Emeritus Professor Peter Little

Featured projects	Duration
Defining a link between periodontal disease and atherosclerotic cardiovascular disease

Bobik, Alex, Cohen, Neale, Jenkins, Alicia J., Kyaw, Tin, Sullivan, David, Wu, Xiaoqian, Yu, Xi-Yong and Little, Peter J. (2023). Emerging Lipoprotein-Related Therapeutics for Patients with Diabetes. Contemporary Diabetes. (pp. 821-878) Cham: Springer International Publishing. doi: 10.1007/978-3-031-26681-2_30

Kamato, Danielle and Little, Peter J. (2023). Lipid: Extracellular Matrix Interactions as Therapeutic Targets in the Atherosclerosis of Diabetes. Lipoproteins in Diabetes Mellitus. (pp. 319-336) Cham, Switzerland: Springer. doi: 10.1007/978-3-031-26681-2_12

Little, Peter J., Chait, Alan, Januszewski, Andrzej S., Bobik, Alex, O'Neal, David and Jenkins, Alicia J. (2014). Emerging lipoprotein-related therapeutics for patients with diabetes. Lipoproteins in diabetes mellitus. (pp. 435-453) edited by Alicia J. Jenkins, Peter P. Toth and Timothy J. Lyons. New York, United States: Springer. doi: 10.1007/978-1-4614-7554-5_23

Osman, Narin and Little, Peter J. (2014). Lipid: extracellular matrix interactions as therapeutic targets in the atherosclerosis of diabetes. Lipoproteins in diabetes mellitus. (pp. 215-229) edited by Alicia J. Jenkins, Peter P. Toth and Timothy J. Lyons. New York, United States: Springer. doi: 10.1007/978-1-4614-7554-5_11

Little, P. J., Topliss, D. J., Mudaliar, S. and Law, R. E. (2004). Peroxisome Proliferator-Activated Receptors and diabetic vasculature. Diabetes and Cardiovascular Disease: Integrating Science and Clinical Medicine. (pp. 75-91) Philadelphia USA: LWW.

Little, P. J. and Dilley, R. J. (2003). Role of Na-H exchange in vascular remodelling in diabetes. Diabetes and Vascular Disease. The sodium-hydrogen exchanger: from molecule to its role in disease. (pp. 160-175) New York: Springer US.

Bobik, A., Agrotis, A. and Little, P. J. (1997). Vascular derived growth factors: potential role in the development of the tumour vasculature. Tumour Angiogenesis. (pp. 169-180) England: Oxford University Press.

Bobik, A., Agrotis, A. and Little, P. J. (1994). Disturbances of vascular smooth muscle cation transport and the pathogenesis of hypertension. Textbook of hypertension. (pp. 175-187) UK: Blackwell Scientific Publications.

Little, P. J. (1992). Na+/H+ exchange in an excitable tissue (Chapter 7). Amiloride and its Analogues: Unique Cation Transport Inhibitors. (pp. 97-120) New York: VCH Press.

Woodcock, E. A., Caroccia, L., McLeod, J. K. and Little, P. J. (1990). Different inositol phosphate responses to angiotensin II and Vasopressin in rat adrenal glomerulosa cells. Advances in Second Messenger and Phosphoprotein Research. The Biology and Medicine of Signal Transduction V. 24. (pp. 134-139) New York: Raven Press.

Bobik, A., Little, P. J., Weissberg, P. L. and Grinpukel, S. (1988). Ionic mechanisms of cytoplasmic pH regulation in vascular smooth muscle. Vascular Neuroeffector Mechanisms. (pp. 209-216) England: Oxford University Press.

Little, P. J., Weissberg, P. L., Cragoe, E. J. and Bobik, A. (1988). Mechanisms influencing Na+ entry in cultured vascular smooth muscle. Progress in Biochemical Pharmacology. (pp. 142-149) Basel: Karger.

Bend, J. R., James, M. O., Little, P. J. and Foureman, G. L. (1981). In vitro and in vivo metabolism of benzo(a)pyrene by selected marine crustacean species. Phyletic Approaches to Cancer. (pp. 179-194) Tokyo: Japan Scientific Societies Press.

James, M. O. and Little, P. J. (1980). Characterisation of cytochrome P-450 dependent mixed function oxidation in the spiny lobster, Panulirus argus. Biochemistry, Biophysics and Regulation of Cytochrome P-450. (pp. 113-120) Amsterdam North-Holland: Elsevier Biomedical Press.

Zhao, Yaping, Wang, Li, Huang, Yu, Evans, Paul C., Little, Peter J., Tian, Xiaoyu, Weng, Jianping and Xu, Suowen (2024). Anthocyanins in vascular health and disease: mechanisms of action and therapeutic potential. Journal of Cardiovascular Pharmacology, 84 (3), 289-302. doi: 10.1097/FJC.0000000000001602

Kumarapperuma, Hirushi, Chia, Zheng J., Malapitan, Sanchia M., Wight, Thomas N., Little, Peter J. and Kamato, Danielle (2024). Response to retention hypothesis as a source of targets for arterial wall-directed therapies to prevent atherosclerosis: A critical review. Atherosclerosis, 397 118552, 118552. doi: 10.1016/j.atherosclerosis.2024.118552

Png, May Ee, Harris, Victoria, Grabey, Jenna, Hart, Nigel, Jani, Bhautesh, Butler, Daniel, Carson-Stevens, Andrew, Coates, Maria, Cureton, Lucy, Dobson, Melissa, Dorward, Jienchi, Evans, Philip, Francis, Nick, Gbinigie, Oghenekome A., Hayward, Gail, Holmes, Jane, Hood, Kerenza, Khoo, Saye, Ahmed, Haroon, Lown, Mark, Mckenna, Micheal, Mort, Sam, Nguyen-Van-Tam, Jonathan S., Rahman, Najib M., Richards, Duncan B., Thomas, Nicholas P. B., van Hecke, Oliver, Hobbs, Richard, Little, Paul ... Petrou, Stavros (2024). Cost-utility analysis of molnupiravir for high-risk, community-based adults with COVID-19: an economic evaluation of the PANORAMIC trial. British Journal of General Practice, 74 (745), E570-E579. doi: 10.3399/BJGP.2023.0444

Zou, Jiami, Zheng, Zhihua, Ye, Weile, Jin, Mei, Yang, Pinglian, Little, Peter J, Wang, Jiaojiao and Liu, Zhiping (2024). Targeting the smooth muscle cell KEAP1-Nrf2-STING axis with pterostilbene attenuates abdominal aortic aneurysm. Phytomedicine, 130 155696, 155696. doi: 10.1016/j.phymed.2024.155696

Geraghty, Adam W A, Becque, Taeko, Roberts, Lisa C, Hill, Jonathan C, Foster, Nadine E, Yardley, Lucy, Stuart, Beth, Turner, David A, Hay, Elaine, Griffiths, Gareth, Webley, Frances, Durcan, Lorraine, Morgan, Alannah, Hughes, Stephanie, Bathers, Sarah, Butler-Walley, Stephanie, Wathall, Simon, Mansell, Gemma, White, Malcolm, Davies, Firoza and Little, Paul (2024). Supporting self-management of low back pain with an internet intervention with and without telephone support in primary care (SupportBack 2): a randomised controlled trial of clinical and cost-effectiveness. The Lancet Rheumatology, 6 (7), e424-e437. doi: 10.1016/s2665-9913(24)00086-9

Hullegie, Saskia, Damoiseaux, Roger A. M. J., Hay, Alastair D., Zuithoff, Nicolaas P. A., van Dongen, Thijs M. A., Little, Paul, Schilder, Anne G. M. and Venekamp, Roderick P. (2024). Topical or oral antibiotics in childhood acute otitis media and ear discharge: a randomized controlled non-inferiority trial. Family Practice, 41 (5), 857-861. doi: 10.1093/fampra/cmae034

Kendrick, Tony, Stuart, Beth, Bowers, Hannah, Sadeghi, Mahboobeh Haji, Page, Helen, Dowrick, Christopher, Moore, Michael, Gabbay, Mark, Leydon, Geraldine M., Yao, Guiqing Lily, Little, Paul, Griffiths, Gareth, Lewis, Glyn, May, Carl, Moncrieff, Joanna, Johnson, Chris F., Macleod, Una, Gilbody, Simon, Dewar-Haggart, Rachel, Williams, Samantha, O'Brien, Wendy, Tiwari, Riya, Woods, Catherine, Patel, Tasneem, Khan, Naila, van Ginneken, Nadja, Din, Amy, Reidy, Claire, Lucier, Rebecca ... Geraghty, Adam W. A. (2024). Internet and Telephone Support for Discontinuing Long-Term Antidepressants: The REDUCE Cluster Randomized Trial. Jama Network Open, 7 (6) ARTN e2418383. doi: 10.1001/jamanetworkopen.2024.18383

Geraghty, Adam W. A., Holt, Sian, Chew-Graham, Carolyn A., Santer, Miriam, Moore, Michael, Kendrick, Tony, Terluin, Berend, Little, Paul, Stuart, Beth, Mistry, Manoj, Richards, Al, Smith, Debs, Newman, Sonia, Rathod, Shanaya, Bowers, Hannah and van Marwijk, Harm (2024). Distinguishing emotional distress from mental disorder in primary care: a qualitative exploration of the Four-Dimensional Symptom Questionnaire. British Journal of General Practice, 74 (744), E434-E441. doi: 10.3399/BJGP.2023.0574

Yu, Wei, Zhao, Yaping, Ilyas, Iqra, Wang, Li, Little, Peter J and Xu, Suowen (2024). The natural polyphenol fisetin in atherosclerosis prevention: a mechanistic review. Journal of Pharmacy and Pharmacology. doi: 10.1093/jpp/rgae053

Wilcox, Christopher R., Odeh, Nour, Clark, Tristan W., Muller, Ingrid, Becque, Taeko, Todd, Alexander, Islam, Nazrul, Little, Paul, Davies, Firoza, Mcgavin, John and Francis, Nick (2024). Use of the FebriDx® host-response point-of-care test may reduce antibiotic use for respiratory tract infections in primary care: a mixed-methods feasibility study. Journal of Antimicrobial Chemotherapy, 79 (6), 1441-1449. doi: 10.1093/jac/dkae127

Lown, Mark, Smith, Kirsten, Muller, Ingrid, Woods, Catherine, Maund, Emma, Rogers, Kirsty, Becque, Taeko, Hayward, Gail, Moore, Michael, Little, Paul, Glogowska, Margaret, Hay, Alastair, Stuart, Beth, Mantzourani, Efi, Wilcox, Christopher R., Thompson, Natalie and Francis, Nick A. (2024). Internet Tool to Support Self-Assessment and Self-Swabbing of Sore Throat: Development and Feasibility Study (vol 25, e39791, 2023). Journal of Medical Internet Research, 26 ARTN e59420, e59420. doi: 10.2196/59420

Khan, Imran, Taylor, Stephanie J. C., Robinson, Clare, Moschopoulou, Elisavet, Mccrone, Paul, Bourke, Liam, Thaha, Mohamed, Bhui, Kamaldeep, Rosario, Derek, Ridge, Damien, Donovan, Sheila, Korszun, Ania, Little, Paul, Morgan, Adrienne, Quentin, Olivier, Roylance, Rebecca, White, Peter and Chalder, Trudie (2024). Study protocol for a pragmatic randomised controlled trial of comparing enhanced acceptance and commitment therapy plus (+) added to usual aftercare versus usual aftercare only, in patients living with or beyond cancer: SUrvivors' Rehabilitation Evaluation after CANcer (SURECAN) trial. Trials, 25 (1) ARTN 228. doi: 10.1186/s13063-024-08062-4

Kumarapperuma, Hirushi, Wang, Ran, Little, Peter J and Kamato, Danielle (2024). Mechanistic insight: linking cardiovascular complications of inflammatory bowel disease. Trends in Cardiovascular Medicine, 34 (3), 203-211. doi: 10.1016/j.tcm.2023.01.002

Lin, Jiuguo, Wang, Jiaojiao, Fang, Jian, Li, Meihang, Xu, Suowen, Little, Peter J., Zhang, Dongmei and Liu, Zhiping (2024). The cytoplasmic sensor, the AIM2 inflammasome: a precise therapeutic target in vascular and metabolic diseases. British Journal of Pharmacology, 181 (12), 1695-1719. doi: 10.1111/bph.16355

Hayward, Gail, Yu, Ly-Mee, Little, Paul, Gbinigie, Oghenekome, Shanyinde, Milensu, Harris, Victoria, Dorward, Jienchi, Saville, Benjamin R., Berry, Nicholas, Evans, Philip H., Thomas, Nicholas P. B., Patel, Mahendra G., Richards, Duncan, Hecke, Oliver V., Detry, Michelle A., Saunders, Christina, Fitzgerald, Mark, Robinson, Jared, Latimer-Bell, Charlotte, Allen, Julie, Ogburn, Emma, Grabey, Jenna, de Lusignan, Simon, Hobbs, F. D. Richard and Butler, Christopher C. (2024). Ivermectin for COVID-19 in adults in the community (PRINCIPLE): An open, randomised, controlled, adaptive platform trial of short- and longer-term outcomes. Journal of Infection, 88 (4) ARTN 106130, 106130. doi: 10.1016/j.jinf.2024.106130

Zhang, Tingting, Zhu, Mengmeng, Ma, Jialing, Liu, Zhenghong, Zhang, Zhidan, Chen, Meijie, Zhao, Yaping, Li, Huaxin, Wang, Shengnan, Wei, Xiaoning, Zhang, Wenwen, Yang, Xiaoxiao, Little, Peter J., Kamato, Danielle, Hu, Hao, Duan, Yajun, Zhang, Baotong, Xiao, Jianbo, Xu, Suowen and Chen, Yuanli (2024). Moscatilin inhibits vascular calcification by activating IL13RA2-dependent inhibition of STAT3 and attenuating the WNT3/β-catenin signalling pathway. Journal of Advanced Research. doi: 10.1016/j.jare.2024.02.020

Chia, Zheng-Jie, Cao, Ying-Nan, Little, Peter J. and Kamato, Danielle (2024). Transforming growth factor-β receptors: versatile mechanisms of ligand activation. Acta Pharmacologica Sinica, 45 (7), 1337-1348. doi: 10.1038/s41401-024-01235-6

Greenwell, Kate, Becque, Taeko, Sivyer, Katy, Steele, Mary, Denison-Day, James, Howells, Laura, Ridd, Matthew J., Roberts, Amanda, Lawton, Sandra, Langan, Sinead M., Hooper, Julie, Wilczynska, Sylvia, Griffiths, Gareth, Sach, Tracey H., Little, Paul, Williams, Hywel C., Thomas, Kim S., Yardley, Lucy, Muller, Ingrid, Santer, Miriam and Stuart, Beth (2024). Online behavioural interventions for children and young people with eczema: a quantitative evaluation. British Journal of General Practice, 74 (743), E393-E400. doi: 10.3399/BJGP.2023.0411

Hogberg, Thomas, Receveur, Jean-Marie, Murray, Anthony, Linget, Jean-Michel, Norregaard, Pia K., Little, Paul B. and Cooper, Martin (2024). Optimizing and characterizing 4-methyl substituted pyrazol-3-carboxamides leading to the peripheral cannabinoid 1 receptor inverse agonist TM38837. Bioorganic and Medicinal Chemistry Letters, 98 129572, 1-11. doi: 10.1016/j.bmcl.2023.129572

Sach, Tracey H., Onoja, Mary, Clarke, Holly, Santer, Miriam, Muller, Ingrid, Becque, Taeko, Stuart, Beth, Hooper, Julie, Steele, Mary, Wilczynska, Sylvia, Ridd, Matthew J., Roberts, Amanda, Ahmed, Amina, Yardley, Lucy, Little, Paul, Greenwell, Kate, Sivyer, Katy, Nuttall, Jacqui, Griffiths, Gareth, Lawton, Sandra, Langan, Sinead M., Howells, Laura, Leighton, Paul, Williams, Hywel C. and Thomas, Kim S. (2024). Cost-effectiveness of two online interventions supporting self-care for eczema for parents/carers and young people. European Journal of Health Economics, 25 (7), 1165-1176. doi: 10.1007/s10198-023-01649-9

