Dr Harendra Parekh
Director of Research & Senior Lecturer
School of Pharmacy and Pharmaceutical Sciences
+61 7 334 61887
Researcher biography
Harendra's research interests span pharmaceutical medicinal chemistry and pharmaceutics as applied to innovative formulation & device co-development, and advanced non-viral, bioresponsive drug/gene delivery system design, synthesis and evaluation. His team at the School of Pharmacy & Pharmaceutical Sciences have been instrumental in developing highly innovative and versatile platform delivery systems: for direct, nose-to-brain delivery of therapeutics with their Sol-Gel platform; a US-patented bioresponsive linker technology for stabilisation of peptide therapeutics in their natural conformation, transforming endogenous molecules into safe & effective medicines; engineering bioresponsive lipid nanoparticles (bLNPs) with tissue targeting and a unique gene 'catch-&-release' feature; micro- & nanobubble formulations, which when used in-conjuction with ultrasound, pave the way for improved rates of 'on-demand' drug delivery and release in target tissue e.g. for ocular indications. Harendra actively engages with pharma industry executives, and investors, globally, to showcase his array of disruptive platforms designed with clinical translation front and centre of all research endeavours.
BScPharm(Hon I), PhD (Nottingham)
Harendra completed his BSc in pharmacy (UK) and registered as a Pharmacist in 1998. He went onto undertake his PhD in Medicinal Chemistry at the University of Nottingham in the same year. Under the supervision of Dr B. Kellam and Dr. S. R. Chhabra he investigated the development of novel linkers for solid phase peptide and glycopeptide synthesis. Harendra was awarded his PhD in 2002, and after a short time working in community pharmacy in the UK relocated to Australia and took up a position as research officer in the School of Chemistry at UQ. He continues to be a member of the Royal Pharmaceutical Society of GB and is also registered with the AHPRA (pharmacist) in QLD.
Dr Parekh was appointed to a teaching and research role in the School of Pharmacy & Pharmaceutical Sciences in 2005. He is Scientific Founder & Chief Research Officer of two start-up companies that hold his platform technologies at their core (www.preveceutical.com; www.biogenetherapeutics.com). He also holds an adjunct-Faculty position at Manipal College of Pharmaceutical Sciences, Manipal University (India).
Book
Singh, Prachi, Kokil, Ganesh R., Tupally, Karnaker R., Poddar, Kingshuk, Tan, Aaron, Venkatesan, Venky, Parekh, Harendra S. and Pastorin, Giorgia (2016). Therapeutic perspectives in Type-1 Diabetes. Singapore: Springer. doi: 10.1007/978-981-10-0602-9
Book Chapters
Tupally, Karnaker Reddy, Seal, Prasenjit, Pandey, Preeti, Lohman, Rink-Jan, Smith, Sean, Ouyang, Defang and Parekh, Haredra (2024). Integration of dendrimer-based delivery technologies with computational pharmaceutics and their potential in the era of nanomedicine. Exploring computational pharmaceutics - AI and modeling in Pharma 4.0. (pp. 328-378) edited by Defang Ouyang. Hoboken, NJ, United States: Wiley. doi: 10.1002/9781119987260.ch10
Manikkath, J., Hegde, A. R., Parekh, H. S. and Mutalik, S. (2016). Peptide dendrimers in delivery of bioactive molecules to skin. Nanoscience in dermatology. (pp. 89-97) edited by Michael R. Hamblin, Pinar Avci and Tarl W. Prow. London, United Kingdom: Academic Press. doi: 10.1016/B978-0-12-802926-8.00007-0
Singh, Prachi, Kokil, Ganesh R., Tupally, Karnaker R., Poddar, Kingshuk, Tan, Aaron, Venkatesan, Venky, Parekh, Harendra S. and Pastorin, Giorgia (2016). Introduction to diabetes and type 1 diabetes. Therapeutic perspectives in type-1 diabetes. (pp. 1-6) edited by Prachi Singh, Ganesh R. Kokil, Karnaker R. Tupally, Kingshuk Poddar, Aaron Tan, Venky Venkatesan, Harendra S. Parekh and Giorgia Pastorin. Singapore, Singapore: Springer. doi: 10.1007/978-981-10-0602-9_1
Tupally, Karnaker R., Kokil, Ganesh K., Thakur, Sachin S., Singh, Prachi and Parekh, Harendra S. (2015). Dendrimers. Controlled release systems: advances in nanobottles and active nanoparticles. (pp. 259-286) edited by Alexander van Herk, Jacqueline Forcada and Giorgia Pastorin. Boca Raton, FL, United States: Taylor & Francis. doi: 10.1201/b19860-15
Thakur, Sachin S., Parekh, Harendra S., Schwable, Carl H., Gan, Yong and Ouyang, Defang (2015). Solubilization of poorly-soluble drugs: cyclodextrin-based formulations. Computational pharmaceutics: application of molecular modeling in drug delivery. (pp. 31-51) edited by Defang Ouyang and Sean C. Smith. Chichester, United Kingdom: John Wiley & Sons.
