.M116.729095
Lewis, Richard J., Inserra, Marco, Vetter, Irina, Holland, William C., Hardison, D. Ransom, Tester, Patricia A. and Litaker, R. Wayne (2016). Rapid extraction and identification of maitotoxin and ciguatoxin-like toxins from Caribbean and Pacific Gambierdiscus using a new functional bioassay. PLoS ONE, 11 (7) e0160006, e0160006. doi: 10.1371/journal.pone.0160006
Mündel, Toby, Nalivaiko, Eugene, Kent, Stephen, Maloney, Shane K. and Vetter, Irina (2016). How hot is it Down Under?. Temperature, 3 (3), 355-357. doi: 10.1080/23328940.2016.1218991
Le Garrec, Raphaele, L'herondelle, Killian, Le Gall-Ianotto, Christelle, Lebonvallet, Nicolas, Leschiera, Raphael, Buhe, Virginie, Talagas, Matthieu, Vetter, Irina, Lewis, Richard J. and Misery, Laurent (2016). Release of neuropeptides from a neuro-cutaneous co-culture model: a novel in vitro model for studying sensory effects of ciguatoxins. Toxicon, 116, 4-10. doi: 10.1016/j.toxicon.2015.11.004
Deuis, Jennifer R, Dekan, Zoltan, Inserra, Marco C., Lee, Tzong-Hsien, Aguilar, Marie-Isabel, Craik, David J., Lewis, Richard J., Alewood, Paul F., Mobli, Mehdi, Schroeder, Christina I., Henriques, Sónia Troeira and Vetter, Irina (2016). Development of a μO-conotoxin analogue with improved lipid membrane interactions and potency for the analgesic target NaV1.8. Journal of Biological Chemistry, 291 (22), 11829-11842. doi: 10.1074/jbc.M116.721662
Ariki, Nathanial K., Muñoz, Lisa E., Armitage, Elizabeth L., Goodstein, Francesca R., George, Kathryn G, Smith, Vanessa L., Vetter, Irina, Herzig, Volker, King, Glenn F. and Loening, Nikolaus M. (2016). Characterization of Three Venom Peptides from the Spitting Spider Scytodes thoracica. PLoS One, 11 (5) e0156291, e0156291. doi: 10.1371/journal.pone.0156291
Yin, Kathleen, Baillie, Gregory J. and Vetter, Irina (2016). Neuronal cell lines as model dorsal root ganglion neurons: a transcriptomic comparison. Molecular Pain, 12, 1-17. doi: 10.1177/1744806916646111
Deuis, Jennifer R., Wingerd, Joshua S., Winter, Zoltan, Durek, Thomas, Dekan, Zoltan, Sousa, Silmara R., Zimmermann, Katharina, Hoffmann, Tali, Weidner, Christian, Nassar, Mohammed A., Alewood, Paul F., Lewis, Richard J. and Vetter, Irina (2016). Analgesic effects of GpTx-1, PF-04856264 and CNV1014802 in a mouse model of NaV1.7-Mediated pain. Toxins, 8 (3) 78, 78. doi: 10.3390/toxins8030078
Deuis, Jennifer R. and Vetter, Irina (2016). The thermal probe test: a novel behavioral assay to quantify thermal paw withdrawal thresholds in mice. Temperature, 3 (2), 199-207. doi: 10.1080/23328940.2016.1157668
Azimi, Iman, Flanagan, Jack U., Stevenson, Ralph J., Inserra, Marco, Vetter, Irina, Monteith, Gregory R. and Denny, William A. (2016). Evaluation of known and novel inhibitors of Orai1-mediated store operated Ca2+ entry in MDA-MB-231 breast cancer cells using a Fluorescence Imaging Plate Reader assay. Bioorganic and Medicinal Chemistry, 25 (1), 440-449. doi: 10.1016/j.bmc.2016.11.007
Bugarcic, Andrea, Vetter, Irina, Chalmers, Silke, Kinna, Genevieve, Collins, Brett M. and Teasdale, Rohan D. (2015). Vps26B-retromer negatively regulates plasma membrane resensitization of PAR-2. Cell Biology International, 39 (11), 1299-1306. doi: 10.1002/cbin.10508
Deuis, Jennifer, Whately, Ella, Brust, Andreas, Inserra, Marco, Asvadi, Naghmeh Hajarol, Lewis, Richard J., Alewood, Paul F., Cabot, Peter J. and Vetter, Irina (2015). Activation of k opioid receptors in cutaneous nerve endings by conorphin-1, a novel subtype-selective conopeptide, does not mediate peripheral analgesia. ACS Chemical Neuroscience, 6 (10), 1751-1758. doi: 10.1021/acschemneuro.5b00113
Himaya S.W.A., Jin, Ai-Hua, Dutertre, Sebastien, Giacomotto, Jean, Mohialdeen, Hoshyar, Vetter, Irina, Alewood, Paul F. and Lewis, Richard J. (2015). Comparative Venomics Reveals the Complex Prey Capture Strategy of the Piscivorous Cone Snail Conus catus. Journal of Proteome Research, 14 (10), 4372-4381. doi: 10.1021/acs.jproteome.5b00630
Paz, Cristian, Becerra, Jose, Silva, Mario, Burgos, Viviana, Heydenreich, Matthias, Schmidt, Bernd, Thu Tran and Vetter, Irina (2015). (-)-Pentylsedinine, a new alkaloid from the leaves of lobelia tupa with agonist activity at nicotinic acetylcholine receptor. Natural Product Communications, 10 (8), 1355-1357. doi: 10.1177/1934578x1501000810