Chen, Mei-Jie, Xu, Yi-Tong, Sun, Lu, Wang, Zhi-Hua, Little, Peter J., Wang, Li, Xian, Xun-De, Weng, Jian-Ping and Xu, Suo-Wen (2024). A novel mouse model of familial combined hyperlipidemia and atherosclerosis. Acta Pharmacologica Sinica, 45 (6), 1316-1320. doi: 10.1038/s41401-024-01241-8

Chen, Meijie, Xiao, Jianbo, El-Seedi, Hesham R., Woźniak, Krystyna Skalicka, Daglia, Maria, Little, Peter J., Weng, Jianping and Xu, Suowen (2024). Kaempferol and atherosclerosis: from mechanism to medicine. Critical Reviews in Food Science and Nutrition, 64 (8), 2157-2175. doi: 10.1080/10408398.2022.2121261

Ye, Weile, Wang, Jiaojiao, Little, Peter J., Zou, Jiami, Zheng, Zhihua, Lu, Jing, Yin, Yanjun, Liu, Hao, Zhang, Dongmei, Liu, Peiqing, Xu, Suowen, Ye, Wencai and Liu, Zhiping (2024). Anti-atherosclerotic effects and molecular targets of ginkgolide B from Ginkgo biloba. Acta Pharmaceutica Sinica B, 14 (1), 1-19. doi: 10.1016/j.apsb.2023.09.014

Ni, Xia-Yun, Feng, Xiao-Jun, Wang, Zhi-Hua, Zhang, Yang, Little, Peter J., Cao, Yang, Xu, Suo-Wen, Tang, Li-Qin and Weng, Jian-Ping (2024). Empagliflozin and liraglutide ameliorate HFpEF in mice via augmenting the Erbb4 signaling pathway. Acta Pharmacologica Sinica, 45 (8), 1604-1617. doi: 10.1038/s41401-024-01265-0

Jiang, Hui, Zhao, Yaping, Su, Meiming, Sun, Lu, Chen, Meijie, Zhang, Zhidan, Ilyas, Iqra, Wang, Zhihua, Little, Peter J., Wang, Li, Weng, Jianping, Ge, Jianjun and Xu, Suowen (2024). A proteome-wide screen identifies the calcium binding proteins, S100A8/S100A9, as clinically relevant therapeutic targets in aortic dissection. Pharmacological Research, 199 107029. doi: 10.1016/j.phrs.2023.107029

Little, Paul, Becque, Taeko, Hay, Alastair D., Francis, Nick A., Stuart, Beth, O'Reilly, Gilly, Thompson, Natalie, Hood, Kerenza, Moore, Michael and Verheij, Theo (2023). Predicting illness progression for children with lower respiratory infections in primary care: a prospective cohort and observational study. British Journal of General Practice, 73 (737), E885-E893. doi: 10.3399/BJGP.2022.0493

Mas-Dalmau, Gemma, Perez-Lacasta, Maria Jose, Alonso-Coello, Pablo, Gorrotxategi-Gorrotxategi, Pedro, Arguelles-Prendes, Emma, Espinazo-Ramos, Oscar, Valls-Duran, Teresa, Gonzalo-Alonso, Maria Encarnacion, Cortes-Viana, Maria Pilar, Menendez-Bada, Tatiana, Vazquez-Fernandez, Marta Esther, Perez-Hernandez, Ana Isabel, Munoz-Ortiz, Laura, Villanueva-Lopez, Carmen, Little, Paul, de la Poza-Abad, Mariam and Carles-Lavila, Misericordia (2023). A trial-based cost-effectiveness analysis of antibiotic prescription strategies for non-complicated respiratory tract infections in children. Bmc Pediatrics, 23 (1) ARTN 497. doi: 10.1186/s12887-023-04235-3

Wilcox, Christopher R., Worswick, Louise, Muller, Ingrid, Moore, Abigail, Hayward, Gail, Lown, Mark, Moore, Michael, Little, Paul and Francis, Nick (2023). Feasibility of a placebo- controlled trial of antibiotics for possible urinary tract infection in care homes: a qualitative interview study. BJGP Open, 7 (3) 20230014, 1-12. doi: 10.3399/BJGPO.2023.0014

Gao, Si, Liu, Xue-ping, Li, Ting-ting, Chen, Li, Feng, Yi-ping, Wang, Yu-kun, Yin, Yan-jun, Little, Peter J., Wu, Xiao-qian, Xu, Suo-wen and Jiang, Xu-dong (2023). Animal models of heart failure with preserved ejection fraction (HFpEF): from metabolic pathobiology to drug discovery. Acta Pharmacologica Sinica, 45 (1), 23-35. doi: 10.1038/s41401-023-01152-0

Smith, Jazzine, Essery, Rosie, Yardley, Lucy, Richardson, Alison, Slodkowska-Barabasz, Joanna, Chavlet, Cassandra, Foster, Claire, Watson, Eila, Grimmett, Chloe, Geraghty, Adam W. A., Little, Paul, Sharman, Geoffrey, Burford, Tamsin, Bacon, Roger, Turner, Lesley and Bradbury, Katherine (2023). Experiences of using a supported digital intervention for cancer survivors in primary care: a qualitative process evaluation. Journal of Cancer Survivorship, 18 (1), 144-156. doi: 10.1007/s11764-023-01412-2

Wu, Xiumei, Xu, Mengyun, Geng, Mengya, Chen, Shuo, Little, Peter J., Xu, Suowen and Weng, Jianping (2023). Targeting protein modifications in metabolic diseases: molecular mechanisms and targeted therapies. Signal Transduction and Targeted Therapy, 8 (1) 220, 1-45. doi: 10.1038/s41392-023-01439-y

Gunnarsson, Ronny K., Ebell, Mark, Centor, Robert, Little, Paul, Verheij, Theo, Lindbaek, Morten and Sundvall, Par-Daniel (2023). Best management of patients with an acute sore throat is still best management for these patients. Infectious Diseases, 55 (7), 521-523. doi: 10.1080/23744235.2023.2212054

Jiang, Peng, Liu, Zhenghong, Fang, Tingyu, Zhang, Zhidan, Zhang, Yu, Wang, Dongdong, Little, Peter J., Xu, Suowen and Weng, Jianping (2023). Growth differentiation factor 15 is dispensable for acetaminophen‐induced liver injury in mice. Basic and Clinical Pharmacology and Toxicology, 132 (4), 343-353. doi: 10.1111/bcpt.13834

Greenwell, Kate, Sivyer, Katy, Howells, Laura, Steele, Mary, Ridd, Matthew J., Roberts, Amanda, Ahmed, Amina, Lawton, Sandra, Langan, Sinead M., Hooper, Julie, Wilczynska, Sylvia, Leighton, Paul, Griffiths, Gareth, Sach, Tracey, Little, Paul, Williams, Hywel C., Thomas, Kim S., Yardley, Lucy, Santer, Miriam and Muller, Ingrid (2023). 'Eczema shouldn't control you; you should control eczema': qualitative process evaluation of online behavioural interventions to support young people and parents/carers of children with eczema. British Journal of Dermatology, 188 (4), 506-513. doi: 10.1093/bjd/ljac115

Hounkpatin, Hilda, Stuart, Beth, Zhu, Shihua, Yao, Guiqing, Moore, Michael, Loffler, Christin, Little, Paul, Kenealy, Timothy, Gillespie, David, Francis, Nick A., Bostock, Jennifer, Becque, Taeko, Arroll, Bruce, Altiner, Attila, Alonso-Coello, Pablo and Hay, Alastair D. (2023). Post-consultation acute respiratory tract infection recovery: a latent class-informed analysis of individual patient data. British Journal of General Practice, 73 (728), E196-E203. doi: 10.3399/BJGP.2022.0229

Little, Paul, Becque, Taeko, Hay, Alastair D., Francis, Nick A., Stuart, Beth, O'Reilly, Gilly, Thompson, Natalie, Hood, Kerenza, Moore, Michael and Verheij, Theo (2023). Antibiotic effectiveness for children with lower respiratory infections: prospective cohort and trial in primary care. British Journal of General Practice, 73 (728), E156-E163. doi: 10.3399/BJGP.2022.0239

Francis, Nick A. A., Becque, Taeko, Willcox, Merlin, Hay, Alastair D. D., Lown, Mark, Clarke, Richard, Stuart, Beth, Yardley, Lucy, Moore, Michael, Houriet, Joelle and Little, Paul (2023). Non-pharmaceutical interventions and risk of COVID-19 infection: survey of UK public from November 2020-May 2021. BMC Public Health, 23 (1) 389, 1-15. doi: 10.1186/s12889-023-15209-6

Butler, Christopher C., Hobbs, F. D. Richard, Gbinigie, Oghenekome A., Rahman, Najib M., Hayward, Gail, Richards, Duncan B., Dorward, Jienchi, Lowe, David M., Standing, Joseph F., Breuer, Judith, Khoo, Saye, Petrou, Stavros, Hood, Kerenza, Nguyen-Van-Tam, Jonathan S., Patel, Mahendra G., Saville, Benjamin R., Marion, Joe, Ogburn, Emma, Allen, Julie, Rutter, Heather, Francis, Nick, Thomas, Nicholas P. B., Evans, Philip, Dobson, Melissa, Madden, Tracie-Ann, Holmes, Jane, Harris, Victoria, Png, May Ee, Lown, Mark ... Little, Paul (2023). Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): an open-label, platform-adaptive randomised controlled trial. The Lancet, 401 (10373), 281-293. doi: 10.1016/S0140-6736(22)02597-1

Adelnia, Hossein, Blakey, Idriss, Little, Peter J. and Ta, Hang Thu (2023). Poly(succinimide) nanoparticles as reservoirs for spontaneous and sustained synthesis of poly(aspartic acid) under physiological conditions: potential for vascular calcification therapy and oral drug delivery. Journal of Materials Chemistry B, 11 (12), 2650-2662. doi: 10.1039/d2tb01867e

White, Peter, Abbey, Susan, Angus, Brian, Ball, Harriet A, Buchwald, Dedra S, Burness, Christine, Carson, Alan J, Chalder, Trudie, Clauw, Daniel J, Coebergh, Jan, David, Anthony S, Dworetzky, Barbara A, Edwards, Mark J, Espay, Alberto J, Etherington, John, Fink, Per, Flottorp, Signe, Garcin, Béatrice, Garner, Paul, Glasziou, Paul, Hamilton, Willie, Henningsen, Peter, Hoeritzauer, Ingrid, Husain, Mujtaba, Huys, Anne-Catherine M L, Knoop, Hans, Kroenke, Kurt, Lehn, Alexander, Levenson, James L ... Zeman, Adam (2023). Anomalies in the review process and interpretation of the evidence in the NICE guideline for chronic fatigue syndrome and myalgic encephalomyelitis. Journal of Neurology, Neurosurgery and Psychiatry, 94 (12) jnnp-2022-330463, 1056-1063. doi: 10.1136/jnnp-2022-330463

Hill, Nathan R., Lasserson, Daniel, Thompson, Ben, Perera-Salazar, Rafael, Wolstenholme, Jane, Bower, Peter, Blakeman, Thomas, Fitzmaurice, David, Little, Paul, Feder, Gene, Qureshi, Nadeem, Taal, Maarten, Townend, Jonathan, Ferro, Charles, McManus, Richard and Hobbs, F. D. Richard (2022). Benefits of Aldosterone Receptor Antagonism in Chronic Kidney Disease (BARACK D) trial-a multi-centre, prospective, randomised, open, blinded end-point, 36-month study of 2,616 patients within primary care with stage 3b chronic kidney disease to compare the efficacy of spironolactone 25 mg once daily in addition to routine care on mortality and cardiovascular outcomes versus routine care alone: study protocol for a randomized controlled trial (vol 15, 160, 2014). Trials, 23 (1) ARTN 999. doi: 10.1186/s13063-022-06972-9

Santer, Miriam, Muller, Ingrid, Becque, Taeko, Stuart, Beth, Hooper, Julie, Steele, Mary, Wilczynska, Sylvia, Sach, Tracey H., Ridd, Matthew J., Roberts, Amanda, Ahmed, Amina, Yardley, Lucy, Little, Paul, Greenwell, Kate, Sivyer, Katy, Nuttall, Jacqui, Griffiths, Gareth, Lawton, Sandra, Langan, Sinead M., Howells, Laura M., Leighton, Paul, Williams, Hywel C. and Thomas, Kim S. (2022). Eczema Care Online behavioural interventions to support self-care for children and young people: two independent, pragmatic, randomised controlled trials. Bmj-British Medical Journal, 379 ARTN e072007, e072007. doi: 10.1136/bmj-2022-072007

Kaussner, Yvonne, Roever, Christian, Heinz, Judith, Hummers, Eva, Debray, Thomas P. A., Hay, Alastair D., Heytens, Stefan, Vik, Ingvild, Little, Paul, Moore, Michael, Stuart, Beth, Wagenlehner, Florian, Kronenberg, Andreas, Ferry, Sven, Monsen, Tor, Lindbaek, Morten, Friede, Tim and Gagyor, Ildiko (2022). Reducing antibiotic use in uncomplicated urinary tract infections in adult women: a systematic review and individual participant data meta-analysis. Clinical Microbiology and Infection, 28 (12), 1558-1566. doi: 10.1016/j.cmi.2022.06.017

Kamato, Danielle, Gabr, Mai, Kumarapperuma, Hirushi, Chia, Zheng J., Zheng, Wenhua, Xu, Suowen, Osman, Narin and Little, Peter J. (2022). Gαq is the specific mediator of PAR-1 transactivation of kinase receptors in vascular smooth muscle cells. International Journal of Molecular Sciences, 23 (22) 14425, 14425. doi: 10.3390/ijms232214425

Gadalla, Amal, Wise, Hannah, Farewell, Daniel, Hughes, Kathryn, Llor, Carl, Moore, Michael, Verheij, Theo J. M., Little, Paul, Butler, Christopher C. and Francis, Nick A. (2022). Antibiotic consumption and time to recovery from uncomplicated urinary tract infection: secondary analysis of observational data from a point-of-care test trial. British Journal of General Practice, 72 (725), E882-E890. doi: 10.3399/BJGP.2022.0011

Ilyas, Iqra, Little, Peter J., Liu, Zhiping, Xu, Yanyong, Kamato, Danielle, Berk, Bradford C., Weng, Jianping and Xu, Suowen (2022). Mouse models of atherosclerosis in translational research. Trends in Pharmacological Sciences, 43 (11), 920-939. doi: 10.1016/j.tips.2022.06.009

Kamato, Danielle, Ilyas, Iqra, Xu, Suowen and Little, Peter J. (2022). Non-mouse models of atherosclerosis: approaches to exploring the translational potential of new therapies. International Journal of Molecular Sciences, 23 (21) 12964, 1-13. doi: 10.3390/ijms232112964

Xu, Mengyun, Wu, Xiumei, Liu, Zhenghong, Ding, Yu, Kong, Weian, Little, Peter J., Xu, Suowen and Weng, Jianping (2022). A novel mouse model of diabetes, atherosclerosis and fatty liver disease using an AAV8-PCSK9-D377Y injection and dietary manipulation in db/db mice. Biochemical and Biophysical Research Communications, 622, 163-169. doi: 10.1016/j.bbrc.2022.07.031

Little, Paul, Read, Robert C., Becque, Taeko, Francis, Nick A., Hay, Alastair D., Stuart, Beth, O'Reilly, Gilly, Thompson, Natalie, Hood, Kerenza, Faust, Saul, Wang, Kay, Moore, Michael and Verheij, Theo (2022). Antibiotics for lower respiratory tract infection in children presenting in primary care (ARTIC-PC): the predictive value of molecular testing. Clinical Microbiology and Infection, 28 (9), 1238-1244. doi: 10.1016/j.cmi.2022.02.033

