Associate Professor Marie-Odile Parat
Chief Examiner
Associate Professor
School of Pharmacy
+61 7 334 61851
Researcher biography
Marie-Odile Parat (MO) joined the School of Pharmacy as Senior Lecturer in December 2007.
MO obtained her Pharm.D. from University Joseph Fourier in Grenoble, France, a Masters in Cutaneous Biology from University Claude Bernard in Lyon, France and her Ph.D. in Cell Biology from University Joseph Fourier in Grenoble, France. She further has post graduate diplomas in the fields of Biomedical and Industrial Pharmacy, Photobiology, Pharmaceutical Management, and Public Health.
MO did her Pharmaceutical Residency at the University Hospitals of Grenoble, France in the Sterile Pharmaceutical Supplies Headquarters, the Department of Nuclear Medicine, and the Laboratory Medicine Department of Biochemistry. Attracted by international working experience, she carried out research within the R&D laboratories of Estee Lauder in Melville, NY. She further worked for the United Nations International Trade center in Geneva, Switzerland, where she was the Product Specialist on market information for pharmaceutical raw materials/essential drugs for three years in collaboration with the World Health Organization.
She later performed post-doctoral research in the Universidade de São Paulo, SP, Brasil and The Cleveland Clinic Foundation in the United States. She was appointed as a Staff Scientist in the Center for Anesthesiology Research of the Cleveland Clinic in 2003, an Assistant Professor of Molecular Medicine in the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, and a Member of the Case Cancer Center.
During her research career MO has attracted awards from various funding agencies including the Research Funding Agency of the State of São Paulo (FAPESP), the American Heart Association, the Ohio Cancer Research Associates, the American Cancer Society, the National Heart Foundation of Australia, Cancer Council Queensland, Australian and New Zealand College of Anaesthetists and the Australia Research Council (ARC).
The long term goal of the Parat laboratory is to provide insight for novel cancer therapies. A basic science team focusses on endothelial and cancer cell migration, invasion, angiogenesis, and specialized plasma membrane subdomains termed caveolae. A translational axis of research evaluates novel mechanisms by which opioids administered to cancer patients modulate the risk of long term tumour recurrence and metastasis.
| Featured projects | Duration |
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| Morphine metabolites and tumour growth and metastasis |
Book Chapters
Saeed, Iqira, La Caze, Adam, Shaw, Paul N. and Parat, Marie-Odile (2022). Opioids and cancer. Perioperative Care of The Cancer Patient. (pp. 140-154) edited by Carin Hagberg, Joseph Nates , Berhard Riedel, Vijaya Gottumukkala and Donal Buggy. Philadelphia, PA United States: Elsevier. doi: 10.1016/B978-0-323-69584-8.00012-8
Nassar, Zeyad D. and Parat, Marie-Odile (2015). Cavin family: new players in the biology of caveolae. International review of cell and molecular biology. (pp. 235-306) edited by Kwang W. Jeon. Maryland Heights, MO, United States: Academic Press. doi: 10.1016/bs.ircmb.2015.07.009
Buggy, Donal, Shannon, Hilary and Parat, Marie-Odile (2013). Could opioids affect cancer recurrence or metastases? Current experimental and translational evidence. Morphine and metastasis. (pp. 79-94) edited by Marie-Odile Parat. Dordrecht , Netherlands: Springer. doi: 10.1007/978-94-007-5678-6_6
Parat, Marie-Odile (2013). Morphine and metastasis: from bench to bedside. Morphine and metastasis. (pp. 1-13) edited by Marie-Odile Para. Dordrecht, Netherlands: Springer. doi: 10.1007/978-94-007-5678-6_1
Parat, Marie-Odile (2009). The biology of caveolae: Achievements and perspectives. International review of cell and molecular biology. (pp. 117-162) edited by Kwang W. Jeon. Maryland Heights, MO, United States: Academic Press. doi: 10.1016/S1937-6448(08)01804-2
Parat, Marie-Odile and Fox, Paul L. (2004). Oxidative Stress, Caveolae and Caveolin-1. Membrane dynamics and domains. (pp. 425-441) edited by Peter. J. Quinn. New York: Springer.