Cardoso, Fernanda C., Deka, Zoltan, Rosengren, K. Johan, Erickson, Andelain, Vetter, Irina, Deuis, Jennifer R., Herzig, Volker, Alewood, Paul F., King, Glenn F. and Lewis, Richard J. (2015). Identification and characterization of ProTx-III [μ-TRTX-Tp1a], a new voltage-gated sodium channel inhibitor from venom of the tarantula Thrixopelma pruriens. Molecular Pharmacology, 88 (2), 291-303. doi: 10.1124/mol.115.098178
Jin, Ai-Hua, Israel, Mathilde R., Inserra, Marco, Smith, Jennifer J., Lewis, Richard J., Alewood, Paul F., Vetter, Irina and Dutertre, Sebastien (2015). δ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails. Proceedings of the Royal Society B: Biological Sciences, 282 (1811) 20150817, 1-8. doi: 10.1098/rspb.2015.0817
Klint, Julie K., Smith, Jennifer J., Vetter, Irina, Rupasinghe, Darshani B., Er, Sing Yan, Senff, Sebastian, Herzig, Volker, Mobli, Mehdi, Lewis, Richard J., Bosmans, Frank and King, Glenn F. (2015). Seven novel modulators of the analgesic target NaV1.7 uncovered using a high-throughput venom-based discovery approach. British Journal of Pharmacology, 172 (10), 2445-2458. doi: 10.1111/bph.13081
Gleeson, Ellen C., Graham, Janease E., Spiller, Sandro, Vetter, Irina, Lewis, Richard J., Duggan, Peter J. and Tuck, Kellie L. (2015). Inhibition of N-type calcium channels by fluorophenoxyanilide derivatives. Marine Drugs, 13 (4), 2030-2045. doi: 10.3390/md13042030
Mueller, Alexander, Starobova, Hana, Inserra, Marco C., Jin, Ai-Hua, Deuis, Jennifer R., Dutertre, Sebastien, Lewis, Richard J., Alewood, Paul F., Daly, Norelle L. and Vetter, Irina (2015). α-conotoxin MrIC is a biased agonist at α7 nicotinic acetylcholine receptors. Biochemical Pharmacology, 94 (2), 155-163. doi: 10.1016/j.bcp.2015.01.011
Coll, Rebecca C., Robertson, Avril A. B., Chae, Jae Jin, Higgins, Sarah C., Muñoz-Planillo, Raúl, Inserra, Marco C., Vetter, Irina, Dungan, Lara S., Monks, Brian G., Stütz, Andrea, Croker, Daniel E., Butler, Mark S., Haneklaus, Moritz, Sutton, Caroline E., Núñez, Gabriel, Latz, Eicke, Kästner, Daniel L., Mills, Kingston H. G., Masters, Seth L., Schroder, Kate, Cooper, Matthew A. and O'Neill, Luke A. J. (2015). A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nature Medicine, 21 (3), 248-257. doi: 10.1038/nm.3806
Yin, Kathleen, Zimmermann, Katharina, Vetter, Irina and Lewis, Richard J. (2015). Therapeutic opportunities for targeting cold pain pathways. Biochemical Pharmacology, 93 (2), 125-140. doi: 10.1016/j.bcp.2014.09.024
Vetter, Irina, Kym, Philip R. and Szallasi, Arpad (2015). Feeling hot, feeling cold: TRP channels - a great story unfolds. Temperature, 2 (2), 150-151. doi: 10.1080/23328940.2015.1047721
Jin, Ai-Hua, Vetter, Irina, Himaya, Siddhihalu W. A., Alewood, Paul F., Lewis, Richard J. and Dutertre, Sébastien (2015). Transcriptome and proteome of Conus planorbis identify the nicotinic receptors as primary target for the defensive venom. Proteomics, 15 (23-24), 4030-4040. doi: 10.1002/pmic.201500220
Zimmermann, Katharina, Eisenblätte, Anneka, Vetter, Irina, Ebbecke, Martin, Friedemann, Miriam and Desel, Herbert (2015). Vergiftung durch Tropenfisch: Ciguatera-Epidemie in Deutschland. Deutsche Medizinische Wochenschrift, 140 (2), 125-130. doi: 10.1055/s-0040-100439
Wan, Jingjing, Huang, Johnny X., Vetter, Irina, Mobli, Mehdi, Lawson, Joshua, Tae, Han-Shen, Abraham, Nikita, Paul, Blessy, Cooper, Matthew A., Adams, David J., Lewis, Richard J. and Alewood, Paul F. (2015). α-Conotoxin dendrimers have enhanced potency and selectivity for homomeric nicotinic acetylcholine receptors. Journal of the American Chemical Society, 137 (9), 3209-3212. doi: 10.1021/jacs.5b00244
Mollica, Adriano, Costante, Roberto, Novellino, Ettore, Stefanucci, Azzurra, Pieretti, Stefano, Zador, Ferenc, Samavati, Reza, Borsodi, Anna, Benyhe, Sandor, Vetter, Irina and Lewis, Richard J. (2014). Design, synthesis and biological evaluation of two opioid agonist and Cav2.2 blocker multitarget ligands. Chemical Biology and Drug Design, 86 (2), 156-162. doi: 10.1111/cbdd.12479
Mattei, Cesar, Vetter, Irina, Eisenblatter, Anneka, Krock, Bernd, Ebbecke, Martin, Desel, Herbert and Zimmermann, Katharina (2014). Ciguatera fish poisoning: a first epidemic in Germany highlights an increasing risk for European countries. Toxicon, 91 (2), 76-83. doi: 10.1016/j.toxicon.2014.10.016
King, Glenn F and Vetter, Irina (2014). No gain, no pain: NaV1.7 as an analgesic target. ACS Chemical Neuroscience, Articles ASAP (9), 749-751. doi: 10.1021/cn500171p