Jiang, Hui, Zhou, Yongwen, Nabavi, Seyed M., Sahebkar, Amirhossein, Little, Peter J., Xu, Suowen, Weng, Jianping and Ge, Jianjun (2022). Mechanisms of oxidized LDL-mediated endothelial dysfunction and its consequences for the development of atherosclerosis. Frontiers in Cardiovascular Medicine, 9 925923, 1-11. doi: 10.3389/fcvm.2022.925923

Babaahmadi‐Rezaei, Hossein, Mohamed, Rafat, Dayati, Parisa, Mehr, Reyhaneh Niayesh, Seif, Faezeh, Sharifat, Narges, khedri, Azam, Kamato, Dannii and Little, Peter J. (2022). Endothelin‐1 dependent expression of GAG genes involves NOX and p38 mediated Smad linker region phosphorylation. Clinical and Experimental Pharmacology and Physiology, 49 (7), 710-718. doi: 10.1111/1440-1681.13650

Mohamed, Raafat, Shajimoon, Aravindra, Afroz, Rizwana, Gabr, Mai, Thomas, Wally, Little, Peter J. and Kamato, Danielle (2022). Akt acts as a switch for GPCR transactivation of the TGF‐β receptor type 1. The FEBS Journal, 289 (9), 2642-2656. doi: 10.1111/febs.16297

Afroz, Rizwana, Kumarapperuma, Hirushi, Nguyen, Quang V. N., Mohamed, Raafat, Little, Peter J. and Kamato, Danielle (2022). Lipopolysaccharide acting via toll-like receptor 4 transactivates the TGF-β receptor in vascular smooth muscle cells. Cellular and Molecular Life Sciences, 79 (2) 121, 121. doi: 10.1007/s00018-022-04159-8

Wu, Xiumei, Xu, Mengyun, Liu, Zhenghong, Zhang, Zhidan, Liu, Yujie, Luo, Sihui, Zheng, Xueying, Little, Peter J., Xu, Suowen and Weng, Jianping (2022). Pharmacological inhibition of IRAK1 and IRAK4 prevents endothelial inflammation and atherosclerosis in ApoE-/- mice. Pharmacological Research, 175 106043, 106043. doi: 10.1016/j.phrs.2021.106043

Zhang, Fan-shun, He, Qing-ze, Qin, Chengxue Helena, Little, Peter J., Weng, Jian-ping and Xu, Suo-wen (2022). Therapeutic potential of colchicine in cardiovascular medicine: a pharmacological review. Acta Pharmacologica Sinica, 43 (9), 2173-2190. doi: 10.1038/s41401-021-00835-w

Babaahmadi-Rezaei, Hossein, Little, Peter J., Mohamed, Raafat, Zadeh, Ghorban Mohammad, Kheirollah, Alireza, Mehr, Reyhaneh Niayesh, Kamato, Danielle and Dayati, Parisa (2022). Endothelin-1 mediated glycosaminoglycan synthesizing gene expression involves NOX-dependent transactivation of the transforming growth factor-β receptor. Molecular and Cellular Biochemistry, 477 (4), 981-988. doi: 10.1007/s11010-021-04342-8

Fang, Tingyu, Wang, Hua, Pan, Xiaoyue, Little, Peter J., Xu, Suowen and Weng, Jianping (2022). Mouse models of nonalcoholic fatty liver disease (NAFLD): pathomechanisms and pharmacotherapies. International Journal of Biological Sciences, 18 (15), 5681-5697. doi: 10.7150/ijbs.65044

Daley, Amanda J., Jolly, Kate, Ives, Natalie, Jebb, Susan A., Tearne, Sarah, Greenfield, Sheila M., Yardley, Lucy, Little, Paul, Tyldesley-Marshall, Natalie, Bensoussane, Hannah, Pritchett, Ruth, Frew, Emma and Parretti, Helen M. (2021). Practice nurse-supported weight self-management delivered within the national child immunisation programme for postnatal women: a feasibility cluster RCT. Health Technology Assessment, 25 (49), 1-22. doi: 10.3310/hta25490

Hussain, Humaira, Cao, Yingnan, Mohamad, Raafat, Afroz, Rizwana, Zhou, Ying, Moyle, Peter, Bansal, Nidhi, Wattoo, Feroza Hamid, Kamato, Danielle and Little, Peter J. (2021). YY‐11, a camel milk‐derived peptide, inhibits TGF‐β‐mediated atherogenic signaling in human vascular smooth muscle cells. Journal of Food Biochemistry, 46 (3) e13882, e13882. doi: 10.1111/jfbc.13882

Xu, Suowen, Liu, Yujie, Ding, Yu, Luo, Sihui, Zheng, Xueying, Wu, Xiumei, Liu, Zhenghong, Ilyas, Iqra, Chen, Suyu, Han, Shuxin, Little, Peter J., Jain, Mukesh K. and Weng, Jianping (2021). The zinc finger transcription factor, KLF2, protects against COVID-19 associated endothelial dysfunction. Signal Transduction and Targeted Therapy, 6 (1) 266, 1-9. doi: 10.1038/s41392-021-00690-5

Xu, Suowen, Ilyas, Iqra, Little, Peter J., Li, Hong, Kamato, Danielle, Zheng, Xueying, Luo, Sihui, Li, Zhuoming, Liu, Peiqing, Han, Jihong, Harding, Ian C., Ebong, Eno E., Cameron, Scott J., Stewart, Alastair G. and Weng, Jianping (2021). Endothelial dysfunction in atherosclerotic cardiovascular diseases and beyond: from mechanism to pharmacotherapies. Pharmacological Reviews, 73 (3), 924-967. doi: 10.1124/pharmrev.120.000096

Little, Peter J., Askew, Christopher D., Xu, Suowen and Kamato, Danielle (2021). Endothelial dysfunction and cardiovascular disease: history and analysis of the clinical utility of the relationship. Biomedicines, 9 (6) 699, 1-9. doi: 10.3390/biomedicines9060699

Feng, Xiaojun, Chen, Wenxu, Ni, Xiayun, Little, Peter J., Xu, Suowen, Tang, Liqin and Weng, Jianping (2021). Metformin, macrophage dysfunction and atherosclerosis. Frontiers in Immunology, 12 682853, 682853. doi: 10.3389/fimmu.2021.682853

Adelnia, Hossein, Tran, Huong D.N., Little, Peter J., Blakey, Idriss and Ta, Hang T. (2021). Poly(aspartic acid) in biomedical applications: from polymerization, modification, properties, degradation, and biocompatibility to applications. ACS Biomaterials Science and Engineering, 7 (6) acsbiomaterials.1c00150, 2083-2105. doi: 10.1021/acsbiomaterials.1c00150

Liu, Zhenghong, Ma, Xiaoxuan, Ilyas, Iqra, Zheng, Xueying, Luo, Sihui, Little, Peter J., Kamato, Danielle, Sahebkar, Amirhossein, Wu, Weiming, Weng, Jianping and Xu, Suowen (2021). Impact of sodium glucose cotransporter 2 (SGLT2) inhibitors on atherosclerosis: from pharmacology to pre-clinical and clinical therapeutics. Theranostics, 11 (9), 4502-4515. doi: 10.7150/THNO.54498

Ma, Xiaoxuan, Liu, Zhenghong, Ilyas, Iqra, Little, Peter J., Kamato, Danielle, Sahebka, Amirhossein, Chen, Zhengfang, Luo, Sihui, Zheng, Xueying, Weng, Jianping and Xu, Suowen (2021). GLP-1 receptor agonists (GLP-1RAs): cardiovascular actions and therapeutic potential. International Journal of Biological Sciences, 17 (8), 2050-2068. doi: 10.7150/ijbs.59965

Zhou, Ying, Little, Peter J., Xu, Suowen and Kamato, Danielle (2021). Curcumin inhibits lysophosphatidic acid mediated mcp-1 expression via blocking rock signalling. Molecules, 26 (8) 2320, 1-12. doi: 10.3390/molecules26082320

Ding, Yu, Zhou, Yongwen, Ling, Ping, Feng, Xiaojun, Luo, Sihui, Zheng, Xueying, Little, Peter J., Xu, Suowen and Weng, Jianping (2021). Metformin in cardiovascular diabetology: a focused review of its impact on endothelial function. Theranostics, 11 (19), 9376-9396. doi: 10.7150/thno.64706

Vazquez-Prada, Karla X., Lam, Jacinta, Kamato, Danielle, Xu, Zhi Ping, Little, Peter J. and Ta, Hang T. (2020). Targeted Molecular Imaging of Cardiovascular Diseases by Iron Oxide Nanoparticles. Arteriosclerosis, Thrombosis, and Vascular Biology, 41 (2) ATVBAHA120315404, ATVBAHA120315404-613. doi: 10.1161/atvbaha.120.315404

Zhou, Ying, Little, Peter J., Cao, Yingnan, Ta, Hang T. and Kamato, Danielle (2020). Lysophosphatidic acid receptor 5 transactivation of TGFBR1 stimulates the mRNA expression of proteoglycan synthesizing genes XYLT1 and CHST3. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1867 (12) 118848, 118848. doi: 10.1016/j.bbamcr.2020.118848

Akther, Fahima, Little, Peter, Li, Zhiyong, Nguyen, Nam-Trung and Ta, Hang T. (2020). Hydrogels as artificial matrices for cell seeding in microfluidic devices. RSC Advances, 10 (71), 43682-43703. doi: 10.1039/d0ra08566a

Heidary Moghaddam, Reza, Samimi, Zeinab, Moradi, Seyed Zachariah, Little, Peter J., Xu, Suowen and Farzaei, Mohammad Hosein (2020). Naringenin and naringin in cardiovascular disease prevention: a preclinical review. European Journal of Pharmacology, 887 173535, 173535. doi: 10.1016/j.ejphar.2020.173535

Farhan, Mohd, Silva, Marta, Li, Shuai, Yan, Fengxia, Fang, Jiankang, Peng, Tangming, Hu, Jim, Tsao, Ming-Sound, Little, Peter and Zheng, Wenhua (2020). The role of FOXOs and autophagy in cancer and metastasis—Implications in therapeutic development. Medicinal Research Reviews, 40 (6), 2089-2113. doi: 10.1002/med.21695

Daley, A. J., Jolly, K., Bensoussane, H., Ives, N., Jebb, S. A., Tearne, S., Greenfield, S. M., Yardley, L., Little, P., Tyldesley-Marshall, N., Pritchett, R. V., Frew, E. and Parretti, H. M. (2020). Feasibility and acceptability of a brief routine weight management intervention for postnatal women embedded within the national child immunisation programme in primary care: randomised controlled cluster feasibility trial. Trials, 21 (1) 757, 1-19. doi: 10.1186/s13063-020-04673-9

Zhao, Xia, Han, Chao, Zeng, Zhiwen, Liu, Linlin, Wang, Haitao, Xu, Jiangping, Feng, Zhong-Ping, Little, Peter J., Quirion, Remi and Zheng, Wenhua (2020). Glutamate attenuates the survival property of IGFR through NR2B containing N-methyl-D-aspartate receptors in cortical neurons. Oxidative Medicine and Cellular Longevity, 2020 5173184, 1-13. doi: 10.1155/2020/5173184

Zhou, Ying, Kumarapperuma, Hirushi, Sichone, Salifya, Chia, Zheng Jie, Little, Peter J., Xu, Suowen and Kamato, Danielle (2020). Artemisinin inhibits glycosaminoglycan chain synthesizing gene expression but not proliferation of human vascular smooth muscle cells. Biochemical and Biophysical Research Communications, 532 (2), 239-243. doi: 10.1016/j.bbrc.2020.08.013

Deng, Mingying, Su, Dan, Xu, Suowen, Little, Peter J., Feng, Xiaojun, Tang, Liqin and Shen, Aizong (2020). Metformin and vascular diseases: a focused review on smooth muscle cell function. Frontiers in Pharmacology, 11 635, 635. doi: 10.3389/fphar.2020.00635

Kamato, Danielle and Little, Peter J. (2020). Smad2 linker region phosphorylation is an autonomous cell signalling pathway: implications for multiple disease pathologies. Biomedicine & Pharmacotherapy, 124 109854, 109854. doi: 10.1016/j.biopha.2020.109854

Afroz, Rizwana, Zhou, Ying, Little, Peter J., Xu, Suowen, Mohamed, Raafat, Stow, Jennifer and Kamato, Danielle (2020). Toll-like receptor 4 stimulates gene expression via Smad2 linker region phosphorylation in vascular smooth muscle cells. ACS Pharmacology and Translational Science, 3 (3) acsptsci.9b00113, 524-534. doi: 10.1021/acsptsci.9b00113

Zhou, Ying, Little, Peter J., Downey, Liam, Afroz, Rizwana, Wu, Yuao, Ta, Hang T., Xu, Suowen and Kamato, Danielle (2020). The Role of Toll-like Receptors in Atherothrombotic Cardiovascular Disease. ACS Pharmacology & Translational Science, 3 (3) acsptsci.9b00100, 457-471. doi: 10.1021/acsptsci.9b00100

Mohamed, Raafat, Cao, Yingnan, Afroz, Rizwana, Xu, Suowen, Ta, Hang T., Barras, Michael, Zheng, Wenhua, Little, Peter J. and Kamato, Danielle (2020). ROS directly activates transforming growth factor β type 1 receptor signalling in human vascular smooth muscle cells. Biochimica et Biophysica Acta. General Subjects, 1864 (1) 129463, 129463. doi: 10.1016/j.bbagen.2019.129463

Luo, Ning, Fang, Jian, Wei, LiQin, Sahebkar, Amirhossein, Little, Peter J., Xu, Suowen, Luo, ChongBin and Li, GuangNing (2020). Emodin in atherosclerosis prevention: Pharmacological actions and therapeutic potential. European Journal of Pharmacology, 890 173617, 173617. doi: 10.1016/j.ejphar.2020.173617

Nguyen, Nguyen H., Nguyen, Minh Tan, Little, Peter J., Do, Anh Thu, Tran, Phuong Trinh, Vo, Xuan Nam and Do, Bich Hang (2020). Vernolide-a and vernodaline: sesquiterpene lactones with cytotoxicity against cancer. Journal of Environmental Pathology, Toxicology and Oncology, 39 (4), 299-308. doi: 10.1615/JEnvironPatholToxicolOncol.2020034066

Adelnia, Hossein, Blakey, Idriss, Little, Peter J. and Ta, Hang T. (2019). Hydrogels based on poly(aspartic acid): synthesis and applications. Frontiers in Chemistry, 7 755, 755. doi: 10.3389/fchem.2019.00755

Zhou, Ying, Little, Peter J., Ta, Hang T., Xu, Suowen and Kamato, Danielle (2019). Lysophosphatidic acid and its receptors: pharmacology and therapeutic potential in atherosclerosis and vascular disease. Pharmacology and Therapeutics, 204 107404, 107404. doi: 10.1016/j.pharmthera.2019.107404

Mohamed, Raafat, Janke, Reearna, Guo, Wanru, Cao, Yingnan, Zhou, Ying, Zheng, Wenhua, Babaahmadi-Rezaei, Hossein, Xu, Suowen, Kamato, Danielle and Little, Peter J. (2019). GPCR transactivation signalling in vascular smooth muscle cells: role of NADPH oxidases and reactive oxygen species. Vascular Biology, 1 (1), R1-R11. doi: 10.1530/vb-18-0004

Kamato, Danielle, Do, Bich Hang, Osman, Narin, Ross, Benjamin P., Mohamed, Raafat, Xu, Suowen and Little, Peter J. (2019). Smad linker region phosphorylation is a signalling pathway in its own right and not only a modulator of canonical TGF-β signalling. Cellular and Molecular Life Sciences, 77 (2), 243-251. doi: 10.1007/s00018-019-03266-3

Whitehead, Amy, Simpson, Catherine, Willcox, Merlin, Webley, Frances, Hay, Alastair D., Butler, Chris, Yao, Lily, Wrixon, Emma, Bell, Margaret, Bostock, Jennifer, Little, Paul, Griffiths, Gareth and Moore, Michael (2019). HATRIC: a study of Pelargonium sidoides root extract EPs®7630 (Kaloba®) for the treatment of acute cough due to lower respiratory tract infection in adults-study protocol for a double blind, placebo-controlled randomised feasibility trial. Pilot and Feasibility Studies, 5 (1) ARTN 98. doi: 10.1186/s40814-019-0478-6

