Publications
Journal Articles
Wang, Haitao, Su, Xiaoying, Fang, Jiankang, Xin, Xingan, Zhao, Xia, Gaur, Uma, Wen, Qiang, Xu, Jiangping, Little, Peter and Zheng, Wenhua (2018). Tanshinone IIA attenuates insulin like growth factor 1 -induced cell proliferation in PC12 cells through the PI3K/Akt and MEK/ERK pathways. International Journal of Molecular Sciences, 19 (9) 2719, 2719. doi: 10.3390/ijms19092719
Rostam, Muhamad Ashraf, Shajimoon, Aravindra, Kamato, Danielle, Mitra, Partha, Piva, Terrence, Getachew, Robel, Cao, Yingnan, Zheng, Wenhua, Osman, Narin and Little, Peter James (2018). Flavopiridol inhibits TGF-β-stimulated biglycan synthesis by blocking linker region phosphorylation and nuclear translocation of Smad2. The Journal of Pharmacology and Experimental Therapeutics, 365 (1), 156-164. doi: 10.1124/jpet.117.244483
Afroz, Rizwana, Cao, Yingnan, Rostam, Muhamad Ashraf, Ta, Hang, Xu, Suowen, Zheng, Wenhua, Osman, Narin, Kamato, Danielle and Little, Peter J. (2018). Signalling pathways regulating galactosaminoglycan synthesis and structure in vascular smooth muscle: implications for lipoprotein binding and atherosclerosis. Pharmacology and Therapeutics, 187, 88-97. doi: 10.1016/j.pharmthera.2018.02.005
Yan, Fengxia, Liao, Rifang, Lin, Shaofen, Deng, Xianguo, Little, Peter J. and Zheng, Wenhua (2017). Forkhead box protein O3 suppresses uveal melanoma development by increasing the expression of Bcl‑2‑like protein 11 and cyclin‑dependent kinase inhibitor 1B. Molecular Medicine Reports, 17 (2), 3109-3114. doi: 10.3892/mmr.2017.8215
Kamato, Danielle, Vijayanand Bhaskarala, Venkata, Mantri, Nitin, Gyu Oh, Tae, Ling, Dora, Janke, Reearna, Zheng, Wenhua, Little, Peter J. and Osman, Narin (2017). RNA sequencing to determine the contribution of kinase receptor transactivation to G protein coupled receptor signalling in vascular smooth muscle cells. PLoS One, 12 (7) e0180842, e0180842. doi: 10.1371/journal.pone.0180842
Kamato, Danielle, Mitra, Partha, Davis, Felicity, Osman, Narin, Chaplin, Rebecca, Cabot, Peter J., Afroz, Rizwana, Thomas, Walter, Zheng, Wenhua, Kaur, Harveen, Brimble, Margaret and Little, Peter J. (2017). Gaq proteins: molecular pharmacology and therapeutic potential. Cellular and Molecular Life Sciences, 74 (8), 1379-1390. doi: 10.1007/s00018-016-2405-9
Wang, Rikang, Yan, Fengxia, Liao, Rifang, Wan, Pei, Little, Peter J. and Zheng, Wenhua (2017). Role of brain-derived neurotrophic factor and nerve growth factor in the regulation of Neuropeptide W in vitro and in vivo. Molecular and Cellular Endocrinology, 447 (C), 71-78. doi: 10.1016/j.mce.2017.02.040
Zheng, Wenhua, Meng, Qian, Wang, Haitao, Yan, Fengxia, Little, Peter J., Deng, Xinguo and Lin, Shaofen (2017). IGF-1-mediated survival from induced death of human primary cultured retinal pigment epithelial cells is mediated by an Akt-dependent signaling pathway. Molecular Neurobiology, 55 (3), 1-13. doi: 10.1007/s12035-017-0447-0
Farhan, Mohd, Wang, Haitao, Gaur, Uma, Little, Peter J., Xu, Jiangping and Zheng, Wenhua (2017). FOXO signaling pathways as therapeutic targets in cancer. International Journal of Biological Sciences, 13 (7), 815-827. doi: 10.7150/ijbs.20052
