Greg studies cellular signalling in disease and the identification of new drug targets.
Following his PhD at the University of Sydney, Greg spent two years at the University of Maryland at Baltimore (USA) in the Department of Physiology, developing novel techniques for the assessment of calcium (Ca2+) in sub-cellular organelles. Since his appointment at the University of Queensland, Greg has established a research program with research funding via NHMRC and National Heart Foundation, Queensland Cancer Fund, Society of biomolecular Screening (USA) and other grants and collaboration with Pharmaceutical companies. His interests are signal transduction in disease, calcium transporters as drug targets and biomolecular screening. In 2006 he recieved a UQ Foundation research excellence award.
Davis FM, Janoshazi A, Janardhan KS, Steinckwich N, D'Agostin DM, Petranka JG, Desai PN, Roberts-Thomson SJ, Bird GS, Tucker DK, Fenton SE, Feske S, Monteith GR, Putney JW Jr. Essential role of Orai1 store-operated calcium channels in lactation. Proc Natl Acad Sci U S A. 5;112(18):5827-32. 2015.
Davis FM, Stewart TA, Thompson EW, Monteith GR. Targeting EMT in cancer: opportunities for pharmacological intervention. Trends Pharmacol Sci. 35:479-88, 2014.
Azimi I, Roberts-Thomson SJ, Monteith GR. Calcium influx pathways in breast cancer: opportunities for pharmacological intervention. Br J Pharmacol. 171:945-60.,2014
Davis FM1, Azimi I, Faville RA, Peters AA, Jalink K, Putney JW Jr, Goodhill GJ, Thompson EW, Roberts-Thomson SJ, Monteith GR. Induction of epithelial-mesenchymal transition (EMT) in breast cancer cells is calcium signal dependent. Oncogene. doi: 10.1038/onc.2013.187, 2013
Peters AA, Simpson PT, Bassett JJ, Lee JM, Da Silva L, Reid LE, Song S, Parat MO, Lakhani SR, Kenny PA, Roberts-Thomson SJ, Monteith GR. Calcium channel TRPV6 as a potential therapeutic target in estrogen receptor-negative breast cancer. Mol Cancer Ther.;11:2158-68, 2012
Feng M, Grice D, Faddy H, Nguyen N, Leitch S, Wang Y, Muend S, Kenny P, Sukumar S, Roberts-Thomson SJ, Monteith GR, Rao R. Store-Independent Activation of Orai1 by SPCA2 in Mammary Tumors. Cell. 143: 84-98. 2010
Monteith GR, McAndrew D, Faddy HM, Roberts-Thomson SJ. Calcium and cancer: targeting Ca2+ transport. Nature Reviews Cancer. 7:519-30, 2007
Monteith GR and Bird St J. High throughput measurement of calcium: back to basics. Trends in Pharmacological Sciences 26(4):218-23, 2005