Parekh, Harendra S., Liu, Gang and Wei, Ming Q. (2014). A new dawn for the use of traditional Chinese medicine in cancer therapy. Recent advances in plant-based, traditional, and natural medicines. (pp. 131-150) edited by Subramayam Vemulpad and Joanne Jamie. Oakville, ON, Canada: Apple Academic Press.
Seefeld, Anne, Kokil, Ganesh R., Tupally, Karnaker R., Parekh, Harendra S. and Herten, Dirk-Peter (2013). Fluorescent nucleic acid probes in living cells. DNA and RNA nanobiotechnologies in medicine: diagnosis and treatment of diseases. (pp. 291-328) edited by Volker A. Erdmann and Jan Barciszewski. Berlin, Germany: Springer. doi: 10.1007/978-3-642-36853-0_12
Shah, Neha, Ouyang, Defang, Mutalik, Srinivas and Parekh, Harendra (2011). Dendrimers as carriers for the effective delivery of drugs and genes. Nanotechnology in health care. (pp. 367-391) edited by P.D. Gupta and N. Udupa. Jaipur, India: S.P. Publications.
Parekh, H. S (2011). An introduction to dendrimers-versatile drug/gene delivery vectors. Nanotechnology in health care. (pp. 355-367) edited by P.D. Gupta and N. Udupa. Nataniyon Ka Rasta, Jaipur: S.P. Publications.
Parekh, Harendra S. and Jing, Jing (2011). An evidence-based perspective of herbal remedies for cancer patients. Evidence-based Anticancer Materia Medica. (pp. 399-422) B.V.: Springer.
Parekh, Harendra S. and Jing, Jing (2011). An evidence-based perspective of herbal remedies for cancer patients.. Evidence-based anticancer herbal medicine. (pp. 399-422) edited by William C.S. Cho. New York, U.S.A.: Springer Verlag.
Journal Articles
Thapa, Ritu, Pandey, Preeti, Parat, Marie-Odile, Gurung, Shila, Trembizki, Ella, Anderson, Taylah, Whiley, David and Parekh, Harendra S. (2025). Investigation of ex vivo vaginal tissue deposition and antimicrobial screening- a proof-of-concept study with doxycycline-infused in situ sol-gel for localised gonorrhoea management. Journal of Pharmaceutical Sciences, 114 (7) 103833, 103833-7. doi: 10.1016/j.xphs.2025.103833
Roy, Amrita Arup, Pandey, Abhijeet, Dhas, Namdev, Hegde, Manasa Manjunath, Parekh, Harendra S., Andugulapati, Sai Balaji, Nandakumar, Krishnadas, Satish Rao, Bola Sadashiva and Mutalik, Srinivas (2025). The Confluence of Nanotechnology and Heat Shock Protein 70 in Pioneering Glioblastoma Multiforme Therapy: Forging Pathways Towards Precision Targeting and Transformation. Advances in Pharmacological and Pharmaceutical Sciences, 2025 (1) 1847197. doi: 10.1155/adpp/1847197
Shreya, Ajjappla Basavaraj, Pandey, Abhijeet, Kulkarni, Sanjay, Bhaskar, K Vijaya, Parekh, Harendra S. and Mutalik, Srinivas (2024). Exploring peptide dendrimers for intestinal lymphatic targeting: formulation and evaluation of peptide dendrimer conjugated liposomes for enhancing the oral bioavailability of Asenapine maleate. Scientific Reports, 14 (1) 28225, 1-22. doi: 10.1038/s41598-024-79372-5
Thapa, Ritu, Pandey, Preeti, Parat, Marie-Odile, Gurung, Shila and Parekh, Harendra S. (2024). Phase transforming in situ gels for sustained and controlled transmucosal drug delivery via the intravaginal route. International Journal of Pharmaceutics, 655 124054, 1-15. doi: 10.1016/j.ijpharm.2024.124054
Almahmoud, Abdallah, Parekh, Harendra S., Paterson, Brett M., Tupally, Karnaker Reddy and Vegh, Viktor (2024). Intranasal delivery of imaging agents to the brain. Theranostics, 14 (13), 5022-5101. doi: 10.7150/thno.98473
Hegde, Aswathi R., Paul, Milan, Kumbham, Soniya, Roy, Amrita Arup, Ahmad, Sheikh F., Parekh, Harendra, Biswas, Swati and Mutalik, Srinivas (2023). Ameliorative anticancer effect of dendrimeric peptide modified liposomes of letrozole: n vitro and in vivo performance evaluations. International Journal of Pharmaceutics, 648 123582, 1-22. doi: 10.1016/j.ijpharm.2023.123582
Harrop, Angus C. F., Tupally, Karnaker R., Pandey, Preeti and Parekh, Harendra S. (2023). Opportunities for bioactive glass in gastrointestinal conditions: a review of production methodologies, morphology, composition, and performance. Molecular Pharmaceutics, 20 (12), 5954-5980. doi: 10.1021/acs.molpharmaceut.3c00188
