Dr Liza Raggatt
Research Fellow
School of Pharmacy and Pharmaceutical Sciences
Researcher biography
Delineation of osteal macrophage function in the bone microenvironment: dual roles in bone dynamics and stem cell niches.
Bone and joint diseases are a national and international health and research priority costing the Australian health system over $10 billion annually. The bony skeleton is a dynamic metabolically active tissue that is continuously remodelled and repaired to maintain calcium homeostasis and structural integrity. The microenvironment at the inner surface of long bones (endosteum), including the bone matrix and associated bone lining cells, is crucial to the dynamic processes of bone modelling and remodelling. I have recently characterized 'osteomacs' as a resident tissue macrophage population within bone lining tissues and have shown that they promote bone mineralization in vitro and are necessary for the maintenance of bone forming osteoblasts in vivo. Thus osteomacs are cellular constituents of endosteal niches and play an osteoblast-support function in this microenvironment. We are investigating the unique phenotype and expression profile (mRNA and protein) of osteomacs in order to fully delineate their functional potential in bone dynamics.
Recently it has been shown that the endosteal environment is also essential for the maintenance of mesenchymal stem cell (MSC) and haematopoietic stem cell (HSC) niches. Osteoblasts need to be present on the bone surface to ensure HSC maintenance in the endosteal niche. Therefore we hypothesised that osteomacs, as a consequence of their presence in the niche and osteoblast support-function, contribute both indirectly and directly to the generation of this stem cell nursery. We have shown that loss of osteomacs and subsequently osteoblasts occurs during G-CSF induced HSC mobilization. Importantly, in vivo depletion of osteomacs (using transgenic Mafia mice) also causes marked egress of HSC from bone marrow into the blood and spleen. These data provide compelling support that osteomacs are required for maintenance of osteoblast bone forming surfaces and provide caretaker support for the endosteal stem cell niches.
My research team has a number of projects that aim to understand the cellular architecture of the endosteal stem cell niches and the role of osteomacs in this environment. This is an essential step toward enhancing clinical HSC mobilization options in order to improve bone marrow transplantation outcomes in multiple myeloma and lymphoma and also ensuring that the promise of MSC therapy is translated into a clinical reality.
Journal Articles
Millard, Susan M., Heng, Ostyn, Opperman, Khatora S., Sehgal, Anuj, Irvine, Katharine M., Kaur, Simranpreet, Sandrock, Cheyenne J., Wu, Andy C., Magor, Graham W., Batoon, Lena, Perkins, Andrew C., Noll, Jacqueline E., Zannettino, Andrew C.W., Sester, David P., Levesque, Jean-Pierre, Hume, David A., Raggatt, Liza J., Summers, Kim M. and Pettit, Allison R. (2021). Fragmentation of tissue-resident macrophages during isolation confounds analysis of single-cell preparations from mouse hematopoietic tissues. Cell Reports, 37 (8) 110058, 110058. doi: 10.1016/j.celrep.2021.110058
Batoon, Lena, Millard, Susan M., Raggatt, Liza J., Wu, Andy C., Kaur, Simranpreet, Sun, Lucas W.H., Williams, Kyle, Sandrock, Cheyenne, Ng, Pei Ying, Irvine, Katharine M., Bartnikowski, Michal, Glatt, Vaida, Pavlos, Nathan J. and Pettit, Allison R. (2021). Osteal macrophages support osteoclast‐mediated resorption and contribute to bone pathology in a postmenopausal osteoporosis mouse model. Journal of Bone and Mineral Research, 36 (11), 2214-2228. doi: 10.1002/jbmr.4413