Kamato, Danielle, Ta, Hang, Afroz, Rizwana, Xu, Suowen, Osman, Narin and Little, Peter J. (2019). Mechanisms of PAR-1 mediated kinase receptor transactivation: Smad linker region phosphorylation. Journal of Cell Communication and Signaling, 13 (4), 539-548. doi: 10.1007/s12079-019-00527-5

Jiang, Yizhou, Peng, Tangming, Gaur, Uma, Silva, Marta, Little, Peter, Chen, Zhong, Qiu, Wei, Zhang, Yandong and Zheng, Wenhua (2019). Role of corticotropin releasing factor in the neuroimmune mechanisms of depression: examination of current pharmaceutical and herbal therapies. Frontiers in Cellular Neuroscience, 13 290, 290. doi: 10.3389/fncel.2019.00290

Seif, Faezeh, Little, Peter J., Niayesh-Mehr, Reyhaneh, Zamanpour, Masoumeh and Babaahmadi-Rezaei, Hossein (2019). Endothelin-1 increases CHSY-1 expression in aortic endothelial cells via transactivation of transforming growth factor β type I receptor induced by type B receptor endothelin-1. Journal of Pharmacy and Pharmacology, 71 (6), 988-995. doi: 10.1111/jphp.13081

Yusof, Nur Nazifah Mohd, McCann, Andrew, Little, Peter J. and Ta, Hang T. (2019). Non-invasive imaging techniques for the differentiation of acute and chronic thrombosis. Thrombosis Research, 177, 161-171. doi: 10.1016/j.thromres.2019.03.009

Tian, Kunming, Ogura, Sayoko, Little, Peter J., Xu, Suo-wen and Sawamura, Tatsuya (2019). Targeting LOX-1 in atherosclerosis and vasculopathy: current knowledge and future perspectives. Annals of the New York Academy of Sciences, 1443 (1), 34-53. doi: 10.1111/nyas.13984

Philpott, Carl, le Conte, Steffi, Beard, David, Cook, Jonathan, Sones, William, Morris, Steve, Clarke, Caroline S., Thomas, Mike, Little, Paul, Vennik, Jane, Lund, Valerie, Blackshaw, Helen, Schilder, Anne, Durham, Stephen, Denaxas, Spiros, Carpenter, James, Boardman, James and Hopkins, Claire (2019). Clarithromycin and endoscopic sinus surgery for adults with chronic rhinosinusitis with and without nasal polyps: study protocol for the MACRO randomised controlled trial. Trials, 20 (1) ARTN 246. doi: 10.1186/s13063-019-3314-7

Zhang, Yicong, Koradia, Aayushi, Kamato, Danielle, Popat, Amirali, Little, Peter J. and Ta, Hang T. (2019). Treatment of atherosclerotic plaque: perspectives on theranostics. Journal of Pharmacy and Pharmacology, 71 (7) jphp.13092, 1029-1043. doi: 10.1111/jphp.13092

Xu, Suowen, Kamato, Danielle, Little, Peter J., Nakagawa, Shinichi, Pelisek, Jaroslav and Jin, Zheng Gen (2019). Targeting epigenetics and non-coding RNAs in atherosclerosis: from mechanisms to therapeutics. Pharmacology and Therapeutics, 196, 15-43. doi: 10.1016/j.pharmthera.2018.11.003

Niu, Niu, Xu, Suowen, Xu, Yanni, Little, Peter J. and Jin, Zheng-Gen (2019). Targeting mechanosensitive transcription factors in atherosclerosis. Trends in Pharmacological Sciences, 40 (4), 253-266. doi: 10.1016/j.tips.2019.02.004

Kamato, Danielle, Burch, Micah, Yang, Zhou, Mohamed, Raafat, Stow, Jennifer L., Osman, Narin and Little, Peter J. (2019). Individual Smad2 linker region phosphorylation sites determine the expression of proteoglycan and glycosaminoglycan synthesizing genes. Cellular Signalling, 53, 365-373. doi: 10.1016/j.cellsig.2018.11.005

Feng, Xiaojun, Li, Yi, Wang, Yanan, Li, Lingli, Little, Peter J., Xu, Suo-wen and Liu, Sheng (2018). Danhong injection in cardiovascular and cerebrovascular diseases: cardiovascular actions, molecular mechanisms, and therapeutic potential. Pharmacological Research, 139, 62-75. doi: 10.1016/j.phrs.2018.11.006

Gray, Susan G., Sweeting, A. N., McGuire, Treasure, Cohen, Neil, Ross, G. P. and Little, P. J. (2018). Hyperglycaemia in pregnancy. Australian Pharmacist, 37 (9), 44-53.

Wang, Haitao, Su, Xiaoying, Fang, Jiankang, Xin, Xingan, Zhao, Xia, Gaur, Uma, Wen, Qiang, Xu, Jiangping, Little, Peter and Zheng, Wenhua (2018). Tanshinone IIA attenuates insulin like growth factor 1 -induced cell proliferation in PC12 cells through the PI3K/Akt and MEK/ERK pathways. International Journal of Molecular Sciences, 19 (9) 2719, 2719. doi: 10.3390/ijms19092719

Wu, Yuao, Yang, Yanchen, Zhao, Wei, Xu, Zhi Ping, Little, Peter J., Whittaker, Andrew K., Zhang, Run and Ta, Hang T. (2018). Novel iron oxide–cerium oxide core–shell nanoparticles as a potential theranostic material for ROS related inflammatory diseases. Journal of Materials Chemistry B: Materials for Biology and Medicine, 6 (30), 4937-4951. doi: 10.1039/c8tb00022k

Gray, Susan G., Sweeting, Arianne N., Mcguire, Treasure M., Cohen, Neale, Ross, Glynis P. and Little, Peter J. (2018). The changing environment of hyperglycaemia in pregnancy: gestational diabetes and diabetes mellitus in pregnancy. Journal of Diabetes, 10 (8), 633-640. doi: 10.1111/1753-0407.12660

Ta, Hang T., Arndt, Nina, Wu, Yuao, Lim, Hui Jean, Landeen, Shea, Zhang, Run, Kamato, Danielle, Little, Peter J., Whittaker, Andrew K. and Xu, Zhi Ping (2018). Activatable magnetic resonance nanosensor as a potential imaging agent for detecting and discriminating thrombosis. Nanoscale, 10 (31), 15103-15115. doi: 10.1039/c8nr05095c

Nafisa, Asma, Gray, Susan G., Cao, Yingnan, Wang, Tinghuai, Xu, Suowen, Wattoo, Feroza H., Barras, Michael, Cohen, Neale, Kamato, Danielle and Little, Peter J. (2018). Endothelial function and dysfunction: impact of metformin. Pharmacology and Therapeutics, 192, 150-162. doi: 10.1016/j.pharmthera.2018.07.007

Rostam, Muhamad Ashraf, Shajimoon, Aravindra, Kamato, Danielle, Mitra, Partha, Piva, Terrence, Getachew, Robel, Cao, Yingnan, Zheng, Wenhua, Osman, Narin and Little, Peter James (2018). Flavopiridol inhibits TGF-β-stimulated biglycan synthesis by blocking linker region phosphorylation and nuclear translocation of Smad2. The Journal of Pharmacology and Experimental Therapeutics, 365 (1), 156-164. doi: 10.1124/jpet.117.244483

Talati, Nirali, Kamato, Danielle, Piva, Terrence J, Little, Peter and Osman, Narin (2018). Thrombin promotes PAI-1 expression and migration in keratinocytes via ERK dependent Smad linker region phosphorylation. Cellular Signalling, 47, 37-43. doi: 10.1016/j.cellsig.2018.03.009

Dayati, Parisa, Rezaei, Hossein Babaahmadi, Sharifat, Narges, Kamato, Danielle and Little, Peter J (2018). G protein coupled receptors can transduce signals through carboxy terminal and linker region phosphorylation of smad transcription factors. Life Sciences, 199, 10-15. doi: 10.1016/j.lfs.2018.03.004

Afroz, Rizwana, Cao, Yingnan, Rostam, Muhamad Ashraf, Ta, Hang, Xu, Suowen, Zheng, Wenhua, Osman, Narin, Kamato, Danielle and Little, Peter J. (2018). Signalling pathways regulating galactosaminoglycan synthesis and structure in vascular smooth muscle: implications for lipoprotein binding and atherosclerosis. Pharmacology and Therapeutics, 187, 88-97. doi: 10.1016/j.pharmthera.2018.02.005

Xu, Suowen, Xu, Yanni, Yin, Meimei, Zhang, Shuya, Liu, Peng, Koroleva, Marina, Si, Shuyi, Little, Peter J., Pelisek, Jaroslav and Jin, Zheng Gen (2018). Flow-dependent epigenetic regulation of IGFBP5 expression by H3K27me3 contributes to endothelial anti-inflammatory effects. Theranostics, 8 (11), 3007-3021. doi: 10.7150/thno.21966

Mohamed, Raafat, Dayati, Parisa, Mehr, Reyhaneh Niayesh, Kamato, Danielle, Seif, Faezeh, Babaahmadi-Rezaei, Hossein and Little, Peter J. (2018). Transforming growth factor–β1 mediated CHST11 and CHSY1 mRNA expression is ROS dependent in vascular smooth muscle cells. Journal of Cell Communication and Signaling, 13 (2), 225-233. doi: 10.1007/s12079-018-0495-x

Yan, Fengxia, Liao, Rifang, Lin, Shaofen, Deng, Xianguo, Little, Peter J. and Zheng, Wenhua (2017). Forkhead box protein O3 suppresses uveal melanoma development by increasing the expression of Bcl‑2‑like protein 11 and cyclin‑dependent kinase inhibitor 1B. Molecular Medicine Reports, 17 (2), 3109-3114. doi: 10.3892/mmr.2017.8215

Kamato, Danielle, Vijayanand Bhaskarala, Venkata, Mantri, Nitin, Gyu Oh, Tae, Ling, Dora, Janke, Reearna, Zheng, Wenhua, Little, Peter J. and Osman, Narin (2017). RNA sequencing to determine the contribution of kinase receptor transactivation to G protein coupled receptor signalling in vascular smooth muscle cells. PLoS One, 12 (7) e0180842, e0180842. doi: 10.1371/journal.pone.0180842

Chaplin, Rebecca, Thach, Lyna, Hollenberg, Morley D., Cao, Yingnan, Little, Peter J. and Kamato, Danielle (2017). Insights into cellular signalling by G protein coupled receptor transactivation of cell surface protein kinase receptors. Journal of Cell Communication and Signaling, 11 (2), 117-125. doi: 10.1007/s12079-017-0375-9

Gray, Susan G., McGuire, Treasure M., Cohen, Neale and Little, Peter J. (2017). The emerging role of metformin in gestational diabetes mellitus. Diabetes, Obesity and Metabolism, 19 (6), 765-772. doi: 10.1111/dom.12893

Asrafuzzaman, Md., Cao, Yingnan, Afroz, Rizwana, Kamato, Danielle, Gray, Susan and Little, Peter J. (2017). Animal models for assessing the impact of natural products on the aetiology and metabolic pathophysiology of Type 2 diabetes. Biomedicine and Pharmacotherapy, 89, 1242-1251. doi: 10.1016/j.biopha.2017.03.010

Kamato, Danielle, Mitra, Partha, Davis, Felicity, Osman, Narin, Chaplin, Rebecca, Cabot, Peter J., Afroz, Rizwana, Thomas, Walter, Zheng, Wenhua, Kaur, Harveen, Brimble, Margaret and Little, Peter J. (2017). Gaq proteins: molecular pharmacology and therapeutic potential. Cellular and Molecular Life Sciences, 74 (8), 1379-1390. doi: 10.1007/s00018-016-2405-9

Wang, Rikang, Yan, Fengxia, Liao, Rifang, Wan, Pei, Little, Peter J. and Zheng, Wenhua (2017). Role of brain-derived neurotrophic factor and nerve growth factor in the regulation of Neuropeptide W in vitro and in vivo. Molecular and Cellular Endocrinology, 447 (C), 71-78. doi: 10.1016/j.mce.2017.02.040

Zheng, Wenhua, Meng, Qian, Wang, Haitao, Yan, Fengxia, Little, Peter J., Deng, Xinguo and Lin, Shaofen (2017). IGF-1-mediated survival from induced death of human primary cultured retinal pigment epithelial cells is mediated by an Akt-dependent signaling pathway. Molecular Neurobiology, 55 (3), 1-13. doi: 10.1007/s12035-017-0447-0

Cao, Y., Kamato, D. and Little, P.J. (2017). Animal models for the evaluation of the cardiometabolic therapeutic potential of traditional Chinese and natural product medicines. International Journal of Diabetology and Vascular Disease Research, 5 (1), 178-182. doi: 10.19070/2328-353x-1700037

Fang, Jian, Little, Peter J. and Xu, Suowen (2017). Atheroprotective effects and molecular targets of tanshinones derived from herbal medicine Danshen. Medicinal Research Reviews, 38 (1), 201-228. doi: 10.1002/med.21438

Farhan, Mohd, Wang, Haitao, Gaur, Uma, Little, Peter J., Xu, Jiangping and Zheng, Wenhua (2017). FOXO signaling pathways as therapeutic targets in cancer. International Journal of Biological Sciences, 13 (7), 815-827. doi: 10.7150/ijbs.20052

Sharifat, Narges, Mohammad Zadeh, Ghorban, Ghaffari, Mohammad-Ali, Dayati, Parisa, Kamato, Danielle, Little, Peter J. and Babaahmadi-Rezaei, Hossein (2017). Endothelin-1 (ET-1) stimulates carboxy terminal Smad2 phosphorylation in vascular endothelial cells by a mechanism dependent on ET receptors and de novo protein synthesis. Journal of Pharmacy and Pharmacology, 69 (1), 66-72. doi: 10.1111/jphp.12654

Fengxia, Yan, Rifang, Liao, Farhan, Mohd, Tinghuai, Wang, Jiashu, Chen, Wang, Zhong, Little, Peter J. and Wenhua, Zheng (2016). Elucidating the role of the FoxO3a transcription factor in the IGF-1-induced migration and invasion of uveal melanoma cancer cells. Biomedicine and Pharmacotherapy, 84, 1538-1550. doi: 10.1016/j.biopha.2016.11.027

Liao, Rifang, Yan, Fengxia, Zeng, Zhuanping, Farhan, Mohd, Little, Peter, Quirion, Remi, Srivastava, Lalit K. and Zheng, Wenhua (2016). Amiodarone-induced retinal neuronal cell apoptosis attenuated by IGF-1 via counter regulation of the PI3k/Akt/FoxO3a pathway. Molecular Neurobiology, 54 (9), 1-13. doi: 10.1007/s12035-016-0211-x

Mishriky, John, Balassone, Jacqueline, Bashour, Zenah, Kaur, Simranjit, Raman, Vini, Getachew, Robel, Osman, Narin, Guidone, Daniel, Chan, Vincent and Little, Peter J. (2016). An investigation of sodium fusidate and recombinant cytochrome P450 enzymes inhibition in-vitro. Drug Metabolism Letters, 10 (3), 180-186. doi: 10.2174/1872312810666160607015045

Mcdonald, Craig, Cotta, Menino O., Little, Peter J., Mcwhinney, Brett, Ungerer, Jacobus P. J., Lipman, Jeffrey and Roberts, Jason A. (2016). Is high-dose beta-lactam therapy associated with excessive drug toxicity in critically ill patients?. Minerva Anestesiologica, 82 (9), 957-965.