Mutalik, Sadhana P., Gaikwad, Shraddha Y., Fernandes, Gasper, More, Ashwini, Kulkarni, Sanjay, Fayaz, Shaik Mohammad Abdul, Tupally, Karnaker, Parekh, Harendra S., Kulkarni, Smita, Mukherjee, Anupam and Mutalik, Srinivas (2023). Anti-CD4 antibody and dendrimeric peptide based targeted nano-liposomal dual drug formulation for the treatment of HIV infection. Life Sciences, 334 122226, 1-17. doi: 10.1016/j.lfs.2023.122226
Bakshi, Shrishty, Pandey, Preeti, Mohammed, Yousuf, Wang, Joanna, Sailor, Michael J., Popat, Amirali, Parekh, Harendra S. and Kumeria, Tushar (2023). Porous silicon embedded in a thermoresponsive hydrogel for intranasal delivery of lipophilic drugs to treat rhinosinusitis. Journal of Controlled Release, 363, 452-463. doi: 10.1016/j.jconrel.2023.09.045
Lohman, Rink-Jan, Tupally, Karnaker Reddy, Kandale, Ajit, Cabot, Peter J and Parekh, Harendra S (2023). Design and development of novel, short, stable dynorphin-based opioid agonists for safer analgesic therapy. Frontiers in Pharmacology, 14 1150313, 1150313-14. doi: 10.3389/fphar.2023.1150313
Rad, Isaac J., Chapman, Luke, Tupally, Karnaker Reddy, Veidt, Martin, Al-Sadiq, Hussain, Sullivan, Robert and Parekh, Harendra S (2023). A systematic review of ultrasound-mediated drug delivery to the eye and critical insights to facilitate a timely path to the clinic. Theranostics, 13 (11), 3582-3638. doi: 10.7150/thno.82884
Lohman, Rink-Jan, Tupally, Karnaker Reddy, Kandale, Ajit, Cabot, Peter J. and Parekh, Harendra S. (2022). Design and development of novel, short, stable dynorphin-based opioid agonists for safer analgesic therapy. British Journal of Pharmacology, 180 (1), 129-129. doi: 10.1111/bph.15862
Tan, Madeleine S. A., Pandey, Preeti, Lohman, Rink-Jan, Falconer, James R., Siskind, Dan J. and Parekh, Harendra S. (2022). Fabrication and Characterization of Clozapine Nanoemulsion Sol–Gel for Intranasal Administration. Molecular Pharmaceutics, 19 (11), 4055-4066. doi: 10.1021/acs.molpharmaceut.2c00513
Thapa, Ritu, Gurung, Shila, Parat, Marie-Odile, Parekh, Harendra S. and Pandey, Preeti (2022). Application of sol–gels for treatment of gynaecological conditions—physiological perspectives and emerging concepts in intravaginal drug delivery. Gels, 8 (2) 99, 99. doi: 10.3390/gels8020099
Tan, Madeleine S. A., Pandey, Preeti, Falconer, James R., Siskind, Dan J., Balmanno, Alexandra and Parekh, Harendra S. (2022). Clozapine-encapsulated binary mixed micelles in thermosensitive sol–gels for intranasal administration. Gels, 8 (1) 38, 38. doi: 10.3390/gels8010038
Qamar, Sadia, Torres, Yady J. M., Parekh, Harendra S. and Falconer, James Robert (2022). Fractional factorial design study for the extraction of cannabinoids from CBD-dominant cannabis flowers by supercritical carbon dioxide. Processes, 10 (1) 93, 93. doi: 10.3390/pr10010093
AlSadiq, Hussain, Tupally, Karnaker Reddy, Vogel, Robert, Parekh, Harendra S. and Veidt, Martin (2022). Multi-physics study of acoustofluidic delivery agents' clustering behavior. Physics in Medicine and Biology, 67 (1) 015002, 015002. doi: 10.1088/1361-6560/ac4666
Qamar, Sadia, Torres, Yady J. M., Parekh, Harendra S. and Falconer, James Robert (2021). Effects of ethanol on the supercritical carbon dioxide extraction of cannabinoids from near equimolar (THCÂ and CBD balanced) cannabis flower. Separations, 8 (9) 154, 154. doi: 10.3390/separations8090154
Fabbron-Appas, Catherine Tolomei, Pandey, Preeti, Parekh, Harendra S., Sales, Caroline Cianga, Duque, Marcelo Dutra, Andreo-Filho, Newton, Lopes, Patricia Santos, de Noronha, Regina Lucia F. and Leite-Silva, Vania Rodrigues (2021). Impact of different emollient esters on body emulsions: sensory, physicochemical, and biometrological characterization. Journal of Sensory Studies, 36 (4) e12660. doi: 10.1111/joss.12660
Qamar, Sadia, Manrique, Yady J., Parekh, Harendra S. and Falconer, James R. (2021). Development and optimization of supercritical fluid extraction setup leading to quantification of 11 cannabinoids derived from medicinal cannabis. Biology, 10 (6) 481, 1-20. doi: 10.3390/biology10060481