Batoon, Lena, Millard, Susan M., Raggatt, Liza J., Sandrock, Cheyenne, Pickering, Edmund, Williams, Kyle, Sun, Lucas W.H., Wu, Andy C., Irvine, Katharine M., Pivonka, Peter, Glatt, Vaida, Wullschleger, Martin E., Hume, David A. and Pettit, Allison R. (2021). Treatment with a long-acting chimeric CSF1 molecule enhances fracture healing of healthy and osteoporotic bones. Biomaterials, 275 120936, 120936. doi: 10.1016/j.biomaterials.2021.120936
Kaur, Simranpreet, Sehgal, Anuj, Wu, Andy C., Millard, Susan M., Batoon, Lena, Sandrock, Cheyenne J., Ferrari-Cestari, Michelle, Levesque, Jean-Pierre, Hume, David A., Raggatt, Liza J. and Pettit, Allison R. (2021). Stable colony-stimulating factor 1 fusion protein treatment increases hematopoietic stem cell pool and enhances their mobilisation in mice. Journal of Hematology and Oncology, 14 (1) 3, 1-19. doi: 10.1186/s13045-020-00997-w
Kaur, Simranpreet, Raggatt, Liza J., Millard, Susan M., Wu, Andy C., Batoon, Lena, Jacobsen, Rebecca N., Winkler, Ingrid G., MacDonald, Kelli P., Perkins, Andrew C., Hume, David A., Levesque, Jean-Pierre and Pettit, Allison R. (2018). Self-repopulating recipient bone marrow resident macrophages promote long-term hematopoietic stem cell engraftment. Blood, 132 (7), 735-749. doi: 10.1182/blood-2018-01-829663
Batoon, Lena, Millard, Susan Marie, Wullschleger, Martin Eduar, Preda, Corina, Wu, Andy Chiu-Ku, Kaur, Simranpreet, Tseng, Hsu-Wen, Hume, David Arthur, Levesque, Jean-Pierre, Raggatt, Liza Jane and Pettit, Allison Robyn (2017). CD169+ macrophages are critical for osteoblast maintenance and promote intramembranous and endochondral ossification during bone repair. Biomaterials, 196, 51-66. doi: 10.1016/j.biomaterials.2017.10.033
Batoon, Lena, Millard, Susan Marie, Raggatt, Liza Jane and Pettit, Allison Robyn (2017). Osteomacs and bone regeneration. Current Osteoporosis Reports, 15 (4), 385-395. doi: 10.1007/s11914-017-0384-x
Alexander, Kylie Anne, Raggatt, Liza-Jane, Millard, Susan, Batoon, Lena, Wu, Andy Chiu-Ku, Chang, Ming-Kang, Hume, David Arthur and Pettit, Allison Robyn (2016). Resting and injury-induced inflamed periosteum contain multiple macrophage subsets that are located at sites of bone growth and regeneration. Immunology and Cell Biology, 95 (1), 7-16. doi: 10.1038/icb.2016.74
Kaur, Simranpreet, Raggatt, Liza Jane, Batoon, Lena, Hume, David Arthur, Levesque, Jean-Pierre and Pettit, Allison Robyn (2016). Role of bone marrow macrophages in controlling homeostasis and repair in bone and bone marrow niches. Seminars in Cell and Developmental Biology, 61, 12-21. doi: 10.1016/j.semcdb.2016.08.009
Millard, Susan M., Pettit, Allison R., Ellis, Rebecca, Chan, Jerry K. Y., Raggatt, Liza J., Khosrotehrani, Kiarash and Fisk, Nicholas M. (2015). Intrauterine bone marrow transplantation in osteogenesis imperfecta mice yields donor osteoclasts and osteomacs but not osteoblasts. Stem Cell Reports, 5 (5), 682-689. doi: 10.1016/j.stemcr.2015.09.017
Raggatt, Liza J., Wullschleger, Martin E., Alexander, Kylie A., Wu, Andy C. K., Millard, Susan M., Kaur, Simranpreet, Maugham, Michelle L., Gregory, Laura S., Steck, Roland and Pettit, Allison R. (2014). Fracture healing via periosteal callus formation requires macrophages for both initiation and progression of early endochondral ossification. American Journal of Pathology, 184 (12), 3192-3204. doi: 10.1016/j.ajpath.2014.08.017
Jacobsen, Rebecca N., Forristal, Catherine E., Raggatt, Liza J., Nowlan, Bianca, Barbier, Valerie, Kaur, Simranpreet, van Rooijen, Nico, Winkler, Ingrid G., Pettit, Allison R. and Levesque, Jean-Pierre (2014). Mobilization with granulocyte colony-stimulating factor blocks medullar erythropoiesis by depleting F4/80+VCAM1+CD169+ER-HR3+Ly6G+ erythroid island macrophages in the mouse. Experimental Hematology, 42 (7), 547-561. doi: 10.1016/j.exphem.2014.03.009
