Dr Alejandra Gallardo-Godoy
Affiliate Senior Research Fellow
School of Pharmacy
Journal Articles
Ehmsen, Kirk T., Ang, Kenny K. H., Wright, William D., Davies, Julia L., Younis, Yassir, Birman, Yuliya, Bryant, Clifford, Gallardo-Godoy, Alejandra, Renslo, Adam R., Neitz, R. Jeffrey, Arkin, Michelle R. and Heyer, Wolf-Dietrich (2019). Small molecule inhibitors of a human recombination-associated ATPase, RAD54. BioRxiv doi: 10.1101/614586
Gallardo-Godoy, Alejandra, Hansford, Karl, Muldoon, Craig, Becker, Bernd, Elliott, Alysha, Huang, Johnny, Pelingon, Ruby, Butler, Mark, Blaskovich, Mark and Cooper, Matthew (2019). Structure-function studies of polymyxin B lipononapeptides. Molecules, 24 (3) 553, 553. doi: 10.3390/molecules24030553
Pope, Lianne, Arrigoni, Cristina, Lou, Hubing, Bryant, Clifford, Gallardo-Godoy, Alejandra, Renslo, Adam R. and Minor, Daniel L. (2018). Protein and chemical determinants of BL-1249 action and selectivity for K2P channels. ACS Chemical Neuroscience, 9 (12), 3153-3165. doi: 10.1021/acschemneuro.8b00337
Velkov, Tony, Gallardo-Godoy, Alejandra, Swarbrick, James D., Blaskovich, Mark A. T., Elliott, Alysha G., Han, Meiling, Thompson, Philip E., Roberts, Kade D., Huang, Johnny X., Becker, Bernd, Butler, Mark S., Lash, Lawrence H., Henriques, Sónia Troeira, Nation, Roger L., Sivanesan, Sivashangarie, Sani, Marc-Antoine, Separovic, Frances, Mertens, Haydyn, Bulach, Dieter, Seemann, Torsten, Owen, Jeremy, Li, Jian and Cooper, Matthew A. (2018). Structure, Function, and Biosynthetic Origin of Octapeptin Antibiotics Active against Extensively Drug-Resistant Gram-Negative Bacteria. Cell Chemical Biology, 25 (4), 380-391.e5. doi: 10.1016/j.chembiol.2018.01.005
Bettington, Emilie, Spinks, Jean, Kelly, Fiona, Gallardo-Godoy, Alejandra, Nghiem, Son and Wheeler, Amanda J. (2018). When is a medicine unwanted, how is it disposed, and how might safe disposal be promoted?: insights from the Australian population. Australian Health Review, 42 (6), 709-717. doi: 10.1071/AH16296
Becker, Bernd, Butler, Mark S., Hansford, Karl A., Gallardo-Godoy, Alejandra, Elliott, Alysha G., Huang, Johnny X., Edwards, David J., Blaskovich, Mark A. T. and Cooper, Matthew A. (2017). Synthesis of octapeptin C4 and biological profiling against NDM-1 and polymyxin-resistant bacteria. Bioorganic and Medicinal Chemistry Letters, 27 (11), 2407-2409. doi: 10.1016/j.bmcl.2017.04.027
Gallardo-Godoy, Alejandra, Muldoon, Craig, Becker, Bernd, Elliott, Alysha G., Lash, Lawrence H, Huang, Johnny X., Butler, Mark S., Pelingon, Ruby, Kavanagh, Angela M., Ramu, Soumya, Phetsang, Wanida, Blaskovich, Mark A. T. and Cooper, Matthew A (2016). Activity and predicted nephrotoxicity of synthetic antibiotics based on polymyxin B. Journal of Medicinal Chemistry, 59 (3), 1068-1077. doi: 10.1021/acs.jmedchem.5b01593