Qamar, Sadia, Torres, Yady J.M., Parekh, Harendra S. and Falconer, James Robert (2021). Extraction of medicinal cannabinoids through supercritical carbon dioxide technologies: a review. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 1167 122581, 1-10. doi: 10.1016/j.jchromb.2021.122581
Tan, Madeleine S. A., Honarparvar, Faraz, Falconer, James R., Parekh, Harendra S., Pandey, Preeti and Siskind, Dan J. (2021). A systematic review and meta-analysis of the association between clozapine and norclozapine serum levels and peripheral adverse drug reactions. Psychopharmacology, 238 (3), 615-637. doi: 10.1007/s00213-020-05746-y
Alsadiq, Hussain, Tupally, Karnaker, Vogel, Robert, Kokil, Ganesh, Parekh, Harendra S. and Veidt, Martin (2021). Shell properties and concentration stability of acoustofluidic delivery agents. Physical and Engineering Sciences in Medicine, 44 (1), 79-91. doi: 10.1007/s13246-020-00954-4
Alsenani, Faisal, Tupally, Karnaker R., Chua, Elvis T., Eltanahy, Eladl, Alsufyani, Hamed, Parekh, Harendra S. and Schenk, Peer M. (2020). Evaluation of microalgae and cyanobacteria as potential sources of antimicrobial compounds. Saudi Pharmaceutical Journal, 28 (12), 1834-1841. doi: 10.1016/j.jsps.2020.11.010
Manikkath, Jyothsna, Parekh, Harendra S. and Mutalik, Srinivas (2020). Surface-engineered nanoliposomes with lipidated and non-lipidated peptide-dendrimeric scaffold for efficient transdermal delivery of a therapeutic agent: Development, characterization, toxicological and preclinical performance analyses. European Journal of Pharmaceutics and Biopharmaceutics, 156, 97-113. doi: 10.1016/j.ejpb.2020.09.001
Tan, Madeleine S. A., Parekh, Harendra S., Pandey, Preeti, Siskind, Dan J. and Falconer, James R. (2020). Nose-to-brain delivery of antipsychotics using nanotechnology: a review. Expert Opinion on Drug Delivery, 17 (6) 17425247.2020.1762563, 839-853. doi: 10.1080/17425247.2020.1762563
de Luca, Sergio, Seal, Prasenjit, Parekh, Harendra S., Tupally, Karnaker R. and Smith, Sean C. (2020). Cell membrane penetration without pore formation: chameleonic properties of dendrimers in response to hydrophobic and hydrophilic environments. Advanced Theory and Simulations, 3 (7) 1900152, 1900152. doi: 10.1002/adts.201900152
Qamar, Sadia, Manrique, Yady J., Parekh, Harendra and Falconer, James Robert (2019). Nuts, cereals, seeds and legumes proteins derived emulsifiers as a source of plant protein beverages: a review. Critical Reviews in Food Science and Nutrition, 60 (16), 1-21. doi: 10.1080/10408398.2019.1657062
Pandey, Preeti, Pandey, Saurabh, Cabot, Peter J., Wallwork, Benjamin, Panizza, Benedict J. and Parekh, Harendra S. (2019). Toxicity evaluation and nasal mucosal tissue deposition of dexamethasone-infused mucoadhesive in situ nasal gelling systems. Saudi Pharmaceutical Journal, 27 (7), 914-919. doi: 10.1016/j.jsps.2019.06.005
Thakur, Sachin S., Chen, Ying-Shan, Houston, Zachary H., Fletcher, Nicholas, Barnett, Nigel L., Thurecht, Kristofer J., Rupenthal, Ilva D. and Parekh, Harendra S. (2019). Ultrasound-responsive nanobubbles for enhanced intravitreal drug migration: An ex vivo evaluation. European Journal of Pharmaceutics and Biopharmaceutics, 136, 102-107. doi: 10.1016/j.ejpb.2019.01.014
Jing, Jing, Tupally, Karnaker R., Kokil, Ganesh R., Qu, Zhi, Chen, Sibao and Parekh, Harendra S. (2019). Development of a hybrid peptide dendrimer micellar carrier system and its application in the reformulation of a hydrophobic therapeutic agent derived from traditional Chinese medicine. RSC Advances, 9 (5), 2458-2463. doi: 10.1039/c8ra09606f
Kokil, Ganesh R., Veedu, Rakesh N., Le, Bao Tri, Ramm, Grant A. and Parekh, Harendra S. (2018). Self-assembling asymmetric peptide-dendrimer micelles - a platform for effective and versatile in vitro nucleic acid delivery. Scientific Reports, 8 (1) 4832, 4832. doi: 10.1038/s41598-018-22902-9