Parat, Marie-Odile and Fox, Paul L (2004). Oxidative stress, caveolae and caveolin-1. Membrane Dynamics and Domains. (pp. 425-441) edited by Quinn, Peter J.. Boston. MA, United States: Springer. doi: 10.1007/978-1-4757-5806-1_13
Journal Articles
Thapa, Ritu, Pandey, Preeti, Parat, Marie-Odile, Gurung, Shila and Parekh, Harendra S. (2024). Phase transforming in situ gels for sustained and controlled transmucosal drug delivery via the intravaginal route. International Journal of Pharmaceutics, 655 124054, 124054. doi: 10.1016/j.ijpharm.2024.124054
Thew, Hin Yee, Boon Keat, Khor, Tan, Yong Chiang, Ong, Yong Sze, Parat, Marie-Odile, Murugaiyah, Vikneswaran, Goh, Bey Hing and Khaw, Kooi Yeong (2024). Probing the anti-Aβ42 aggregation and protective effects of prenylated xanthone against Aβ42-induced toxicity in transgenic Caenorhabditis elegans model. Chemico-Biological Interactions, 394 110978, 110978. doi: 10.1016/j.cbi.2024.110978
Muusse, Timothy W., Lee, Morris Y.L., Kim, Hyoyoung, Parat, Marie-Odile, Nanson, Jeffrey D., Kobe, Bostjan, Vajjhala, Parimala R. and Stacey, Katryn J. (2022). Flow cytometric reporter assays provide robust functional analysis of signaling complexes. Journal of Biological Chemistry, 298 (12) 102666, 102666. doi: 10.1016/j.jbc.2022.102666
Yang, Dan, Zheng, Qiuda, Ahmed, Fahad, Parat, Marie-Odile and Tscharke, Benjamin J. (2022). A simple liquid extraction for simultaneous determination of 12 opioid ligands in plasma by LC-MS/MS. Analytical Methods, 14 (15), 1523-1528. doi: 10.1039/d1ay01631h
Thapa, Ritu, Gurung, Shila, Parat, Marie-Odile, Parekh, Harendra S. and Pandey, Preeti (2022). Application of sol–gels for treatment of gynaecological conditions—physiological perspectives and emerging concepts in intravaginal drug delivery. Gels, 8 (2) 99, 99. doi: 10.3390/gels8020099
Scroope, Claudia A., Singleton, Zane, Hollmann, Markus W. and Parat, Marie-Odile (2021). Opioid receptor-mediated and non-opioid receptor-mediated roles of opioids in tumour growth and metastasis. Frontiers in Oncology, 11 792290, 792290. doi: 10.3389/fonc.2021.792290
Michell, Danielle L., Shihata, Waled A., Andrews, Karen L., Abidin, Nurul Aisha Zainal, Jefferis, Ann-Maree, Sampson, Amanda K., Lumsden, Natalie G., Huet, Olivier, Parat, Marie-Odile, Jennings, Garry L., Parton, Robert G., Woollard, Kevin J., Kaye, David M., Chin-Dusting, Jaye P. F. and Murphy, Andrew J. (2021). High intraluminal pressure promotes vascular inflammation via caveolin-1. Scientific Reports, 11 (1) 5894, 5894. doi: 10.1038/s41598-021-85476-z
Gabr, Mai Mahmoud, Saeed, Iqira, Miles, Jared A., Ross, Benjamin P., Shaw, Paul Nicholas, Hollmann, Markus W. and Parat, Marie-Odile (2021). Interaction of opioids with TLR4—mechanisms and ramifications. Cancers, 13 (21) 5274, 5274. doi: 10.3390/cancers13215274
Saeed, Iqira, La Caze, Adam, Hollmann, Markus W., Shaw, Paul N. and Parat, Marie-Odile (2021). New insights on tramadol and immunomodulation. Current Oncology Reports, 23 (11) 123, 123. doi: 10.1007/s11912-021-01121-y
Dinh, Thao Nhu, Parat, Marie-Odile, Ong, Yong Sze and Khaw, Kooi Yeong (2021). Anticancer activities of dietary benzyl isothiocyanate: A comprehensive review. Pharmacological Research, 169 105666, 105666. doi: 10.1016/j.phrs.2021.105666
McMahon, Kerrie-Ann, Stroud, David A., Gambin, Yann, Tillu, Vikas, Bastiani, Michele, Sierecki, Emma, Polinkovsky, Mark E., Hall, Thomas E., Gomez, Guillermo A., Wu, Yeping, Parat, Marie-Odile, Martel, Nick, Lo, Harriet P., Khanna, Kum Kum, Alexandrov, Kirill, Daly, Roger, Yap, Alpha, Ryan, Michael T. and Parton, Robert G. (2021). Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response. eLife, 10 e61407, 1-35. doi: 10.7554/elife.61407
Khaw, Kooi-Yeong, Shaw, Paul Nicholas, Parat, Marie-Odile, Pandey, Saurabh and Falconer, James Robert (2020). Compound identification and in vitro cytotoxicity of the supercritical carbon dioxide extract of papaya freeze-dried leaf juice. Processes, 8 (5) 610, 610. doi: 10.3390/pr8050610
Nassar, Zeyad D. and Parat, Marie-Odile (2020). Caveola-forming proteins and prostate cancer. Cancer and Metastasis Reviews, 39 (2), 415-433. doi: 10.1007/s10555-020-09874-x
Pu, Wenjun, Qiu, Jiawen, Nassar, Zeyad D., Shaw, Paul N., McMahon, Kerrie‐Ann, Ferguson, Charles, Parton, Robert G., Riggins, Gregory J., Harris, Jonathan M. and Parat, Marie‐Odile (2020). A role for caveola‐forming proteins caveolin‐1 and CAVIN1 in the pro‐invasive response of glioblastoma to osmotic and hydrostatic pressure. Journal of Cellular and Molecular Medicine, 24 (6) jcmm.15076, 3724-3738. doi: 10.1111/jcmm.15076
Pu, Wenjun, Qiu, Jiawen, Riggins, Gregory J. and Parat, Marie-Odile (2020). Matrix protease production, epithelial-to-mesenchymal transition marker expression and invasion of glioblastoma cells in response to osmotic or hydrostatic pressure. Scientific Reports, 10 (1) 2634, 2634. doi: 10.1038/s41598-020-59462-w