Rostam, Muhamad A., Kamato, Danielle, Piva, Terence J., Zheng, Wenhua, Little, Peter J. and Osman, Narin (2016). The role of specific Smad linker region phosphorylation in TGF-β mediated expression of glycosaminoglycan synthesizing enzymes in vascular smooth muscle. Cellular Signalling, 28 (8), 956-966. doi: 10.1016/j.cellsig.2016.05.002

Al Gwairi, Othman, Osman, Narin, Getachew, Robel, Zheng, Wenhua, Liang, X. -L., Kamato, Danielle, Thach, Lyna and Little, Peter J. (2016). Multiple growth factors, but not VEGF, stimulate glycosaminoglycan hyperelongation in retinal choroidal endothelial cells. International Journal of Biological Sciences, 12 (9), 1041-1051. doi: 10.7150/ijbs.16134

Gulliford, Martin C., Moore, Michael V., Little, Paul, Hay, Alastair D., Fox, Robin, Prevost, A. Toby, Juszczyk, Dorota, Charlton, Judith and Ashworth, Mark (2016). Safety of reduced antibiotic prescribing for self limiting respiratory tract infections in primary care: cohort study using electronic health records. Bmj-British Medical Journal, 354 ARTN i3410. doi: 10.1136/bmj.i3410

Thrimawithana, Thilini, Abdelmalek, Sandra, Al-Maliki, Saja, Ali, Saabreen, Gupta, Arushi, Hassan, Nourhan, Little, Peter J. and Stuchbery, Peter (2016). Multidisciplinary involvement in completion of a hospital medication management plan in a tertiary hospital in Australia. Journal of Pharmacy Practice and Research, 46 (2), 192-194. doi: 10.1002/jppr.1146

Zeng, Zhiwen, Wang, Xue, Bhardwaj, Sanjeev K., Zhou, Xuanhe, Little, Peter J., Quirion, Remi, Srivastava, Lalit K. and Zheng, Wenhua (2016). The atypical antipsychotic agent, clozapine, protects against corticosterone-induced death of PC12 cells by regulating the Akt/FoxO3a signaling pathway. Molecular Neurobiology, 54 (5), 1-12. doi: 10.1007/s12035-016-9904-4

Xu, Suowen, Yin, Meimei, Koroleva, Marina, Mastrangelo, Michael A., Zhang, Wenbo, Bai, Peter, Little, Peter J. and Jin, Zheng Gen (2016). SIRT6 protects against endothelial dysfunction and atherosclerosis in mice. Aging, 8 (5), 1064-1078. doi: 10.18632/aging.100975

Bernard, Rebekah, Getachew R., Kamato, D., Thach L., Osman N., Chan V., Zheng W. and Little P. J. (2016). Evaluation of the potential synergism of imatinib-related poly kinase inhibitors using growth factor stimulated proteoglycan synthesis as a model response. Journal of Pharmacy and Pharmacology, 68 (3), 368-378. doi: 10.1111/jphp.12530

Little, P. J., Hollenberg, M. D, Kamato, D., Thomas, W., Chen, J., Wang, T., Zheng, W. and Osman, N. (2016). Integrating the GPCR transactivation-dependent and biased signalling paradigms in the context of PAR1 signalling. British Journal of Pharmacology, 173 (20), 2992-3000. doi: 10.1111/bph.13398

Afroz, R., Tanvir, E and Little, P.J. (2016). Honey-derived flavonoids: natural products for the prevention of atherosclerosis and cardiovascular diseases. Clinical and Experimental Pharmacology, 6 (3). doi: 10.4172/2161-1459.1000208

Al Gwairi, Othman, Thach, Lyna, Zheng, Wenhua, Osman, Narin and Little, Peter J. (2016). Cellular and molecular pathology of age-related macular degeneration: potential role for proteoglycans. Journal of Ophthalmology, 2016 2913612, 2913612-7. doi: 10.1155/2016/2913612

Kamato, Danielle, Thach, Lyna, Getachew, Robel, Burch, Micah, Hollenberg, Morley D., Zheng, Wenhua, Little, Peter J. and Osman, Narin (2016). Protease activated receptor-1 mediated dual kinase receptor transactivation stimulates the expression of glycosaminoglycan synthesizing genes. Cellular Signalling, 28 (1), 110-119. doi: 10.1016/j.cellsig.2015.11.003

Afroz, R, Tanvir, EM, Zheng, W and Little, PJ (2016). Molecular Pharmacology of Honey. Clinical and Experimental Pharmacology, 06 (03) doi: 10.4172/2161-1459.1000212

Wang, Haitao, Quirion, Remi, Little, Peter J., Cheng, Yufang, Feng, Zhong-Ping, Sun, Hong-Shuo, Xu, Jiangping and Zheng, Wenhua (2015). Forkhead box O transcription factors as possible mediators in the development of major depression. Neuropharmacology, 99, 527-537. doi: 10.1016/j.neuropharm.2015.08.020

Zeng, Zhiwen, Wang, Haitao, Shang, Fu, Zhou, Lihua, Little, Peter J., Quirion, Remi and Zheng, Wenhua (2015). Lithium ions attenuate serum-deprivation-induced apoptosis in PC12 cells through regulation of the Akt/FoxO1 signaling pathways. Psychopharmacology, 233 (5), 785-794. doi: 10.1007/s00213-015-4168-7

Smith, Clare L., Ackerly, Trevor, Best, Stephen P., Gagliardi, Frank, Kie, Katahira, Little, Peter J., McCorkell, Giulia, Sale, Charlotte A., Tsunei, Yusuke, Tominaga, Takahiro, Volaric, Sloe See and Geso, Moshi (2015). Determination of dose enhancement caused by gold-nanoparticles irradiated with proton, X-rays (kV and MV) and electron beams, using alanine/EPR dosimeters. Radiation Measurements, 82, 122-128. doi: 10.1016/j.radmeas.2015.09.008

Dima, Alexandra, Lewith, George T., Little, Paul, Moss-Morris, Rona, Foster, Nadine E., Hankins, Matthew, Surtees, George and Bishop, Felicity L. (2015). Patients' treatment beliefs in low back pain : development and validation of a questionnaire in primary care. Pain, 156 (8), 1489-1500. doi: 10.1097/j.pain.0000000000000193

Little, Peter J., Getachew, Robel, Kamto, Danielle, Ashraf Rostam, Muhamad, Cohen, Neale, Chan, Vincent and Osman, Narin (2015). Methotrexate Inhibits Proliferation but not Proteoglycan Synthesis or Glycosaminoglycan Hyperelongation in Human Vascular Smooth Muscle Cells. Clinical & Experimental Pharmacology, 5 (4). doi: 10.4172/2161-1459.1000181

Guidone, Daniel, Getachew, Robel, Osman, Narin, Ward, Michael, Chan, Vincent and Little, Peter J. (2015). Sodium fusidate inhibits rCYP3A4 in vitro-a possible mechanism defining the interaction with statins. Clinical and Experimental Pharmacology, 5 (3), 1000174.1-1000174.4. doi: 10.4172/2161-1459.1000174

Wang, Haitao, Liao, Sufen, Geng, Ruojun, Zheng, Yongxin, Liao, Rifang, Yan, Fengxia, Thrimawithana, Thilini, Little, Peter J., Feng, Zhong-Ping, Lazarovici, Philip and Zheng, Wenhua (2015). IGF-1 signaling via the PI3K/Akt pathway confers neuroprotection in human retinal pigment epithelial cells exposed to sodium nitroprusside insult. Journal of Molecular Neuroscience, 55 (4), 931-940. doi: 10.1007/s12031-014-0448-7

Kamato, Danielle, Thach, Lyna, Bernard, Rebekah, Chan, Vincent, Zheng, Wenhua, Kaur, Harveen, Brimble, Margaret, Osman, Narin and Little, Peter J. (2015). Structure, function, pharmacology, and therapeutic potential of the G protein, GÎ±/q,11. Frontiers in Cardiovascular Medicine, 2 14. doi: 10.3389/fcvm.2015.00014

Chen, Qian, Wang, Haitao, Liao, Sufen, Gao, Yang, Liao, Rifang, Little, Peter J., Xu, Jiangping, Feng, Zhong-Ping, Zheng, Yongxin and Zheng, Wenhua (2015). Nerve growth factor protects retinal ganglion cells against injury induced by retinal ischemia-reperfusion in rats. Growth Factors, 33 (2), 149-159. doi: 10.3109/08977194.2015.1010642

Kaur, Harveen, Harris, Paul W. R., Little, Peter J. and Brimblet, Margaret A. (2015). Total synthesis of the cyclic depsipeptide YM-280193, a platelet aggregation inhibitor. Organic Letters, 17 (3), 492-495. doi: 10.1021/ol503507g

Rostam, Muhamad A., Piva, Terrence J., Rezaei, Hossein B., Kamato, Danielle, Little, Peter J., Zheng, Wenhua and Osman, Narin (2015). Peptidyl-prolyl isomerases: functionality and potential therapeutic targets in cardiovascular disease. Clinical and Experimental Pharmacology and Physiology, 42 (2), 117-124. doi: 10.1111/1440-1681.12335

Read, Evan D., Eu, Peter, Little, Peter J. and Piva, Terrence J. (2015). The status of radioimmunotherapy in CD20+ non-Hodgkin's lymphoma. Targeted Oncology, 10 (1), 15-26. doi: 10.1007/s11523-014-0324-y

Kamato, Danielle, Rostam, Muhamad Ashraf, Bernard, Rebekah, Piva, Terrence J., Mantri, Nitin, Guidone, Daniel, Zheng, Wenhua, Osman, Narin and Little, Peter J. (2015). The expansion of GPCR transactivation-dependent signalling to include serine/threonine kinase receptors represents a new cell signalling frontier. Cellular and Molecular Life Sciences, 72 (4), 799-808. doi: 10.1007/s00018-014-1775-0

Kamato, Danielle, Rostam, Muhamad Ashraf, Piva, Terence J., Rezaei, Hossein Babaahmadi, Getachew, Robel, Thach, Lyna, Bernard, Rebekah, Zheng, Wenhua, Little, Peter J. and Osman, Narin (2014). Transforming growth factor β-mediated site-specific Smad linker region phosphorylation in vascular endothelial cells. Journal of Pharmacy and Pharmacology, 66 (12), 1722-1733. doi: 10.1111/jphp.12298

Bernard, Rebekah, Thach, Lyna, Kamato, Danielle, Osman, Narin and Little, Peter J. (2014). Assessing the role of Gαq/11 in cellular responses: an analysis of investigative tools. Clinical and Experimental Pharmacology, 4 (5), 1-4. doi: 10.4172/2157-7420.1000164

Wang, Rikang, Yang, Jian, Liao, Sufen, Xiao, Gaokeng, Luo, Jun, Zhang, Lang, Little, Peter J., Chen, Heru and Zheng, Wenhua (2014). Stereoselective reduction of 1-O-isopropyloxygenipin enhances its neuroprotective activity in neuronal cells from apoptosis induced by sodium nitroprusside. ChemMedChem, 9 (7), 1397-1401. doi: 10.1002/cmdc.201400051

Xu, Suowen, Bai, Peter, Little, Peter J. and Liu, Peiqing (2014). Poly(ADP-ribose) Polymerase 1 (PARP1) in Atherosclerosis: From Molecular Mechanisms to Therapeutic Implications. Medicinal Research Reviews, 34 (3), 644-675. doi: 10.1002/med.21300

Al-aryahi, Sefaa, Kamato, Danielle, Getachew, Robel, Zheng, Wenhua, Potocnik, Simon J., Cohen, Neale, Guidone, Daniel, Osman, Narin and Little, Peter J. (2014). Atherogenic, fibrotic and glucose utilising actions of glucokinase activators on vascular endothelium and smooth muscle. Cardiovascular Diabetology, 13 (80) 80, 1-15. doi: 10.1186/1475-2840-13-80

Guidone, Daniel M. and Little, Peter J. (2014). Fixed-dose statins with no lipid targets: a new paradigm of dosing?. Journal of Pharmacy Practice and Research, 44 (1), 64-65. doi: 10.1002/j.2055-2335.2014.tb00020.x

Liu, Zhiping, Wang, Jiaojiao, Huang, Erwen, Gao, Si, Li, Hong, Lu, Jing, Tian, Kunming, Little, Peter J., Shen, Xiaoyan, Xu, Suowen and Liu, Peiqing (2014). Tanshinone IIA suppresses cholesterol accumulation in human macrophages: Role of heme oxygenase-1. Journal of Lipid Research, 55 (2), 201-213. doi: 10.1194/jlr.M040394

Wang, Haitao, Wang, Rikang, Thrimawithana, Thilini, Little, Peter J., Xu, Jiangping, Feng, Zhong-Ping and Zheng, Wenhua (2014). The nerve growth factor signaling and its potential as therapeutic target for glaucoma. Biomed Research International, 2014 759473, 1-10. doi: 10.1155/2014/759473

Osman, Narin, Getachew, Robel, Thach, Lyna, Wang, Haitao, Su, Xiaoying, Zheng, Wenhua and Little, Peter J. (2014). Platelet-derived growth factor-stimulated versican synthesis but not glycosaminoglycan elongation in vascular smooth muscle is mediated via akt phosphorylation. Cellular Signalling, 26 (5), 912-916. doi: 10.1016/j.cellsig.2014.01.019

Bernard, Rebekah, Thach, Lyna, Kamato, Danielle, Osman, Narin and Little, Peter J. (2014). Assessing the Role of Gαq/11 in Cellular Responses: An Analysis of Investigative Tools. Clinical & Experimental Pharmacology, 04 (05). doi: 10.4172/2161-1459.1000164

Kamato, Danielle, Burch, Micah L., Piva, Terrence J., Rezaei, Hossein Babaahmadi, Rostam, Muhamad Ashraf, Xu, Suowen, Zheng, Wenhua, Little, Peter J. and Osman, Narin (2013). Transforming growth factor-β signalling: role and consequences of Smad linker region phosphorylation. Cellular Signalling, 25 (10), 2017-2024. doi: 10.1016/j.cellsig.2013.06.001

Xu, Suowen, Ogura, Sayoko, Chen, Jiawei, Little, Peter J., Moss, Joel and Liu, Peiqing (2013). LOX-1 in atherosclerosis: biological functions and pharmacological modifiers. Cellular and Molecular Life Sciences, 70 (16), 2859-2872. doi: 10.1007/s00018-012-1194-z

Little, Peter J., Rostam, Muhamad Ashraf, Piva, Terrence J., Getachew, Robel, Kamato, Danielle, Guidone, Daniel, Ballinger, Mandy L., Zheng, Wenhua and Osman, Narin (2013). Suramin inhibits PDGF-stimulated receptor phosphorylation, proteoglycan synthesis and glycosaminoglycan hyperelongation in human vascular smooth muscle cells. Journal of Pharmacy and Pharmacology, 65 (7), 1055-1063. doi: 10.1111/jphp.12064

Kamato, Danielle, Rezaei, Hossein Babaahmadi, Getachew, Robel, Thach, Lyna, Guidone, Daniel, Osman, Narin, Roufogalis, Basil, Duke, Colin C., Van Hoan Tran, Zheng, Wenhua and Little, Peter J. (2013). (S)-[6]-Gingerol inhibits TGF-β-stimulated biglycan synthesis but not glycosaminoglycan hyperelongation in human vascular smooth muscle cells. Journal of Pharmacy and Pharmacology, 65 (7), 1026-1036. doi: 10.1111/jphp.12060

Little, Peter J. (2013). GPCR responses in vascular smooth muscle can occur predominantly through dual transactivation of kinase receptors and not classical Gαq protein signalling pathways. Life Sciences, 92 (20-21), 951-956. doi: 10.1016/j.lfs.2013.03.017

Musyoka, James N., Liu, Mira C. P., Pouniotis, Dodie S., Wong, Christina S. F., Bowtell, David D., Little, Peter J., Getachew, Robel, Moeller, Andreas and Darby, Ian A. (2013). Siah2-deficient mice show impaired skin wound repair. Wound Repair and Regeneration, 21 (3), 437-447. doi: 10.1111/wrr.12045

van Vugt, Saskia F., Broekhuizen, Berna D. L., Lammens, Christine, Zuithoff, Nicolaas P. A., de Jong, Pim A., Coenen, Samuel, Ieven, Margareta, Butler, Chris C., Goossens, Herman, Little, Paul and Verheij, Theo J. M. (2013). Use of serum C reactive protein and procalcitonin concentrations in addition to symptoms and signs to predict pneumonia in patients presenting to primary care with acute cough: diagnostic study. Bmj-British Medical Journal, 346 ARTN f2450. doi: 10.1136/bmj.f2450