Andréo-Filho, Newton, Bim, Antonio Vinicius Kosiski, Kaneko, Telma Mary, Kitice, Nidia Ayumi, Haridass, Isha N., Abd, Eman, Santos Lopes, Patricia, Thakur, Sachin S., Parekh, Harendra S., Roberts, Michael S., Grice, Jeffrey E., Benson, Heather A.E. and Leite-Silva, Vânia Rodrigues (2018). Development and Evaluation of Lipid Nanoparticles Containing Natural Botanical Oil for Sun Protection: Characterization and in vitro and in vivo Human Skin Permeation and Toxicity. Skin Pharmacology and Physiology, 31 (1), 1-9. doi: 10.1159/000481691
Vogel, Robert, Pal, Anoop K, Jambhrunkar, Siddharth, Patel, Pragnesh, Thakur, Sachin S, Reátegui, Eduardo, Parekh, Harendra S, Saá, Paula, Stassinopoulos, Adonis and Broom, Murray F (2017). High-Resolution Single Particle Zeta Potential Characterisation of Biological Nanoparticles using Tunable Resistive Pulse Sensing. Scientific reports, 7 (1) 17479, 17479. doi: 10.1038/s41598-017-14981-x
Shetty, Pallavi Krishna, Manikkath, Jyothsna, Tupally, Karnaker, Kokil, Ganesh, Hegde, Aswathi R., Raut, Sushil Y., Parekh, Harendra S. and Mutalik, Srinivas (2017). Skin delivery of EGCG and silibinin: potential of peptide dendrimers for enhanced skin permeation and deposition. AAPS PharmSciTech, 18 (6), 2346-2357. doi: 10.1208/s12249-017-0718-0
Hegde, Aswathi R., Rewatkar, Prarthana V., Manikkath, Jyothsna, Tupally, Karnaker, Parekh, Harendra S. and Mutalik, Srinivas (2017). Peptide dendrimer-conjugates of ketoprofen: synthesis and ex vivo and in vivo evaluations of passive diffusion, sonophoresis and iontophoresis for skin delivery. European Journal of Pharmaceutical Sciences, 102, 237-249. doi: 10.1016/j.ejps.2017.03.009
Thakur, Sachin S., Ward, Micheal S., Popat, Amirali, Flemming, Nicole B., Parat, Marie-Odile, Barnett, Nigel L. and Parekh, Harendra S. (2017). Stably engineered nanobubbles and ultrasound - An effective platform for enhanced macromolecular delivery to representative cells of the retina. Plos One, 12 (5) e0178305, e0178305. doi: 10.1371/journal.pone.0178305
Manikkath, Jyothsna, Hegde, Aswathi R., Kalthur, Guruprasad, Parekh, Harendra S. and Mutalik, Srinivas (2017). Influence of peptide dendrimers and sonophoresis on the transdermal delivery of ketoprofen. International Journal of Pharmaceutics, 521 (1-2), 110-119. doi: 10.1016/j.ijpharm.2017.02.002
Pandey, Preeti, Cabot, Peter J., Wallwork, Benjamin, Panizza, Benedict J. and Parekh, Harendra S. (2017). Formulation, functional evaluation and ex vivo performance of thermoresponsive soluble gels - a platform for therapeutic delivery to mucosal sinus tissue. European Journal of Pharmaceutical Sciences, 96, 499-507. doi: 10.1016/j.ejps.2016.10.017
De Luca, Sergio, Seal, Prasenjit, Ouyang, Defang, Parekh, Harendra S., Kannam, Sridhar Kumar and Smith, Sean C. (2016). Dynamical interactions of 5-fluorouracil drug with dendritic peptide vectors: the impact of dendrimer generation, charge, counterions, and structured water. Journal of Physical Chemistry B, 120 (25), 5732-5743. doi: 10.1021/acs.jpcb.6b00533
Rewatkar, Prartana V., Sester, David P., Parekh, Harendra S. and Parat, Marie-Odile (2016). Express in vitro plasmid transfection achieved with 16+ asymmetric peptide dendrimers. ACS Biomaterials Science and Engineering, 2 (3), 438-445. doi: 10.1021/acsbiomaterials.6b00033
Rewatkar, Prartana V., Parekh, Harendra S. and Parat, Marie-Odile (2016). Molecular determinants of the cellular entry of asymmetric peptide dendrimers and role of caveolae. PLoS One, 11 (1) e0147491, e0147491.1-e0147491.15. doi: 10.1371/journal.pone.0147491
Soo, Ernest, Thakur, Sachin, Qu, Zhi, Jambhrunkar, Siddharth, Parekh, Harebdra S. and Popat, Amirali (2016). Enhancing delivery and cytotoxicity of resveratrol through a dual nanoencapsulation approach. Journal of Colloid and Interface Science, 462, 368-374. doi: 10.1016/j.jcis.2015.10.022
Kokil, Ganesh R., Veedu, Rakesh N., Ramm, Grant A., Prins, Johannes B. and Parekh, Harendra S. (2015). Type 2 diabetes mellitus: limitations of conventional therapies and intervention with nucleic acid-based therapeutics. Chemical Reviews, 115 (11), 4719-4743. doi: 10.1021/cr5002832
