Dr Narin Osman
Honorary Associate Professor
School of Pharmacy
Publications
Journal Articles
Dulull, Nabeela, Kwa, Faith, Osman, Narin, Rai, Uma, Shaikh, Bilal and Thrimawithana, Thilini R. (2019). Recent advances in the management of diabetic retinopathy. Drug Discovery Today, 24 (8), 1499-1509. doi: 10.1016/j.drudis.2019.03.028
Kamato, Danielle, Burch, Micah, Yang, Zhou, Mohamed, Raafat, Stow, Jennifer L., Osman, Narin and Little, Peter J. (2019). Individual Smad2 linker region phosphorylation sites determine the expression of proteoglycan and glycosaminoglycan synthesizing genes. Cellular Signalling, 53, 365-373. doi: 10.1016/j.cellsig.2018.11.005
Rostam, Muhamad Ashraf, Shajimoon, Aravindra, Kamato, Danielle, Mitra, Partha, Piva, Terrence, Getachew, Robel, Cao, Yingnan, Zheng, Wenhua, Osman, Narin and Little, Peter James (2018). Flavopiridol inhibits TGF-β-stimulated biglycan synthesis by blocking linker region phosphorylation and nuclear translocation of Smad2. The Journal of Pharmacology and Experimental Therapeutics, 365 (1), 156-164. doi: 10.1124/jpet.117.244483
Talati, Nirali, Kamato, Danielle, Piva, Terrence J, Little, Peter and Osman, Narin (2018). Thrombin promotes PAI-1 expression and migration in keratinocytes via ERK dependent Smad linker region phosphorylation. Cellular Signalling, 47, 37-43. doi: 10.1016/j.cellsig.2018.03.009
Afroz, Rizwana, Cao, Yingnan, Rostam, Muhamad Ashraf, Ta, Hang, Xu, Suowen, Zheng, Wenhua, Osman, Narin, Kamato, Danielle and Little, Peter J. (2018). Signalling pathways regulating galactosaminoglycan synthesis and structure in vascular smooth muscle: implications for lipoprotein binding and atherosclerosis. Pharmacology and Therapeutics, 187, 88-97. doi: 10.1016/j.pharmthera.2018.02.005
Kamato, Danielle, Vijayanand Bhaskarala, Venkata, Mantri, Nitin, Gyu Oh, Tae, Ling, Dora, Janke, Reearna, Zheng, Wenhua, Little, Peter J. and Osman, Narin (2017). RNA sequencing to determine the contribution of kinase receptor transactivation to G protein coupled receptor signalling in vascular smooth muscle cells. PLoS One, 12 (7) e0180842, e0180842. doi: 10.1371/journal.pone.0180842
Chan, Xian Yang, Singh, Alamdeep, Osman, Narin and Piva, Terrence J. (2017). Role played by signalling pathways in overcoming BRAF inhibitor resistance in melanoma. International Journal of Molecular Sciences, 18 (7) 1527, 1527.1-1527.13. doi: 10.3390/ijms18071527
Kamato, Danielle, Mitra, Partha, Davis, Felicity, Osman, Narin, Chaplin, Rebecca, Cabot, Peter J., Afroz, Rizwana, Thomas, Walter, Zheng, Wenhua, Kaur, Harveen, Brimble, Margaret and Little, Peter J. (2017). Gaq proteins: molecular pharmacology and therapeutic potential. Cellular and Molecular Life Sciences, 74 (8), 1379-1390. doi: 10.1007/s00018-016-2405-9
Rostam, Muhamad A., Kamato, Danielle, Piva, Terence J., Zheng, Wenhua, Little, Peter J. and Osman, Narin (2016). The role of specific Smad linker region phosphorylation in TGF-β mediated expression of glycosaminoglycan synthesizing enzymes in vascular smooth muscle. Cellular Signalling, 28 (8), 956-966. doi: 10.1016/j.cellsig.2016.05.002
Al Gwairi, Othman, Osman, Narin, Getachew, Robel, Zheng, Wenhua, Liang, X. -L., Kamato, Danielle, Thach, Lyna and Little, Peter J. (2016). Multiple growth factors, but not VEGF, stimulate glycosaminoglycan hyperelongation in retinal choroidal endothelial cells. International Journal of Biological Sciences, 12 (9), 1041-1051. doi: 10.7150/ijbs.16134
Bernard, Rebekah, Getachew R., Kamato, D., Thach L., Osman N., Chan V., Zheng W. and Little P.J. (2016). Evaluation of the potential synergism of imatinib-related poly kinase inhibitors using growth factor stimulated proteoglycan synthesis as a model response. Journal of Pharmacy and Pharmacology, 68 (3), 368-378. doi: 10.1111/jphp.12530
