School of Pharmacy

Dr Peter Moyle

Senior Lecturer & Associate Professor
School of Pharmacy
Director of Higher Degrees by Research
+61 7 334 61869
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Researcher biography

Dr Moyle's laboratory (www.moylelab.com) uses cutting edge technologies for the synthesis of peptides, protein expression, and protein semi-synthesis to gain insights into the functional roles played by various biochemical pathways, to engineer better protein and peptide therapeutics, and to improve the delivery characteristics of various therapeutic molecules. Specific current areas of interest are detailed below:

  1. Subunit Vaccine Development: methods to develop improved vaccines through the combination of recombinant and synthetic approaches to improve immunopotency and tailor immune responses (links to reseach articles on semisynthetic vaccines and peptide vaccines; reviews on vaccine development).
  2. Oligonucleotide Delivery Systems: multi-component synthetic approaches to improve the cellular uptake, and targeted delivery of various oligonucleotide molecules (e.g. siRNA and pDNA) as an exciting approach to treat or prevent various diseases (links to research articles and reviews).
  3. Deciphering the Roles of Post-Translational Modifications: The combination of peptide synthesis and protein semisynthesis to enable the production of large amounts of site-specifically modified species, that can be used to deconvolute the roles played by various post-translational modifications (links to research articles).
  4. Peptide/Protein Drugs and Delivery: The study of methods to improve the delivery characteristics of peptide/protein drugs (e.g. poor oral absorption, instability to chemical/enzymatic degradation, and the inability to reach their site/s of action) through chemical engineering approaches.
  5. New Approaches for Superbugs: the development of antivirulence approaches, and formulations, which reduce the ability for microbes to cause disease, and make them more readily treated with antimicrobials, by providing access to synergistic combinations, and reducing the risk of antimicrobial resistance.

Information for Potential Students:

The Moyle lab considers applications from potential students and postdoctoral fellows with an interest in: i) infection control (including subunit vaccine and antimicrobial development); ii) delivery systems for peptide therapeutics; iii) targeted delivery systems; iv) studying the function of posttranslational modifications; and v) delivery systems for oligonucleotide therapeutics (e.g. siRNA, shRNA, miRNA). If you are interested in working in any of these areas please feel free to contact Dr Moyle (p.moyle@uq.edu.au). Please ensure that you supply an up to date CV; describe why you would like to work in the Moyle lab; provide a listing of publications (preferably with impact factors and citation counts); and indicate what skills you would bring to the lab. Detailed information on our laboratory is available at www.moylelab.com. Preference will be given to students and postdoctoral fellows who have their own funding.

Dr Moyle Biosketch:

Dr Moyle (H-index 27, 2022 citations; 92 publications; 19/12/2022; Google Scholar, ORCID, ResearcherID, and Publons profiles) received a PhD (Dec 2006) and a Bachelor of Pharmacy (Hons I) (Dec 2001) from The University of Queensland (UQ); graduated from the Pharmaceutical Society of Australia pre-registration pharmacist-training course (Nov 2002); and is registered with the Pharmacy Board of Australia. He currently works as an Associate Professor in the UQ School of Pharmacy, where he has been based since 2014.

Dr Moyle works in the fields of medicinal chemistry, chemical biology, and drug formulation, investigating subunit vaccine development, outcomes associated with histone post-translational modifications, and methods to improve the delivery characteristics of oligonucleotide (e.g. siRNA and pDNA), peptide, and protein therapeutics. During his PhD, Dr Moyle developed methods that enabled the synthesis of pure, lipid adjuvanted peptide vaccines, using advanced chemical ligation techniques. In addition, the conjugation of mannose to combined prophylactic/therapeutic human papillomavirus type-16 vaccines, to target dendritic cells, was demonstrated to significantly improve vaccine anti-tumour activity. This work, conducted with leading researchers at the QIMR Berghofer Medical Research Institute (Prof Michael Good & Dr Colleen Olive), established Dr Moyle's national and international profile in the field of vaccine development, resulting in 11 peer reviewed papers, including top journals in the field (J Med Chem; J Org Chem), as well as 6 review articles and 2 invited book chapters.

Dr Moyle undertook his postdoctoral training in the laboratory of one of the world's premier chemical biologists, Professor Tom Muir (the Rockefeller University, NY, USA; now at Princeton University, NJ, USA). During this time he developed an extensive knowledge of techniques for protein expression, bioconjugation, bioassays, and proteomics, which represent an essential skill set required for this proposal. As part of this work, Dr Moyle developed novel synthetic routes to generate site-specific ADP-ribose conjugated peptides and proteins. This research was hailed as a major breakthrough in the field, leading to several collaborations, and an exemplary publication in the prestigious chemistry journal JACS. This vast body of work identified the enzyme (PARP10) responsible for mono-ADP-ribosylation of histone H2B, and demonstrated interactions between this modification and several proteins, including BAL, which is associated with B cell lymphomas. In addition, a number of robust chemical methods were developed to enable the synthesis of a complete library of methyl-arginine containing histones, which were incorporated into synthetic chemically-defined chromatin to investigate the site-specific effects of arginine methylation on histone acetylation. This work led to a collaboration with colleagues at Rockefeller to investigate the effects of histone arginine methylation on transcription.