Karas, John A., Scanlon, Denis B., Forbes, Briony E., Vetter, Irina, Lewis, Richard J., Gardiner, James, Separovic, Frances, Wade, John D. and Hossain, Mohammed A. (2014). 2-nitroveratryl as a photocleavable thiol-protecting group for directed disulfide bond formation in the chemical synthesis of insulin.. Chemistry: A European Journal, 20 (31), 9549-9552. doi: 10.1002/chem.201403574
Wang, Ching-I Anderson, Reeks, Timothy, Vetter, Irina, Vergara, Irene, Kovtun, Oleksiy, Lewis, Richard J., Alewood, Paul F. and Durek, Thomas (2014). Isolation and structural and pharmacological characterization of α-elapitoxin-Dpp2d, an amidated three finger toxin from black mamba venom. Biochemistry, 53 (23), 3758-3766. doi: 10.1021/bi5004475
Baumann, Kate, Casewell, Nicholas R., Ali, Syed A., Jackson, Timothy N. W., Vetter, Irina, Dobson, James S., Cutmore, Scott C., Nouwens, Amanda, Lavergne, Vincent and Fry, Bryan G. (2014). A ray of venom: Combined proteomic and transcriptomic investigation of fish venom composition using barb tissue from the blue-spotted stingray (Neotrygon kuhlii). Journal of Proteomics, 109, 188-198. doi: 10.1016/j.jprot.2014.06.004
Dutertre, Sébastien, Jin, Ai-Hua, Vetter, Irina, Hamilton, Brett, Sunagar, Kartik, Lavergne, Vincent, Dutertre, Valentin, Fry, Bryan G., Antunes, Agostinho, Venter, Deon J., Alewood, Paul F. and Lewis, Richard J. (2014). Evolution of separate predation- and defence-evoked venoms in carnivorous cone snails. Nature Communications, 5 (3521) 3521, 1-9. doi: 10.1038/ncomms4521
Jin, Ai-Hua, Vetter, Irina, Dutertre, Sébastien, Abraham, Nikita, Emidio, Nayara B., Inserra, Marco, Murali, Swetha S., Christie, MacDonald J., Alewood, Paul F. and Lewis, Richard J. (2014). MrIC, a novel alpha-conotoxin agonist in the presence of PNU at endogenous alpha-7 nicotinic acetylcholine receptors. Biochemistry, 53 (1), 1-3. doi: 10.1021/bi400882s
Dantas De Araujo, Aline, Mobli, Mehdi, Castro, Joel, Harrington, Andrea M., Vetter, Irina, Dekan, Zoltan, Muttenthale, Markus, Wan, JingJing, Lewis, Richard J., King, Glenn F., Brierley, Stuart M. and Alewood, Paul F. (2014). Selenoether oxytocin analogues have analgesic properties in a mouse model of chronic abdominal pain. Nature Communications, 5 (1) 3165, 3165.1-3165.12. doi: 10.1038/ncomms4165
Deuis, Jennifer R., Lim, Yu Ling, Rodrigues de Sousa, Silmara, Lewis, Richard J., Alewood, Paul F., Cabot, Peter J. and Vetter, Irina (2014). Analgesic effects of clinically used compounds in novel mouse models of polyneuropathy induced by oxaliplatin and cisplatin. Neuro-Oncology, 16 (10), 1324-1332. doi: 10.1093/neuonc/nou048
Vetter, Irina, Hein, Alexander, Sattler, Simon, Hessler, Sabine, Touska, Filip, Bressan, Elisangela, Parra, Andres, Hager, Ulrich, Leffler, Andreas, Boukalova, Stepana, Nissen, Matthias, Lewis, Richard J., Belmonte, Carlos, Alzheimer, Christian, Huth, Tobias, Vlachova, Viktorie, Reeh, Peter W. and Zimmermann, Katharina (2013). Amplified Cold Transduction in Native Nociceptors by M-Channel Inhibition. Journal of Neuroscience, 33 (42), 16627-16641. doi: 10.1523/JNEUROSCI.1473-13.2013
Zimmermann, Katharina, Deuis, Jennifer R., Inserra, Marco C., Collins, Lindon S., Namer, Barbara, Cabot, Peter J., Reeh, Peter W., Lewis, Richard J. and Vetter, Irina (2013). Analgesic treatment of ciguatoxin-induced cold allodynia. Pain, 154 (10), 1999-2006. doi: 10.1016/j.pain.2013.06.015
Deuis, Jennifer R., Zimmermann, Katharina, Romanovsky, Andrej A., Possani, Lourival D., Cabot, Peter J., Lewis, Richard J. and Vetter, Irina (2013). An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Na(v)1.6 in peripheral pain pathways. Pain, 154 (9), 1749-1757. doi: 10.1016/j.pain.2013.05.032
Inserra, Marco C., Kompella, Shiva N., Vetter, Irina, Brust, Andreas, Daly, Norelle L., Cuny, Hartmut, Craik, David J., Alewood, Paul F., Adams, David J. and Lewis, Richard J. (2013). Isolation and characterization of alpha-conotoxin LsIA with potent activity at nicotinic acetylcholine receptors. Biochemical Pharmacology, 86 (6), 791-799. doi: 10.1016/j.bcp.2013.07.016
Durek, Thomas, Vetter, Irina, Wang, Ching-I Anderson, Motin, Leonid, Knapp, Oliver, Adams, David J., Lewis, Richard J. and Alewood, Paul F. (2013). Chemical engineering and structural and pharmacological characterization of the alpha-scorpion toxin OD1. ACS Chemical Biology, 8 (6), 1215-1222. doi: 10.1021/cb400012k
