Dr Narin Osman
Honorary Associate Professor
School of Pharmacy
Publications
Journal Articles
Sarkar, Sanjib, Osman, Narin, Thrimawithana, Thilini, Wann, Sawlang Borsingh, Kalita, Jatin and Manna, Prasenjit (2024). Alleviation of Diabetic Retinopathy by Glucose-Triggered Delivery of Vitamin D via Dextran-Gated Functionalized Mesoporous Silica Nanoparticles. ACS Applied Bio Materials, 7 (2), 1260-1270. doi: 10.1021/acsabm.3c01200
Kamato, Danielle, Gabr, Mai, Kumarapperuma, Hirushi, Chia, Zheng J., Zheng, Wenhua, Xu, Suowen, Osman, Narin and Little, Peter J. (2022). Gαq is the specific mediator of PAR-1 transactivation of kinase receptors in vascular smooth muscle cells. International Journal of Molecular Sciences, 23 (22) 14425, 14425. doi: 10.3390/ijms232214425
Kamato, Danielle, Do, Bich Hang, Osman, Narin, Ross, Benjamin P., Mohamed, Raafat, Xu, Suowen and Little, Peter J. (2019). Smad linker region phosphorylation is a signalling pathway in its own right and not only a modulator of canonical TGF-β signalling. Cellular and Molecular Life Sciences, 77 (2), 243-251. doi: 10.1007/s00018-019-03266-3
Dulull, Nabeela, Kwa, Faith, Osman, Narin, Rai, Uma, Shaikh, Bilal and Thrimawithana, Thilini R. (2019). Recent advances in the management of diabetic retinopathy. Drug Discovery Today, 24 (8), 1499-1509. doi: 10.1016/j.drudis.2019.03.028
Kamato, Danielle, Ta, Hang, Afroz, Rizwana, Xu, Suowen, Osman, Narin and Little, Peter J. (2019). Mechanisms of PAR-1 mediated kinase receptor transactivation: Smad linker region phosphorylation. Journal of Cell Communication and Signaling, 13 (4), 539-548. doi: 10.1007/s12079-019-00527-5
Kamato, Danielle, Burch, Micah, Yang, Zhou, Mohamed, Raafat, Stow, Jennifer L., Osman, Narin and Little, Peter J. (2019). Individual Smad2 linker region phosphorylation sites determine the expression of proteoglycan and glycosaminoglycan synthesizing genes. Cellular Signalling, 53, 365-373. doi: 10.1016/j.cellsig.2018.11.005
Rostam, Muhamad Ashraf, Shajimoon, Aravindra, Kamato, Danielle, Mitra, Partha, Piva, Terrence, Getachew, Robel, Cao, Yingnan, Zheng, Wenhua, Osman, Narin and Little, Peter James (2018). Flavopiridol inhibits TGF-β-stimulated biglycan synthesis by blocking linker region phosphorylation and nuclear translocation of Smad2. The Journal of Pharmacology and Experimental Therapeutics, 365 (1), 156-164. doi: 10.1124/jpet.117.244483
Talati, Nirali, Kamato, Danielle, Piva, Terrence J, Little, Peter and Osman, Narin (2018). Thrombin promotes PAI-1 expression and migration in keratinocytes via ERK dependent Smad linker region phosphorylation. Cellular Signalling, 47, 37-43. doi: 10.1016/j.cellsig.2018.03.009
Afroz, Rizwana, Cao, Yingnan, Rostam, Muhamad Ashraf, Ta, Hang, Xu, Suowen, Zheng, Wenhua, Osman, Narin, Kamato, Danielle and Little, Peter J. (2018). Signalling pathways regulating galactosaminoglycan synthesis and structure in vascular smooth muscle: implications for lipoprotein binding and atherosclerosis. Pharmacology and Therapeutics, 187, 88-97. doi: 10.1016/j.pharmthera.2018.02.005
Kamato, Danielle, Vijayanand Bhaskarala, Venkata, Mantri, Nitin, Gyu Oh, Tae, Ling, Dora, Janke, Reearna, Zheng, Wenhua, Little, Peter J. and Osman, Narin (2017). RNA sequencing to determine the contribution of kinase receptor transactivation to G protein coupled receptor signalling in vascular smooth muscle cells. PLoS One, 12 (7) e0180842, e0180842. doi: 10.1371/journal.pone.0180842
Chan, Xian Yang, Singh, Alamdeep, Osman, Narin and Piva, Terrence J. (2017). Role played by signalling pathways in overcoming BRAF inhibitor resistance in melanoma. International Journal of Molecular Sciences, 18 (7) 1527, 1527.1-1527.13. doi: 10.3390/ijms18071527
Kamato, Danielle, Mitra, Partha, Davis, Felicity, Osman, Narin, Chaplin, Rebecca, Cabot, Peter J., Afroz, Rizwana, Thomas, Walter, Zheng, Wenhua, Kaur, Harveen, Brimble, Margaret and Little, Peter J. (2017). Gaq proteins: molecular pharmacology and therapeutic potential. Cellular and Molecular Life Sciences, 74 (8), 1379-1390. doi: 10.1007/s00018-016-2405-9