Teaching:

Dr Moyle teaches into the following subjects in the UQ School of Pharmacy.

  • PHRM3011 (Quality Use of Medicines) - course coordinator
  • PHRM4021 (Integrated Pharmaceutical Development)
  • PHRM3021 (Dosage Form Design)
  • PHRM2040 (Drug Discovery)

Awards:

2016 - Health and Behavioural Sciences (HABS) faculty commendation for Early Career Citations for Outstanding Contributions to Student Learning (ECCOSL)

2015 - ChemMedChem top 10 cited article of 2013 (link)

2014 - Highest ranked NHMRC development grant (2013; APP1074899)

2013 - Institute for Molecular Biology (IMB) Division of Chemistry and Structural Biology Prize

Featured projects Duration
Cloning and expression of engineered protein antigens for inclusion in novel vaccine formulations
 2017

Publications

Book Chapters (3)
Journal Articles (60)
Conference Papers (30)
Thesis (1)

Book Chapters

Moyle, Peter Michael (2015). Progress in vaccine development. Current Protocols in Microbiology. (pp. 18.1.1-18.1.26) edited by Richard Coico. Hoboken, NJ, United States: John Wiley & Sons. doi: 10.1002/9780471729259.mc1801s36
Jackson, David C., Chua, Brendon Y., Brown, Lorena E., Moyle, Peter and Toth, Istvan (2010). Lipopeptide-based vaccines. New generation vaccines. (pp. 315-326) edited by Myron M. Levine. New York, U.S.A.; London, U.K.: Informa Healthcare. doi: 10.3109/9781420060744-32
Simerska, Pavla, Moyle, Peter M., Olive, Colleen and Toth, Istvan (2009). Strategies in oral immunization. Oral Delivery of Macromolecular Drugs: Barriers, Strategies and Future Trends. (pp. 195-222) edited by Bernkop-Schnurch, Andreas. New York, United States: Springer. doi: 10.1007/978-1-4419-0200-9_11