Weinsanto, Ivan, Mouheiche, Jinane, Laux-Biehlmann, Alexis, Delalande, Francois, Marquette, Arnaud, Chavant, Virginie, Gabel, Florian, Cianferani, Sarah, Charlet, Alexandre, Parat, Marie-Odile and Goumon, Yannick (2019). Corrigendum: Morphine binds creatine kinase B and inhibits its activity (vol 12, 464, 2018). Frontiers in Cellular Neuroscience, 13 292, 292. doi: 10.3389/fncel.2019.00292
Pu, Wenjun, Nassar, Zeyad D., Khabbazi, Samira, Xie, Nan, McMahon, Kerrie-Ann, Parton, Robert G., Riggins, Gregory J., Harris, Jonathan M. and Parat, Marie-Odile (2019). Correlation of the invasive potential of glioblastoma and expression of caveola-forming proteins caveolin-1 and CAVIN1. Journal of Neuro-Oncology, 143 (2), 207-220. doi: 10.1007/s11060-019-03161-8
Dighe, Satish N., De la Mora, Eugenio, Chan, Stephen, Kantham, Srinivas, McColl, Gawain, Miles, Jared A., Veliyath, Suresh Kumar, Sreenivas, B. Yogi, Nassar, Zeyad D., Silman, Israel, Sussman, Joel L., Weik, Martin, McGeary, Ross P., Parat, Marie-Odile, Brazzolotto, Xavier and Ross, Benjamin P. (2019). Rivastigmine and metabolite analogues with putative Alzheimer’s disease-modifying properties in a Caenorhabditis elegans model. Communications Chemistry, 2 (1) 35. doi: 10.1038/s42004-019-0133-4
Khaw, Kooi-Yeong, Parat, Marie-Odile, Shaw, Paul Nicholas, Nguyen, Thao T. T., Pandey, Saurabh, Thurecht, Kristofer J. and Falconer, James Robert (2019). Factorial design-assisted supercritical carbon-dioxide extraction of cytotoxic active principles from Carica papaya leaf juice. Scientific Reports, 9 (1) 1716, 1716. doi: 10.1038/s41598-018-37171-9
Weinsanto, Ivan, Mouheiche, Jinane, Laux-Biehlmann, Alexis, Delalande, Francois, Marquette, Arnaud, Chavant, Virginie, Gabel, Florian, Cianferani, Sarah, Charlet, Alexandre, Parat, Marie-Odile and Goumon, Yannick (2018). Morphine binds creatine kinase B and inhibits its activity. Frontiers in Cellular Neuroscience, 12 464, 464. doi: 10.3389/fncel.2018.00464
Weinsanto, Ivan, Laux-Biehlmann, Alexis, Mouheiche, Jinane, Maduna, Tando, Delalande, François, Chavant, Virginie, Gabel, Florian, Darbon, Pascal, Charlet, Alexandre, Poisbeau, Pierrick, Lamshöft, Marc, Van Dorsselaer, Alain, Cianferani, Sarah, Parat, Marie-Odile and Goumon, Yannick (2018). Stable isotope-labelled morphine to study in vivo central and peripheral morphine glucuronidation and brain transport in tolerant mice. British Journal of Pharmacology, 175 (19), 3844-3856. doi: 10.1111/bph.14454
Xie, Nan, Matigian, Nicholas, Vithanage, Tharindu D., Gregory, Kye, Nassar, Zeyad D., Cabot, Peter J., Shaw, Paul Nicholas, Kirkpatrick, Carl Mj, Lê Cao, Kim-Anh, Sturgess, David and Parat, Marie-Odile (2018). Effect of perioperative opioids on cancer-relevant circulating parameters: mu opioid receptor and TLR4 activation potential, and proteolytic profile. Clinical Cancer Research, 24 (10), 2319-2327. doi: 10.1158/1078-0432.CCR-18-0172
Weinsanto, Ivan, Mouheiche, Jinane, Laux-Biehlmann, Alexis, Aouad, Maya, Maduna, Tando, Petit-Demoulière, Nathalie, Chavant, Virginie, Poisbeau, Pierrick, Darbon, Pascal, Charlet, Alexandre, Giersch, Anne, Parat, Marie-Odile and Goumon, Yannick (2018). Lithium reverses mechanical allodynia through a mu opioid-dependent mechanism. Molecular Pain, 14, 1744806917754142. doi: 10.1177/1744806917754142
Kantham, Srinivas, Chan, Stephen, McColl, Gawain, Miles, Jared A., Veliyath, Suresh Kumar, Deora, Girdhar Singh, Dighe, Satish N., Khabbazi, Samira, Parat, Marie-Odile and Ross, Benjamin P. (2017). Effect of the Biphenyl Neolignan Honokiol on Aβ42-Induced Toxicity in Caenorhabditis elegans, Aβ42 Fibrillation, Cholinesterase Activity, DPPH Radicals, and Iron(II) Chelation. ACS Chemical Neuroscience, 8 (9), 1901-1912. doi: 10.1021/acschemneuro.7b00071
Deora, Girdhar Singh, Kantham, Srinivas, Chan, Stephen, Dighe, Satish N, Veliyath, Suresh K, McColl, Gawain, Parat, Marie-Odile, McGeary, Ross P and Ross, Benjamin P (2017). Multifunctional Analogs of Kynurenic Acid for the Treatment of Alzheimer's Disease: Synthesis, Pharmacology, and Molecular Modeling Studies. ACS chemical neuroscience, 8 (12), 2667-2675. doi: 10.1021/acschemneuro.7b00229
Xie, Nan, Khabbazi, Samira, Nassar, Zeyad D, Gregory, Kye, Vithanage, Tharindu, Anand-Apte, Bela, Cabot, Peter J, Sturgess, David, Shaw, Paul N and Parat, Marie-Odile (2017). Morphine alters the circulating proteolytic profile in mice: functional consequences on cellular migration and invasion. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 31 (12), 5208-5216. doi: 10.1096/fj.201700546R
Khaw, Kooi-Yeong, Parat, Marie-Odile, Shaw, Paul Nicholas and Falconer, James Robert (2017). Solvent supercritical fluid technologies to extract bioactive compounds from natural sources: a review. Molecules, 22 (7) 1186, 1186. doi: 10.3390/molecules22071186
Thakur, Sachin S., Ward, Micheal S., Popat, Amirali, Flemming, Nicole B., Parat, Marie-Odile, Barnett, Nigel L. and Parekh, Harendra S. (2017). Stably engineered nanobubbles and ultrasound - An effective platform for enhanced macromolecular delivery to representative cells of the retina. Plos One, 12 (5) e0178305, e0178305. doi: 10.1371/journal.pone.0178305