Giles, Kurt, Berry, David B., Condello, Carlo, Hawley, Ronald C., Gallardo-Godoy, Alejandra, Bryant, Clifford, Oehler, Abby, Elepano, Manuel, Bhardwaj, Sumita, Patel, Smita, Silber, B. Michael, Guan, Shenheng, DeArmond, Stephen J., Renslo, Adam R. and Prusiner, Stanley B. (2015). Different 2-aminothiazole therapeutics produce distinct patterns of scrapie prion neuropathology in mouse brains. Journal of Pharmacology and Experimental Therapeutics, 355 (1), 2-12. doi: 10.1124/jpet.115.224659
Neitz, R. Jeffrey, Chen, Steven, Supek, Frantisek, Yeh, Vince, Kellar, Danielle, Gut, Jiri, Bryant, Clifford, Gallardo-Godoy, Alejandra, Molteni, Valentina, Roach, Steven L., Khare, Shilpi, Stinson, Monique, Chatterjee, Arnab K., Robertson, Stephanie, Renslo, Adam R., Arkin, Michelle, Glynne, Richard, McKerrow, James and Siqueira-Neto, Jair L. (2015). Erratum: Lead identification to clinical candidate selection: drugs for Chagas disease (Journal of Biomolecular Screening (2015) 20 (101-111). Journal of Biomolecular Screening, 20 (7), 927-927. doi: 10.1177/1087057115593092
Neitz, R. Jeffrey, Chen, Steven, Supek, Frantisek, Yeh, Vince, Kellar, Danielle, Gut, Jiri, Bryant, Clifford, Gallardo-Godoy, Alejandra, Molteni, Valentina, Roach, Steven L., Chatterjee, Arnab K., Robertson, Stephanie, Renslo, Adam R., Arkin, Michelle, Glynne, Richard, McKerrow, James and Siqueira-Neto, Jair L. (2015). Lead identification to clinical candidate selection: drugs for Chagas disease. Journal of Biomolecular Screening, 20 (1), 101-111. doi: 10.1177/1087057114553103
Silber, B. Michael, Gever, Joel R., Li, Zhe, Gallardo-Godoy, Alejandra, Renslo, Adam R., Widjaja, Kartika, Irwin, John J., Rao, Satish, Jacobson, Matthew P., Ghaemmaghami, Sina and Prusiner, Stanley B. (2013). Antiprion compounds that reduce PrPSc levels in dividing and stationary-phase cells. Bioorganic and Medicinal Chemistry, 21 (24), 7999-8012. doi: 10.1016/j.bmc.2013.09.022
Bagriantsev S.N., Ang K.-H., Gallardo-Godoy A., Clark K.A., Arkin M.R., Renslo A.R. and Minor D.L. (2013). A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K2P channels. ACS Chemical Biology, 8 (8), 1841-1851. doi: 10.1021/cb400289x
Li Z., Silber B.M., Rao S., Gever J.R., Bryant C., Gallardo-Godoy A., Dolghih E., Widjaja K., Elepano M., Jacobson M.P., Prusiner S.B. and Renslo A.R. (2013). 2-Aminothiazoles with Improved Pharmacotherapeutic Properties for Treatment of Prion Disease. ChemMedChem, 8 (5), 847-857. doi: 10.1002/cmdc.201300007
Silber B.M., Rao S., Fife K.L., Gallardo-Godoy A., Renslo A.R., Dalvie D.K., Giles K., Freyman Y., Elepano M., Gever J.R., Li Z., Jacobson M.P., Huang Y., Benet L.Z. and Prusiner S.B. (2013). Pharmacokinetics and metabolism of 2-aminothiazoles with antiprion activity in mice. Pharmaceutical Research, 30 (4), 932-950. doi: 10.1007/s11095-012-0912-4
Cueva J.P., Gallardo-Godoy A., Juncosa J.I., Vidi P.A., Lill M.A., Watts V.J. and Nichols D.E. (2011). Probing the steric space at the floor of the D 1 dopamine receptor orthosteric binding domain: 7α-, 7β-, 8α-, and 8β-methyl substituted dihydrexidine analogues. Journal of Medicinal Chemistry, 54 (15), 5508-5521. doi: 10.1021/jm200334c