Journal Articles

Rivera-Hernandez, Tania, Carnathan, Diane G., Richter, Johanna, Marchant, Patrick, Cork, Amanda J., Elangovan, Gayathiri, Henningham, Anna, Cole, Jason N., Choudhury, Biswa, Moyle, Peter M., Toth, Istvan, Batzloff, Michael R., Good, Michael F., Agarwal, Paresh, Kapoor, Neeraj, Nizet, Victor, Silvestri, Guido and Walker, Mark J. (2024). Efficacy of Alum-Adjuvanted Peptide and Carbohydrate Conjugate Vaccine Candidates against Group A Streptococcus Pharyngeal Infection in a Non-Human Primate Model. Vaccines, 12 (4), 382. doi: 10.3390/vaccines12040382
Sinclair, Frazer, Begum, Anjuman A., Dai, Charles C., Toth, Istvan and Moyle, Peter M. (2023). Recent advances in the delivery and applications of nonviral CRISPR/Cas9 gene editing. Drug Delivery and Translational Research, 13 (5), 1500-1519. doi: 10.1007/s13346-023-01320-z
Alharthi, Sitah, Popat, Amirali, Ziora, Zyta Maria and Moyle, Peter Michael (2023). Sortase A Inhibitor Protein Nanoparticle Formulations Demonstrate Antibacterial Synergy When Combined with Antimicrobial Peptides. Molecules, 28 (5) 2114, 1-17. doi: 10.3390/molecules28052114
Alharthi, Sitah, Ziora, Zyta M., Janjua, Taskeen, Popat, Amirali and Moyle, Peter M. (2022). Formulation and biological evaluation of mesoporous silica nanoparticles loaded with combinations of sortase A inhibitors and antimicrobial peptides. Pharmaceutics, 14 (5) 986, 986. doi: 10.3390/pharmaceutics14050986
Alharthi, Sitah, Ziora, Zyta Maria and Moyle, Peter Michael (2021). Optimized protocols for assessing libraries of poorly soluble sortase A inhibitors for antibacterial activity against medically-relevant bacteria, toxicity and enzyme inhibition. Bioorganic and Medicinal Chemistry, 52 116527, 116527. doi: 10.1016/j.bmc.2021.116527
Alharthi, Sitah, Ebrahim Alavi, Seyed, Michael Moyle, Peter and Maria Ziora, Zyta (2021). Sortase A (SrtA) inhibitors as an alternative treatment for superbug infections. Drug Discovery Today, 26 (9), 2164-2172. doi: 10.1016/j.drudis.2021.03.019
Hussain, Humaira, Cao, Yingnan, Mohamad, Raafat, Afroz, Rizwana, Zhou, Ying, Moyle, Peter, Bansal, Nidhi, Wattoo, Feroza Hamid, Kamato, Danielle and Little, Peter J. (2021). YY‐11, a camel milk‐derived peptide, inhibits TGF‐β‐mediated atherogenic signaling in human vascular smooth muscle cells. Journal of Food Biochemistry, 46 (3) e13882, e13882. doi: 10.1111/jfbc.13882
Andrzejewski, Sławomir, Moyle, Peter M., Stringer, Brett W., Steel, Jason C. and Layton, Christopher J. (2021). Neutralisation of adeno-associated virus transduction by human vitreous humour. Gene Therapy, 28 (5), 242-255. doi: 10.1038/s41434-020-0162-8
Alavi, Seyed Ebrahim, Cabot, Peter J., Raza, Aun and Moyle, Peter M. (2021). Developing GLP-1 conjugated self-assembling nanofibers using copper-catalyzed alkyne–azide cycloaddition and evaluation of their biological activity. Bioconjugate Chemistry, 32 (4), 810-820. doi: 10.1021/acs.bioconjchem.1c00091
Rivera-Hernandez, Tania, Carnathan, Diane G., Jones, Scott, Cork, Amanda J., Davies, Mark R., Moyle, Peter M., Toth, Istvan, Batzloff, Michael R., McCarthy, James, Nizet, Victor, Goldblatt, David, Silvestri, Guido and Walker, Mark J. (2020). Erratum for: An experimental group a Streptococcus vaccine that reduces pharyngitis and tonsillitis in a nonhuman primate model (mBio, (2019) 10, 2, 10.1128/mBio.00693-19). mBio, 11 (6) e02995-20, 1-1. doi: 10.1128/mBio.02995-20
Alavi, Seyed Ebrahim, Cabot, Peter John, Yap, Gee Yi and Moyle, Peter Michael (2020). Optimized methods for the production and bioconjugation of site-specific, alkyne-modified glucagon-like peptide-1 (GLP-1) analogs to azide-modified delivery platforms using copper-catalyzed alkyne–azide cycloaddition. Bioconjugate Chemistry, 31 (7) acs.bioconjchem.0c00291, 1820-1834. doi: 10.1021/acs.bioconjchem.0c00291
Maqbool, Faheem, Falconer, James R. and Moyle, Peter M. (2020). Supercritical fluid assembly of albendazole liposomes targeting gastrin-releasing peptide receptor overexpressing tumors. Nanomedicine, 15 (13), 1315-1330. doi: 10.2217/nnm-2020-0048
Xu, Zhenghui, Rivera-Hernandez, Tania and Moyle, Peter Michael (2020). Development of an enzyme-mediated, site-specific method to conjugate toll-like receptor 2 agonists onto protein antigens: toward a broadly protective, four component, group A streptococcal self-adjuvanting lipoprotein–fusion combination vaccine. ACS Infectious Diseases, 6 (7) acsinfecdis.0c00047, 1770-1782. doi: 10.1021/acsinfecdis.0c00047