Wu, Andy C., Raggatt, Liza J., Alexander, Kylie A. and Pettit, Allison R. (2013). Unraveling macrophage contributions to bone repair. BoneKEy Reports, 2 (373), 1-1. doi: 10.1038/bonekey.2013.107
Raggatt, Liza J., Alexander, Kylie A., Kaur, Simranpreet, Wu, Andy C., MacDonald, Kelli P. A. and Pettit, Allison R. (2013). Absence of B cells does Not compromise intramembranous bone formation during healing in a tibial injury model. American Journal of Pathology, 182 (5), 1501-1508. doi: 10.1016/j.ajpath.2013.01.046
Roberts, Tara L., Ho, Uda, Luff, John, Lee, C. Soon, Apte, Simon H., MacDonald, Kelli P. A., Raggatt, Liza-Jane, Pettit, Allison R., Morrow, Carl A., Waters, Michael J., Chen, Phil, Woods, Rick G., Thomas, Gethin P., St. Pierre, Liam, Farah, Camile S., Clarke, Raymond A., Brown, James A. L. and Lavin, Martin F. (2013). Smg1 haploinsufficiency predisposes to tumor formation and inflammation. PNAS: Proceedings of the National Academy of Sciences of the United States of America, 110 (4), E285-E294. doi: 10.1073/pnas.1215696110
Winkler, I. G., Pettit, A. R., Raggatt, L. J., Jacobsen, R. N., Forristal, C. E., Barbier, V., Nowlan, B., Cisterne, A., Bendall, L. J., Sims, N. A. and Levesque, J-P. (2012). Hematopoietic stem cell mobilizing agents G-CSF, cyclophosphamide or AMD3100 have distinct mechanisms of action on bone marrow HSC niches and bone formation. Leukemia, 26 (7), 1594-1601. doi: 10.1038/leu.2012.17
Alexander, Kylie A., Chang, Ming K., Maylin, Erin R., Kohler, Thomas, Meuller, Ralph, Wu, Andy C., van Rooijen, Nico, Sweet, Matthew J ., Hume, David A., Raggatt, Liza J. and Pettit, Allison R. (2011). Osteal tissue macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model. Journal of Bone And Mineral Research, 26 (7), 1517-1532. doi: 10.1002/jbmr.354
Winkler, Ingrid G., Sims, Natalie A., Pettit, Allison R., Barbier, Valérie, Nowlan, Bianca, Helwani, Falak, Poulton, Ingrid J., van Rooijen, Nico van, Alexander, Kylie A., Raggatt, Liza J. and Levesque, Jean-Pierre (2010). Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs. Blood, 116 (23), 4815-4828. doi: 10.1182/blood-2009-11-253534
Raggatt, Liza J. and Partridge, Nicola C. (2010). Cellular and molecular mechanisms of bone remodeling. Journal of Biological Chemistry, 285 (33), 25103-25108. doi: 10.1074/jbc.R109.041087
Summers, Kim M., Bokil, Nilesh J., Baisden, John M., West, Malcolm J., Sweet, Matthew J., Raggatt, Liza J. and Hume, David A. (2009). Experimental and bioinformatic characterisation of the promoter region of the Marfan syndrome gene, FBN1. Genomics, 94 (4), 233-240. doi: 10.1016/j.ygeno.2009.06.005
Markey, KA, Banovic, T, Kuns, RD, Olver, SD, Don, ALJ, Raffelt, NC, Wilson, YA, Raggatt, LJ, Pettit, AR, Bromberg, JS, Hill, GR and MacDonald, KPA (2009). Conventional dendritic cells are the critical donor APC presenting alloantigen after experimental bone marrow transplantation. BLOOD, 113 (22), 5644-5649. doi: 10.1182/blood-2008-12-191833
Pettit, A. R., Chang, M. K., Hume, D. A. and Raggatt, L. J. (2008). Osteal macrophages: A new twist on coupling during bone dynamics. Bone, 43 (6), 976-982. doi: 10.1016/j.bone.2008.08.128
Chang, Ming K., Raggatt, Liza-Jane, Alexander, Kylie A., Kuliwaba, Julia S., Fazzalari, Nicola L., Schroder, Kate, Maylin, Erin R., Ripoll, Vera M, Hume, David A. and Pettit, Allison R. (2008). Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and In Vivo. The Journal of Immunology, 181 (2), 1232-1244. doi: 10.4049/jimmunol.181.2.1232
Pettit, Allison R., Hume, David A. and Raggatt, Liza-Jane (2008). Re: Structural and cellular differences between metaphyseal and diaphyseal periosteum in different-aged rats. Bone, 42 (4), 825-825. doi: 10.1016/j.bone.2007.12.217