Rewatkar, Prarthana V., Parton, Robert G., Parekh, Harendra S. and Parat, Marie-Odile (2015). Are caveolae a cellular entry route for non-viral therapeutic delivery systems?. Advanced Drug Delivery Reviews, 91, 92-108. doi: 10.1016/j.addr.2015.01.003
Dong, Haiyan, Parekh, Harendra S. and Xu, Zhi Ping (2015). Particle size- and number-dependent delivery to cells by layered double hydroxide nanoparticles. Journal of Colloid And Interface Science, 437 (1), 10-16. doi: 10.1016/j.jcis.2014.09.010
Dong, Haiyan, Parekh, Harendra S. and Xu, Zhi Ping (2014). Enhanced cellular delivery and biocompatibility of a small layered double hydroxide–liposome composite system. Pharmaceutics, 6 (4), 584-598. doi: 10.3390/pharmaceutics6040584
Lu, Yang, Jing, Jing, Ren, Weichao, Zhu, Jing, Qiu, Zhixia, Li, Ning, Li, Xiaonan, Zhao, Di, Parekh, Harendra S. and Chen, Xijing (2014). Biliary excretion of glycyrrhetinic acid: glucuronide-conjugate determination following a pharmacokinetic study of rat bile. Phytotherapy Research, 28 (12), 1887-1889. doi: 10.1002/ptr.5170
Dong, Haiyan, Chen, Min, Rahman, Shafiur, Parekh, Harendra S., Cooper, Helen M. and Xu, Zhi Ping (2014). Engineering small MgAl-layered double hydroxide nanoparticles for enhanced gene delivery. Applied Clay Science, 100 (C), 66-75. doi: 10.1016/j.clay.2014.04.028
Thakur, Sachin S., Barnett, Nigel L., Donaldson, Mark J. and Parekh, Harendra S. (2014). Intravitreal drug delivery in retinal disease: are we out of our depth?. Expert Opinion on Drug Delivery, 11 (10), 1575-1590. doi: 10.1517/17425247.2014.927864
Shah, Neha D., Parekh, Harendra S. and Steptoe, Raymond J. (2014). Asymmetric peptide dendrimers are effective linkers for antibody-mediated delivery of diverse payloads to B cells in vitro and in vivo. Pharmaceutical Research, 31 (11), 3150-3160. doi: 10.1007/s11095-014-1408-1
Mutalik, Srinivas, Shetty, Pallavi K., Kumar, Aravind, Kalra, Rohit and Parekh, Harendra S. (2014). Enhancement in deposition and permeation of 5-fluorouracil through human epidermis assisted by peptide dendrimers.. Drug Delivery, 21 (1), 44-54. doi: 10.3109/10717544.2013.845861
Liang, Xianrui, Du, Liping, Su, Feng, Parekh, Harendra S. and Sua, Weike (2014). The application of quantitative NMR for the facile, rapid and reliable determination of clindamycin phosphate in a conventional tablet formulation. Magnetic Resonance in Chemistry, Early View (4), 1-5. doi: 10.1002/mrc.4048
Qiu, Zhixia, Li, Ning, Song, Ling, Lu, Yang, Jing, Jing, Parekha, Harendra S., Gao, Wenchao, Tian, Fengjie, Wang, Xin, Ren, Shuangxia and Chen, Xijing (2013). Contributions of intestine and plasma to the presystemic bioconversion of Vicagrel, an acetate of clopidogrel. Pharmaceutical Research, 31 (1), 238-251. doi: 10.1007/s11095-013-1158-5
Jing, Jing, Ren, Wei C., Li, Chun, Bose, Utpal, Parekh, Harendra S. and Wei, Ming Q. (2013). Rapid identification of primary constituents in parotoid gland secretions of the Australian cane toad using HPLC/MS-Q-TOF. Biomedical Chromatography, 27 (6), 685-687. doi: 10.1002/bmc.2858
Jing, Jing, Ren, Weichao, Chen, Si Bao, Wei, Ming and Parekh, Harendra S. (2013). Advances in analytical technologies to evaluate the quality of traditional Chinese medicines. Trends in Analytical Chemistry, 44, 39-45. doi: 10.1016/j.trac.2012.11.006
Mutalik, S., Parekh, H. S., Anissimov, Y. G., Grice, J. E. and Roberts, M. S. (2013). Iontophoresis-Mediated Transdermal Permeation of Peptide Dendrimers across Human Epidermis. Skin Pharmacology and Physiology, 26 (3), 127-138. doi: 10.1159/000348469
Rahman, Shafiur, Cao, Siyu, Steadman, Kathryn J., Wei, Ming and Parekh, Harendra S. (2012). Native and β-cyclodextrin-enclosed curcumin: entrapment within liposomes and their in vitro cytotoxicity in lung and colon cancer. Drug Delivery, 19 (7), 346-353. doi: 10.3109/10717544.2012.721143
Mutalik, Srinivas, Nayak, Usha Y., Kalra, Rohit, Kumar, Aravind, Kulkarni, Raghavendra V. and Parekh, Harendra (2012). Sonophoresis-mediated permeation and retention of peptide dendrimers across human epidermis. Skin Research and Technology, 18 (1), 101-107. doi: 10.1111/j.1600-0846.2011.00539.x