Xu, Zhenghui, Rivera-Hernandez, Tania, Chatterjee, Oishee, Walker, Mark J. and Moyle, Peter M. (2020). Semisynthetic, self-adjuvanting vaccine development: efficient, site-specific sortase A-mediated conjugation of Toll-like receptor 2 ligand FSL-1 to recombinant protein antigens under native conditions and application to a model group A streptococcal vaccine. Journal of Controlled Release, 317, 96-108. doi: 10.1016/j.jconrel.2019.11.018
Xu, Zhenghui and Moyle, Peter Michael (2020). A self‐adjuvanting vaccine platform: optimization of site‐specific sortase a mediated conjugation of toll‐like receptor 2 ligands onto the carboxyl or amino terminus of recombinant protein antigens. ChemPlusChem, 85 (1), 227-236. doi: 10.1002/cplu.201900687
Syed-Ab-Rahman, Sharifah Farhana, Carvalhais, Lilia C., Chua, Elvis T., Chung, Fong Yi, Moyle, Peter M., Eltanahy, Eladl G. and Schenk, Peer M. (2019). Soil bacterial diffusible and volatile organic compounds inhibit Phytophthora capsici and promote plant growth. Science of the Total Environment, 692, 267-280. doi: 10.1016/j.scitotenv.2019.07.061
Hussein, Waleed M., Cheong, Yee S., Liu, Chang, Liu, Genan, Begum, Anjuman Ara, Attallah, Maria Adly, Moyle, Peter Michael, Torchilin, Vladimir, Smith, Roger and Toth, Istvan (2019). Peptide-based targeted polymeric nanoparticles for siRNA delivery. Nanotechnology, 30 (41) 415604, 415604. doi: 10.1088/1361-6528/ab313d
Begum, Anjuman A., Toth, Istvan, Hussein, Waleed M. and Moyle, Peter Michael (2019). Advances in targeted gene delivery. Current Drug Delivery, 16 (7), 588-608. doi: 10.2174/1567201816666190529072914
Begum, Anjuman A., Toth, Istvan and Moyle, Peter M. (2019). Gastrin-releasing peptide receptor-targeted hybrid peptide/phospholipid pDNA/siRNA delivery systems. Nanomedicine, 14 (9), 1153-1171. doi: 10.2217/nnm-2018-0380
Alavi, Seyed Ebrahim, Cabot, Peter J. and Moyle, Peter M. (2019). Glucagon-like peptide-1 receptor agonists and strategies to improve their efficiency. Molecular Pharmaceutics, 16 (6) acs.molpharmaceut.9b00308, 2278-2295. doi: 10.1021/acs.molpharmaceut.9b00308
Maqbool, Faheem, Moyle, Peter M., Thurecht, Kristofer J. and Falconer, James R. (2019). Dispersibility of phospholipids and their optimization for the efficient production of liposomes using supercritical fluid technology. International Journal of Pharmaceutics, 563, 174-183. doi: 10.1016/j.ijpharm.2019.03.053
Rivera-Hernandez, Tania, Carnathan, Diane G., Jones, Scott, Cork, Amanda J., Davies, Mark R., Moyle, Peter M., Toth, Istvan, Batzloff, Michael R., McCarthy, James, Nizet, Victor, Goldblatt, David, Silvestri, Guido and Walker, Mark J. (2019). An experimental Group A Streptococcus vaccine that reduces pharyngitis and tonsillitis in a nonhuman primate model. mBio, 10 (2) e00693-19. doi: 10.1128/mBio.00693-19
Maqbool, Faheem, Moyle, Peter M., Tan, Madeleine S. A., Thurecht, Kristofer J. and Falconer, James R. (2019). Preparation of albendazole-loaded liposomes by supercritical carbon dioxide processing. Artificial Cells, Nanomedicine, and Biotechnology, 46 (sup3), 1-7. doi: 10.1080/21691401.2018.1536059
Cheang, Jia Ying and Moyle, Peter Michael (2018). Glucagon-like peptide-1 (GLP-1)-based therapeutics: current status and future opportunities beyond type 2 diabetes. ChemMedChem, 13 (7), 662-671. doi: 10.1002/cmdc.201700781
Begum, Anjuman Ara, Wan, Yu, Toth, Istvan and Moyle, Peter M. (2018). Bombesin/oligoarginine fusion peptides for gastrin releasing peptide receptor (GRPR) targeted gene delivery. Bioorganic and Medicinal Chemistry, 26 (2), 516-526. doi: 10.1016/j.bmc.2017.12.013
Xu, Zhenghui and Moyle, Peter Michael (2017). Bioconjugation approaches to produce subunit vaccines composed of protein or peptide antigens and covalently attached toll-like receptor ligands. Bioconjugate Chemistry, 29 (3), 572-586. doi: 10.1021/acs.bioconjchem.7b00478
Wan, Yu, Dai, Wei, Nevagi, Reshma J., Toth, Istvan and Moyle, Peter M. (2017). Multifunctional peptide-lipid nanocomplexes for efficient targeted delivery of DNA and siRNA into breast cancer cells. Acta Biomaterialia, 59, 257-268. doi: 10.1016/j.actbio.2017.06.032
Moyle, Peter Michael (2017). Biotechnology approaches to produce potent, self-adjuvanting antigen-adjuvant fusion protein subunit vaccines. Biotechnology Advances, 35 (3), 375-389. doi: 10.1016/j.biotechadv.2017.03.005