Raggatt, Liza-Jane, Qin, Ling, Tamasi, Joseph, Jefcoat, Jr., Stephen C., Shimizu, Emi, Selvamurugan, Nagarajan, Liew, Foo Y., Bevelock, Laura, Feyen, Jean H. M. and Partridge, Nicola C. (2008). Interleukin-18 is regulated by parathyroid hormone and is required for its bone anabolic actions. The Journal of Biological Chemistry, 283 (11), 6790-6798. doi: 10.1074/jbc.M709909200
Ripoll, V. M, Meadows, N. A., Raggatt, L. J., Chang, M. K., Pettit, A. R., Cassady, A. I. and Hume, D. A. (2008). Microphthalmia transcription factor regulates the expression of the novel osteoclast factor GPNMB. Gene, 413 (1-2), 32-41. doi: 10.1016/j.gene.2008.01.014
Keen, I., Raggatt, L.J., Cool, S.M., Nurcombe, V., Fredericks, P., Trau, M. and Grondahl, L. (2007). Investigations into poly(3-hydroxybutyrate-co-3-hydroxyvalerate) surface properties causing delayed osteoblast growth. Journal of Biomaterials Science-polymer Edition, 18 (9), 1101-1123. doi: 10.1163/156856207781554046
Raggatt, L. J., Jefcoat, S. C., Choudhury, I., Williams, S., Tiku, M. and Partridge, N. C. (2006). Matrix metalloproteinase-13 influences ERK signalling in articular rabbit chondrocytes. Osteoarthritis and cartilage, 14 (7), 680-689. doi: 10.1016/j.joca.2006.01.006
Qin, Ling, Tamasi, Joseph, Raggatt, Liza, Li, Xin, Feyen, Jean H. M., DiCicco-Bloom|, Emanuel and Partridge, Nicola C. (2005). Amphiregulin Is a Novel Growth Factor Involved in Normal Bone Development and in the Cellular Response to Parathyroid Hormone Stimulation. Journal of Biological Chemistry, 280 (5), 3974-3981. doi: 10.1074/jbc.M409807200
Qin, Ling, Raggatt, Liza J. and Partridge, Nicola C. (2004). Parathyroid Hormone: a Double-Edged Sword for Bone Metabolism. Trends in Endocrinology & Metabolism, 15 (2), 60-65. doi: 10.1016/j.tem.2004.01.006
Walling, H. W., Raggatt, L. J., Irvine, D. W., Barmina, O. Y., Toledano, J. E., Goldring, M. B., Hruska, K. A., Adkisson, H. D., Burdge, R. E., Gatt, C. J. Jr., Harwood, D. A. and Partridge, N. C. (2003). Impairment of the Collagenase-3 Endocytotic Receptor System in Cells from Patients with Osteoarthritis. Osteoarthritis and Cartilage, 11 (12), 854-863. doi: 10.1016/S1063-4584(03)00170-5
Findlay, D. M., Raggatt, L. J., Bouralexis, S., Hay, S., Atkins, G. J. and Evdokiou, A. (2002). Calcitonin Decreases the Adherence and Survival of HEK-293 Cells by a Caspase-Independent Mechanism. Journal of Endocrinology, 175 (3), 715-725. doi: 10.1677/joe.0.1750715
Raggatt, Liza J. and Partridge, Nicola C. (2002). HMG-CoA Reductase Inhibitors as Immunomodulators: Potential Use in Transplant Rejection. Drugs, 62 (15), 2185-2191. doi: 10.2165/00003495-200262150-00002
Evdokiou, A., Atkins, G. J., Bouralexis, S., Hay, S., Raggatt, L. J, Cowled, P. A., Graves, S. E., Clayer, M. and Findlay, D. M. (2001). Expression of Alternatively-spliced MDM2 Transcripts in Giant Cell Tumours of Bone. International Journal of Oncology, 19 (3), 625-632.
Evdokiou, A., Raggatt, L. J., Sakai, T. and Findlay, M. D. (2000). Identification of a novel calcitonin receptor response element in the promoter of the human p21WAF1/CIP1 gene. Journal Of Molecular Endocrinology, 25 (2), 195-206. doi: 10.1677/jme.0.0250195
Raggatt, L. J., Evdokiou, A. and Findlay, D. M. (2000). Sustained Activation of Erk1/2 MAPK and Cell Growth Suppression by the Insert-negative, but not the Insert-positive Isoform of the Human Calcitonin Receptor. Journal of Endocrinology, 167 (1), 93-105. doi: 10.1677/joe.0.1670093
Evdokiou, Andreas, Raggatt, Liza-Jane, Atkins, Gerald J. and Findlay, David M. (1999). Calcitonin receptor-mediated growth suppression of HEK-293 cells is accompanied by induction of p21WAF1/CIP1 and G2/M arrest. Molecular Endocrinology, 13 (10), 1738-1750. doi: 10.1210/me.13.10.1738
Raggatt, L. J., Evdokiou, A. and Findlay, D. M. (1999). Activation of the insert negative human calcitonin receptor: Phosphorylation of MAP kinase and inhibition of cellular proliferation. Journal of Bone and Mineral Research, 14 (SA042 Suppl.), x.