Osman, Narin, Getachew, Robel and Little, Peter J. (2013). Aortic Smooth Muscle Cells from ApoE(-/-) Mice Secrete Biglycan with Hyperelongated Glycosaminoglycan Chains. Clinical and Experimental Pharmacology, 3 (3). doi: 10.4172/2161-1459.1000125

Kamato, Danielle, Burch, Micah L., Osman, Narin, Zheng, Wenhua and Little, Peter J. (2013). Therapeutic implications of endothelin and thrombin G-protein-coupled receptor transactivation of tyrosine and serine/threonine kinase cell surface receptors. Journal of Pharmacy and Pharmacology, 65 (4), 465-473. doi: 10.1111/j.2042-7158.2012.01577.x

Burch, Micah L., Getachew, Robel, Osman, Narin, Febbraio, Mark A. and Little, Peter J. (2013). Thrombin-mediated proteoglycan synthesis utilizes both protein-tyrosine kinase and serine/threonine kinase receptor transactivation in vascular smooth muscle cells. Journal of Biological Chemistry, 288 (10), 7410-7419. doi: 10.1074/jbc.M112.400259

Osman, Narin, Grande-Allen, K. Jane, Ballinger, Mandy L., Getachew, Robel, Marasco, Silvana, O'Brien, Kevin D. and Little, Peter J. (2013). Smad2-dependent glycosaminoglycan elongation in aortic valve interstitial cells enhances binding of LDL to proteoglycans. Cardiovascular Pathology, 22 (2), 146-155. doi: 10.1016/j.carpath.2012.07.002

Getachew, Robel, Ballinger, Mandy L., Burch, Micah L., Reid, Julianne J., Khachigian, Levon M., Wight, Thomas N., Little, Peter J. and Osman, Narin (2013). PDGF β-receptor kinase activity and ERK1/2 mediate glycosaminoglycan elongation on biglycan and increases binding to LDL. Endocrinology, 151 (9), 4356-4367. doi: 10.1210/en.2010-0027

van Vugt, Saskia, Broekhuizen, Lidewij, Zuithoff, Nicolaas, Butler, Christopher, Hood, Kerenza, Coenen, Samuel, Goossens, Herman, Little, Paul, Almirall, Jordi, Blasi, Francesco, Chlabicz, Slawomir, Davies, Mel, Godycki-Cwirko, Maciek, Hupkova, Helena, Kersnik, Janko, Moore, Michael, Schaberg, Tom, De Sutter, An, Torres, Antoni and Verheij, Theo (2012). Airway Obstruction and Bronchodilator Responsiveness in Adults With Acute Cough. Annals of Family Medicine, 10 (6), 523-529. doi: 10.1370/afm.1416

Little, Peter J., Burch, Micah L. and Osman, Narin (2012). The Growing Promiscuity of G Protein Coupled Receptors. Clinical and Experimental Pharmacology, 2 (3), 1000e110.1-1000e110.2. doi: 10.4172/2161-1459.1000e110

Little, Peter J., Getachew, Robel, Rezaei, Hossein Babaahmadi, Sanchez-Guerrero, Estella, Khachigian, Levon M., Wang, Haitao, Liao, Sufen, Zheng, Wenhua, Ballinger, Mandy L. and Osman, Narin (2012). Genistein inhibits PDGF-stimulated proteoglycan synthesis in vascular smooth muscle without blocking PDGFβ receptor phosphorylation. Archives of Biochemistry and Biophysics, 525 (1), 25-31. doi: 10.1016/j.abb.2012.05.025

Zheng, Wenhua, Wang, Haitao, Zeng, Zhiwen, Lin, Jun, Little, Peter J., Srivastava, Lalit K. and Quirion, Remi (2012). The possible role of the Akt signaling pathway in schizophrenia. Brain Research, 1470, 145-158. doi: 10.1016/j.brainres.2012.06.032

Xu, Suowen, Liu, Zhiping, Huang, Yan, Le, Kang, Tang, Futian, Huang, Heqing, Ogura, Sayoko, Little, Peter J., Shen, Xiaoyan and Liu, Peiqing (2012). Tanshinone II-A inhibits oxidized LDL-induced LOX-1 expression in macrophages by reducing intracellular superoxide radical generation and NF-κB activation. Translational Research, 160 (2), 114-124. doi: 10.1016/j.trsl.2012.01.008

Rezaei, Hossein B., Kamato, Danielle, Ansari, Ghazaleh, Osman, Narin and Little, Peter J. (2012). Cell biology of Smad2/3 linker region phosphorylation in vascular smooth muscle. Clinical and Experimental Pharmacology and Physiology, 39 (8), 661-667. doi: 10.1111/j.1440-1681.2011.05592.x

Wang, Haitao, Zhang, Qishan, Zhang, Lang, Little, Peter J., Xie, Xiaochun, Meng, Qian, Ren, Yannan, Zhou, Lihua, Gao, Guoquan, Quirion, Remi and Zheng, Wenhua (2012). Insulin-like growth factor-1 induces the phosphorylation of PRAS40 via the PI3K/Akt signaling pathway in PC12 cells. Neuroscience Letters, 516 (1), 105-109. doi: 10.1016/j.neulet.2012.03.068

Wen, Qiang, Wang, Haitao, Little, Peter J., Quirion, Remi and Zheng, Wenhua (2012). Forkhead family transcription factor FoxO and neural differentiation. Neurogenetics, 13 (2), 105-113. doi: 10.1007/s10048-012-0320-2

Burch, Micah L., Osman, Narin, Getachew, Robel, Al-aryahi, Sefaa, Poronnik, Philip, Zheng, Wenhua, Hill, Michael A. and Little, Peter J. (2012). G protein coupled receptor transactivation: extending the paradigm to include serine/threonine kinase receptors. International Journal of Biochemistry and Cell Biology, 44 (5), 722-727. doi: 10.1016/j.biocel.2012.01.018

Gao, Si, Liu, Zhiping, Li, Hong, Little, Peter J., Liu, Peiqing and Xu, Suowen (2012). Corrigendum to: cardiovascular actions and therapeutic potential of tanshinone IIA [Atherosclerosis 220 (2012) 3-10]. Atherosclerosis, 221 (2), 604. doi: 10.1016/j.atherosclerosis.2012.01.014

Gao, Si, Liu, Zhiping, Li, Hong, Little, Peter J., Liu, Peiqing and Xu, Suowen (2012). Cardiovascular actions and therapeutic potential of tanshinone IIA. Atherosclerosis, 220 (1), 3-10. doi: 10.1016/j.atherosclerosis.2011.06.041

Xu, Suowen, Little, Peter J., Lan, Tian, Huang, Yan, Le, Kang, Wu, Xiaoqian, Shen, Xiaoyan, Huang, Heqing, Cai, Yi, Tang, Futian, Wang, Hua and Liu, Peiqing (2011). Tanshinone II-A attenuates and stabilizes atherosclerotic plaques in Apolipoprotein-E knockout mice fed a high cholesterol diet. Archives of Biochemistry and Biophysics, 515 (1-2), 72-79. doi: 10.1016/j.abb.2011.08.006

Little, Peter J., Chait, Alan and Bolbik, Alex (2011). Cellular and cytokine-based inflammatory processes as novel therapeutic targets for the prevention and treatment of atherosclerosis. Pharmacology and Therapeutics, 131 (3), 255-268. doi: 10.1016/j.pharmthera.2011.04.001

Wen, Qiang, Duan, Xiaolu, Liao, Rifang, Little, Peter, Gao, Guoquan, Jiang, Hao, Lalit, Srivastava, Quirion, Remi and Zheng, Wenhua (2011). Characterization of intracellular translocation of Forkhead transcription factor O (FoxO) members induced by NGF in PC12 cells. Neuroscience Letters, 498 (1), 31-36. doi: 10.1016/j.neulet.2011.04.055

Little, Peter J., Burch, Micah L., Al-aryahi, Sefaa and Zheng, Wenhua (2011). The paradigm of G protein receptor transactivation: a mechanistic definition and novel example. The Scientific World Journal, 11, 709-714. doi: 10.1100/tsw.2011.75

Burch, Micah L., Zheng, Wenhua and Little, Peter J. (2011). Smad linker region phosphorylation in the regulation of extracellular matrix synthesis. Cellular and Molecular Life Sciences, 68 (1), 97-107. doi: 10.1007/s00018-010-0514-4

Osman, Narin, Getachew, Robel, Burch, Micah, Lancaster, Graeme, Wang, Rikang, Wang, Haitau, Zheng, Wenhua and Little, Peter J. (2011). TGF-β stimulates biglycan core protein synthesis but not glycosaminoglycan chain elongation via Akt phosphorylation in vascular smooth muscle. Growth Factors, 29 (5), 203-210. doi: 10.3109/08977194.2011.615747

Yang, Sundy N. Y., Burch, Micah L., Tannock, Lisa R., Evanko, Stephen, Osman, Narin and Little, Peter J. (2010). Transforming growth factor-β regulation of proteoglycan synthesis in vascular smooth muscle: contribution to lipid binding and accelerated atherosclerosis in diabetes. Journal of Diabetes, 2 (4), 233-242. doi: 10.1111/j.1753-0407.2010.00089.x

Little, Peter J., Bhattacharya, Runa, Moreyra, Abel E. and Korichneva, Irina L. (2010). Zinc and cardiovascular disease. Nutrition, 26 (11-12), 1050-1057. doi: 10.1016/j.nut.2010.03.007

Little, Peter J., Burch, Micah L., Getachew, Robel, Al-aryahi, Sefaa and Osman, Narin (2010). Endothelin-1 stimulation of proteoglycan synthesis in vascular smooth muscle is mediated by endothelin receptor transactivation of the transforming growth factor-β type I receptor. Journal of Cardiovascular Pharmacology, 56 (4), 360-368. doi: 10.1097/FJC.0b013e3181ee6811

Burch, Micah L., Ballinger, Mandy L., Yang, Sundy N. Y., Getachew, Robel, Itman, Catherine, Loveland, Kate, Osman, Narin and Little, Peter J. (2010). Thrombin stimulation of proteoglycan synthesis in vascular smooth muscle is mediated by protease-activated receptor-1 transactivation of the transforming growth factor βtype I receptor. Journal of Biological Chemistry, 285 (35), 26798-26805. doi: 10.1074/jbc.M109.092767

Cardoso, Luiz E. M., Little, Peter J., Ballinger, Mandy L., Chan, Christina K., Braun, Kathleen R., Potter-Perigo, Susan, Bornfeldt, Karin E., Kinsella, Michael G. and Wight, Thomas N. (2010). Platelet-derived Growth Factor Differentially Regulates the Expression and Post-translational Modification of Versican by Arterial Smooth Muscle Cells through Distinct Protein Kinase C and Extracellular Signal-regulated Kinase Pathways. Journal of Biological Chemistry, 285 (10), 6987-6995. doi: 10.1074/jbc.M109.088674

Getachew, Robel, Ballinger, Mandy L., Burch, Micah L., Little, Peter J. and Osman, Narin (2010). Characterisation of Ki11502 as a potent inhibitor of PDGF β receptor-mediated proteoglycan synthesis in vascular smooth muscle cells. European Journal of Pharmacology, 626 (2-3), 186-192. doi: 10.1016/j.ejphar.2009.09.066

Burch, Micah L., Yang, Sundy N. Y., Ballinger, Mandy L., Getachew, Robel, Osman, Narin and Little, Peter J. (2010). TGF-β stimulates biglycan synthesis via p38 and ERK phosphorylation of the linker region of Smad2. Cellular and Molecular Life Sciences, 67 (12), 2077-2090. doi: 10.1007/s00018-010-0315-9

Ballinger, Mandy L., Osman, Narin, Hashimura, Kazuhiko, de Haan, Judy B., Jandeleit-Dahm, Karin, Allen, Terri, Tannock, Lisa R., Rutledge, John C. and Little, Peter J. (2010). Imatinib inhibits vascular smooth muscle proteoglycan synthesis and reduces LDL binding in vitro and aortic lipid deposition in vivo. Journal of Cellular and Molecular Medicine, 14 (6 B), 1408-1418. doi: 10.1111/j.1582-4934.2009.00902.x

Ivey, Melanie E., Osman, Narin and Little, Peter J. (2009). Fish oil supplementation improves endothelial function in normoglycemic offspring of patients with type 2 diabetes. Atherosclerosis, 206 (2), 569-574. doi: 10.1016/j.atherosclerosis.2009.03.006

Yang, Sundy N. Y., Osman, Narin, Burch, Micah L. and Little, Peter J. (2009). Factors affecting proteoglycan synthesis and structure that modify the interaction with lipoproteins. Future Lipidology, 4 (4), 479-492. doi: 10.2217/CLP.09.37

Ballinger, M. L., Ivey, M. E., Osman, N., Thomas, W. G. and Little, P. J. (2009). Endothelin-1 activates ETA receptors on human vascular smooth muscle cells to yield proteoglycans with increased binding to LDL. Atherosclerosis, 205 (2), 451-457. doi: 10.1016/j.atherosclerosis.2009.01.024

Yang, Sundy N. Y., Burch, Micah L., Getachew, Robel, Ballinger, Mandy L., Osman, Narin and Little, Peter J. (2009). Growth factor-mediated hyper-elongation of glycosaminoglycan chains on biglycan requires transcription and translation. Archives of Physiology and Biochemistry, 115 (3), 147-154. doi: 10.1080/13813450903110754

Little, Peter J., Cohen, Neale and Morahan, Grant (2009). Potential of small molecule protein tyrosine kinase inhibitors as immunomodulators and inhibitors of the development of diabetes. The Scientific World Journal, 9, 224-228. doi: 10.1100/tsw.2009.28

Ivey, Melanie E. and Little, Peter J. (2008). Thrombin regulates vascular smooth muscle cell proteoglycan synthesis via PAR-1 and multiple downstream signalling pathways. Thrombosis Research, 123 (2), 288-297. doi: 10.1016/j.thromres.2008.04.019

Osman, Narin, Ballinger, Mandy L., Dadlani, Harsha M., Getachew, Robel, Burch, Micah L. and Little, Peter J. (2008). p38 MAP kinase mediated proteoglycan synthesis as a target for the prevention of atherosclerosis. Cardiovascular and Hematological Disorders - Drug Targets, 8 (4), 287-292. doi: 10.2174/187152908786786205

Ballinger, Mandy L., Osman, Narin, Wilks, Andrew F., Su, Stephen, Phd, Christopher J. Burns, Bu, Xianyong and Little, Peter J. (2008). Pyrido-Pyrimidine Derivative CYC10424 Inhibits Glycosaminoglycan Changes on vascular Smooth Muscle-derived Proteoglycans and Reduces Lipoprotein Binding. Journal of Cardiovascular Pharmacology, 52 (5), 403-412. doi: 10.1097/FJC.0b013e31818a8907

Little, Peter J., Osman, Narin and O'Brien, Kevin D. (2008). Hyperelongated biglycan: the surreptitious initiator of atherosclerosis. Current Opinion in Lipidology, 19 (5), 448-454. doi: 10.1097/MOL.0b013e32830dd7c4

Ivey, Melanie E., Osman, Narin and Little, Peter J. (2008). Endothelin-1 signalling in vascular smooth muscle: Pathways controlling cellular functions associated with atherosclerosis. Atherosclerosis, 199 (2), 237-247. doi: 10.1016/j.atherosclerosis.2008.03.006

Little, Peter J., Drennon, Katherine D. and Tannock, Lisa R. (2008). Glucosamine inhibits the synthesis of glycosaminoglycan chains on vascular smooth muscle cell proteoglycans by depletion of ATP. Archives of Physiology and Biochemistry, 114 (2), 120-126. doi: 10.1080/13813450802033909