Xie, Nan, Gomes, Fabio P., Deora, Vandana, Gregory, Kye, Vithanage, Tharindu, Nassar, Zeyad D., Cabot, Peter J., Sturgess, David, Shaw, Paul N. and Parat, Marie-Odile (2017). Activation of μ-opioid receptor and Toll-like receptor 4 by plasma from morphine-treated mice. Brain, Behavior, and Immunity, 61, 244-258. doi: 10.1016/j.bbi.2016.12.002
Nguyen, Chau T. H., Webb, Richard I., Lambert, Lynette K., Strounina, Ekaterina, Lee, Edward C., Parat, Marie-Odile, McGuckin, Michael A., Popat, Amirali, Cabot, Peter J. and Ross, Benjamin P. (2017). Bifunctional succinylated ε-polylysine-coated mesoporous silica nanoparticles for pH-responsive and intracellular drug delivery targeting the colon. ACS Applied Materials and Interfaces, 9 (11), 9470-9483. doi: 10.1021/acsami.7b00411
Khabbazi, Samira, Xie, Nan, Pu, Wenjun, Goumon, Yannick and Parat, Marie-Odile (2016). The TLR4-active morphine metabolite morphine-3-glucuronide does not elicit macrophage classical activation in vitro. Frontiers in Pharmacology, 7 (NOV) 441, 441. doi: 10.3389/fphar.2016.00441
Dighe, Satish N., Deora, Girdhar Singh, De la Mora, Eugenio, Nachon, Florian, Chan, Stephen, Parat, Marie-Odile, Brazzolotto, Xavier and Ross, Benjamin P. (2016). Discovery and structure-activity relationships of a highly selective butyrylcholinesterase inhibitor by Structure-based virtual screening. Journal of Medicinal Chemistry, 59 (16), 7683-7689. doi: 10.1021/acs.jmedchem.6b00356
Khabbazi, Samira, Nassar, Zeyad D., Goumon, Yannick and Parat, Marie-Odile (2016). Morphine decreases the pro-angiogenic interaction between breast cancer cells and macrophages in vitro. Scientific Reports, 6 (1) 31572, 31572. doi: 10.1038/srep31572
Rewatkar, Prartana V., Sester, David P., Parekh, Harendra S. and Parat, Marie-Odile (2016). Express in vitro plasmid transfection achieved with 16+ asymmetric peptide dendrimers. ACS Biomaterials Science and Engineering, 2 (3), 438-445. doi: 10.1021/acsbiomaterials.6b00033
Nguyen, Thao T., Parat, Marie-Odile, Shaw, Paul N., Hewavitharana, Amitha K. and Hodson, Mark P. (2016). Traditional aboriginal preparation alters the chemical profile of carica papaya leaves and impacts on cytotoxicity towards human squamous cell carcinoma. PLoS ONE, 11 (2) e0147956, e0147956. doi: 10.1371/journal.pone.0147956
Rewatkar, Prartana V., Parekh, Harendra S. and Parat, Marie-Odile (2016). Molecular determinants of the cellular entry of asymmetric peptide dendrimers and role of caveolae. PLoS One, 11 (1) e0147491, e0147491.1-e0147491.15. doi: 10.1371/journal.pone.0147491
Nguyen, Thao T., Parat, Marie-Odile, Hodson, Mark P., Pan, Jenny, Shaw, Paul N. and Hewavitharana, Amitha K. (2016). Chemical characterization and in vitro cytotoxicity on squamous cell carcinoma cells of Carica papaya leaf extracts. Toxins, 8 (1), 7.1-7.11. doi: 10.3390/toxins8010007
Xie, Nan and Parat, Marie-Odile (2015). Opioid analgesic agents and cancer cell biology. Current Anesthesiology Reports, 5 (3), 278-284. doi: 10.1007/s40140-015-0118-5
Hiller, Jonathan G., Parat, Marie-Odile and Ben-Eliyahu, Shamgar (2015). The role of perioperative adjuncts in cancer outcomes: beta-adrenergic receptor antagonists, NSAIDs and anti-fibrinolytics. Current Anesthesiology Reports, 5 (3), 291-304. doi: 10.1007/s40140-015-0113-x
Zeyad Nassar, Hill, Michelle, Parton, Robert G., Francois, Mathias and Parat, Marie-Odile (2015). Non-caveolar caveolin-1 expression in prostate cancer cells promotes lymphangiogenesis. Oncoscience, 2 (7), 635-645. doi: 10.18632/oncoscience.180
Khabbazi, Samira, Goumon, Yannick and Parat, Marie-Odile (2015). Morphine modulates interleukin-4- or breast cancer cell-induced pro-metastatic activation of macrophages. Scientific Reports, 5 (1) 11389, 11389.1-11389.12. doi: 10.1038/srep11389
Rewatkar, Prarthana V., Parton, Robert G., Parekh, Harendra S. and Parat, Marie-Odile (2015). Are caveolae a cellular entry route for non-viral therapeutic delivery systems?. Advanced Drug Delivery Reviews, 91, 92-108. doi: 10.1016/j.addr.2015.01.003
Buggy, D. J., Borgeat, A., Cata, J., Doherty, D. G., Doornebal, C. W., Forget, P., Gottumukkala, V., Gottschalk, A., Gupta, A., Gupta, K., Hales, T. G., Hemmings, H. C., Hollmann, M. W., Kurz, A., Ma, D., Parat, M. O., Sessler, D. I., Shorten, G. and Singleton, P. (2015). Consensus statement from the BJA workshop on cancer and anaesthesia. British Journal of Anaesthesia, 114 (1), 2-3. doi: 10.1093/bja/aeu262
Moon, Hyeongsun, Ruelcke, Jayde E., Choi, Eunju, Sharpe, Laura J., Nassar, Zeyad D., Bielefeldt-ohmann, Helle, Parat, Marie-Odile, Shah, Anup, Francois, Mathias, Inder, Kerry L., Brown, Andrew J., Russell, Pamela J., Parton, Robert G. and Hill, Michelle M. (2015). Diet-induced hypercholesterolemia promotes androgenindependent prostate cancer metastasis via IQGAP1 and caveolin-1. Oncotarget, 6 (10), 7438-7453. doi: 10.18632/oncotarget.3476