Jing, Jing, Chan, Chi-on, Xu, Lijia, Jin, Dengping, Cao, Xinwei, Mok, Daniel K. W., Parekh, H. S. and Chen, Sibao (2011). Development of an in-line HPLC fingerprint ion-trap mass spectrometric method for identification and quality control of Radix Scrophulariae. Journal of Pharmaceutical and Biomedical Analysis, 56 (4), 830-835. doi: 10.1016/j.jpba.2011.07.032
Ouyang, Defang, Zhang, Hong, Parekh, Harendra and Smith, Sean C. (2011). The effect of pH on PAMAM dendrimer-siRNA complexation - Endosomal considerations as determined by molecular dynamics simulation. Biophysical Chemistry, 158 (2-3), 126-133. doi: 10.1016/j.bpc.2011.06.003
Shah, Neha, Steptoe, Raymond J. and Parekh, Harendra S. (2011). Low-generation asymmetric dendrimers exhibit minimal toxicity and effectively complex DNA. Journal of Peptide Science, 17 (6), 470-478. doi: 10.1002/psc.1347
Ouyang, D. F., Zhang, H., Herten, D. P., Parekh, H. S. and Smith, S. C. (2010). Structure, dynamics, and energetics of siRNA-cationic vector complexation: A molecular dynamics study. Journal of Physical Chemistry B, 114 (28), 9220-9230. doi: 10.1021/jp911906e
Ouyang, Defang, Zhang, Hong, Parekh, Harendra S. and Smith, Sean C. (2010). Structure and dynamics of multiple cationic vectors-siRNA complexation by all-atomic molecular dynamics simulations. Journal of Physical Chemistry B, 114 (28), 9231-9237. doi: 10.1021/jp911913c
Dutta, Tathagata, Burgess, Melinda, McMillan, Nigel A. J. and Parekh, Harendra S. (2010). Dendrosome-based delivery of siRNA against E6 and E7 oncogenes in cervical cancer. Nanomedicine: Nanotechnology, Biology, and Medicine, 6 (3), 463-470. doi: 10.1016/j.nano.2009.12.001
Mutalik, S., Hewavitharana, A., Shaw, P. N., Anissimov, Y. G., Roberts, M. S. and Parekh, H. S. (2009). Development and validation of a reversed-phase high-performance liquid chromatographic method for quantification of peptide dendrimers in human skin permeation experiments. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 877 (29), 3556-3562. doi: 10.1016/j.jchromb.2009.08.039
Ouyang, Defang, Zhang, Hong, Herten, Dirk-Peter, Parekh, Harendra S. and Smith, Sean C (2009). Flexibility of short-strand RNA in aqueous solution as revealed by molecular dynamics simulation: Are A-RNA and A'-RNA distinct conformational structures?. Australian Journal of Chemistry, 62 (9), 1054-1061. doi: 10.1071/CH09090
Parekh, Harendra S., Liu, Gang and Wei, Ming Q. (2009). A new dawn for the use of traditional Chinese medicine in cancer therapy. Molecular Cancer, 8 (1) 21, 21.1-21.8. doi: 10.1186/1476-4598-8-21
Ouyang, D., Shah, N., Zhang, H, Smith, S. C. and Parekh, H. S. (2009). Reducible disulfide-based non-viral gene delivery systems. Mini-Reviews in Medicinal Chemistry, 9 (10), 1242-1250. doi: 10.2174/138955709789055225
Mutalik, S., Parekh, H., Davies, N. M. and Udupa, Nayanabhirama (2009). A combined approach of chemical enhancers and sonophoresis for the transdermal delivery of tizanidine hydrochloride. Drug Delivery, 16 (2), 82-91. doi: 10.1080/10717540802605053
Parekh, H. S. (2007). The advance of dendrimers - A versatile targeting platform for gene/drug delivery. Current Pharmaceutical Design, 13 (27), 2837-2850. doi: 10.2174/138161207781757024
Parekh, H. S., Marano, R. J., Rakoczy, E. P., Blanchfield, J. and Toth, I. (2006). Synthesis of a library of polycationic lipid core dendrimers and their evaluation in the delivery of an oligonucleotide with hVEGF inhibition. Bioorganic & Medicinal Chemistry, 14 (14), 4775-4780. doi: 10.1016/j.bmc.2006.03.029
Chhabra, S. R., Parekh, H., Khan, A., Bycroft, B. and Kellam, B. (2001). A Dde-based carboxy linker for solid-phase synthesis. Tetrahedron Letters, 42 (11), 2189-2192. doi: 10.1016/S0040-4039(01)00101-0
Conference Papers
Saifuddin, D., Lohman, R.-J., Tupally, K., Parekh, H. and Cabot, P. (2023). Bivalent kappa-selective opioid peptides with enhanced metabolic stability and potency. 81st FIP World Congress Of Pharmacy And Pharmaceutical Sciences, Brisbane, QLD Australia, 24-28 September 2023. PKP Publishing.