Rostam, Muhamad A., Kamato, Danielle, Piva, Terence J., Zheng, Wenhua, Little, Peter J. and Osman, Narin (2016). The role of specific Smad linker region phosphorylation in TGF-β mediated expression of glycosaminoglycan synthesizing enzymes in vascular smooth muscle. Cellular Signalling, 28 (8), 956-966. doi: 10.1016/j.cellsig.2016.05.002
Al Gwairi, Othman, Osman, Narin, Getachew, Robel, Zheng, Wenhua, Liang, X. -L., Kamato, Danielle, Thach, Lyna and Little, Peter J. (2016). Multiple growth factors, but not VEGF, stimulate glycosaminoglycan hyperelongation in retinal choroidal endothelial cells. International Journal of Biological Sciences, 12 (9), 1041-1051. doi: 10.7150/ijbs.16134
Bernard, Rebekah, Getachew R., Kamato, D., Thach L., Osman N., Chan V., Zheng W. and Little P. J. (2016). Evaluation of the potential synergism of imatinib-related poly kinase inhibitors using growth factor stimulated proteoglycan synthesis as a model response. Journal of Pharmacy and Pharmacology, 68 (3), 368-378. doi: 10.1111/jphp.12530
Little, P. J., Hollenberg, M. D, Kamato, D., Thomas, W., Chen, J., Wang, T., Zheng, W. and Osman, N. (2016). Integrating the GPCR transactivation-dependent and biased signalling paradigms in the context of PAR1 signalling. British Journal of Pharmacology, 173 (20), 2992-3000. doi: 10.1111/bph.13398
Al Gwairi, Othman, Thach, Lyna, Zheng, Wenhua, Osman, Narin and Little, Peter J. (2016). Cellular and molecular pathology of age-related macular degeneration: potential role for proteoglycans. Journal of Ophthalmology, 2016 2913612, 2913612-7. doi: 10.1155/2016/2913612
Kamato, Danielle, Thach, Lyna, Getachew, Robel, Burch, Micah, Hollenberg, Morley D., Zheng, Wenhua, Little, Peter J. and Osman, Narin (2016). Protease activated receptor-1 mediated dual kinase receptor transactivation stimulates the expression of glycosaminoglycan synthesizing genes. Cellular Signalling, 28 (1), 110-119. doi: 10.1016/j.cellsig.2015.11.003
Bernard, Rebekah, Thach, Lyna, Kamato, Danielle, Osman, Narin and Little, Peter J. (2014). Assessing the Role of Gαq/11 in Cellular Responses: An Analysis of Investigative Tools. Clinical & Experimental Pharmacology, 04 (05). doi: 10.4172/2161-1459.1000164
Kamato, Danielle, Burch, Micah L., Piva, Terrence J., Rezaei, Hossein Babaahmadi, Rostam, Muhamad Ashraf, Xu, Suowen, Zheng, Wenhua, Little, Peter J. and Osman, Narin (2013). Transforming growth factor-β signalling: role and consequences of Smad linker region phosphorylation. Cellular Signalling, 25 (10), 2017-2024. doi: 10.1016/j.cellsig.2013.06.001
Kamato, Danielle, Rezaei, Hossein Babaahmadi, Getachew, Robel, Thach, Lyna, Guidone, Daniel, Osman, Narin, Roufogalis, Basil, Duke, Colin C., Van Hoan Tran, Zheng, Wenhua and Little, Peter J. (2013). (S)-[6]-Gingerol inhibits TGF-β-stimulated biglycan synthesis but not glycosaminoglycan hyperelongation in human vascular smooth muscle cells. Journal of Pharmacy and Pharmacology, 65 (7), 1026-1036. doi: 10.1111/jphp.12060
Little, Peter J., Rostam, Muhamad Ashraf, Piva, Terrence J., Getachew, Robel, Kamato, Danielle, Guidone, Daniel, Ballinger, Mandy L., Zheng, Wenhua and Osman, Narin (2013). Suramin inhibits PDGF-stimulated receptor phosphorylation, proteoglycan synthesis and glycosaminoglycan hyperelongation in human vascular smooth muscle cells. Journal of Pharmacy and Pharmacology, 65 (7), 1055-1063. doi: 10.1111/jphp.12064
Kamato, Danielle, Burch, Micah L., Osman, Narin, Zheng, Wenhua and Little, Peter J. (2013). Therapeutic implications of endothelin and thrombin G-protein-coupled receptor transactivation of tyrosine and serine/threonine kinase cell surface receptors. Journal of Pharmacy and Pharmacology, 65 (4), 465-473. doi: 10.1111/j.2042-7158.2012.01577.x
Osman, Narin, Grande-Allen, K. Jane, Ballinger, Mandy L., Getachew, Robel, Marasco, Silvana, O'Brien, Kevin D. and Little, Peter J. (2013). Smad2-dependent glycosaminoglycan elongation in aortic valve interstitial cells enhances binding of LDL to proteoglycans. Cardiovascular Pathology, 22 (2), 146-155. doi: 10.1016/j.carpath.2012.07.002