Smith, Jennifer J., Vetter, Irina, Lewis, Richard J., Peigneur, Steve, Tytgat, Jan, Lam, Alexander, Gallant, Esther M., Beard, Nicole A., Alewood, Paul F. and Dulhunty, Angela F. (2013). Multiple actions of phi-LITX-Lw1a on ryanodine receptors reveal a functional link between scorpion DDH and ICK toxins. Proceedings of the National Academy of Sciences of the United States of America, 110 (22), 8906-8911. doi: 10.1073/pnas.1214062110
Sousa, Silmara R., Vetter, Irina, Ragnarsson, Lotten and Lewis, Richard J. (2013). Expression and pharmacology of endogenous Ca-v channels in SH-SY5Y human neuroblastoma cells. PloS One, 8 (3) e59293, e59293. doi: 10.1371/journal.pone.0059293
Brust, Andreas, Sunagar, Kartik, Eivind Undheim, Vetter, Irina, Yang, Daryl C., Casewell, Nicholas R., Ruder, Tim, Jackson, Timothy N. W., Koludarov, Ivan, Alewood, Paul F., Hodgson, Wayne C., Lewis, Richard J., King, Glenn F., Antunes, Agostinho, Hendrikx, Iwan and Fry, Bryan G. (2013). Differential evolution and neofunctionalization of snake venom metalloprotease domains. Molecular and Cellular Proteomics, 12 (3), 651-663. doi: 10.1074/mcp.M112.023135
Sousa, Silmara R., Vetter, Irina and Lewis, Richard J. (2013). Venom peptides as a rich source of Cav2.2 channel blockers. Toxins, 5 (2), 286-314. doi: 10.3390/toxins5020286
Brust, Andreas, Sunagar, Kartik, Undheim, Eivind A. B., Vetter, Irina, Yang, Daryl C., Casewell, Nicholas R., Jackson, Timothy N. W., Koludarov, Ivan, Alewood, Paul F., Hodgson, Wayne C., Lewis, Richard J., King, Glenn F., Antunes, Agostinho, Hendrikx, Iwan and Fry, Bryan G. (2012). Differential Evolution and Neofunctionalization of Snake Venom Metalloprotease Domains (vol 12, pg 651, 2013). Molecular & Cellular Proteomics, 12 (5), 1488-1488. doi: 10.1074/mcp.M112.023135
Tranberg, Charlotte Elisabet, Yang, Aijun, Vetter, Irina, McArthur, Jeffrey R., Baell, Jonathan B., Lewis, Richard J., Tuck, Kellie L. and Duggan, Peter J. (2012). omega-Conotoxin GVIA Mimetics that Bind and Inhibit Neuronal Ca(v)2.2 Ion Channels. Marine Drugs, 10 (10), 2349-2368. doi: 10.3390/md10102349
Vetter, Irina, Touska, Filip, Hess, Andreas, Hinsbey, Rachel, Sattler, Simon, Lampert, Angelika, Sergejeva, Marina, Sharov, Anastasia, Collins, Lindon S., Eberhardt, Mirjam, Engel, Matthias, Cabot, Peter J., Wood, John N., Vlachova, Viktorie, Reeh, Peter W., Lewis, Richard J. and Zimmermann, Katharina (2012). Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling. EMBO Journal, 31 (19), 3795-3808. doi: 10.1038/emboj.2012.207
Marcon, Francesca, Leblanc, Mathieu, Vetter, Irina, Lewis, Richard J., Escoubas, Pierre and Nicholson, Graham M. (2012). Pharmacological characterization of α-elapitoxin-Al2a from the venom of the Australian pygmy copperhead (Austrelaps labialis): an atypical long-chain α-neurotoxin with only weak affinity for α7 nicotinic receptors. Biochemical Pharmacology, 84 (6), 851-863. doi: 10.1016/j.bcp.2012.06.024
Vetter, Irina, Dekan, Zoltan, Knapp, Oliver, Adams, David J., Alewood, Paul F. and Lewis, Richard J. (2012). Isolation, characterization and total regioselective synthesis of the novel μO-conotoxin MfVIA from Conus magnificus that targets voltage-gated sodium channels. Biochemical Pharmacology, 84 (4), 540-548. doi: 10.1016/j.bcp.2012.05.008
Vetter, Irina and Lewis, Richard J. (2012). Therapeutic potential of cone snail venom peptides (conopeptides). Current Topics in Medicinal Chemistry, 12 (14), 1546-1552. doi: 10.2174/156802612802652457
Vetter, Irina, Mozar, Christine A., Durek, Thomas, Wingerd, Joshua S., Alewood, Paul F., Christie, Macdonald J. and Lewis, Richard J. (2012). Characterisation of Na-v types endogenously expressed in human SH-SY5Y neuroblastoma cells. Biochemical Pharmacology, 83 (11), 1562-1571. doi: 10.1016/j.bcp.2012.02.022
Lewis, Richard J., Dutertre, Sebastien, Vetter, Irina and Christie, MacDonald J. (2012). Conus venom peptide pharmacology. Pharmacological Reviews, 64 (2), 259-298. doi: 10.1124/pr.111.005322
Dekan, Zoltan, Vetter, Irina, Daly, Norelle L., Craik, David J., Lewis, Richard J. and Alewood, Paul F. (2011). α-Conotoxin ImI incorporating stable cystathionine bridges maintains full potency and identical three-dimensional structure. Journal of the American Chemical Society, 133 (40), 15866-15869. doi: 10.1021/ja206408q