Wan, Yu, Moyle, Peter M., Gn, Pei Z. and Toth, Istvan (2017). Design and evaluation of a stearylated multicomponent peptide-siRNA nanocomplex for efficient cellular siRNA delivery.. Nanomedicine, 12 (4), 281-293. doi: 10.2217/nnm-2016-0354
Begum, Anjuman Ara, Moyle, Peter M. and Toth, Istvan (2016). Investigation of Bombesin peptide as a targeting ligand for the gastrin releasing peptide (GRP) receptor. Bioorganic and Medicinal Chemistry, 24 (22), 5834-5841. doi: 10.1016/j.bmc.2016.09.039
Kamaruzaman, Khairul A., Moyle, Peter M. and Toth, Istvan (2016). Peptide-based multicomponent oligonucleotide delivery systems: optimisation of poly-l-lysine dendrons for plasmid DNA delivery. International Journal of Peptide Research and Therapeutics, 23 (1), 1-16. doi: 10.1007/s10989-016-9545-5
Rivera-Hernandez, Tania, Pandey, Manisha, Henningham, Anna, Cole, Jason, Choudhury, Biswa, Cork, Amanda J., Gillen, Christine M., Ghaffar, Khairunnisa Abdul, West, Nicholas P., Silvestri, Guido, Good, Michael F., Moyle, Peter M., Toth, Istvan, Nizet, Victor, Batzloff, Michael R. and Walker, Mark J. (2016). Differing efficacies of lead Group A Streptococcal vaccine candidates and full-length M protein in cutaneous and invasive disease models. mBio, 7 (3) e00618-16, e00618-16.1-e00618-16.9. doi: 10.1128/mBio.00618-16
Wan, Yu, Moyle, Peter M., Christie, Michelle P. and Toth, Istvan (2016). Nanosized, peptide-based multicomponent DNA delivery systems: optimization of endosome escape activity. Nanomedicine, 11 (8), 907-919. doi: 10.2217/nnm.16.27
Hussein, Waleed M., Liu, Tzu-Yu, Maruthayanar, Pirashanthini, Mukaida, Saori, Moyle, Peter M., Wells, James W., Toth, Istvan and Skwarczynski, Mariusz (2016). Double conjugation strategy to incorporate lipid adjuvants into multiantigenic vaccines. Chemical Science, 7 (3), 2308-2321. doi: 10.1039/C5SC03859F
Moyle, Peter M., Dai, Wei, Liu, Tzu-Yu, Hussein, Waleed M., Maruthayanar, Pirashanthini, Wells, James W., McMillan, Nigel A. J., Skwarczynski, Mariusz and Toth, Istvan (2015). Combined synthetic and recombinant techniques for the development of lipoprotein-based, self-adjuvanting vaccines targeting human papillomavirus type-16 associated tumors. Bioorganic and Medicinal Chemistry Letters, 25 (23), 5570-5575. doi: 10.1016/j.bmcl.2015.10.049
Wan, Yu, Moyle, Peter M and Toth, Istvan (2015). Endosome escape strategies for improving the efficacy of oligonucleotide delivery systems. Current Medicinal Chemistry, 22 (29), 3326-3346. doi: 10.2174/0929867322666150825162941
Rosli, Nurlina, Christie, Michelle, Moyle, Peter M. and Toth, Istvan (2015). Peptide based DNA nanocarriers incorporating a cell-penetrating peptide derived from neurturin protein and poly-L-lysine dendrons. Bioorganic & Medicinal Chemistry, 23 (10), 2470-2479. doi: 10.1016/j.bmc.2015.03.058
Zaman, Mehfuz, Chandrudu, Saranya, Giddam, Ashwini K., Reiman, Jennifer, Skwarczynski, Mariusz, McPhun, Virginia, Moyle, Peter M., Batzloff, Michael R., Good, Michael F. and Toth, Istvan (2014). Group A Streptococcal vaccine candidate: contribution of epitope to size, antigen presenting cell interaction and immunogenicity. Nanomedicine, 9 (17), 2613-2624. doi: 10.2217/NNM.14.190
Rivera-Hernandez, Tania, Carnathan, Diane G., Moyle, Peter M., Toth, Istvan, West, Nicholas P., Young, Paul L., Silvestri, Guido and Walker, Mark J. (2014). The contribution of non-human primate models to the development of human vaccines. Discovery Medicine, 18 (101), 313-322.
Moyle, Peter M., Dai, Wei, Zhang, Yingkai, Batzloff, Michael R., Good, Michael F. and Toth, Istvan (2014). Site-specific incorporation of three toll-like receptor 2 targeting adjuvants into semisynthetic, molecularly defined nanoparticles: application to group A streptococcal vaccines. Bioconjugate Chemistry, 25 (5), 965-978. doi: 10.1021/bc500108b
Ahmad Fuaad, Abdullah A. H., Jia, Zhongfan, Hartas, Jon, Ziora, Zyta M., Lin, I-Chun, Moyle, Peter M., Batzloff, Michael R., Good, Michael F., Monteiro, Michael J., Skwarczynski, Mariusz and Toth, Istvan (2014). Polymer–peptide hybrids as a highly immunogenic single-dose nanovaccine. Nanomedicine, 9 (1), 35-43. doi: 10.2217/NNM.13.7
Moyle, Peter M., Hartas, Jon, Henningham, Anna, Batzloff, Michael R., Good, Michael F. and Toth, Istvan (2013). An efficient, chemically-defined semisynthetic lipid-adjuvanted nanoparticulate vaccine development system. Nanomedicine: Nanotechnology, Biology and Medicine, 9 (7), 935-944. doi: 10.1016/j.nano.2013.01.009