Little, Peter J., Getachew, Robel, Rezaei, Hossein Babaahmadi, Sanchez-Guerrero, Estella, Khachigian, Levon M., Wang, Haitao, Liao, Sufen, Zheng, Wenhua, Ballinger, Mandy L. and Osman, Narin (2012). Genistein inhibits PDGF-stimulated proteoglycan synthesis in vascular smooth muscle without blocking PDGFβ receptor phosphorylation. Archives of Biochemistry and Biophysics, 525 (1), 25-31. doi: 10.1016/j.abb.2012.05.025
Burch, Micah L., Osman, Narin, Getachew, Robel, Al-aryahi, Sefaa, Poronnik, Philip, Zheng, Wenhua, Hill, Michael A. and Little, Peter J. (2012). G protein coupled receptor transactivation: extending the paradigm to include serine/threonine kinase receptors. International Journal of Biochemistry and Cell Biology, 44 (5), 722-727. doi: 10.1016/j.biocel.2012.01.018
Osman, Narin, Getachew, Robel, Burch, Micah, Lancaster, Graeme, Wang, Rikang, Wang, Haitau, Zheng, Wenhua and Little, Peter J. (2011). TGF-β stimulates biglycan core protein synthesis but not glycosaminoglycan chain elongation via Akt phosphorylation in vascular smooth muscle. Growth Factors, 29 (5), 203-210. doi: 10.3109/08977194.2011.615747
Little, Peter J., Burch, Micah L., Getachew, Robel, Al-aryahi, Sefaa and Osman, Narin (2010). Endothelin-1 stimulation of proteoglycan synthesis in vascular smooth muscle is mediated by endothelin receptor transactivation of the transforming growth factor-β type I receptor. Journal of Cardiovascular Pharmacology, 56 (4), 360-368. doi: 10.1097/FJC.0b013e3181ee6811
Burch, Micah L., Ballinger, Mandy L., Yang, Sundy N. Y., Getachew, Robel, Itman, Catherine, Loveland, Kate, Osman, Narin and Little, Peter J. (2010). Thrombin stimulation of proteoglycan synthesis in vascular smooth muscle is mediated by protease-activated receptor-1 transactivation of the transforming growth factor βtype I receptor. Journal of Biological Chemistry, 285 (35), 26798-26805. doi: 10.1074/jbc.M109.092767
Getachew, Robel, Ballinger, Mandy L., Burch, Micah L., Little, Peter J. and Osman, Narin (2010). Characterisation of Ki11502 as a potent inhibitor of PDGF β receptor-mediated proteoglycan synthesis in vascular smooth muscle cells. European Journal of Pharmacology, 626 (2-3), 186-192. doi: 10.1016/j.ejphar.2009.09.066
Burch, Micah L., Yang, Sundy N. Y., Ballinger, Mandy L., Getachew, Robel, Osman, Narin and Little, Peter J. (2010). TGF-β stimulates biglycan synthesis via p38 and ERK phosphorylation of the linker region of Smad2. Cellular and Molecular Life Sciences, 67 (12), 2077-2090. doi: 10.1007/s00018-010-0315-9
Ballinger, M. L., Ivey, M. E., Osman, N., Thomas, W. G. and Little, P. J. (2009). Endothelin-1 activates ETA receptors on human vascular smooth muscle cells to yield proteoglycans with increased binding to LDL. Atherosclerosis, 205 (2), 451-457. doi: 10.1016/j.atherosclerosis.2009.01.024
Ivey, Melanie E., Osman, Narin and Little, Peter J. (2008). Endothelin-1 signalling in vascular smooth muscle: Pathways controlling cellular functions associated with atherosclerosis. Atherosclerosis, 199 (2), 237-247. doi: 10.1016/j.atherosclerosis.2008.03.006
Dadlani, Harsha, Osman, Narin, Ballinger, Mandy L., Marasco, Silvana and Little, Peter J. (2008). Calcific aortic valve disease and hypertension. Current Hypertension Reviews, 4 (2), 107-113. doi: 10.2174/157340208784245884
Sudhir, Krishnankutty, Nigro, Julie, Osman, Narin and Little, Peter J. (2005). Androgens: New effects on proteoglycan biosynthesis and its consequences for atherosclerosis. Thescientificworldjournal, 5, 521-526. doi: 10.1100/tsw.2005.75
Nigro, Julie, Ballinger, Mandy L., Survase, Soniya, Osman, Narin and Little, Peter J. (2005). New approaches to regulating the chondroitin/dermatan sulfate glycosaminoglycan component of the vascular extracellular matrix. Thescientificworldjournal, 5 (2), 515-520. doi: 10.1100/tsw.2005.69