Vetter, Irina, Davis, Jasmine L., Rash, Lachlan D., Anangi, Raveendra, Mobli, Mehdi, Alewood, Paul F., Lewis, Richard J. and King, Glenn F. (2011). Venomics: A new paradigm for natural products-based drug discovery. Amino Acids, 40 (1), 15-28. doi: 10.1007/s00726-010-0516-4
Grice, Desma M., Vetter, Irina, Faddy, Helen M., Kenny, Paraic A., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2010). Golgi calcium pump secretory Pathway calcium ATPase 1 (SPCA1) is a key regulator of Insulin-like Growth Factor Receptor (IGF1R) processing in the basal-like breast cancer cell line MDA-MB-231. Journal of Biological Chemistry, 285 (48), 37458-37466. doi: 10.1074/jbc.M110.163329
Morales, Rodrigo A. V., Daly, Norelle L., Vetter, Irina, Mobli, Mehdi, Napier, Ian A., Craik, David J., Lewis, Richard J., Christie, MacDonald J., King, Glenn F., Alewood, Paul F. and Durek, Thomas (2010). Chemical synthesis and structure of the prokineticin Bv8. ChemBioChem, 11 (13), 1882-1888. doi: 10.1002/cbic.201000330
Vetter, I, Pujic, Z and Goodhill, GJ (2010). The response of dorsal root ganglion axons to nerve growth factor gradients depends on spinal level. Journal of Neurotrauma, 27 (8), 1379-1386. doi: 10.1089/neu.2010.1279
Vetter, Irina and Lewis, Richard J. (2010). Characterization of endogenous calcium responses in neuronal cell lines. Biochemical Pharmacology, 79 (6), 908-920. doi: 10.1016/j.bcp.2009.10.020
Mortimer, D., Pujic, Z., Vaughan, T., Thompson, A. W., Feldner, J., Vetter, I. and Goodhill, G. J. (2010). Axon guidance by growth-rate modulation. Proceedings of the National Academy of Sciences of the United States of America, 107 (11), 5202-5207. doi: 10.1073/pnas.0909254107
Mortimer, Duncan, Feldner, Julia, Vaughan, Timothy, Vetter, Irina, Pujic, Zac, Rosoff, William J., Burrage, Kevin, Dayan, Peter, Richards, Linda J. and Goodhill, Geoffrey J. (2009). A Bayesian model predicts the response of axons to molecular gradients. Proceedings of the National Academy of Sciences of the United States of America, 106 (25), 10296-10301. doi: 10.1073/pnas.0900715106
Vetter, Irina, Cheung, Wei, Peiris, Madusha, Wyse, Bruce D., Roberts-Thomson, Sarah J., Zheng, Jie, Monteith, Gregory R. and Cabot, Peter J (2008). Rapid, Opiod-sensitive mechanisms involved in transient receptor potential vanilloid 1 sensitization. Journal of Biological Chemistry, 283 (28), 19540-19550. doi: 10.1074/jbc.M707865200
Vetter, Irina, Wyse, Bruce D., Roberts-Thomson, Sarah J., Monteith, Gregory R. and Cabot, Peter J. (2008). Mechanisms involved in potentiation of transient receptor potential vanilloid 1 responses by ethanol. European Journal of Pain, 12 (4), 441-454. doi: 10.1016/j.ejpain.2007.07.001
Vetter, Irina, Wyse, Bruce D., Monteith, Gregory R., Roberts-Thomson, Sarah J. and Cabot, Peter J. (2006). The μ opioid agonist morphine modulates potentiation of capsaicin-evoked TRPV1 responses through a cyclic AMP-dependent protein kinase A pathway. Molecular Pain, 2 (22) 22, 1-16. doi: 10.1186/1744-8069-2-22
Vetter, I., Kapitzke, D., Hermanussen, S., Monteith, G. R. and Cabot, P. J. (2006). The Effects of pH on Beta-Endorphin and Morphine Inhibition of Calcium Transients in Dorsal Root Ganglion Neurons. The Journal of Pain, 7 (7), 488-499. doi: 10.1016/j.jpain.2006.01.456
Kapitzke, Daniel, Vetter, Irina and Cabot, Peter J. (2005). Endogenous opioid analgesia in peripheral tissues and the clinical implications for pain control. Therapeutics and Clinical Risk Management, 1 (4), 279-297.
Conference Papers
Van Cutsem, Eric, Ochsenreither, Sebastian, Collignon, Joelle, Eefsen, Rikke Løvendahl, Ivanauskas, Audrius, Shatunova, Svetlana, Vetter, Irina, Gyllenbäck, Elin Jaensson, Skoog, Petter, Losic, Nedjad, Tersago, Dominique and Starobova, Hana (2024). Impact on chemotherapy induced peripheral neuropathy of nadunolimab, a first-in-class monoclonal antibody against IL1RAP, in patients with pancreatic cancer, with supportive mouse model data. 2024 ASCO Annual Meeting, Chicago, IL United States, 31 May - 4 June 2024. Alexandria, VA United States: American Society of Clinical Oncology. doi: 10.1200/jco.2024.42.16_suppl.4148
Hasan, Mahadhi, Abraham, Nikita, Cardoso, Fernanda C., Ragnarsson, Lotten, Starobova, Hana, Mueller, Alexander, Vetter, Irina and Lewis, Richard J. (2021). Subcutaneous analgesic actions and mode of action of binding of ω-conotoxins at Cav2.2. Venom to Drugs, Daydream Island, QLD Australia, 15 - 19 March 2021.