Afsharimani, B., Doornebal, C. W., Cabot, P. J., Hollmann, M. W. and Parat, M.-O. (2015). Comparison and analysis of the animal models used to study the effect of morphine on tumour growth and metastasis. British Journal of Pharmacology, 172 (2), 251-259. doi: 10.1111/bph.12589
Afsharimani, B., Cabot, P. J. and Parat, M.-O. (2014). Effect of lysine antifibrinolytics and cyclooxygenase inhibitors on the proteolytic profile of breast cancer cells interacting with macrophages or endothelial cells. British Journal of Anaesthesia, Advance Access (SUPPL. 1), 1-10. doi: 10.1093/bja/aet468
Nassar, Zeyad D., Moon, Hyeongsun, Duong, Tam, Neo, LiQi, Hill, Michelle M., Francois, Mathias, Parton, Robert G. and Parat, Marie-Odile (2013). PTRF/Cavin-1 decreases prostate cancer angiogenesis and lymphangiogenesis. Oncotarget, 4 (10), 1844-1855. doi: 10.18632/oncotarget.1300
Afsharimani, Banafsheh, Baran, JoAnne, Watanabe, Satoshi, Lindner, Daniel, Cabot, Peter J. and Parat, Marie-Odile (2013). Morphine and breast tumor metastasis: the role of matrix-degrading enzymes. Clinical and Experimental Metastasis, Online First (2), 1-10. doi: 10.1007/s10585-013-9616-3
Nassar, Zeyad D., Hill, Michelle M., Parton, Robert G. and Parat, Marie-Odile (2013). Caveola-forming proteins caveolin‑1 and PTRF in prostate cancer. Nature Reviews Urology, 10 (9), 529-536. doi: 10.1038/nrurol.2013.168
Davis, Felicity M., Parsonage, Michelle T., Cabot, Peter J., Parat, Marie-Odile, Thompson, Erik W., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2013). Assessment of gene expression of intracellular calcium channels, pumps and exchangers with epidermal growth factor-induced epithelial-mesenchymal transition in a breast cancer cell line. Cancer Cell International, 13 (76) 76, 1-7. doi: 10.1186/1475-2867-13-76
Nguyen, Thao T. T., Shaw, Paul N., Parat, Marie-Odile and Hewavitharana, Amitha K. (2013). Anticancer activity of Carica papaya: a review. Molecular Nutrition and Food Research, 57 (1), 153-164. doi: 10.1002/mnfr.201200388
Fu, Yi, Moore, Xiao-Lei, Lee, Man K. S., Fernández-Rojo, Manuel A., Parat, Marie-Odile, Parton, Robert G., Meikle, Peter J., Sviridov, Dmitri and Chin-Dusting, Jaye P. F. (2012). Caveolin-1 plays a critical role in the differentiation of monocytes into macrophages. Arteriosclerosis, Thrombosis, and Vascular Biology, 32 (9), e117-e125. doi: 10.1161/ATVBAHA.112.254151
Hill, Michelle M., Daud, Noor Huda, Aung, Cho Sanda, Loo, Dorothy, Martin, Sally, Murphy, Samantha, Black, Debra M., Barry, Rachael, Simpson, Fiona, Liu, Libin, Pilch, Paul F, Hancock, John F., Marie-Odile Parat and Parton, Robert G. (2012). Co-regulation of cell polarization and migration by caveolar proteins PTRF/cavin-1 and caveolin-1. PLoS One, 7 (8) e43041, e43041.1-e43041.9. doi: 10.1371/journal.pone.0043041
Peters, Amelia A., Simpson, Peter T., Bassett, Johnathon J., Lee, Jane M., Da Silva, Leonard, Reid, Lynne E., Song, Sarah, Parat, Marie-Odile, Lakhani, Sunil R., Kenny, Paraic A., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2012). Calcium channel TRPV6 as a potential therapeutic target in estrogen receptor negative breast cancer. Molecular Cancer Therapeutics, 11 (10), 2158-2168. doi: 10.1158/1535-7163.MCT-11-0965
Parat, Marie-Odile and Riggins, Gregory J. (2012). Caveolin-1, caveolae, and glioblastoma. Neuro-Oncology, 14 (6), 679-688. doi: 10.1093/neuonc/nos079
Davis, Felicity M., Peters, Amelia A., Grice, Desma M., Cabot, Peter J., Parat, Marie-Odile, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2012). Non-stimulated, agonist-stimulated and store-operated ca2+ influx in MDA-MB-468 breast cancer cells and the effect of EGF-induced EMT on calcium entry. PLoS One, 7 (5) e36923, e36923.1-e36923.11. doi: 10.1371/journal.pone.0036923
Morais, Christudas, Ebrahem, Quteba, Anand-Apte, Bela and Parat, Marie-Odile (2012). Altered angiogenesis in caveolin-1 gene-deficient mice is restored by ablation of endothelial nitric oxide synthase. American Journal of Pathology, 180 (4), 1702-1714. doi: 10.1016/j.ajpath.2011.12.018
Weber, Genevieve L., Parat, Marie-Odile, Binder, Zev A., Gallia, Gary L. and Riggins, Gregory J. (2011). Abrogation of PIK3CA or PIK3R1 reduces proliferation, migration, and invasion in glioblastoma multiforme cells. Oncotarget, 2 (11), 833-849. doi: 10.18632/oncotarget.346
Afsharimani, Banafsheh, Cabot, Peter J. and Parat, Marie-Odile (2011). Morphine use in cancer surgery. Frontiers in Pharmacology, 2 (46) Article 46, 1-8. doi: 10.3389/fphar.2011.00046
Davis, Felicity M., Kenny, Paraic A., Soo, Eliza T.-L., van Denderen, Bryce J. W., Thompson, Erik W., Cabot, Peter J., Parat, Marie-Odile, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2011). Remodeling of purinergic receptor-mediated Ca(2+) signaling as a consequence of EGF-induced epithelial-mesenchymal transition in breast cancer cells. PLoS One, 6 (8) e23464, e23464.1-e23464.9. doi: 10.1371/journal.pone.0023464
Hill, Michelle M., Parat, Marie-Odile, Parton, Robert G. and Lee, C. Soon (2011). Clearing the confusion of Cav1 and caveolae in cancer compartments. Cell Online, 146 (1).