Conference Papers
Pettit, Allison R., Batoon, Lena, Heng, Ostyn, Hume, David, Irvine, Kate, Kaur, Simranpreet, Levesque, Jean-Pierre, Magor, Graham, Millard, Susan, Noll, Jacqueline, Perkins, Andrew, Raggatt, Liza, Sandrock, Cheyenne, Sehgal, Anuj, Sester, David, Opperman, Khatora Shanae, Summers, Kim, Wu, Andy and Zannettino, Andrew (2022). Appearances Can Be Deceiving: Macrophage Fragmentation Confounds Ex Vivo Haematopoietic Tissue Analysis. 51st Annual Scientific Meeting of the ISEH - International Society for Experimental Hematology, Edinburgh, United Kingdom, 1-4 September 2022. Philadelphia, PA United States: Elsevier. doi: 10.1016/j.exphem.2022.07.018
Kaur, Simranpreet, Sehgal, Anuj, Wu, Andy, Millard, Susan, Batoon, Lena, Sandrock, Cheyenne, Levesque, Jean-Pierre, Hume, David, Raggatt, Liza and Pettit, Allison (2020). 3092 – Stable colony stimulating factor 1 fusion protein treatment increases the hematopoietic stem cell pool and enhances their mobilization in mice. 49th Annual Scientific Meeting of the ISEH - International Society for Experimental Hematology, New York, NY USA, 20-23 August 2020. Philadelphia, PA USA: Elsevier. doi: 10.1016/j.exphem.2020.09.105
Pettit, Allison, Batoon, Lena, Millard, Susan, Wu, Andy and Raggatt, Liza (2019). Osteal macrophage contributions to adult bone homeostasis and postmenopausal osteoporosis bone pathology. Annual Meeting of the American Society for Bone and Mineral Research, Orlando, FL, United States, 20-23 September, 2019. Hoboken, NJ, United States: Wiley-Blackwell Publishing Asia.
Pettit, Allison, Kaur, Simranpreet, Raggatt, Liza, Millard, Susan, Wu, Andy, Batoon, Lena, Jacobsen, Rebecca, Winkler, Ingrid, MacDonald, Kelli, Perkins, Andrew, Hume, David and Levesque, Jean-Pierre (2018). Self-repopulating recipient bone marrow recipient macrophages promote hematopoietic stem cell engraftment post autologous transplantation. 47th Annual Scientific Meeting of the International Society for Experimental Hematology, Los Angeles, CA, United States, 23-26 August 2018. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.exphem.2018.06.117
Kaur, S., Raggatt, L. J., Jacobsen, R. N., Millard, S., Batoon, L., Winkler, I. G., Macdonald, K. P. A., Perkins, A. C., Hume, D. A., Levesque, J. P. and Pettit, A. R. (2016). Recipient bone marrow (BM) macrophages (Macs) are vital for haematopoietic stem cell (HSC) engraftment post autologous transplantation. International Congress of Immunology (ICI), Melbourne, VIC, Australia, 21-26 August 2016. Weinheim, Germany: Wiley - VCH. doi: 10.1002/eji.201670200
Levesque, Jean-Pierre, Kaur, Simranpreet, Jacobsen, Rebecca, Millard, Susan, Batoon, Lena, Winkler, Ingrid, Macdonald, Kelli, Perkins, Andrew, Hume, David, Raggatt, Liza and Pettit, Allison (2016). Radio-resistant recipient bone marrow (BM) macrophages (Macs) are necessary for hematopoietic stem cell (HSC) engraftment post transplantation. 45th Annual Scientific Meeting of the ISEH – International Society for Experimental Hematology, San Diego, CA, United States, 25-28 August, 2016. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.exphem.2016.06.049
Pettit, A., Raggatt, L., Wullschleger, M., Alexander, K., Steck, R., Kaur, S. and Wu, A. (2013). Fracture Healing Via Periosteal Callus Formation Requires Macrophages for Both Initiation and Progression of Endochondral Ossification. Annual Meeting of the American Society for Bone and Mineral Research, Baltimore MD United States, 4-7 October 2013. Hoboken, NJ United States: Wiley-Blackwell.
Jacobsen, Rebecca, Pettit, Allison R., Raggatt, Liza J., Nowlan, Bianca, Barbier, Valerie, Forristal, Catherine E., Winkler, Ingrid G. and Levesque, Jean-Pierre (2013). Mobilizing Doses Of G-CSF Stop Medullary Erythropoiesis By Depleting F4/8o+VCAM1+ER-HR3+CD169+Erythroid-Island Macrophages. 55th Annual Meeting of the American-Society-of-Hematology, New Orleans, LA, United States, 7-10 December 2013. WASHINGTON: AMER SOC HEMATOLOGY.
Jacobsen, Rebecca, Pettit, Allison, Barbier, Valerie, Nowlan, Bianca, Raggatt, Liza, Winkler, Ingrid and Levesque, Jean-Pierre (2013). Mobilising Doses of G-Csf Stop Medullary Erythropoiesis by Depleting Cd169+Macrophages. 42nd Annual Scientific Meeting of ISEH - Society for Hematology and Stem Cells, Vienna, Austria, 22-25 August 2013. Philadelphia, PA United States: Elsevier Inc. doi: 10.1016/j.exphem.2013.05.230
Levesque, Jean-Pierre, Bendall, Linda J., Pettit, Allison R., Raggatt, Liza, Jacobsen, Rebecca, Barbier, Valarie, Nowlan, Bianca, Shen, Yi Shen, Sims, Natalie A. and Winkler, Ingrid G. (2011). Mobilizing agents G-CSF, cyclophosphamide or AMD3100 (Plerixafor) Have distinct effects on osteoblasts, hematopoietic stem cell niches, and B-Lymphopoiesis. 53rd Annual Meeting and Exposition of the American Society of Hematology (ASH), San Diego CA, United States, 10-13 December 2011. Washington, DC, United States: American Society of Hematology.