Moyle, Peter Michael and Toth, Istvan (2013). Modern subunit vaccines: development, components, and research opportunities. ChemMedChem, 8 (3), 360-376. doi: 10.1002/cmdc.201200487
Rafiee, Amirreza, Mansfeld, Friederike M., Moyle, Peter M. and Toth, Istvan (2013). Synthesis and characterization of luteinizing hormone-releasing hormone (LHRH)-functionalized mini-dendrimers. International Journal of Chemistry, 3 (1), 51-57. doi: 10.4236/ijoc.2013.31006
Simerska, Pavla, Moyle, Peter M. and Toth, Istvan (2011). Modern lipid-, carbohydrate-, and peptide-based delivery systems for peptide, vaccine, and gene products. Medicinal Research Reviews, 31 (4), 520-547. doi: 10.1002/med.20191
Moyle, Peter M. and Muir, Tom W (2010). Method for the synthesis of mono-ADP-ribose conjugated peptides. Journal of the American Chemical Society, 132 (45), 15878-15880. doi: 10.1021/ja1064312
Simerska, Pavla, Moyle, Peter M., Olive, Colleen and Toth, Istvan (2009). Oral vaccine delivery - New strategies and technologies. Current Drug Delivery, 6 (4), 347-358. doi: 10.2174/156720109789000537
Simerska, Pavla, Abdel-Aal, Abu-Baker M., Fujita, Yoshio, Moyle, Peter M., McGeary, Ross P., Batzloff, Michael R., Olive, Colleen, Good, Michael F. and Toth, Istvan (2008). Development of a liposaccharide-based delivery system and its application to the design of Group A streptococcal vaccines. Journal of Medicinal Chemistry, 51 (5), 1447-1452. doi: 10.1021/jm701410p
Abdel-Aal, Abu-Baker M., Batzloff, Michael R., Fujita, Yoshio, Barozzi, Nadia, Faria, Andres, Simerska, Pavla, Moyle, Peter M., Good, Michael F. and Toth, Istvan (2008). Structure-activity relationship of a series of synthetic lipopeptide self-adjuvanting group A streptococcal vaccine candidates. Journal of Medicinal Chemistry, 51 (1), 167-172. doi: 10.1021/jm701091d
Moyle, P.M. and Toth, I. (2008). Self-adjuvanting lipopeptide vaccines. Current Medicinal Chemistry, 15 (5), 506-516. doi: 10.2174/092986708783503249
Olive, C., Moyle, P. and Toth, I. (2007). Towards the Development of a Broadly Protective Group A Streptococcal Vaccine Based on the Lipid-Core Peptide System. Current Medicinal Chemistry, 14 (28), 2976-2988. doi: 10.2174/092986707782794069
Moyle, PM, Hari, Y, Huang, N, Olive, C, Good, MF and Toth, I (2007). A technique for the synthesis of highly-pure, mono-epitopic, multi-valent lipid core peptide vaccines. Tetrahedron Letters, 48 (29), 4965-4967. doi: 10.1016/j.tetlet.2007.05.129
Moyle, Peter M., Olive, Colleen, Ho, Mei-Fong, Pandey, Manisha, Dyer, Joanne, Suhrbier, Andreas, Fujita, Yoshio and Toth, Istvan (2007). Toward the development of prophylactic and therapeutic human papillomavirus type-16 lipopeptide vaccines. Journal of Medicinal Chemistry, 50 (19), 4721-4727. doi: 10.1021/jm070287b
Moyle, P. M., Olive, C., Ho, M. F., Burgess, M., Karpati, L., Good, M. F. and Toth, I. (2006). Method for the Synthesis of Multi-Epitopic Streptococcus pyogenes Lipopeptide Vaccines Using Native Chemical Ligation. Journal of Organic Chemistry, 71 (18), 6846-6850. doi: 10.1021/jo060960p
Toth, Istvan, Moyle, Peter, Karpati, Levente, Horvath, Aniko, Olive, Colleen and Good, Michael (2006). The lipid core peptide system in vaccine delivery. International Congress Series, 1289, 307-310. doi: 10.1016/j.ics.2005.11.057
Moyle, P. M., Olive, C., Ho, M.-F., Burgess, M., Karpati, L., Good, M. F. and Toth, I. (2006). Towards the synthesis of a highly pure, multiepitopic, mucosal group A streptoccal lipopeptide vaccine. International Congress Series, 1289, 324-328. doi: 10.1016/j.ics.2005.11.084
Moyle, P. M., Olive, C., Ho, M. F., Good, M. F. and Toth, I. (2006). Synthesis of a highly pure lipid core peptide based self-adjuvanting triepitopic group A Streptococcal vaccine, and subsequent immunological evaluation. Journal of Medicinal Chemistry, 49 (21), 6364-6370. doi: 10.1021/jm060475m
Moyle, P. M., Olive, C., Good, M. F. and Toth, I. (2006). Method for the synthesis of highly pure vaccines using the lipid core peptide system. Journal of Peptide Science, 12 (12), 800-807. doi: 10.1002/psc.815
Moyle, P.M., McGeary, R. P., Blanchfield, J. T. and Toth, I. (2004). Mucosal immunization: Adjuvants and delivery systems. Current Drug Delivery, 1 (4), 385-396. doi: 10.2174/1567201043334588
Moyle, P. M., Horvath, A., Olive, C., Good, M. F. and Toth, I. (2003). Development of lipid-core-peptide (LCP) based vaccines for the prevention of the group A streptococcal (GAS) infection. Letters In Peptide Science, 10 (5-6), 605-613. doi: 10.1007/BF02442594