Fengxia, Yan, Rifang, Liao, Farhan, Mohd, Tinghuai, Wang, Jiashu, Chen, Wang, Zhong, Little, Peter J. and Wenhua, Zheng (2016). Elucidating the role of the FoxO3a transcription factor in the IGF-1-induced migration and invasion of uveal melanoma cancer cells. Biomedicine and Pharmacotherapy, 84, 1538-1550. doi: 10.1016/j.biopha.2016.11.027
Liao, Rifang, Yan, Fengxia, Zeng, Zhuanping, Farhan, Mohd, Little, Peter, Quirion, Remi, Srivastava, Lalit K. and Zheng, Wenhua (2016). Amiodarone-induced retinal neuronal cell apoptosis attenuated by IGF-1 via counter regulation of the PI3k/Akt/FoxO3a pathway. Molecular Neurobiology, 54 (9), 1-13. doi: 10.1007/s12035-016-0211-x
Al Gwairi, Othman, Osman, Narin, Getachew, Robel, Zheng, Wenhua, Liang, X. -L., Kamato, Danielle, Thach, Lyna and Little, Peter J. (2016). Multiple growth factors, but not VEGF, stimulate glycosaminoglycan hyperelongation in retinal choroidal endothelial cells. International Journal of Biological Sciences, 12 (9), 1041-1051. doi: 10.7150/ijbs.16134
Zeng, Zhiwen, Wang, Xue, Bhardwaj, Sanjeev K., Zhou, Xuanhe, Little, Peter J., Quirion, Remi, Srivastava, Lalit K. and Zheng, Wenhua (2016). The atypical antipsychotic agent, clozapine, protects against corticosterone-induced death of PC12 cells by regulating the Akt/FoxO3a signaling pathway. Molecular Neurobiology, 54 (5), 1-12. doi: 10.1007/s12035-016-9904-4
Little, P. J., Hollenberg, M. D, Kamato, D., Thomas, W., Chen, J., Wang, T., Zheng, W. and Osman, N. (2016). Integrating the GPCR transactivation-dependent and biased signalling paradigms in the context of PAR1 signalling. British Journal of Pharmacology, 173 (20), 2992-3000. doi: 10.1111/bph.13398
Al Gwairi, Othman, Thach, Lyna, Zheng, Wenhua, Osman, Narin and Little, Peter J. (2016). Cellular and molecular pathology of age-related macular degeneration: potential role for proteoglycans. Journal of Ophthalmology, 2016 2913612, 2913612-7. doi: 10.1155/2016/2913612
Zeng, Zhiwen, Wang, Haitao, Shang, Fu, Zhou, Lihua, Little, Peter J., Quirion, Remi and Zheng, Wenhua (2015). Lithium ions attenuate serum-deprivation-induced apoptosis in PC12 cells through regulation of the Akt/FoxO1 signaling pathways. Psychopharmacology, 233 (5), 785-794. doi: 10.1007/s00213-015-4168-7
Wang, Haitao, Wang, Rikang, Thrimawithana, Thilini, Little, Peter J., Xu, Jiangping, Feng, Zhong-Ping and Zheng, Wenhua (2014). The nerve growth factor signaling and its potential as therapeutic target for glaucoma. Biomed Research International, 2014 759473, 1-10. doi: 10.1155/2014/759473
Wang, Haitao, Zhang, Qishan, Zhang, Lang, Little, Peter J., Xie, Xiaochun, Meng, Qian, Ren, Yannan, Zhou, Lihua, Gao, Guoquan, Quirion, Remi and Zheng, Wenhua (2012). Insulin-like growth factor-1 induces the phosphorylation of PRAS40 via the PI3K/Akt signaling pathway in PC12 cells. Neuroscience Letters, 516 (1), 105-109. doi: 10.1016/j.neulet.2012.03.068
Wen, Qiang, Wang, Haitao, Little, Peter J., Quirion, Remi and Zheng, Wenhua (2012). Forkhead family transcription factor FoxO and neural differentiation. Neurogenetics, 13 (2), 105-113. doi: 10.1007/s10048-012-0320-2
Little, Peter J., Burch, Micah L., Al-aryahi, Sefaa and Zheng, Wenhua (2011). The paradigm of G protein receptor transactivation: a mechanistic definition and novel example. The Scientific World Journal, 11, 709-714. doi: 10.1100/tsw.2011.75