Kazandjian, Taline, Petras, Daniel, Robinson, Sam, Undheim, Eivind, Arbuckle, Kevin, Whiteley, Gareth, Albulescu, Laura-Oana, Ainsworth, Stuart, Wagstaff, Simon, Wuster, Wolfgang, Harrison, Robert, Vetter, Irina, Calvete, Juan and Casewell, Nicholas (2020). Convergent evolution of defensive venom components in spitting cobras. 20th World Congress of the International Society on Toxinology, Buenos Aires, Argentina, 8-13 September 2019. Oxford, United Kingdom: Elsevier . doi: 10.1016/j.toxicon.2019.12.059
Nixon, Samantha, Agwa, Akello, Robinson, Sam, Walker, Andrew, Touchard, Axel, Schroeder, Christina, Vetter, Irina, Kotze, Andrew C., Herzig, Volker and King, Glenn F. (2020). Discovery and characterisation of novel peptides from Amazonian stinging ant venoms with antiparasitic activity. 20th World Congress of the International-Society-on-Toxinology, Buenos Aires, Argentina, 8-13 September 2019. Oxford, United Kingdom: Elsevier.
Weuring, W. J., Singh, S., Volkers, L., Rook, M., van't Slot, R. H., Inserra, M., Vetter, I., Verhoeven-Duif, N. M., Braun, K. P. J., Rivara, M. and Koeleman, B. P. C. (2019). Efficacy Of Voltage-Gated Sodium Channel Subtype Selective Compounds In A Novel Zebrafish Model For Dravet Syndrome. 33rd International Epilepsy Congress, Bangkok Thailand, Jun 22-26, 2019. HOBOKEN: WILEY.
Hasan, Mahadhi, Mueller, Alexander, Starobova, Hana, Vetter, Irina, Cardoso, Fernanda C. and Lewis, Richard J. (2019). New insights in ω-conotoxin analgesic efficacy in postsurgical pain and oxaliplatin/cisplatin induced peripheral neuropathy. Brisbane Pain Research Symposium: Multidisciplinary Perspectives & Therapeutics 2019, Brisbane, QLD Australia, 29 November 2019.
Ferraz, C. R., Cardos, F. C., Clissa, P. B., Vetter, I., Verri Jr, W. A. and Lewis, R. J. (2018). Jararhagin, a metalloproteinase from Bothrops jararaca venom, induces mechanical and thermal hyperalgesia through TRPV1 channel activation. Brisbane Pain Research: Multidisciplinary Perspectives & Therapeutics 2018, Brisbane, QLD, Australia, 7 December 2018.
Schroeder, Christina, Agwa, Akello, Mueller, Alexander, Chow, Chun Yuen, Peigneur, Steve, Lawrence, Nicole, Deplazes, Evelyne, Mark, Alan, Craik, David, Tytgat, Jan, King, Glenn, Vetter, Irina and Henriques, Sonia Troeira (2018). The use of peptide-membrane interactions in the design of selective and potent sodium channel inhibitors. 35th European Peptide Symposium, Dublin City University, Ireland, 26-31 August 2018. Oxford, United Kingdom: John Wiley & Sons.
Schroeder, Christina I., Deuis, Jennifer, Henriques, Sonia Troeria, Dekan, Zoltan, Inserra, Marco, Mobli, Mehdi and Vetter, Irina (2016). Rational design and synthesis of a novel membrane binding NaV1.8 selective inhibitor with in vivo activity in pain models. 60th Annual Meeting of the Biophysical Society, Los Angeles, CA, United States, 27 Feb - 2 Mar 2016. CAMBRIDGE: CELL PRESS. doi: 10.1016/j.bpj.2015.11.247
L'herondelle, K., Philippe, R., Mignen, O., Vetter, I., Lewis, R. J., Misery, L. and Le Garrec, R. (2016). Study of the involvement of itch mediators in the neuropeptide release induced by Pacific-Ciguatoxin-2 in a co-culture model of sensory neurons and keratinocytes. 22nd Meeting of the French-Society-of-Toxinology (SFET), Paris, France, 10-11 December 2014. Kidlington, Oxford, United Kingdom: Pergamon Press. doi: 10.1016/j.toxicon.2016.01.007
Muttenthaler, Markus, Andersson, Asa, Ragnarsson, Lotten, Vetter, Irina, Busnelli, Marta, Chini, Bice, Arrowsmith, Sarah, Wray, Susan, de Araujo, Aline Dantas, Dutertre, Sebastien, Mobli, Mehdi, Lewis, Richard J., Gruber, Christian W. and Alewood, Paul F. (2016). Miklos Bodanszky Award Lecture Probing the Functional Complexity of Ancient Oxytocin in Health and Disease. 34th European Peptide Symposium, Leipzig, Germany, 4‐9 September 2016. Hoboken, NJ United States: Wiley.
Rahnama, S., Lachlan, R., Cardoso, F. C., Smith, J., Deuis, J., Vetter, I., King, G. F. and Mobli, M. (2015). Rational development of novel analgesics for the treatment of chronic pain: Structure-Function studies of an engineered Nav1.7 blocker. The 40th Lorne Conference on Protein Structure and Function, Lorne VIC, Australia, 8-12 February 2015.
Yapa, K., Peters, A. A., Vetter, I., Roberts-Thomson, S. J. and Monteith, G. R. (2014). AMTB, an inhibitor of calcium permeable ion channel TRPM8 and its effect on breast cancer cells. FEBS EMBO 2014 Conference, Paris, France, 30 August - 4 September 2014 . Chichester, West Sussex United Kingdom: Wiley-Blackwell.