Conference Papers

Andrzejewski, Slawomir, Moyle, Peter M., Stringer, Brett W., Steel, Jason and Layton, Christopher J. (2020). Recombinant Adeno-Associated Virus Vector Tropism in Human Retina. In: 23rd Annual Meeting of the American Society for Gene and Cell Therapy, Electr Network, (254-254). 12-15 May 2020.
Maqbool, Faheem, Moyle, Peter M. and Falconer, James R. (2019). Production of liposomes using supercritical fluid technology and active targeting peptide to a gastrointestinal receptor in cancer cells. Controlled Release Society (CRS), Valencia, Spain, 21-24 July 2019.
Andrzejewski, S., Moyle, P., Stringer, B., Steel, J. and Layton, C. J. (2019). Effect of human vitreous humour components and neutralising antibodies on transduction activity of recombinant AAV2, AAV5, AAV6 and AAV8. Annual Conference of the British-Society-for-Gene-and-Cell-Therapy, Sheffield, United Kingdom , 19-21 June 2019. New Rochelle, NY, United States: Mary Ann Liebert.
Maqbool, Faheem, Moyle, Peter M. and Falconer, James R. (2018). Novel preparation of proliposomes with various phospholipids in Supercritical Carbon Dioxide. Controlled Release Society (CRS), New York City, United States, 22-25 July 2018.
Maqbool, Faheem, Moyle, Peter M. and Falconer, James R. (2017). A static and gravimetric method for the determination of solubility of Albendazole and its characterization in supercritical carbon dioxide. Drug Delivery Australia (DDA), Wollongong, Australia, 23-24 October 2017.
Toth, Istvan, Moyle, Peter M., Simerska, Pavla, Fujita, Yoshio, Olive, Colleen and Good, Michael F. (2009). Vaccine delivery: Synthesis and investigation of a highly pure, multi-epitopic lipopeptide vaccine candidate. 20th American Peptide Symposium, Montréal, Quebec, Canada, 26-30 June 2007. New York: Springer. doi: 10.1007/978-0-387-73657-0_154
Simerska, Pavla, McGeary, Ross P., Abdel-Aal, Abu-Baker M., Moyle, Peter M., Olive, Colleen, Good, Michael F. and Toth, Istvan (2009). Vaccine delivery utilizing liposaccharides. The 20th American Peptide Symposium, Montreal, Canada, 26-30 June, 2007. United States: Springer. doi: 10.1007/978-0-387-73657-0_153
Fujita, Yoshio, Moyle, Peter M., Hieu, Suzanne, Simerska, Pavla and Toth, Istvan (2008). Investigation toward multi-epitope vaccine candidates using native chemical ligation. Hoboken, NJ, U.S.A.: John Wiley & Sons. doi: 10.1002/bip.21002
Simerska, P., Moyle, P. M., Abdel-Aal, A. M., Fujita, Y., Olive, C., Batzloff, M. R., Good, M. F. and Toth, I. (2007). Liposaccharides in Peptide Vaccine Delivery. 4th International Peptide Symposium, Cairns, 21-25 October 2007. Australia: Australian Peptide Association.
Toth, I., Moyle, P. M., Simerska, P., Fujita, Y., Olive, C. and Good, M. F. (2007). Vaccine delivery: Synthesis and investigation of a highly pure, multi-epitopic lipopeptide vaccine candidate. 20th American Peptide Symposium, Montréal, Quebec, Canada, 26-30 June 2007. HOBOKEN: Wiley Periodicals. doi: 10.1002/bip.20783
Fujita, Y., Moyle, P., Abdel-Aal, A., Batzloff, M., Good, M. and Toth, I. (2007). Development of a Multivalent Heteroepitopic Group A Streptococcus Vaccine. 4th International Peptide Symposium, Cairns, 21-25 October 2007. Australia: Australian Peptide Association.
Simerska, P., Moyle, P. M., Zhong, W., McGeary, R., Abdel-Aal, A. B., Good, M. F. and Toth, I. (2007). Vaccine Delivery Utilizing Liposaccharides. 20th American Peptide Symposium, Montréal, Quebec, Canada, 26-30 June 2007. Hoboken: John Wiley & Sons. doi: 10.1002/bip.20783
Simerska, P., Abdel-Aal, A. B., McGeary, R., Moyle, P.M., Fujita, Y., Good, M.F. and Toth, I. (2007). Peptide-lipid-carbohydrate based vaccine against group A Streptococcal infection.. 13th International Congress of Immunology, Rio de Janeiro, Brazil, August 21-25.
Toth, I., Moyle, P. M., Simerska, P., Fujita, Y., Olive, C. and Good, M. F. (2007). Novel lipoamino acid based vaccine adjuvant carrier system. International Congress of Immunology, Rio de Janeiro, Brazil, 21-25 August 2007. Toronto, Canada: Hogrefe & Huber.
Simerska, P., Moyle, P. M., Olive, C., Sun, H. K., Ho, M. F., Pandy, M. G., Dyer, J. R., Burgess, M. L. and Toth, I. (2006). Development of vaccines for the prevention and/or treatment of human papillomavirus type-16 associated cervical cancer. GPEN 2006, Lawrence, USA, 25-27 October, 2006.