Pettit, A. R., Kaur, S., Alexander, K. A., MacDonald, K. P. A. and Raggatt, L. J. (2011). B Cells Do Not Influence Intramembranous Bone Modelling in Vivo. IOF Regionals 2nd Asia-Pacific Osteoporosis and Bone Meeting / ANZBMS Annual Scientific Meeting held with the JSBMR, Gold Coast, QLD Australia, 4-8 September 2011. London, United Kingdom: Springer.
Jacobsen, RN, Levesque, JP, Barbier, V, Raggatt, LJ and Pettit, AR (2010). DEPLETION OF BONE MARROW PHAGOCYTES CAUSES THE MOBILIZATION OF LONG-TERM RECONSTITUTING HEMATOPOIETIC STEM CELLS. 39th Annual Scientific Meeting of the ISEH - Society-for-Hematology-and-Stem-Cells, Melbourne AUSTRALIA, SEP 15-18, 2010. NEW YORK: ELSEVIER SCIENCE INC.
Alexander, K. A., Raggatt, L. J., Chang, M. K., Maylin, E. R., Muller, R., Kohler, T., Wu, A. C. K., Hume, D. A. and Pettit, A. R. (2009). Osteomacs are critical for optimal intramembranous bone formation in a tibial defect model of bone healing. 2nd Joint Meeting of the International Bone & Mineral Society and the Australian & New Zealand Bone & Mineral Society, Sydney, NSW, Australia, 21-25 March 2009. United States: Elsevier. doi: 10.1016/j.bone.2009.01.076
Raggatt, L., Chang, M., Alexander, K., Maylin, E., Walsh, N., Gravallese, E., Hume, D. and Pettit, A. (2009). Osteomacs: Osteoclast Precursors During Inflammatory Bone Disease but Regulators of Physiologic Bone Remodeling. Australian Society of Bone and Mineral Research (ASBMR) 31st Annual Meeting, Denver, CO, United States, 11-15 September, 2009. United States: American Society for Bone and Mineral Research.
Pettit, A. R., Sims, N. A., Winkler, I. G., Alexander, K. A., Helwani, F., Raggatt, L. J. and Levesque, J. P. (2009). Osteomacs maintain the endosteal hematopoietic stem cell niche and participate in mobilization. 2nd Joint Meeting of the International Bone and Mineral Society/Australian New Zealand Bone and Mineral Society, Sydney, Australia, 21-25 March, 2009. United States: Elsevier Inc.. doi: 10.1016/j.bone.2009.01.082
Raggatt, L. J., Chang, M. K., Alexander, K. A., Maylin, E. R., Walsh, N. C., Gravallese, E. M., Hume, D. A. and Pettit, A. R. (2009). Osteomacs: osteoclast precursors during inflammatory bone disease but regulators of physiologic bone remodelling. 2nd Joint Meeting of the International Bone & Mineral Society and the Australian & New Zealand Bone & Mineral Society, Sydney, Australia, 21-25 March, 2009. New York: Elsevier Science. doi: 10.1016/j.bone.2009.01.300
Alexander, K. A., Raggatt, L., Chang, M., Maylin, E., Muller, R., Kohler, T., Wu, A., Hume, D. and Pettit, A. (2009). Osteomacs are Critical for Optimal Intramembranous Bone Formation in a Tibial Defect Model of Bone Healing. Australian Society of Bone and Mineral Research (ASBMR) 31st Annual Meeting, Denver, Colorado, USA, 11-15 September, 2009. United States: American Society for Bone and Mineral Research.
Levesque, J. P., Raggatt, L. J., Pettit, A. R., Sims, N. A., Bendall, L. J. and Helwani, F. (2009). Endosteal Macrophages Maintain the Hematopoietic Stem Cell (Hsc) Niche and Participate in Hsc Mobilization Induced by G-Csf or Chemotherapy. 38th Annual Scientific Meeting of the ISEH Society for Hematology and Stem Cells, Athens, Greece, 9-12 September 2009. NEW YORK: ELSEVIER SCIENCE INC.