Nigro, Julie, Potter-Perigo, Susan, Ivey, Melanie E., De Dios, Stephanie T., Evanko, Stephen P., Wight, Thomas N. and Little, Peter J. (2008). The effect of PPAR ligands to modulate glucose metabolism alters the incorporation of metabolic precursors into proteoglycans synthesized by human vascular smooth muscle cells. Archives of Physiology and Biochemistry, 114 (3), 171-177. doi: 10.1080/13813450802181013

Dadlani, Harsha, Osman, Narin, Ballinger, Mandy L., Marasco, Silvana and Little, Peter J. (2008). Calcific aortic valve disease and hypertension. Current Hypertension Reviews, 4 (2), 107-113. doi: 10.2174/157340208784245884

Dadlani, Harsha, Ballinger, Mandy L., Osman, Narin, Getachew, Robel and Little, Peter J. (2008). Smad and p38 MAP kinase-mediated signaling of proteoglycan synthesis in vascular smooth muscle. Journal of Biological Chemistry, 283 (12), 7844-7852. doi: 10.1074/jbc.M703125200

Dilley, Rodney J. and Little, Peter J. (2008). Another piece of cell biology in the puzzle of inflammation, glucose and diabetic vascular disease. Journal of Hypertension, 26 (3), 396-398. doi: 10.1097/HJH.0b013e3282f4e35d

Little, Peter J., Ballinger, Mandy L., Survase, Soniya, Osman, Narin, Ogru, Esra, Geytenbeek, Stephen, Bruemmer, Dennis and Nigro, Julie (2008). Phosphorylated troglitazone activates PPAR gamma and inhibits vascular smooth muscle cell proliferation and proteoglycan synthesis. Journal of Cardiovascular Pharmacology, 51 (3), 274-279. doi: 10.1097/FJC.0b013e3181626ce7

Little, Peter J., Ivey, Melanie E. and Osman, Narin (2008). Endothelin-1 actions on vascular smooth muscle cell functions as a target for the prevention of atherosclerosis. Current Vascular Pharmacology, 6 (3), 195-203. doi: 10.2174/157016108784911966

Little, Peter J., Ballinger, Mandy L., Burch, Micah L. and Osman, Narin (2008). Biosynthesis of natural and hyperelongated chondroitin sulfate glycosaminoglycans: new insights into an elusive process. The Open Biochemistry Journal, 2, 135-142. doi: 10.2174/1874091X00802010135

Little, Peter J., Osman, Narin, de Dios, Stephanie T., Cemerlang, Nelly, Ballinger, Mandy and Nigro, Julie (2007). Anti-proliferative activity of oral anti-hyperglycemic agents on human vascular smooth muscle cells: thiazolidinediones (glitazones) have enhanced activity under high glucose conditions. Cardiovascular Diabetology, 6 33. doi: 10.1186/1475-2840-6-33

Grande-Allen, K. J., Osman, N., Ballinger, M. L., Dadlani, H., Marasco, S. and Little, P. J. (2007). Glycosaminoglycan synthesis and structure as targets for the prevention of calcific aortic valve disease. Cardiovascular Research, 76 (1), 19-28. doi: 10.1016/j.cardiores.2007.05.014

Little, Peter J., Ballinger, Mandy L. and Osman, Narin (2007). Vascular wall proteoglycan synthesis and structure as a target for the prevention of atherosclerosis. Vascular Health and Risk Management, 3 (1), 117-124.

de Dios, Stephanie T., Frontanilla, Karen V., Nigro, Julie, Ballinger, Mandy L., Ivey, Melanie E., Cawson, Elizabeth A. and Little, Peter J. (2007). Regulation of the atherogenic properties of vascular smooth muscle proteoglycans by oral anti-hyperglycemic agents. Journal of Diabetes and its Complications, 21 (2), 108-117. doi: 10.1016/j.jdiacomp.2006.03.003

Nigro, Julie, Osman, Narin, Dart, Anthony M. and Little, Peter J. (2006). Insulin resistance and atherosclerosis. Endocrine Reviews, 27 (3), 242-259. doi: 10.1210/er.2005-0007

de Dios, Stephanie T., O'Brien, Richard C. and Little, Peter J. (2006). Clinical thiazolidinediones as PPARγ ligands with the potential for the prevention of cardiovascular disease in diabetes. Current Diabetes Reviews, 2 (2), 227-239. doi: 10.2174/157339906776818622

Dilley, Rodney J., Farrelly, Caroline A., Allen, Terri J., Jandeleit-Dahm, Karin, Cooper, Mark E., Morahan, Grant and Little, Peter J. (2005). Diabetes induces Na/H exchange activity and hypertrophy of rat mesenteric but not basilar arteries. Diabetes Research and Clinical Practice, 70 (3), 201-208. doi: 10.1016/j.diabres.2005.03.038

Ballinger, Mandy L., Thomas, Merlin C., Nigro, Julie, Ivey, Melanie E., Dilley, Rodney J. and Little, Peter J. (2005). Glycated and carboxy-methylated proteins do not directly activate human vascular smooth muscle cells. Kidney International, 68 (6), 2756-2765. doi: 10.1111/j.1523-1755.2005.00746.x

Survase, Soniya, Ivey, Melanie E, Nigro, Julie, Osman, Narin and Little, Peter J (2005). Actions of calcium channel blockers on vascular proteoglycan synthesis: relationship to atherosclerosis. Vascular health and risk management, 1 (3), 199-208.

Nigro, Julie, Ballinger, Mandy L., Survase, Soniya, Osman, Narin and Little, Peter J. (2005). New approaches to regulating the chondroitin/dermatan sulfate glycosaminoglycan component of the vascular extracellular matrix. Thescientificworldjournal, 5 (2), 515-520. doi: 10.1100/tsw.2005.69

Sudhir, Krishnankutty, Nigro, Julie, Osman, Narin and Little, Peter J. (2005). Androgens: New effects on proteoglycan biosynthesis and its consequences for atherosclerosis. Thescientificworldjournal, 5, 521-526. doi: 10.1100/tsw.2005.75

Hashimura, Kazuhiko, Sudhir, Krishnankutty, Nigro, Julie, Ling, Shanhong, Williams, Maro R. I., Komesaroff, Paul A. and Little, Peter J. (2005). Androgens stimulate human vascular smooth muscle cell proteoglycan biosynthesis and increase lipoprotein binding. Endocrinology, 146 (4), 2085-2090. doi: 10.1210/en.2004-1242

Nigro, J, Ballinger, ML, Dilley, RJ, Jennings, GLR, Wight, T and Little, PJ (2004). Fenofibrate modifies human vascular smooth muscle proteoglycans and reduces lipoprotein binding. Diabetologia, 47 (12), 2105-2113. doi: 10.1007/s00125-004-1588-z

Ballinger, M. L., Nigro, J., Frontanilla, K. V., Dart, A. M. and Little, P. J. (2004). Regulation of glycosaminoglycan structure and atherogenesis. Cellular and Molecular Life Sciences, 61 (11), 1296-1306. doi: 10.1007/s00018-004-3389-4

Tannock, L. R., Little, P. J., Tsoi, C., Barrett, P. H. R., Wight, T. N. and Chait, A. (2004). Thiazolidinedlones reduce the LDL binding affinity of non-human primate vascular cell proteoglycans. Diabetologia, 47 (5), 837-843. doi: 10.1007/s00125-004-1358-y

de Dios, Stephanie T., Bruemmer, Dennis, Dilley, Rodney J., Ivey, Melanie E., Jennings, Garry L.R., Law, Ronald E. and Little, Peter J. (2003). Inhibitory activity of clinical thiazolidinedione peroxisome proliferator activating receptor-γ ligands toward internal mammary artery, radial artery, and saphenous vein smooth muscle cell proliferation. Circulation, 107 (20), 2548-2550. doi: 10.1161/01.CIR.0000074040.31731.96

Hannan, Katherine M., Dilley, Rodney J., de Dios, Stephanie T. and Little, Peter J. (2003). Troglitazone stimulates repair of the endothelium and inhibits neointimal formation in denuded rat aorta. Arteriosclerosis, Thrombosis, and Vascular Biology, 23 (5), 762-768. doi: 10.1161/01.ATV.0000069210.46539.0D

Solin, Peter, Kaye, David M., Little, Peter J., Bergin, Peter, Richardson, Meroula and Naughton, Matthew T (2003). Impact of sleep apnea on sympathetic nervous system activity in heart failure. Chest, 123 (4), 1119-1126. doi: 10.1378/chest.123.4.1119

Little, Peter J., Allen, Terri J., Hashimura, Kazuhiko, Nigro, Julie, Farrelly, Caroline A. and Dilley, Rodney J. (2003). High glucose potentiates mitogenic responses of cultured ovine coronary smooth muscle cells to platelet derived growth factor and transforming growth factor-β1. Diabetes Research and Clinical Practice, 59 (2), 93-101. doi: 10.1016/S0168-8227(02)00201-2

Nigro, Julie, Dilley, Rodney J. and Little, Peter J. (2002). Differential effects of gemfibrozil on migration, proliferation and proteoglycan production in human vascular smooth muscle cells. Atherosclerosis, 162 (1), 119-129. doi: 10.1016/S0021-9150(01)00704-3

Ling, SH, Little, PJ, Williams, MRI, Dai, A, Hashimura, K, Liu, JP, Komesaroff, PA and Sudhir, K (2002). High glucose abolishes the antiproliferative effect of 17 beta-estradiol in human vascular smooth muscle cells. American Journal of Physiology-Endocrinology and Metabolism, 282 (4), E746-E751. doi: 10.1152/ajpendo.00111.2001

Little, Peter J., Tannock, Lisa, Olin, Katherine L., Chait, Alan and Wight, Thomas N. (2002). Proteoglycans synthesized by arterial smooth muscle cells in the presence of transforming growth factor-β1 exhibit increased binding to LDLs. Arteriosclerosis, Thrombosis, and Vascular Biology, 22 (1), 55-60. doi: 10.1161/hq0102.101100

Tannock, LR, Little, PJ, Wight, TN and Chait, A (2002). Arterial smooth muscle cell proteoglycans synthesized in the presence of glucosamine demonstrate reduced binding to LDL. Journal of Lipid Research, 43 (1), 149-157.

Sudhir, Krishnankutty, Hashimura, Kazuhiko, Bobik, Alex, Dilley, Rodney J., Jennings, Garry L. and Little, Peter J. (2001). Mechanical strain stimulates a mitogenic response in coronary vascular smooth muscle cells via release of basic fibroblast growth factor. American Journal of Hypertension, 14 (11), 1128-1134. doi: 10.1016/S0895-7061(01)02189-6

de Dios, Stephanie T., Hannan, Katherine M., Dilley, Rodney J., Hill, Michael A. and Little, Peter J. (2001). Troglitazone, but not rosiglitazone, inhibits Na/H exchange activity and proliferation of macrovascular endothelial cells. Journal of Diabetes and its Complications, 15 (3), 120-127. doi: 10.1016/S1056-8727(01)00141-6

Jandeleit-Dahm, K, Hannan, KM, Farrelly, CA, Allen, TJ, Rumble, JR, Gilbert, RE, Cooper, ME and Little, PJ (2000). Diabetes-induced vascular hypertrophy is accompanied by activation of Na+-H+ exchange and prevented by Na+-H+ exchange inhibition. Circulation Research, 87 (12), 1133-1140. doi: 10.1161/01.RES.87.12.1133

Scanlan, MF, Roebuck, T, Little, PJ, Redman, JR and Naughton, MT (2000). Effect of moderate alcohol upon obstructive sleep apnoea. European Respiratory Journal, 16 (5), 909-913. doi: 10.1183/09031936.00.16590900

Solin, P., Little, P. J., Roebuck, T., Richardson, M., Bergin, P., Kaye, D. M., Walters, E. H. and Naughton, M. T. (1999). Overnight urinary noradrenaline and awake pulmonary capillary wedge pressure in heart failure with central sleep apnoea. Respirology, 4 (SUPPL. 1)

Speed, CJ, Neylon, CB, Little, PJ and Mitchell, CA (1999). Underexpression of the 43 kDa inositol polyphosphate 5-phosphatase is associated with spontaneous calcium oscillations and enhanced calcium responses following endothelin-1 stimulation. Journal of Cell Science, 112 (5), 669-679.

Haikerwal, D, Dart, AM, Little, PJ and Kaye, DM (1999). Identification of a novel, inhibitory action of amiodarone on vesicular monoamine transport. Journal of Pharmacology and Experimental Therapeutics, 288 (2), 834-837.

Autelitano, DJ, Tang, F and Little, PJ (1999). Rapid regulation of adrenomedullin in metabolically compromised vascular smooth muscle cells. Journal of Hypertension, 17 (3), 373-379. doi: 10.1097/00004872-199917030-00010

Du, XJ, Woodcock, EA, Little, PJ, Esler, MD and Dart, AM (1998). Protection of neuronal uptake-1 inhibitors in ischemic and anoxic hearts by norepinephrine-dependent and -independent mechanisms. Journal of Cardiovascular Pharmacology, 32 (4), 621-628. doi: 10.1097/00005344-199810000-00015

Stepanova, V, Bobik, A, Bibilashvily, R, Belogurov, A, Rybalkin, I, Domogatsky, S, Little, PJ, Goncharova, E and Tkachuk, V (1997). Urokinase plasminogen activator induces smooth muscle cell migration: Key role of growth factor-like domain. FEBS Letters, 414 (2), 471-474. doi: 10.1016/S0014-5793(97)00993-9

Du, XJ, Bobik, A, Little, PJ, Esler, MD and Dart, AM (1997). Role of Ca2+ in metabolic inhibition-induced norepinephrine release in rat brain synaptosomes. Circulation Research, 80 (2), 179-188. doi: 10.1161/01.RES.80.2.179

Tkachuk, V, Stepanova, V, Little, PJ and Bobik, A (1996). Regulation and role of urokinase plasminogen activator in vascular remodelling. Clinical and Experimental Pharmacology and Physiology, 23 (9), 759-765. doi: 10.1111/j.1440-1681.1996.tb01177.x

Speed, CJ, Little, PJ, Hayman, JA and Mitchell, CA (1996). Underexpression of the 43 kDa inositol polyphosphate 5-phosphatase is associated with cellular transformation. Embo Journal, 15 (18), 4852-4861.

Smith, RE, Little, PJ, Maguire, JA, SteinOakley, AN and Krozowski, ZS (1996). Vascular localization of the 11 beta-hydroxysteroid dehydrogenase type II enzyme. Clinical and Experimental Pharmacology and Physiology, 23 (6-7), 549-551. doi: 10.1111/j.1440-1681.1996.tb02776.x

McClive, PJ, Little, PJ and Morahan, G (1996). Na+/H+ exchanger-1 alleles: Strain distribution and correlation with activity. Immunogenetics, 43 (3), 163-164.

Speed, Caroline J., Little, Peter J., Hayman, John A. and Mitchell, Christina A. (1996). Underexpression of the 43 KDA inositol polyphosphate 5-phosphatase is associated with cellular transformation. Biochemical Society Transactions, 24 (4)

Bochkov, VN, Sorokin, EV, Byzova, TV, Mazurov, AV, Little, P, Bobick, A and Tkachuk, VA (1995). Glycoproteins Iib/iiia Involved in the Activation of Human Platelets by Low-Density Lipoproteins. Biochemistry-Moscow, 60 (8), 897-902.

Bochkov, V. N., Sorokin, E. V., Byzova, T. V., Mazurov, A. V., Little, P., Bobik, A. and Tkachuk, V. A. (1995). Do glycoproteins IIb/IIIa participate in activation of human platelet s by low density lipoproteins? Uchastvuiut li glikoproteidy IIb/IIIa v aktivatsii trombotsitov cheloveka lipoproteidami nizkoǐ plotnosti?. Biokhimiya, 60 (8), 1187-1194.