Moyle, P. M., Olive, C., Ho, M.-F., Good, M F and Toth, I (2006). Highly pure, multi-epitopic lipopeptide vaccine delivery system: Synthesis and investigation. Brisbane Biological & Organic Chemistry Symposium, Brisbane, 24 Nov 2006.
Toth, I, Moyle, P. M., Koda, Y., Olive, C. and Good, M F (2006). Liposaccharides in peptide, gene and vaccine delivery. 10th Naples Workshop on Bioactive Peptides, Naples, 11-14 June, 2006.
Fujita, Y., Moyle, P., Olive, C., Good, M. and Toth, I. (2006). Multi-epitopic lipid core peptide vaccine with broad protective immune responses against Group A Streptococcus. CHICHESTER: JOHN WILEY & SONS LTD.
Moyle, Peter M., Horvath, Aniko, Karpati, Levente, Olive, Colleen, Barozzi, Nadia, Wimmer, Norbert, Good, Michael and Toth, Istvan (2006). Development of peptide vaccines against HPV-16 associated cervical cancer and group a streptococci. 19th American Peptide Symposium, San Diego, United States, 18-23 June 2005. New York, United States: Springer. doi: 10.1007/978-0-387-26575-9_169
Moyle, P. M., Olive, C., Ho, M.-F. and Toth, I (2006). Highly pure, multi-epitopic lipopeptide vaccine delivery system: Synthesis and investigation. GPEN 2006, Lawrence, USA, 25 - 27 Oct, 2006.
Toth, I., Moyle, P. M., Simerska, P., Fujita, Y., Olive, C. and Good, M. F. (2006). Liposaccharides in peptide, gene and vaccine delivery. Drug Design Amongst the Vines, Hunter Valley, 3 - 7 December, 2006.
Simerska, P., Bong, Y. K., McGeary, R. P., Moyle, P. M. and Toth, I. (2006). Liposaccharide based vaccine carrier adjuvant systems. Drug Design Amongst the Vines, Hunter Valley, 3 - 7 December 2006.
Simerska, P, Moyle, P. M., Olive, C., Sun, H., Ho, M.-F., Pandy, M.G., Dyer, J. R., Burgess, M L and Toth, I (2006). Development of vaccines for the prevention and/or treatment of human papillomavirus type-16 associated cervical cancer. Brisbane Biological & Organic Chemistry Symposium, Brisbane, 24 November 2006.
Toth, I., Moyle, P. M., Karpati, L., Horvath, A., Olive, C. and Good, M. F. (2006). The lipid core peptide system in vaccine delivery. XVIth Lancefield International Symposium on Streptococci and Streptococcal Diseases, Palm Cove, Australia, 25 and 29 September 2005. Amsterdam, The Netherlands: Excerpta Medica Foundation. doi: 10.1016/j.ics.2005.11.057
Toth, I., Moyle, P. M., Koda, Y., Olive, C. and Good, M. F. (2006). Liposaccharides in peptide, gene and vaccine delivery. 33rd Annual Meeting and Exposition of the Controlled Release Soy, Vienna, 22-26 July, 2006.
Fujita, Y, Moyle, P. M., Olive, C., Good, M F and Toth, I (2006). Multi-epitopic lipid core peptide vaccine with broad protective immune responses against Group A streptococcus. 29th European Peptide Symposium, Gdansk, 3-8 Sept, 2006.
Moyle, Peter Michael, Olive, Colleen, Karpati, Levente, Barozzi, Nadia, Ho, Mei-Fong, Dyer, Joanne, Sun, Hsien Kuo, Good, Michael and Toth, Istvan (2006). Synthesis and immunological evaluation of M protein targeted tetra-valent and tri-valent group A streptococcal vaccine candidates based on the lipid-core peptide system. 6th Australian Peptide Conference, Whitsunday Islands, Australia, 9-14 October, 2005. Netherlands: Springer. doi: 10.1007/s10989-006-9021-8
Moyle, Peter M., Olive, Colleen, Sun, Hsien, Good, Michael and Toth, Istvan (2005). The synthesis and immunological activity of a lipid-core peptide (LCP) based Human Papillomavirus (HPV) type-16 vaccine. 3rd International Peptide Symposium and 28th European Peptide Symposium, Prague, Czech Republic, 5-10 September 2004. GENEVA 1: Kenes International.
Toth, I., Horvath, A., Karpati, L., Moyle, P., Olive, C. and Good, M. (2004). Liposaccharides for drug and vaccine delivery. 3rd International and 28th European Peptide Symposium, Prague, Czech Republic, 5–10 September 2004. Chichester, West Sussex, United Kingdom: John Wiley & Sons. doi: 10.1002/psc.618
Moyle, P.M., Mcgeary, R. P. and Toth, I. (2001). Solid-phase synthesis of oligosaccharides utilising a novel Dde-based linker. APSA Annual Conference 2001, Melbourne, 9-12 Dec 2001. Melbourne: Australasian Pharmaceutical Science Association.

Thesis

Moyle, Peter Michael (2006). Vaccine-adjuvant-carrier design against group A streptococcus and human papillomavirus type-16 infection. PhD Thesis, School of Pharmacy, The University of Queensland.