Gallardo-Godoy, Alejandra, Gever, Joel, Fife, Kimberly L., Silber, B. Michael, Prusiner, Stanley B. and Renslo, Adam R. (2011). 2-aminothiazoles as therapeutic leads for prion diseases. Journal of Medicinal Chemistry, 54 (4), 1010-1021. doi: 10.1021/jm101250y
Gallardo-Godoy, Alejandra, Torres-Altoro, Melissa I., White, Kellie J., Barker, Eric L. and Nichols, David E. (2007). 1-Methylpyridinium-4-(4-phenylmethanethiosulfonate) iodide, MTS-MPP+, a novel scanning cysteine accessibility method (SCAM) reagent for monoamine transporter studies. Bioorganic & Medicinal Chemistry, 15 (1), 305-311. doi: 10.1016/j.bmc.2006.09.058
McLean, Thomas H., Parrish, Jason C., Braden, Michael R., Marona-Lewicka, Danuta, Gallardo-Godoy, Alejandra and Nichols, David E. (2006). 1-Aminomethylbenzocycloalkanes: conformationallyrestricted hallucinogenic phenylamine analogues as functionally-selective 5-HT2A receptor agonists. Journal of Medicinal Chemistry, 49 (19), 5794-5803. doi: 10.1021/jm060656o
Gallardo-Godoy, Alejandra, Fierro, Angelica, McLean, Thomas H., Castillo, Mariano, Cassels, Bruce K., Reyes-Parada, Miguel and Nichols, David E. (2005). Sulfur-substituted alpha-alkyl phenethylamines as selective and reversible MAO-A inhibitors: biological activities, CoMFA analysis, and active site modeling. Journal of Medicinal Chemistry, 48 (7), 2407-2419. doi: 10.1021/jm0493109
Gallardo-Godoy, Alejandra, Hernandez, Mar, Sanz, Elisenda and Unzeta, Mercedes (2004). Synthesis of 4-methylthiophenylpropylamine and the evaluation of its interaction with different amine oxidases. Bioorganic & Medicinal Chemistry, 12 (1), 273-279. doi: 10.1016/j.bmc.2003.10.007
Conference Papers
Giles, Kurt, Berry, David, Condello, Carlo, Bhardwaj, Sumita, Oehler, Abby, Gallardo-Godoy, Alejandra, DeArmond, Stephen, Renslo, Adam and Prusiner, Stanley (2015). Improving therapeutic efficacy of 2-aminothiazoles in PrP prion disease. New York, United States: Taylor & Francis. doi: 10.1080/19336896.2015.1033248
Gallardo-Godoy, Alejandra, Phuan, Puay-wah, Fife, Kimberly, Gever, Joel, Freyman, Yevgeniy, Lessard, Pierre, Silber, Michael, Prusiner, Stanley and Renslo, Adam (2010). Chemical optimization of a novel class of orally available small molecules targeting Prion disease. Unknown, Unknown, Unknown. Washington, DC United States: American Chemical Society.
Patents
Gallardo-Goday, Alejandra, Cooper, Matthew, Blaskovich, Mark, Hansford, Karl and Elliott, Alysha (2019). Peptide antibiotics. WO2019084628.
Levine, Jon D. and Gallardo-Godoy, Alejandra (2019). Analgesic compounds and methods of use. US 10167295 B2, US 20160068541 A1, WO 2014146111 A3, WO 2014146111 A2.
Gallardo-Godoy, Alejandra (2016). Isothiazolopyridinones useful for the treatment of (inter alia) cystic fibrosis. US 9399648 B2, EP 2187884 B1, CN 101827593 B, WO 2009038913 A3, JP 5389030 B2.
Renslo, Adam R., Gallardo-Godoy, Alejandra, Silber, Michael B., Prusiner, Stanley B., Giles, Kurt, Li, Zhe and Neitz, R. Jeffrey (2014). Novel antiprion compounds. US 20140329863 A, WO 2013033037 A3, WO 2013033037 A2.