Our laboratory has studied in depth the effect of morphine on tumour growth and metastasis in vitro and in vivo. In addition to opioid receptor-mediated actions, opioids are able to interact with the non-opioid receptor TLR4 which is present on cancer and stromal, especially immune cells in a tumour. We now propose to test the effect of the opioid receptor-inactive but TLR4 active morphine metabolite M3G on tumour growth and metastasis in vitro. The project will involve cell-based assays.

Expected outcomes and deliverables:

Successful applicants can expect to learn laboratory based techniques such as cell culture or qRT-PCR, generate data, analyse them and organize them for dissemination.

Suitable for:

This project is open to applications from students with laboratory skills and a background in pharmacy, chemistry, biology. Previous experience with cell culture or qRT-PCR is an advantage.

Project members

Associate Professor Marie-Odile Parat

Chief Examiner
Associate Professor
School of Pharmacy