Little, P. J., Neylon, C. B., Farrelly, C. A., Weissberg, P. L., Cragoe Jr., E. J. and Bobik, A. (1995). Intracellular pH in vascular smooth muscle: Regulation by sodium-hydrogen exchange and multiple sodium dependent HCO3- mechanisms. Cardiovascular Research, 29 (2), 239-246. doi: 10.1016/0008-6363(96)88576-2

Morahan, G, McClive, P, Huang, DX, Little, P and Baxter, A (1994). Genetic and physiological association of diabetes susceptibility with raised Na+/H+ exchange activity. Proceedings of the National Academy of Sciences of the United States of America, 91 (13), 5898-5902. doi: 10.1073/pnas.91.13.5898

Neylon, CB, Bryant, SM, Little, PJ and Bobik, A (1994). Transforming growth factor-β1 regulates the expression of ryanodine-sensitive Ca2+ oscillations in cardiac myocytes. Biochemical and Biophysical Research Communications, 204 (2), 678-684. doi: 10.1006/bbrc.1994.2513

Little, PJ, Neylon, CB, Farrelly, CA, Weissberg, PL, Cragoe, EJ and Bobik, A (1994). Intracellular pH in vascular smooth muscle: Regulation by sodium-hydrogen exchange and multiple sodium dependent HCO3 mechanisms. Cardiovascular Research, 28 (9), 239-246. doi: 10.1016/S0008-6363(96)88576-2

Yun, Chc, Little, PJ, Nath, SK, Levine, SA, Pouyssegur, J, Tse, CM and Donowitz, M (1993). Leu143 in the Putative Fourth Membrane Spanning Domain Is Critical for Amiloride Inhibition of an Epithelial Na+/H+ Exchanger Isoform (NHE-2). Biochemical and Biophysical Research Communications, 193 (2), 532-539. doi: 10.1006/bbrc.1993.1656

Tse, Chung-Ming, Levine, Susan A., Yun, C. H. Chris, Montrose, Marshall H., Little, Peter J., Pouyssegur, Jacques and Donowitz, Mark (1993). Cloning and expression of a rabbit cDNA encoding a serum-activated ethylisopropylamiloride-resistant epithelial Na+/H+ exchanger isoform (NHE-2). Journal of Biological Chemistry, 268 (16), 11917-11924.

Agrotis, A, Little, PJ, Saltis, J and Bobik, A (1993). Dihydropyridine Ca2+ channel antagonists inhibit the salvage pathway for DNA synthesis in human vascular smooth muscle cells. European Journal of Pharmacology: Molecular Pharmacology, 244 (3), 269-275. doi: 10.1016/0922-4106(93)90152-Y

Neylon, Craig B., Nickashin, Alex, Little, Peter J., Tkachuk, Vsevolod A. and Bobik, Alex (1992). Thrombin-induced Ca2+ mobilization in vascular smooth muscle utilizes a slowly ribosylating pertussis toxin-sensitive G protein: evidence for the involvement of a G protein in inositol trisphosphate-dependent Ca2+ release. Journal of Biological Chemistry, 267 (11), 7295-7302.

Little, PJ, Neylon, CB, Tkachuk, VA and Bobik, A (1992). Endothelin-1 and endothelin-3 stimulate calcium mobilization by different mechanisms in vascular smooth muscle. Biochemical and Biophysical Research Communications, 183 (2), 694-700. doi: 10.1016/0006-291X(92)90538-V

Saltis, J, Little, P and Bobik, A (1991). Multiple Growth Abnormalities in Vascular Smooth-Muscle From Spontaneously Hypertensive Rats. Clinical and Experimental Pharmacology and Physiology, 18 (5), 319-322. doi: 10.1111/j.1440-1681.1991.tb01454.x

Bobik, A, Grooms, A, Little, PJ, Cragoe, EJ and Grinpukel, S (1991). Ethylisopropylamiloride-Sensitive Ph Control Mechanisms Modulate Vascular Smooth-Muscle Cell-Growth. American Journal of Physiology, 260 (3), C581-C588. doi: 10.1152/ajpcell.1991.260.3.C581

Bobik, A, Little, PJ and Neylon, CB (1991). Ionic Mechanisms Regulating Sodium Entry Into Vascular Smooth-Muscle. Clinical and Experimental Pharmacology and Physiology, 18 (2), 117-120. doi: 10.1111/j.1440-1681.1991.tb01419.x

Woodcock, EA, Little, PJ and Tanner, JK (1990). Inositol Phosphate Release and Steroidogenesis in Rat Adrenal Glomerulosa Cells - Comparison of the Effects of Endothelin, Angiotensin-Ii and Vasopressin. Biochemical Journal, 271 (3), 791-796. doi: 10.1042/bj2710791

Neylon, CB, Little, PJ, Cragoe, EJ and Bobik, A (1990). Intracellular Ph in Human Arterial Smooth-Muscle - Regulation by Na+/h+ Exchange and a Novel 5-(N-Ethyl-N-Isopropyl)Amiloride-Sensitive Na+-Dependent and Hco3--Dependent Mechanism. Circulation Research, 67 (4), 814-825. doi: 10.1161/01.RES.67.4.814

Bobik, A, Neylon, CB, Little, PJ, Cragoe, EJ and Weissberg, PL (1990). Sodium-Dependent, Ethylisopropylamiloride-Sensitive Mechanisms Regulate Intracellular Ph in Human Vascular Smooth-Muscle. Clinical and Experimental Pharmacology and Physiology, 17 (4), 297-301. doi: 10.1111/j.1440-1681.1990.tb01324.x

Woodcock, EA, Tanner, JK, Caroccia, LM and Little, PJ (1990). Mechanisms Involved in the Stimulation of Aldosterone Production by Angiotensin-Ii, Vasopressin and Endothelin. Clinical and Experimental Pharmacology and Physiology, 17 (4), 263-267. doi: 10.1111/j.1440-1681.1990.tb01318.x

Bobik, A, Grinpukel, S, Little, PJ, Grooms, A and Jackman, G (1990). Angiotensin II and noradrenaline increase PDGF-BB receptors and potentiate PDGF-BB stimulated DNA synthesis in vascular smooth muscle. Biochemical and Biophysical Research Communications, 166 (2), 580-588. doi: 10.1016/0006-291X(90)90848-H

Woodcock, EA, Caroccia, L, McLeod, JK and Little, PJ (1990). Different Inositol Phosphate Responses to Angiotensin-Ii and Vasopressin in Rat Adrenal Glomerulosa Cells. Advances in Second Messenger and Phosphoprotein Research, 24, 134-139.

Weissberg, PL, Little, PJ and Bobik, A (1989). Spontaneous Oscillations in Cytoplasmic Calcium-Concentration in Vascular Smooth-Muscle. American Journal of Physiology, 256 (5), C951-C957.

Weissberg, PL, Little, PJ, Cragoe, EJ and Bobik, A (1989). The Ph of Spontaneously Beating Cultured Rat-Heart Cells Is Regulated by An Atp-Calmodulin-Dependent Na+/h+ Antiport. Circulation Research, 64 (4), 676-685. doi: 10.1161/01.RES.64.4.676

Bobik, A, Grooms, A, Grinpukel, S and Little, PJ (1988). The Effects of Alterations in Membrane Sodium-Transport On Rat Aortic Smooth-Muscle Proliferation. Journal of Hypertension, 6 (4), S219-S221. doi: 10.1097/00004872-198812040-00065

Little, Peter J., Weissberg, Peter L., Cragoe, Edward J. and Bobik, Alex (1988). Dependence of Na+/H+ antiport activation in cultured rat aortic smooth muscle on calmodulin, calcium, and ATP: evidence for the involvement of calmodulin-dependent kinases. Journal of Biological Chemistry, 263 (32), 16780-16786.

Cocks, TM, Little, PJ, Angus, JA and Cragoe, EJ (1988). Amiloride Analogs Cause Endothelium-Dependent Relaxation in the Canine Coronary-Artery Invitro - Possible Role of Na+/ca2+ Exchange. British Journal of Pharmacology, 95 (1), 67-76. doi: 10.1111/j.1476-5381.1988.tb16549.x

Bobik, A, Weissberg, PL and Little, PJ (1988). Spontaneous Oscillations in Cytoplasmic Free Calcium-Concentration in Vascular Smooth-Muscle - a Potential Mechanism Associated with Myogenic Tone. Clinical and Experimental Pharmacology and Physiology, 15 (4), 281-284. doi: 10.1111/j.1440-1681.1988.tb01073.x

Scott, PJ, Little, PJ and Bobik, A (1988). Circulating Digoxin-Like Immunoreactivity in Renal Hypertensive Rabbits - Lack of Modulation by Alterations in Dietary-Sodium Intake. Journal of Hypertension, 6 (3), 205-209. doi: 10.1097/00004872-198803000-00004

Little, P. J., Weissberg, P. L., Cragoe Jr., E. J. and Bobik, A. (1988). Mechanisms influencing sodium entry to cultured vascular smooth muscle. Progress in biochemical pharmacology, 23, 142-149.

Weissberg, PL, Little, PJ, Cragoe, EJ and Bobik, A (1987). Na-H Antiport in Cultured Rat Aortic Smooth-Muscle - its Role in Cytoplasmic Ph Regulation. American Journal of Physiology, 253 (2), C193-C198. doi: 10.1152/ajpcell.1987.253.2.C193

Bobik, A, Weissberg, PL and Little, PJ (1987). Regulation of Sodium Influx and Sodium, Potassium Pump Activity by a Sodium-Hydrogen Antiport in Rat Vascular Smooth-Muscle. Clinical and Experimental Pharmacology and Physiology, 14 (3), 191-195. doi: 10.1111/j.1440-1681.1987.tb00374.x

Weissberg, P. L., Little, P. J. and Bobik, A. (1986). Glimpses of the mechanisms of hypertension. BMJ, 293 (6559), 1436-1437. doi: 10.1136/bmj.293.6559.1436-c

Little, PJ, Cragoe, EJ and Bobik, A (1986). Na-H Exchange Is a Major Pathway for Na Influx in Rat Vascular Smooth-Muscle. American Journal of Physiology, 251 (5), C707-C712. doi: 10.1152/ajpcell.1986.251.5.C707

Rosenfeldt, F.L., Rabinov, M., Little, P. and Campbell, G. (1986). The Relationship Between Coronary Pressure During Reperfusion and Myocardial Recovery After Hypothermic Cardioplegia. Journal of Thoracic and Cardiovascular Surgery, 92 (3), 414-424.

Little, PJ, James, MO, Foureman, GL, Weatherby, RP and Bend, JR (1986). 1-C-14 N-Hexadecane Disposition in the Spiny Lobster, Panulirus-Argus and the American Lobster, Homarus-Americanus. Journal of Environmental Pathology Toxicology and Oncology, 6 (5-6), 13-27.

Little, P. J., James, M. O. and Foureman, G. L. (1986). 1-14C-n-hexadecane disposition in the spiny lobster, Panulirus argus and the American lobster, Homarus americanus. Journal of Environmental Pathology, Toxicology and Oncology, 6 (5-6), 13-27.

Little, PJ and Bobik, A (1985). Effects of alterations in cell phenotype and hypokalemia on sodium-potassium pump activity in rabbit vascular smooth muscle. Clinical and Experimental Hypertension, A7 (11), 1563-1582. doi: 10.3109/10641968509073610

LITTLE, PJ, JAMES, MO, PRITCHARD, JB and BEND, (1985). TEMPERATURE-DEPENDENT DISPOSITION OF [C-14] BENZO(A)PYRENE IN THE SPINY LOBSTER, PANULIRUS-ARGUS. Toxicology and Applied Pharmacology, 77 (2), 325-333. doi: 10.1016/0041-008X(85)90332-1

Esler, M. D., Jennings, G. L., Johns, J., Burke, F., Little, P. J. and Leonard, P. (1984). Estimation of 'total' renal, cardiac and splanchnic sympathetic nervous tone in essential hypertension from measurements of noradrenaline release. Journal of Hypertension, 2 (SUPPL. 3), 123-125.

Little, PJ, James, MO, Pritchard, JB and Bend, JR (1984). Benzo(A)Pyrene Metabolism in Hepatic Microsomes From Feral and 3-Methycholanthrene-Treated Southern Flounder, Paralichthys-Lethostigma. Journal of Environmental Pathology Toxicology and Oncology, 5 (4-5), 309-320.

James, MO and Little, PJ (1984). 3-Methylcholanthrene does not induce in vitro xenobiotic metabolism in spiny lobster hepatopancreas, or affect in vivo disposition of benzo[a]pyrene. Comparative Biochemistry and Physiology. Part C, Comparative, 78 (1), 241-245. doi: 10.1016/0742-8413(84)90076-8

Esler, M, Willett, I, Leonard, P, Hasking, G, Johns, J, Little, P and Jennings, G (1984). Plasma noradrenaline kinetics in humans. Journal of the Autonomic Nervous System, 11 (2), 125-144. doi: 10.1016/0165-1838(84)90071-7

Bobik, A and Little, PJ (1984). Role of Cyclic-Amp in Cardiac Beta-Adrenoceptor Desensitization - Studies Using Prenalterol and Inhibitors of Phosphodiesterase. Journal of Cardiovascular Pharmacology, 6 (5), 795-801. doi: 10.1097/00005344-198409000-00009

Little, PJ, Campbell, JH, Skews, H and Bobik, A (1984). Mechanism of Isoprenaline Induced Desensitization of Rabbit Aortic Smooth-Muscle Beta-Adrenoceptor Responses. Clinical and Experimental Pharmacology and Physiology, 11 (5), 503-511.

Bobik, A, Campbell, JH and Little, PJ (1984). Desensitization of the Alpha1-Adrenoceptor System in Vascular Smooth-Muscle. Biochemical Pharmacology, 33 (7), 1143-1145. doi: 10.1016/0006-2952(84)90527-6

Ohehir, R, Esler, M, Jennings, G, Leonard, P, Little, P, Johns, J and Panetta, F (1984). 2 Patients with Abnormalities of Regional Sympathetic Nervous Tone. Australian and New Zealand Journal of Medicine, 14 (6), 855-859. doi: 10.1111/j.1445-5994.1984.tb03789.x

Bobik, A, Campbell, J, Snow, P and Little, PJ (1983). The effects of endogenous phospholipase A2 activation on beta adrenoceptor function in cardiac cells. Journal of Molecular and Cellular Cardiology, 15 (11), 759-767. doi: 10.1016/0022-2828(83)90335-8

James, MO and Little, PJ (1983). Modification of Benzo(A)Pyrene Metabolism in Hepatic Microsomes From Untreated and Induced Rats by Imidazole Derivatives Which Inhibit Monooxygenase Activity and Enhance Epoxide Hydrolase Activity. Drug Metabolism and Disposition, 11 (4), 350-354.

Little, PJ and Ryan, AJ (1982). Inhibitors of hepatic mixed function oxidases-V. Inhibition of aminopyrine N-demethylation and enhancement of aniline hydroxylation by benzoxazole derivatives. Biochemical Pharmacology, 31 (9), 1795-1798. doi: 10.1016/0006-2952(82)90690-6

Murray, M, Ryan, AJ and Little, PJ (1982). Inhibition of Rat Hepatic-Microsomal Aminopyrine N-Demethylase Activity by Benzimidazole Derivatives - Quantitative Structure Activity Relationships. Journal of Medicinal Chemistry, 25 (8), 887-892. doi: 10.1021/jm00350a002

Little, PJ, Jennings, GL, Skews, H and Bobik, A (1982). Bioavailability of Dihydroergotamine in Man. British Journal of Clinical Pharmacology, 13 (6), 785-790. doi: 10.1111/j.1365-2125.1982.tb01866.x

Little, PJ and Ryan, AJ (1982). Inhibitors of Hepatic Mixed-Function Oxidases .4. Effects of Benzimidazole and Related-Compounds On Aryl-Hydrocarbon Hydroxylase-Activity From Phenobarbitone and 3-Methylcholanthrene Induced Rats. Journal of Medicinal Chemistry, 25 (6), 622-626. doi: 10.1021/jm00348a003

Little, P. J., Campbell, J. and Bobik, A. (1982). Agonist-induced modulation of β-adrenoceptor responsiveness in cultured rabbit aorta smooth muscle cells. Clinical and Experimental Pharmacology and Physiology, 9 (4)

Little, PJ, James, MO, Bend, JR and

Emeritus Professor Peter Little

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