Tan, Madeleine S.A., Pandey, Preeti, Falconer, James R., Siskind, Dan J. and Parekh, Harendra S. (2021). Thermosensitive nanoemulsion-based Sol-Gel of Clozapine for nose-to-brain delivery. Micro and Nanoparticles in Drug and Vaccine Delivery Symposium, Brisbane, QLD Australia, 3 December 2021.
Tan, Madeleine S. A., Pandey, Preeti, Falconer, James R., Siskind, Dan J. and Parekh, Harendra S. (2021). Nanoemulsion-based sol-gel of Clozapine for nose-to-brain delivery. Drug Delivery Australia Virtual Meeting: Advanced Materials in Drug Delivery, Online, 18 - 19 November 2021.
AL-Sadiq, H. A., Tupally, K. R., Parekh, H S. and M Veidt, M. (2021). Shell properties of a new acoustofluidic delivery agent. EPSM 2020, Engineering and Physical Sciences in Medicine, Brisbane, QLD Australia, 28-29 October 2020. Dordrecht, Netherlands: Springer Netherlands.
Tan, Madeleine SA, Pandey, Preeti, Balmanno, Alexandra, Falconer, James R., Siskind, Dan J. and Parekh, Harendra S. (2021). Thermosensitive Micellar Hydrogels of Clozapine for Nose-to-Brain Delivery. 2021 CRS Virtual Annual Meeting, Mount Laurel, NJ United States, 25-29 July 2021 .
Saifuddin, Danial, Lohman, Rink-Jan, Tupally, Karnaker Reddy, Parekh, Harendra S. and Cabot, Peter J. (2021). Novel opioid peptides as allosteric modulators of nociception. ASMR medical research week: Queensland virtual symposium, Online, 9-10 June 2021.
Tan, Madeleine S. A., Honarparvar, Faraz , Falconer, James R., Parekh, Harendra S., Pandey, Preeti and Siskind, Dan J. (2020). Can monitoring clozapine and norclozapine levels reduce the occurrence of peripheral ADRs?. ASCEPT-APSA Joint Virtual Scientific Meeting, Hamilton Central, QLD, Australia, 24-26 November 2020.
Tan, Madeleine , Honarparvar, Faraz , Falconer, James , Parekh, Harendra , Pandey, Preeti and Siskind, Dan (2020). Therapeutic drug monitoring as a tool for clozapine therapy in minimising peripheral ADRs. Australian Society for Medical Research (ASMR) Queensland Post Graduate Students Virtual Scientific Symposium, Sydney, NSW Australia, 10-11 November 2020.
Tan, Madeleine S. A. , Parekh, Harendra S., Pandey, Preeti , Siskind, Dan J. and Falconer, James R. (2020). Development and optimization of clozapine-loaded PLGA nanoparticles for nose-to-brain delivery using supercritical fluid technology. 7th FIP Pharmaceutical Sciences World Congress, The Hague, Netherlands, 4-6 October 2020.
Alsadiq, H., Tupally, K. R., Kokil, G. R., Vogel, R., Parekh, H. S. and Veidt, M. (2019). Concentration stability of monolayer and bilayer lipid microbubbles–a precursor for new drug delivery applications. Drug Delivery Australia 2019 Conference, Brisbane, QLD Australia, 18-19 November 2019.
Alsadiq, Hussain, Reddy, Karnaker, Parekh, Harendra and Veidt, Martin (2018). Influence of acoustofluidic parameters on velocity streaming of sonicated medical microbubbles. AAS2018: Acoustics 2018: Hear to Listen, Adelaide, SA Australia, 6-9 November 2018. Adelaide, SA Australia: Australian Acoustical Society.
Mutalik, Srinivas, Parekh, Harendra S., Hewavitharana, Amitha K., Shaw, P. Nick, Anissimov, Yuri G. and Roberts, Michael S. (2008). Development and validation of RP-HPLC method for quantification of peptide dendrimers in skin permeation experiments. Australian Pharmaceutical Science Association Conference 2008, Canberra, ACT Australia, 6-9 December 2008.
Patents
Pandey, Preeti and Parekh, Harendra (2024). Cannabinoid Formulations And Methods Of Use. EP4203946A4.
Tupally, Karnaker, Cabot, Peter, Nandkumar, Ajit and Parekh, Harendra (2024). Peptides and uses thereof. EP4175970A1.
Parekh, Harendra and Tupally, Karnaker Reddy (2023). Disulfide bond containing compounds and uses thereof. US11566044B2.
Parekh, Harendra and Pandey, Preeti (2022). Sol-gel composition. WO2022040751A1.
Parekh, Harendra, Tupally, Karnaker, Cabot, Peter and Kandale, Ajit (2021). Peptides and uses thereof. 2021300202.
Parekh, Harendra, Cabot, Peter, Tupally, Karnaker and Kandale, Ajit (2020). A cyclic peptide. 2020212659.
Parekh, Harendra, Cabot, Peter, Tupally, Karnaker and Kandale, Ajit (2020). A Cyclic Peptide. US-20220089646-A1.