Little, P. J., Hollenberg, M. D, Kamato, D., Thomas, W., Chen, J., Wang, T., Zheng, W. and Osman, N. (2016). Integrating the GPCR transactivation-dependent and biased signalling paradigms in the context of PAR1 signalling. British Journal of Pharmacology, 173 (20), 2992-3000. doi: 10.1111/bph.13398
Al Gwairi, Othman, Thach, Lyna, Zheng, Wenhua, Osman, Narin and Little, Peter J. (2016). Cellular and molecular pathology of age-related macular degeneration: potential role for proteoglycans. Journal of Ophthalmology, 2016 2913612, 2913612-7. doi: 10.1155/2016/2913612
Kamato, Danielle, Thach, Lyna, Getachew, Robel, Burch, Micah, Hollenberg, Morley D., Zheng, Wenhua, Little, Peter J. and Osman, Narin (2016). Protease activated receptor-1 mediated dual kinase receptor transactivation stimulates the expression of glycosaminoglycan synthesizing genes. Cellular Signalling, 28 (1), 110-119. doi: 10.1016/j.cellsig.2015.11.003
Bernard, Rebekah, Thach, Lyna, Kamato, Danielle, Osman, Narin and Little, Peter J. (2014). Assessing the Role of Gαq/11 in Cellular Responses: An Analysis of Investigative Tools. Clinical & Experimental Pharmacology, 04 (05). doi: 10.4172/2161-1459.1000164
Kamato, Danielle, Burch, Micah L., Piva, Terrence J., Rezaei, Hossein Babaahmadi, Rostam, Muhamad Ashraf, Xu, Suowen, Zheng, Wenhua, Little, Peter J. and Osman, Narin (2013). Transforming growth factor-β signalling: role and consequences of Smad linker region phosphorylation. Cellular Signalling, 25 (10), 2017-2024. doi: 10.1016/j.cellsig.2013.06.001
Little, Peter J., Rostam, Muhamad Ashraf, Piva, Terrence J., Getachew, Robel, Kamato, Danielle, Guidone, Daniel, Ballinger, Mandy L., Zheng, Wenhua and Osman, Narin (2013). Suramin inhibits PDGF-stimulated receptor phosphorylation, proteoglycan synthesis and glycosaminoglycan hyperelongation in human vascular smooth muscle cells. Journal of Pharmacy and Pharmacology, 65 (7), 1055-1063. doi: 10.1111/jphp.12064
Kamato, Danielle, Rezaei, Hossein Babaahmadi, Getachew, Robel, Thach, Lyna, Guidone, Daniel, Osman, Narin, Roufogalis, Basil, Duke, Colin C., Van Hoan Tran, Zheng, Wenhua and Little, Peter J. (2013). (S)-[6]-Gingerol inhibits TGF-β-stimulated biglycan synthesis but not glycosaminoglycan hyperelongation in human vascular smooth muscle cells. Journal of Pharmacy and Pharmacology, 65 (7), 1026-1036. doi: 10.1111/jphp.12060
Kamato, Danielle, Burch, Micah L., Osman, Narin, Zheng, Wenhua and Little, Peter J. (2013). Therapeutic implications of endothelin and thrombin G-protein-coupled receptor transactivation of tyrosine and serine/threonine kinase cell surface receptors. Journal of Pharmacy and Pharmacology, 65 (4), 465-473. doi: 10.1111/j.2042-7158.2012.01577.x
Osman, Narin, Grande-Allen, K. Jane, Ballinger, Mandy L., Getachew, Robel, Marasco, Silvana, O'Brien, Kevin D. and Little, Peter J. (2013). Smad2-dependent glycosaminoglycan elongation in aortic valve interstitial cells enhances binding of LDL to proteoglycans. Cardiovascular Pathology, 22 (2), 146-155. doi: 10.1016/j.carpath.2012.07.002
Burch, Micah L., Ballinger, Mandy L., Yang, Sundy N. Y., Getachew, Robel, Itman, Catherine, Loveland, Kate, Osman, Narin and Little, Peter J. (2010). Thrombin stimulation of proteoglycan synthesis in vascular smooth muscle is mediated by protease-activated receptor-1 transactivation of the transforming growth factor βtype I receptor. Journal of Biological Chemistry, 285 (35), 26798-26805. doi: 10.1074/jbc.M109.092767
Nigro, Julie, Ballinger, Mandy L., Survase, Soniya, Osman, Narin and Little, Peter J. (2005). New approaches to regulating the chondroitin/dermatan sulfate glycosaminoglycan component of the vascular extracellular matrix. Thescientificworldjournal, 5 (2), 515-520. doi: 10.1100/tsw.2005.69
Sudhir, Krishnankutty, Nigro, Julie, Osman, Narin and Little, Peter J. (2005). Androgens: New effects on proteoglycan biosynthesis and its consequences for atherosclerosis. Thescientificworldjournal, 5, 521-526. doi: 10.1100/tsw.2005.75