Researcher biography

Christine graduated with a Bachelor of Pharmacy degree (honours class 1) from the University of Queensland in 1996.

She registered as a pharmacist in Australia in 1997 and in the United Kingdom in 2003 and has worked at the Redlands, Princess Alexandra and Wesley Hospitals in Brisbane and the Western Infirmary in Glasgow. In 2002 she was awarded a PhD from the University of Queensland, with a thesis focusing on improving usage of the immunosuppressant agent tacrolimus in solid organ transplant recipients.

In 2004 she was the recipient of a National Health and Medical Research Council (NHMRC) Neil Hamilton Fairley fellowship. This award enabled her to training overseas in the field of Pharmacometrics within the Department of Medicine and Therapeutics at the University of Glasgow (Scotland) and the Department of Pharmaceutical Biosciences at Uppsala University (Sweden).

On her return to Brisbane, Christine was the recipient of a Lions Medical Research Fellowship and was the chief investigator on a three year NHMRC Project Grant. She has also been a team member on an Amgen-Transplant Society of Australia and New Zealand Research Grant and a Cellcept Australia Research Grant. Over her research career Christine has attracted grants and awards totaling more than 1.7 million AUD from various funding agencies.

Research Interests

Christine has a wide range of interests in the fields of Quality Use of Medicine and Pharmacometrics. Her work to date has primarily been directed towards optimising usage of immunosuppressant drugs in solid organ transplant recipients and antibiotics in patients with life-threatening infections.

Christine has published over 70 peer reviewed papers and 75 conference abstracts on these topics. Her publications have been cited on more than 2700 occasions, with twelve cited more than 50 times.

Christine has successfully supervised to completion fourteen higher research degree students and enjoys helping students meet their career goals.

Christine's current projects include:

  • Individualising immunosuppressant therapy in autoimmune disease to improve patient outcomes
  • Comparing the efficacy and safety of continuous versus intermittent administration of beta-lactams in critically ill patients
  • Examining the relationship between immunosuppression and non-melanoma skin cancer in renal transplant recipients
  • Improving individualisation of immunosuppressant therapy in adult kidney transplant recipients
  • Improving gentamycin dosing in paediatric oncology patients
  • Examining tobramycin monitoring in cystic fibrosis patients in Australia and the United Kingdom
  • Investigating the relationship between prednisolone exposure and drug-related toxicity in paediatric and adult kidney transplant recipients
  • Comparing different therapeutic drug monitoring methods for dosage adjustment of once daily intravenous tobramycin treatment in children with cystic fibrosis

Projects currently available for interested research higher degree students include:

  • Population pharmacokinetic and pharmacodynamic modeling of the newer immunosuppressant drugs
  • Investigating the relationship between prednisolone exposure and drug-related toxicity in transplant recipients
  • Developing a limited sampling strategy for sirolimus in adult kidney transplant recipients
  • Examining the international use of immunosuppressant and anti-rheumatic drugs
  • Population pharmacokinetic and pharmacodynamic modeling of gentamycin therapy in paediatric oncology patients
  • Examining the influence of plasma exchange on immunosuppressant drug exposure

Christine invites potential honours and post-graduate students to contact her via email to discuss research opportunities.

Teaching interests

Co-ordinates:

  • PHRM3052- Biological Fate of Drugs

Teaches in:

  • PHRM3052- Biological Fate of Drugs
  • PHRM3011- Quality Use of Medicines