Cardoso, F. C., Dekan, Z., Anangi, R., Rosengren, K. J., Erickson, A., Vetter, I., Herzig, V., Alewood, P., King, G. F. and Lewis, R. J. (2014). Discovery of voltage-gated sodium channel inhibitors from tarantula venoms. Venom to Drugs Conference 2014, Kingscliffe, NSW, Australia, 19-23 October 2014.
L'herondelle, K., Philippe, R., Mignen, O., Vetter, I., Lewis, R. J., Misery, L. and Le Garrec, R. (2014). Effets de la ciguatoxine P-CTX-2 sur la liberation induite de neuropeptides dans un modele de co-culture keratinocytes-neurones sensoriels. 32e Congrès Annuel de Recherche Dermatologique (CARD), Océanopolis, Brest, France, 25-27 June, 2014. Issy les Moulineaux, France: Elsevier Masson. doi: 10.1016/j.annder.2014.04.154
Yapa, Kunsala T.D.S, Peters, Amelia A., Vetter, Irina and Roberts-Thomson, Sarah J. (2014). AMTB, a TRPM8 channel blocker also inhibits voltage gated sodium channels (Nav) in breast cancer cells. ASCEPT-MPGPCR Joint Scientific Meeting, Melbourne, VIC, Australia, 7-11 December 2014.
Le Garrec, Raphaele, Vetter, Irina, Lewis, Richard J. and Misery, Laurent (2013). Ciguatoxin-Induced Release of Neuropeptides in a Sensory Neuron-Keratinocyte Coculture Model. World Congress on Itch (WCI), Boston, MA United States, 21–23 September 2013. UPPSALA: ACTA DERMATO-VENEREOLOGICA. doi: 10.2340/00015555-1701
de Valliere, Cheryl, Vidal, Solange, Vetter, Irina, Inserra, Marco, Lewis, Richard J., Cooper, Matthew A., Bentz, Susanne, Wang, Yu, Ludwig, Marie-Gabrielle, Kullak-Ublick, Gerd A., Seuwen, Klaus, Wagner, Carsten A., Rogler, Gerhard and Eloranta, Jyrki J. (2012). The gene encoding the G protein-coupled receptor 68 (GPR68/OGR1) is regulated by TNF, hypoxia, and low pH in human monocytic cells. Digestive Disease Week (DDW), San Diego, CA, United States, 19-22 May 2012. Maryland Heights, MO, United States: W. B. Saunders Co..
de Valliere, Cheryl, Vidal, Solange, Eloranta, Jyrki J., Lang, Silvia, Vetter, Irina, Inserra, Marco, Lewis, Richard J., Cooper, Matthew A., Wang, Yu, Ludwig, Marie-Gabrielle, Kullak-Ublick, Gerd A., Wagner, Carsten A., Rogler, Gerhard and Seuwen, Klaus (2012). Functional consequences of G protein-coupled receptor 68 (GPR68/OGR1) overexpression in intestinal epithelial cells. Digestive Disease Week (DDW), San Diego, CA, United States, 19-22 May 2012. Maryland Heights, MO, United States: WB Saunders Co..
Sousa, Silmara R., Ragnarsson, Lotten, Vetter, Irina, Herzig, Volker, King, Glenn F. and Lewis, Richard J. (2012). Development of high throughput calcium channel assays to accelerate the discovery of novel toxins targeting human cav2.2 channels. 7th World Congress of the International Society on Toxinology & Venom Week 2012, 4th International Scientific Symposium on All Things Venomous, Honolulu, Hawaii, 8 - 13 July 2012. Oxford, United Kingdom: Pergamon. doi: 10.1016/j.toxicon.2012.04.033
Muttenthaler, M., Dawson, P. E., Gruber, C. W., Bergmayr, C., Freissmuth, M., Andersson, A., Vetter, I., Dutertre, S., Lewis, R. J. and Alewood, P. F. (2012). Novel sources for potent and selective GPCR modulators. unknown, unknown, unknown. Chichester, West Sussex, United Kingdom: John Wiley & Sons. doi: 10.1002/psc.2447
Vetter, Irina and Lewis, Richard J. (2011). Accelerated biodiscovery of ion channel modulators. 84th Annual Meeting of the Japanese Pharmacological Society/11th Southeast Asian Western Pacific Regional Meeting of Pharmacologists, Yokohama, Japan, 22-24 March 2011. Kyoto, Japan: Nihon Yakuri Gakkai Henshuubu.
DE Valliere, C, Hiller, C, Kellermeier, S, Crucet, M, Vetter, I, Inserra, M, Lewis, RJ, Cooper, MA, Vidal, S, Seuwen, K, Wagner, CA, Fried, M, Kullak-Ublick, GA, Rogler, G and Eloranta, JJ (2011). Expression of the G Protein-Coupled Receptor 68 is Increased by TNF-Mediated Inflammatory Signalling. Conference on Digestive Disease Week 2011, Chicago Il, May 07-10, 2011. PHILADELPHIA: W B SAUNDERS CO-ELSEVIER INC.
DE Valliere, C, Hiller, C, Kellermeier, S, Vetter, I, Inserra, M, Lewis, RJ, Cooper, MA, Vidal, S, Seuwen, K, Wagner, CA, Fried, M, Kullak-Ublick, GA, Rogler, G and Eloranta, JJ (2011). Expression of Proton-Sensing G Protein-Coupled Receptor 68 (ogr1) Is Increased by Tnf-Mediated Inflammatory Signalling. unknown, unknown, unknown. MALDEN: WILEY-BLACKWELL.