Afsharimani, Banafsheh, Cabot, Peter and Parat, Marie-Odile (2011). Morphine and tumor growth and metastasis. Cancer and Metastasis Reviews, 30 (2), 225-238. doi: 10.1007/s10555-011-9285-0
Cho, Sanda Aung, Hill, Michelle M., Bastiani, Michele, Parton, Robert G. and Parat, Marie-Odile (2011). PTRF-cavin -1 expression decreases the migration of PC3 prostate cancer cells: Role of matrix metalloprotease 9. European Journal of Cell Biology, 90 (2-3), 136-142. doi: 10.1016/j.ejcb.2010.06.004
Parat, Marie, Blanchet, Jonathan and De Léan, André (2010). Role of juxtamembrane and transmembrane domains in the mechanism of natriuretic peptide receptor a activation. Biochemistry, 49 (22), 4601-4610. doi: 10.1021/bi901711w
Daud, Noor Huda, Aung, Cho Sanda, Hewavitharana, Amitha K., Wilkinson, Ashley S., Pierson, Jean-Thomas, Roberts-Thomson, Sarah J., Shaw, P. Nicholas, Monteith, Gregory R., Gidley, Michael J. and Parat, Marie-Odile (2010). Mango extracts and the mango component mangiferin promote endothelial cell migration. Journal of Agricultural and Food Chemistry, 58 (8), 5181-5186. doi: 10.1021/jf100249s
Sessler, Daniel I., Ben-Eliyahu, Shamgar, Mascha, Edward J., Parat, Marie-Odile and Buggy, Donal J. (2008). Can regional analgesia reduce the risk of recurrence after breast cancer?: Methodology of a multicenter randomized trial. Contemporary Clinical Trials, 29 (4), 517-526. doi: 10.1016/j.cct.2008.01.002
Baran, J., Mundy, D. I., Vasanji, A. and Parat, M-O. (2008). Altered localization of H-Ras in caveolin-1-null cells is palmitoylation-independent. Journal of Cell Communication and Signaling, 1 (3-4), 195-204. doi: 10.1007/s12079-008-0017-3
Hill, Michelle M., Scherbakov, Nadja, Schiefermeier, Natalia, Baran, JoAnne, Hancock, John F., Huber, Lukas A., Parton, Robert G. and Parat, Marie-Odile (2007). Reassessing the Role of Phosphocaveolin-1 in Cell Adhesion and Migration. Traffic, 8 (12), 1695-1705. doi: 10.1111/j.1600-0854.2007.00653.x
Santilman, V., Baran, J., Anand-Apte, B., Evans, R. M. and Parat, M. (2007). Caveolin-1 polarization in transmigrating endothelial cells requires binding to intermediate filaments. Angiogenesis, 10 (4), 297-305. doi: 10.1007/s10456-007-9083-z
Santilman, Virginie, Baran, JoAnne, Anand-Apte, Bela, Fox, Paul L. and Parat, Marie-Odile (2006). Caveolin-1 polarization in migrating endothelial cells is directed by substrate topology not chemoattractant gradient. Cell Motility and the Cytoskeleton, 63 (11), 673-680. doi: 10.1002/cm.20153
Parat, M. O. (2006). Could Endothelial Caveolae be the Target of General Anaesthetics. British Journal of Anaesthesia, 96 (5), 547-550. doi: 10.1093/bja/ael079
Navarro, Angels, Anand-Apte, Bela and Parat, Marie-Odile (2004). A role for caveolae in cell migration. The FASEB Journal, 18 (15), 1801-1811. doi: 10.1096/fj.04-2516rev
Parat, Marie-Odile and Fox, Paul L (2004). Oxidative stress, caveolae and caveolin-1. Sub-cellular biochemistry, 37, 425-441.
Parat, Marie-Odile and Fox, Paul L (2004). Oxidative stress, caveolae and caveolin-1. Sub-cellular biochemistry, 37, 425-41.