Chang, M. K., Pettit, A. R., Schroder, K., Ripoll, V. M., Alexander, K. A., Hume, D. A. and Raggatt, L. (2008). Primary murine osteoblast cultures contain macrophages that enhance osteoblast mineralisation. ECTS 35th European Symposium on Calcified Tissues, Barcelona, Spain, 24-28 May 2008. New York, NY, U.S.A.: Springer New York. doi: 10.1007/s00223-008-9118-5
Alexander, K. A., Chang, M. K., Hume, D. A., Pettit, A. R., Raggatt, L., Ripoli, V. M. and Schroder, K. (2008). Primary murine osteoblast cultures contain macrophages that enhance osteoblast mineralization. 35th European Symposium on Calcified Tissues, Barcelona, Spain, 24-28 May 2008. New York, USA: Springer. doi: 10.1007/s00223-008-9118-5
Raggatt, L. J., Alexander, K. A., Kuliwaba, J. S., Fazzalari, N. L., Hume, D. A. and Pettit, A. R. (2007). Osteal macrophages: Novel regulators of bone formation. 29th Annual Meeting of the American Society for Bone and Mineral Research, Honolulu, HI, United States, 16-19 September 2007.
Chang, M., Hume, D. A., Pettit, A. R., Raggatt, L., Ripoll, V. M. and Schroder, K. (2007). Primary Murine Osteoblast Cultures Contain Macrophages that Enhance Osteoblast Mineralisation. 29th Annual Meeting of the American Society for Bone and Mineral Research (ASBMR), Honolulu, Hawaii, USA, 16th - 19th September, 2007. Washington, D. C.: American Society for Bone and Mineral Research.
Raggatt, L. J., Chang, M. K., Alexander, K. A., Kuiliwaba, J. S., Fazzalari, N. L., Hume, D. A. and Pettit, A. R. (2007). Osteal Macrophages: Novel regulators of Bone Formation. 29th Annual Meeting of the American Society for Bone and Mineral Research, Honolulu, HI, 16th -19th September, 2007. Washington, D.C., United States: American Society for Bone and Mineral Research.
Pettit, A. R., Chang, M. K., Alexander, K. A., Wu, A. C., Hume, D. A. and Raggatt, L. J. (2007). The endosteal bone niche contains macrophages that regulate osteoblast function. 17th Scientific Meeting of the International Bone & Mineral Society, Montreal, Canada, 24-29 June 2007. New York: Elsevier Science. doi: 10.1016/j.bone.2007.04.166
Grondahl, L, Keen, I, Raggatt, L, Chandler-Temple, A. F., Cool, S M and Trau, M (2006). Tailoring poly(3-hydroxybutyrate-co-3-hydroxyvalerate) for bone tissue engineering. 28th Australasian Polymer Symposium & Aust Society for Biomat, Rotorua, 5-9 Feb, 2006.
Raggatt, L. J., Qin, L., Cool, S., Nurcombe, V. and Partridge, N. (2005). Parathyroid hormone stimulation of syndecan-4 in osteoblastic cells.. 27th Annual Meeting of the American-Society-for-Bone-and-Mineral-Research, Nashville, TN USA, 23-27 September 2005. Hoboken, NJ USA: Wiley-Blackwell Publishing.
Raggatt, J. L., Qin, L., Cool, S. M., Nurcombe, V. and Partridge N. C. (2005). Parathyroid hormone stimulation of Syndecan-4 in osteoblastic cells. 27th Annual Meeting of the American Society for Bone and Mineral Research, Nashville, TN USA, 24-26 September, 2005. Malden, MA USA: American Society for Bone and Mineral Research.
Raggatt, J. L., Qin, L., Cool, S. M., Nurcombe, V. and Partridge, N. C. (2005). Parathyroid hormone regulation of syndecan-4 in osteoblast cells. 27th Annual Meeting of the American Society for Bone and Mineral Research, Nashville, TN USA, 23-27 September 2005. Washington, DC USA: Wiley-Blackwell.
Keen, I., Raggatt, L., Cool, S. M., Nurcombe, V., Fredericks, P., Trau, M. and Grondahl, L. (2005). Response of osteoblast cells to the surface properties of Poly(3-hydroxybutyrate-co-hydroxyvalerate) PHBV. 2nd ARC Centre For Functional Nanomaterials Annual Conference, Maroochydore, Nov, 2005.
Qin, L., Tamasi, J., Raggatt, L., Li, X., Feyen, J., Lee, D., DiCicco-Bloom, E. and Partridge, N. C. (2004). Amphiregulin is a novel growth factor in bone stimulated by parathyroid hormone and required for normal bone development. Annual Meeting of the American Society for Biochemistry-and-Molecular-Biology/8th Congress of the International Union for Biochemistry and Molecular Biology, Boston, MA, USA, 12-16 June 2004. Bethesda, MD, USA: Federation of American Societies for Experimental Biology.
Keen, I., Grondahl, L., Raggatt, L., Fredericks, P.M., Nurcombe, V., Trau, M. and Cool, S. M. (2004). Influence of solvent on the surface properties of PHBV solvent cast films. 27th Australasian Polymer Symposium, Adelaide, Nov, 2004.