Muttenthaler, M., Gruber, C. W., Andersson, A., Vetter, I., Nevin, S. T., Grishin, A. A., Dutertre, S., Daly, N. L., Craik, D. J., Adams, D. J., Lewis, R. J. and Alewood, P. F. (2011). Conotoxins - blueprints for GPCR drug discovery?. 22nd American Peptide Symposium, San Diego, CA, United States, 25-30 June 2011. Hoboken, NJ, United States: John Wiley & Sons.
Muttenthaler, M. M., de Araujo, A. D., Andersson, A., Vetter, I., Gruber, C., Ramos, Y. Garcia, Feytens, D., Bergmayr, C., Freissmuth, M., Lewis, R. and Alewood, P. (2010). Oxytocin agonist design - A selenocysteine mimetic reveals a functional selectivity switch for the human oxytocin receptor. 31st European Peptide Symposium, Copenhagen, Denmark, 5-9 September 2010. Chichester, West Sussex, U.K.: John Wiley & Sons. doi: 10.1002/psc.1303
Grice, Desma, Vetter, Irina, Faddy, Helen, Paraic, Kenny A, Monteith, Gregory R. and Roberts-Thomson, Sarah J. (2010). Consequences of siRNA-mediated inhibition of the secretory pathway calcium ATPase 1 in human breast cancer cell line. New Horizons in Calcium Signaling, Beijiing, China, October 10-13 2010.
Grice, Desma, Vetter, Irina, Faddy, Helen, Kenny, P.A, Monteith, Gregory R. and Roberts-Thomson, Sarah J. (2010). The golgi-localised calcium atpase in breast cancer. OzBio 2010 - The Molecules of Life - from Discovery to Biotechnology, Melbourne, 26th September to 1st October 2010.
Vetter, I., Wyse, B. D., Monteith, G. R., Roberts-Thomson, S. J. and Cabot, P. J. (2006). Effects of the Mu opioid receptor agonist morphine on TRPV1-mediated capsaicin responses potentiated through PKC and cAMP-dependent PKA pathways. 2006 Neuroscience, Georgia World Congress Center / Altana, Georgia, U.S.A., 11-18 October, 2006. Washington DC, U.S.A.: Society for Neuroscience.
Vetter, I., Wyse, B. D., Monteith, G. R., Roberts-Thomson, S. J. and Cabot, P. J. (2006). Modulation of TRPV1-mediated capsaicin responses potentiated through PKC and camp-dependent PKA pathways by the Mu opioid receptor agonist morphine. ComBio 2006, Brisbane Convention Centre, Brisbane, Australia, 24-28 September, 2006. Kent Town, South Australia: Australian Society for Biochemistry and Molecular Biology.
Vetter, I., Wyse, B. D., Monteith, G. R., Roberts-Thomson, S. J. and Cabot, P. J. (2005). Opioid inhibition of TRPV1-mediated calcium currents in cultured dorsal root ganglion neurones and a HEK293 cell line stably expressing TRPV1 and MOR. 11th World Congress on Pain, Sydney, NSW, Australia, 21-26 August, 2005. Seattle, WA, U.S.A.: International Association for the Study of Pain (IASP) Press.
Kapitzke, D., Hermanussen, S.F., Jenkins, N., Hua, S., Vetter, I., Monteith, G.R. and Cabot, P.J. (2005). Acidic pH enhances morphine inhibition of high-K2+ induced Ca2+ responses in dorsal root ganglion neurons. 11th World Congress on Pain, Sydney, NSW, Australia, 21-26 August, 2005. Seattle, WA, U.S.A.: IASP Press.
Chan, J, Sturtevant, JM, Pillans, PI, Vetter, I, Kane, L and Du, L (2004). Drug utilisation evaluation of parenteral proton pump inhibitors. 8th World Congress of Clinical Pharmacology and Therapeutics, Brisbane Australia, Aug 01-06, 2004. BLACKWELL PUBLISHING ASIA.
Vetter, I., Hermanussen, S. F., Monteith, G. R. and Cabot, P. J. (2004). Beta-endorphin inhibition of capsaicin induced calcium responses in cultured dorsal root ganglion neurones is enhanced at acidic pH. 4th Annual Queensland Health and Medical Scientific Meeting, Brisbane, 30th November - 1st December, 2004. Brisbane: Queensland Government.
Vetter, I., Hermanussen, S. F., Monteith, G. R. and Cabot, P. J. (2004). Beta -endorphin inhibition of capsaicin induced calcium responses in cultured dorsal root ganglion neurones is enhanced at acidic pH's. CPT2004: 8th World Conference on Clinical Pharmacology & Therapeutics 2004, Brisbane, Qld, Australia, 1-6 August, 2004. Melbourne, Vic, Australia: Blackwell Publishing.
Chan, J., Sturtevant, J. M., Pillans, P., Vetter, I., Kane, L. and Du, L. (2004). Drug utilization evaluation of parenteral proton pump inhibitors. 8th World Congress on Clinical Pharmacology & Therapeutics, Brisbane, Australia, 1-7 Augus,t 2004. Oxford: Blackwell Synergy. doi: 10.1111/j.1440-1681.2004.v31_i11_abs.x
Thesis
Vetter, Irina (2007). Mechanisms involved in functional interactions between the Transient Receptor Potential Vanilloid 1 and μ opioid receptor. PhD Thesis, School of Pharmacy, The University of Queensland. doi: 10.14264/158764