Parat, M. O., Anande-Apte, B. and Fox, P. L. (2003). Differential Caveolin-1 Polarization in Endothelial Cells during Migration in Two and Three Dimensions. Molecular biology of the cell, 14 (8), 3156-3168. doi: 10.1091/mbc.E02-11-0761
Parat, M. O., Stachowicz, R. Z. and Fox, P. L. (2002). Oxidative stress inhibits caveolin-1 palmitoylation and trafficking in endothelial cells. Biochemical Journal, 361 (3), 681-688. doi: 10.1042/0264-6021:3610681
Parat, Marie-Odile and Fox, Paul L. (2001). Palmitoylation of caveolin-1 in endothelial cells is post-translational but irreversible. Journal of Biological Chemistry, 276 (19), 15776-15782. doi: 10.1074/jbc.M006722200
Parat, Marie-Odile, Richard, Marie-Jeanne, Meplan, Catherine, Favier, Alain and Beani, Jean-Claude (1999). Impairment of cultured cell proliferation and metallothionein expression by metal chelator NNN'N'-tetrakis-(2-pyridylmethyl)ethylene diamine. Biological Trace Element Research, 70 (1), 51-68. doi: 10.1007/BF02783849
Parat, Marie-Odile, Richard, Marie-Jeanne, Favier, Alain and Beani, Jean-Claude (1998). Metal chelator NNN'N'-tetrakis-(2-pyridylmethyl)ethylene diamine inhibits the induction of heat shock protein 70 synthesis by heat in cultured keratinocytes. Biological Trace Element Research, 65 (3), 261-270. doi: 10.1007/BF02789101
Verhaegh, Gerald W., Parat, Marie-Odile, Richard, Marie-Jeanne and Hainaut, Pierre (1998). Modulation of p53 protein conformation and DNA-binding activity by intracellular chelation of zinc. Molecular Carcinogenesis, 21 (3), 205-214. doi: 10.1002/(SICI)1098-2744(199803)21:3<205::AID-MC8>3.0.CO;2-K
Parat, Marie-Odile, Richard, Marie-Jeanne, Beani, Jean-Claude and Favier, Alain (1997). Involvement of zinc in intracellular oxidant/antioxidant balance. Biological Trace Element Research, 60 (3), 187-204. doi: 10.1007/BF02784439
Parat, Marie-Odile, Richard, Marie-Jeanne, Pollet, Ségolène, Hadjur, Christophe, Favier, Alain and Beani, Jean-Claude (1997). Zinc and DNA fragmentation in keratinocyte apoptosis: its inhibitory effect in UVB irradiated cells. Journal of Photochemistry and Photobiology B: Biology, 37 (1-2), 101-106. doi: 10.1016/S1011-1344(96)07334-4
Hadjur, Christophe, Richard, Marie-Jeanne, Parat, Marie-Odile, Jardon, Pierre and Favier, Alain (1996). Photodynamic effects of hypericin on lipid peroxidation and antioxidant status in melanoma cells. Photochemistry and Photobiology, 64 (2), 375-381. doi: 10.1111/j.1751-1097.1996.tb02474.x
Hadjur, C., Richard, M. J., Parat, M. O., Favier, A. and Jardon, P. (1995). Photodynamically induced cytotoxicity of hypericin dye on human fibroblast cell line MRC5. Journal of Photochemistry and Photobiology B: Biology, 27 (2), 139-146. doi: 10.1016/1011-1344(94)07064-U
Parat, Marie-Odile, Richard, Marie-Jeanne, Leccia, Marie Thérèse, Amblard, Pierre, Favier, Alain and Béani, Jean Claude (1995). Does manganese protect cultured human skin fibroblasts against oxidative injury by UVA, dithranol and hydrogen peroxide?. European Journal of Endocrinology, 23 (4), 339-351. doi: 10.3109/10715769509065255
Conference Papers
Sheikh, M., Alcala, K., Mariosa, D., Feng, X., Sarich, P., Weber, M., Fournier, A., Brennan, P., Parat, M.-O., Pearson, S.-A. and Robbins, H.A. (2023). Regular Use of Pharmaceutical Opioids and Subsequent Risk of Lung Cancer. 2023 World Conference on Lung Cancer, Singapore, 9-12 September 2023. New York, NY United States: Elsevier. doi: 10.1016/j.jtho.2023.09.132
Patil, A., Fitzgerald, M., Shaw, Paul N. and Parat, M. O. (2017). Bioactivity in Australian native willow: comparative analysis of leaf extracts on cell viability. International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA 2017), Basel, Switzerland, 3-7 September 2017. Stuttgart, Germany: Georg Thieme Verlag KG. doi: 10.1055/s-0037-1608430
Khaw, Kooi Yeong, Parat, Marie-Odile, Shaw, Paul N. and Falconer, James R. (2017). Screening of parameters affecting supercritical CO2 extraction of freeze-dried leaf juice of Carica papaya. Drug Delivery Australia (DDA), Wollongong, NSW Australia, 23-24 October 2017.
Xie, Nan, Cabot, Peter, Shaw, Paul N., Sturgess, David and Parat, Marie-Odile (2016). Establishment of new methods to quantify the Mu-opioid and Tlr-4 receptor activation potential in biological samples to assess the influence of opioids on tumor metastasis. COSA's 43rd and ANZBCTG's 38th Annual Scientific Meetings. Partners for Progress in Breast Cancer Research and Care, Gold Coast, QLD, Australia, 15–17 November 2016. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing.
Parat, M. O., Xie, N., Cabot, P., Shaw, N., Gregory, K. and Sturgess, D. (2015). Quantification the mu-opioid and TLR4 receptor activation potential in the circulation of mice and humans to assess the influence of morphine on tumour metastasis. Australian and New Zealand College of Anaesthetists Annual Scientific Meeting, Adelaide AU, 2-5 May 2015.