Qin, L, Raggatt, L, Li, X, Tamasi, J, Feyen, JHM and Partridge, NC (2003). Amphiregulin: A possible mediator of parathyroid hormone's anabolic actions in bone.. 25th Annual Meeting of the American-Society-for-Bone-and-Mineral-Research, Minneapolis Minnesota, Sep 19-23, 2003. WASHINGTON: AMER SOC BONE & MINERAL RES.
Raggatt, LJ, Qin, L and Partridge, NC (2003). Parathyroid hormone stimulation of IL-18 in osteoblastic cells.. 25th Annual Meeting of the American-Society-for-Bone-and-Mineral-Research, Minneapolis Minnesota, Sep 19-23, 2003. WASHINGTON: AMER SOC BONE & MINERAL RES.
Choudhury, I., Williams, S., Raggatt, L. J, Byrne, M. H., Krane, S. M. and Partridge, N. C. (2003). Interaction of Collagenase-3 with its Specific Receptor and LRP-1. Experimental Biology 2003 Meeting, San Diego, California, USA, 11th - 15th April, 2003. Bethesda, MD: Federation of American Societies for Experimental Biology.
Raggatt, Liza Jane, Qin, Ling and Partridge, Nicola (2003). Parathyroid hormone stimulation of IL-18 gene expression in osteoblasts. AAA Annual Meeting at Experimental Biology 2003, San Diego, CA, U.S.A., 11-15 April 2003. Bethesda, MD, U.S.A.: Federation of American Societies for Experimental Biology.
Qin, Ling, Raggatt, L., Li, X., Tamasi, J., Feyen, J. H. M. and Partridge, N. C. (2003). Amphiregulin: A possible mediator of parathyroid hormone's anabolic actions in bone. 25th Annual Meeting of the American Society for Bone and Mineral Research, Minneapolis, Minnesota, U.S.A., 19-23 September, 2003. Washington, D.C., U.S.: American Society for Bone and Mineral Research.
Raggatt, L. J., Qin, L. and Partridge, N. C. (2003). Parathyroid hormone stimulation of IL-18 in osteoblastic cells. 25th Annual Meeting of the American Society for Bone and Mineral Research, Minneapolis, U.S., 19-23 September, 2003. Washington, D.C., U.S.: American Society for Bone and Mineral Research.
Choudhury, I, Williams, S, Raggatt, LJ, Byrne, MH, Krane, SM and Partridge, NC (2002). Characterization of collagenase-3 binding to the collagenase-3 specific receptor and LRP1.. 24th Annual Meeting of the American-Society-for-Bone-and-Mineral-Research, San Antonio Texas, Sep 20-24, 2002. WASHINGTON: AMER SOC BONE & MINERAL RES.
Raggatt, LJ, Choudhury, I, Williams, S, Tiku, ML and Partridge, NC (2002). Characterization of collagenase-3 binding and internalization by rabbit chondrocytes.. 24th Annual Meeting of the American-Society-for-Bone-and-Mineral-Research, San Antonio Texas, Sep 20-24, 2002. WASHINGTON: AMER SOC BONE & MINERAL RES.
Raggatt, L. J., Choudhury, I., Williams, S., Tiku ,M. L. and Partridge, N. C. (2002). Characterization of Collagenase-3 Binding and Internalization by Rabbit Chondrocytes. 24th Annual Meeting of the American Society for Bone and Mineral Research, San Antonio, Texas, USA, 20th - 24th September, 2002. Washington, D. C.: American Society for Bone and Mineral Research.
Choudhury, I., Williams, S., Raggatt, L. J., Byrne, M. H., Krane, S. M. and Partridge, N. C (2002). Characterization of Collagenase-3 Binding to the Collagenase-3 Specific Receptor and LRP1. 24th Annual Meeting of the American Society for Bone and Mineral Research, San Antonio, Texas, USA, 20th - 24th September, 2002. Washington, D. C.: American Society for Bone and Mineral Research.
Raggatt, LJ, Evdokiou, A and Findlay, DM (1999). Activation of the insert negative human calcitonin receptor: Phosphorylation of MAP kinase and inhibition of cellular proliferation.. DURHAM: AMER SOC BONE & MINERAL RES.
Evdokiou, A., Atkins, G. J., Bouralexis, S., Hay, S. J., Raggatt, L. J., Graves, S. E. and Findlay, D. M. (1999). Differential expression of MDM2 splice variants in bone tumors. *, *, 1999. Bethesda, MD United States: American Society for Cell Biology.
Evdokiou, A, Raggatt, L, Atkins, GJ and Findlay, DM (1998). Growth inhibition by calcitonin of HEK293 cells is accompanied by induction of p21/WAF1/CIP1 and G2/M arrest. BETHESDA: AMER SOC CELL BIOLOGY.