Nguyen, Thao, Parat, Marie-Odile, Hodson, Mark P., Shaw, P. Nicholas and Hewavitharana, Amitha K. (2014). Investigation of compounds with cytotoxic activity in Carica papaya leaves. ICDDT 2014: 6th International Conference on Drug Discovery and Therapy, Dubai, United Arab Emirates, February 2014. Saif Zone, Sharjah, UAE:
Moon, Hyeongsun, Sharpe, Laura, Choi, Eunju, Bielefeldt-Ohmann, Helle, Nassar, Zeyad, Parat, Marie-Odile, Francois, Mathias, Lee, C. Soon, Brown, Andrew, Russell, Pamela, Inder, Kerry and Hill, Michelle (2014). Hypercholesterolemia promotes prostate cancer PC-3 metastases in orthotopic xenograft mice. 105th Annual Meeting of the American Association for Cancer Research (AACR), San Diego, CA United States, 05-09 April 2014. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.AM2014-4950
Sturgess, D., Morrison, S., Turner, M., Gregory, K. and Parat, M.-O. (2014). Carbetocin use during caesarean section is independently associated with a reduction in post-partum haemorrhage. Australian and New Zealand College of Anaesthetists Annual Scientific Meeting, Singapore, 5-9 May 2014.
Nassar, Z.D., Francois, M., Parton, R.G. and Parat, M.O. (2014). 1588P - Caveolin-1 Modulates Vegf-A and Vegf-C Expression and Enhances Prostate Cancer Lymphangiogenesis Potential. 39th ESMO Congress (ESMO 2014), Madrid, Spain, 26 – 30 September 2014. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/annonc/mdu358.19
Imani, Banafsheh Afshar, Baran, JoAnne, Cabot, Peter J. and Parat, Marie-Odile (2013). Morphine modulates the paracrine interaction between breast tumor cells and macrophages. 104th Annual Meeting of the American-Association-for-Cancer-Research (AACR), Washington Dc, 6 - 10 April 2013. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.AM2013-2808
Peters, A. A., Simpson, P. T., Bassett, J. J., Lee, J. M., Song, S., Parat, M. O., Lakhani, S. R., Kenny, P. A., Roberts-Thomson, S. J. and Monteith, G. R. (2012). Calcium channel transient receptor potential V6 (TRPV6) as a potential therapeutic target for some breast cancers. 24th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, Dublin, Ireland, 6-9 November 2012. Oxford, United Kingdom: Pergamon. doi: 10.1016/S0959-8049(12)72328-6
Davis, Felicity, Kenny, P. A., Soo, E. T. L., van Denderen, B. J., Thompson, E. W., Cabot, Peter J., Parat, Marie-Odile, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2011). Alterations in purinergic receptor-mediated signalling as a consequence of epidermal growth factor-induced epithelial mesenchymal transition (EMT) in breast cancer cells. 3rd EMBO Meeting, Vienna, Austria, 10-13 September 2011.
Davis, Felicity, Kenny, Paraic A., Soo, Eliza T.-L., van Denderen, Bryce J. W., Thompson, Erik W., Cabot, Peter J., Marie-Odile Parat, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2011). Remodeling of purinergic receptor-mediated calcium signalling during epidermal growth factor-induced EMT in a breast cancer cell line. 5th International Epithelial-Mesenchymal Transition Meeting, Singapore, 10-13 October 2011.
Davis, Felicity, Paraic, Kenny A, Cabot, Peter J., Parat, Marie-Odile, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2010). Growth factor-mediated changes in purinergic receptor signaling in breast cancer cells. ASCEPT Annual Scientific Meeting 2010, Melbourne, 28 November - 1 December 2010.
Davis, Felicity, Paraic, Kenny A, Cabot, Peter J., Parat, Marie-Odile, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2010). Growth factor-mediated changes in receptor-stimulated calcium signaling in breast cancer cells. New Horizons in Calcium Signaling, Beijiing, China, October 10-13 2010.
Parat, M. O., Anand-Apte, B. and Fox, P. L. (2003). Differential caveolin-1 polarization in endothelial cells during migration in 2-and 3-dimensions. Experimental Biology 2003 Meeting, San Diego CA, United States, 11-15 April 2003. Bethesda, MD, United States: Federation of American Societies for Experimental Biology.
Richard, Marie-Jeanne, Emonet-Piccardi, Nathalie, Didier, Christine, Jourdan, Eric, Leccia, Marie-Thérèse, Parat, Marie-Odile, Cadet, Jean, Beani, Jean Claude and Favier, Alain (2002). Cooperative effects of zinc/selenium and thiols in the protection against UV-induced genomic DNA damage. 10th International Symposium on Trace Elements in Man and Animals (TEMA 10), Evian les Bains, France, 2 - 7 May 1999. 9780306463785: Springer.
Parat, M. O. and Fox, P. L. (2000). Palmitoylation of caveolin-1 in endothelial cells: recycling does not occur due to absence of depalmitoylation. -, -, -. Bethesda, MD, United States: American Society for Cell Biology.
Parat, M. O., Richard, M. J., Favier, A., Amblard, P. and Beani, J. C. (1996). Zinc and DNA fragmentation in keratinocyte apoptosis. Congrès Annuel de Recherche Dermatologique 96, -, 1996. London, United Kingdom: Nature Publishing Group. doi: 10.1111/1523-1747.ep12329774
Parat, M.O., Mammone, T., Richard, M.J., Amblard, P., Beani, J.C. and Favier, A. (1995). Zinc and UVB cytotoxicity on cultured transformed keratinocytes. Meeting, unknown, 1995. London, United Kingdom: Nature Publishing Group.